JP2012162493A - 光学活性含フッ素2,3−ジヒドロピリドン誘導体及びその製造方法。 - Google Patents
光学活性含フッ素2,3−ジヒドロピリドン誘導体及びその製造方法。 Download PDFInfo
- Publication number
- JP2012162493A JP2012162493A JP2011024628A JP2011024628A JP2012162493A JP 2012162493 A JP2012162493 A JP 2012162493A JP 2011024628 A JP2011024628 A JP 2011024628A JP 2011024628 A JP2011024628 A JP 2011024628A JP 2012162493 A JP2012162493 A JP 2012162493A
- Authority
- JP
- Japan
- Prior art keywords
- optically active
- trifluoromethyl
- tert
- reaction
- active fluorine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 15
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 title claims abstract description 12
- 239000011737 fluorine Substances 0.000 title claims abstract description 12
- 229910052731 fluorine Inorganic materials 0.000 title claims abstract description 12
- FPGGLMIYNLQOID-UHFFFAOYSA-N 3h-pyridin-2-one Chemical class O=C1CC=CC=N1 FPGGLMIYNLQOID-UHFFFAOYSA-N 0.000 title claims abstract description 10
- 239000002253 acid Substances 0.000 claims abstract description 6
- 238000006243 chemical reaction Methods 0.000 claims description 18
- 239000002841 Lewis acid Substances 0.000 claims description 7
- 150000007517 lewis acids Chemical class 0.000 claims description 7
- 150000001993 dienes Chemical class 0.000 claims description 4
- CWZUWENORGSFBV-UHFFFAOYSA-N COC=CC(=C)O[Si](F)(F)F Chemical compound COC=CC(=C)O[Si](F)(F)F CWZUWENORGSFBV-UHFFFAOYSA-N 0.000 abstract description 4
- -1 trifluoromethyl tert-butyl sulfine imine Chemical class 0.000 abstract description 4
- 239000003905 agrochemical Substances 0.000 abstract description 3
- 239000003814 drug Substances 0.000 abstract description 3
- 239000011541 reaction mixture Substances 0.000 abstract 1
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 9
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 8
- 150000001875 compounds Chemical class 0.000 description 8
- 239000002904 solvent Substances 0.000 description 8
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- 238000006077 hetero Diels-Alder cycloaddition reaction Methods 0.000 description 5
- 238000005481 NMR spectroscopy Methods 0.000 description 4
- 239000012043 crude product Substances 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- VXUYXOFXAQZZMF-UHFFFAOYSA-N titanium(IV) isopropoxide Chemical compound CC(C)O[Ti](OC(C)C)(OC(C)C)OC(C)C VXUYXOFXAQZZMF-UHFFFAOYSA-N 0.000 description 3
- 238000005160 1H NMR spectroscopy Methods 0.000 description 2
- FRPBQTFQWOFMEI-UHFFFAOYSA-N 2-(difluoromethyl)-1-(1-phenylethyl)-2,3-dihydropyridin-4-one Chemical class C=1C=CC=CC=1C(C)N1C=CC(=O)CC1C(F)F FRPBQTFQWOFMEI-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- YNQLUTRBYVCPMQ-UHFFFAOYSA-N Ethylbenzene Chemical compound CCC1=CC=CC=C1 YNQLUTRBYVCPMQ-UHFFFAOYSA-N 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 229910052938 sodium sulfate Inorganic materials 0.000 description 2
- 235000011152 sodium sulphate Nutrition 0.000 description 2
- CESUXLKAADQNTB-UHFFFAOYSA-N tert-butanesulfinamide Chemical compound CC(C)(C)S(N)=O CESUXLKAADQNTB-UHFFFAOYSA-N 0.000 description 2
- IDIMFLKKUCXTDH-UHFFFAOYSA-N tert-butyl 4-oxo-2-(trifluoromethyl)-2,3-dihydropyridine-1-carboxylate Chemical class C(C)(C)(C)OC(=O)N1C(CC(C=C1)=O)C(F)(F)F IDIMFLKKUCXTDH-UHFFFAOYSA-N 0.000 description 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 2
- GETTZEONDQJALK-UHFFFAOYSA-N (trifluoromethyl)benzene Chemical compound FC(F)(F)C1=CC=CC=C1 GETTZEONDQJALK-UHFFFAOYSA-N 0.000 description 1
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 1
- LWILBNUCDOFKEF-UHFFFAOYSA-N 1-(1-phenylethyl)-2-(trifluoromethyl)-2,3-dihydropyridin-4-one Chemical class C=1C=CC=CC=1C(C)N1C=CC(=O)CC1C(F)(F)F LWILBNUCDOFKEF-UHFFFAOYSA-N 0.000 description 1
- JVTSHOJDBRTPHD-UHFFFAOYSA-N 2,2,2-trifluoroacetaldehyde Chemical compound FC(F)(F)C=O JVTSHOJDBRTPHD-UHFFFAOYSA-N 0.000 description 1
- HLEPWSHQXFPJSP-UHFFFAOYSA-N 2-(oxomethylidene)piperidin-4-one Chemical compound O=C=C1CC(=O)CCN1 HLEPWSHQXFPJSP-UHFFFAOYSA-N 0.000 description 1
- YDYIQSNDNIDHTG-UHFFFAOYSA-N 2-methyl-2,3-dihydro-1h-pyridin-4-one Chemical class CC1CC(=O)C=CN1 YDYIQSNDNIDHTG-UHFFFAOYSA-N 0.000 description 1
- OBOSXEWFRARQPU-UHFFFAOYSA-N 2-n,2-n-dimethylpyridine-2,5-diamine Chemical compound CN(C)C1=CC=C(N)C=N1 OBOSXEWFRARQPU-UHFFFAOYSA-N 0.000 description 1
- IWWDWOYKHMTHSL-UHFFFAOYSA-N 4-methoxybuta-1,3-dien-2-yl(trimethyl)silane Chemical compound COC=CC(=C)[Si](C)(C)C IWWDWOYKHMTHSL-UHFFFAOYSA-N 0.000 description 1
- KEDNSMBVYXSBFC-UHFFFAOYSA-N 6-bromo-2-chloroquinoline-4-carbonyl chloride Chemical compound C1=C(Br)C=C2C(C(=O)Cl)=CC(Cl)=NC2=C1 KEDNSMBVYXSBFC-UHFFFAOYSA-N 0.000 description 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 1
- HWKBVGOZKKJECD-UHFFFAOYSA-N C(C)(C)(C)OSN1C(CC(C=C1)=O)C(F)(F)F Chemical compound C(C)(C)(C)OSN1C(CC(C=C1)=O)C(F)(F)F HWKBVGOZKKJECD-UHFFFAOYSA-N 0.000 description 1
- SAWPRQAGDJXIED-UHFFFAOYSA-N C(C)(C)(C)SN1C(CC(C=C1)=O)C(F)(F)F Chemical compound C(C)(C)(C)SN1C(CC(C=C1)=O)C(F)(F)F SAWPRQAGDJXIED-UHFFFAOYSA-N 0.000 description 1
- MEGIJGYJHKHEQO-UHFFFAOYSA-N C(C)O[Ce] Chemical compound C(C)O[Ce] MEGIJGYJHKHEQO-UHFFFAOYSA-N 0.000 description 1
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 1
- GNXGTKAMKLQVOQ-UHFFFAOYSA-N FC(C1NC=CC(C1)=O)(F)F Chemical compound FC(C1NC=CC(C1)=O)(F)F GNXGTKAMKLQVOQ-UHFFFAOYSA-N 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 235000002597 Solanum melongena Nutrition 0.000 description 1
- 244000061458 Solanum melongena Species 0.000 description 1
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 description 1
- MPZQTUXRABUJPR-UHFFFAOYSA-N [Sm+3].CC[O-].CC[O-].CC[O-] Chemical compound [Sm+3].CC[O-].CC[O-].CC[O-] MPZQTUXRABUJPR-UHFFFAOYSA-N 0.000 description 1
- SFQFALFFPZWZMC-UHFFFAOYSA-N [Yb].C(C)O[SiH](OCC)OCC Chemical compound [Yb].C(C)O[SiH](OCC)OCC SFQFALFFPZWZMC-UHFFFAOYSA-N 0.000 description 1
- MEMUCXUKCBNISQ-UHFFFAOYSA-N acetonitrile;trifluoroborane Chemical compound CC#N.FB(F)F MEMUCXUKCBNISQ-UHFFFAOYSA-N 0.000 description 1
- 238000005804 alkylation reaction Methods 0.000 description 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- JOAPBVRQZQYKMS-UHFFFAOYSA-N buta-1,3-dien-2-yloxy(trimethyl)silane Chemical compound C[Si](C)(C)OC(=C)C=C JOAPBVRQZQYKMS-UHFFFAOYSA-N 0.000 description 1
- UQGOYQLRRBTVFM-UHFFFAOYSA-N buta-1,3-dienoxy(trimethyl)silane Chemical compound C[Si](C)(C)OC=CC=C UQGOYQLRRBTVFM-UHFFFAOYSA-N 0.000 description 1
- VYLVYHXQOHJDJL-UHFFFAOYSA-K cerium trichloride Chemical compound Cl[Ce](Cl)Cl VYLVYHXQOHJDJL-UHFFFAOYSA-K 0.000 description 1
- FCSYOKKSVLQUBC-UHFFFAOYSA-N cerium(3+);methanolate Chemical compound [Ce+3].[O-]C.[O-]C.[O-]C FCSYOKKSVLQUBC-UHFFFAOYSA-N 0.000 description 1
- PHSMPGGNMIPKTH-UHFFFAOYSA-K cerium(3+);trifluoromethanesulfonate Chemical compound [Ce+3].[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F PHSMPGGNMIPKTH-UHFFFAOYSA-K 0.000 description 1
- MOOUSOJAOQPDEH-UHFFFAOYSA-K cerium(iii) bromide Chemical compound [Br-].[Br-].[Br-].[Ce+3] MOOUSOJAOQPDEH-UHFFFAOYSA-K 0.000 description 1
- WQAJKGNQVZTJAE-UHFFFAOYSA-M chloro(diethoxy)alumane Chemical compound [Cl-].CCO[Al+]OCC WQAJKGNQVZTJAE-UHFFFAOYSA-M 0.000 description 1
- IFMWVBVPVXRZHE-UHFFFAOYSA-M chlorotitanium(3+);propan-2-olate Chemical compound [Cl-].[Ti+4].CC(C)[O-].CC(C)[O-].CC(C)[O-] IFMWVBVPVXRZHE-UHFFFAOYSA-M 0.000 description 1
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 description 1
- SHALBPKEGDBVKK-VOTSOKGWSA-N danishefsky's diene Chemical compound CO\C=C\C(=C)O[Si](C)(C)C SHALBPKEGDBVKK-VOTSOKGWSA-N 0.000 description 1
- ODWTVGWVVYTUKA-UHFFFAOYSA-M dimethoxyalumanylium;chloride Chemical compound [Cl-].CO[Al+]OC ODWTVGWVVYTUKA-UHFFFAOYSA-M 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- CCUCUHRUAPGBHB-UHFFFAOYSA-N ethanolate europium(3+) Chemical compound [Eu+3].CC[O-].CC[O-].CC[O-] CCUCUHRUAPGBHB-UHFFFAOYSA-N 0.000 description 1
- NPAJGHOZGYPSTK-UHFFFAOYSA-N ethanolate;lanthanum(3+) Chemical compound [La+3].CC[O-].CC[O-].CC[O-] NPAJGHOZGYPSTK-UHFFFAOYSA-N 0.000 description 1
- QMYQAWPIPPLING-UHFFFAOYSA-N ethanolate;scandium(3+) Chemical compound [Sc+3].CC[O-].CC[O-].CC[O-] QMYQAWPIPPLING-UHFFFAOYSA-N 0.000 description 1
- KEQVPIDOPAGWCP-UHFFFAOYSA-N ethanolate;yttrium(3+) Chemical compound [Y+3].CC[O-].CC[O-].CC[O-] KEQVPIDOPAGWCP-UHFFFAOYSA-N 0.000 description 1
- ASBGGHMVAMBCOR-UHFFFAOYSA-N ethanolate;zirconium(4+) Chemical compound [Zr+4].CC[O-].CC[O-].CC[O-].CC[O-] ASBGGHMVAMBCOR-UHFFFAOYSA-N 0.000 description 1
- 239000004210 ether based solvent Substances 0.000 description 1
- LTCGYPJIBNZNSY-UHFFFAOYSA-N europium(3+) methanolate Chemical compound [Eu+3].[O-]C.[O-]C.[O-]C LTCGYPJIBNZNSY-UHFFFAOYSA-N 0.000 description 1
- QEDFUJZRPHEBFG-UHFFFAOYSA-K europium(3+);tribromide Chemical compound Br[Eu](Br)Br QEDFUJZRPHEBFG-UHFFFAOYSA-K 0.000 description 1
- TWNOVENTEPVGEJ-UHFFFAOYSA-K europium(3+);trifluoromethanesulfonate Chemical compound [Eu+3].[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F TWNOVENTEPVGEJ-UHFFFAOYSA-K 0.000 description 1
- NNMXSTWQJRPBJZ-UHFFFAOYSA-K europium(iii) chloride Chemical compound Cl[Eu](Cl)Cl NNMXSTWQJRPBJZ-UHFFFAOYSA-K 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- MEANOSLIBWSCIT-UHFFFAOYSA-K gadolinium trichloride Chemical compound Cl[Gd](Cl)Cl MEANOSLIBWSCIT-UHFFFAOYSA-K 0.000 description 1
- SWWHAAYWGDMRLB-UHFFFAOYSA-N gadolinium(3+) methanolate Chemical compound [Gd+3].[O-]C.[O-]C.[O-]C SWWHAAYWGDMRLB-UHFFFAOYSA-N 0.000 description 1
- KGOKDPWKDBWITQ-UHFFFAOYSA-K gadolinium(3+);tribromide Chemical compound Br[Gd](Br)Br KGOKDPWKDBWITQ-UHFFFAOYSA-K 0.000 description 1
- DYOBTPTUHDTANY-UHFFFAOYSA-K gadolinium(3+);trifluoromethanesulfonate Chemical compound [Gd+3].[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F DYOBTPTUHDTANY-UHFFFAOYSA-K 0.000 description 1
- 150000008282 halocarbons Chemical class 0.000 description 1
- FBAFATDZDUQKNH-UHFFFAOYSA-M iron chloride Chemical compound [Cl-].[Fe] FBAFATDZDUQKNH-UHFFFAOYSA-M 0.000 description 1
- RCFZUDZONKPRJX-UHFFFAOYSA-N lanthanum(3+) methanolate Chemical compound [La+3].[O-]C.[O-]C.[O-]C RCFZUDZONKPRJX-UHFFFAOYSA-N 0.000 description 1
- WGJJZRVGLPOKQT-UHFFFAOYSA-K lanthanum(3+);trifluoromethanesulfonate Chemical compound [La+3].[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F WGJJZRVGLPOKQT-UHFFFAOYSA-K 0.000 description 1
- XKUYOJZZLGFZTC-UHFFFAOYSA-K lanthanum(iii) bromide Chemical compound Br[La](Br)Br XKUYOJZZLGFZTC-UHFFFAOYSA-K 0.000 description 1
- ICAKDTKJOYSXGC-UHFFFAOYSA-K lanthanum(iii) chloride Chemical compound Cl[La](Cl)Cl ICAKDTKJOYSXGC-UHFFFAOYSA-K 0.000 description 1
- ZEIWWVGGEOHESL-UHFFFAOYSA-N methanol;titanium Chemical compound [Ti].OC.OC.OC.OC ZEIWWVGGEOHESL-UHFFFAOYSA-N 0.000 description 1
- PXAINRSJFSAUAN-UHFFFAOYSA-N methanolate samarium(3+) Chemical compound [Sm+3].[O-]C.[O-]C.[O-]C PXAINRSJFSAUAN-UHFFFAOYSA-N 0.000 description 1
- DHOHUZQEYNZEHZ-UHFFFAOYSA-N methanolate ytterbium(3+) Chemical compound [Yb+3].[O-]C.[O-]C.[O-]C DHOHUZQEYNZEHZ-UHFFFAOYSA-N 0.000 description 1
- GAZQTPCOHATOHJ-UHFFFAOYSA-N methanolate;scandium(3+) Chemical compound [Sc+3].[O-]C.[O-]C.[O-]C GAZQTPCOHATOHJ-UHFFFAOYSA-N 0.000 description 1
- WVLGTKBIJRAYME-UHFFFAOYSA-N methanolate;yttrium(3+) Chemical compound [Y+3].[O-]C.[O-]C.[O-]C WVLGTKBIJRAYME-UHFFFAOYSA-N 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- FVSKHRXBFJPNKK-UHFFFAOYSA-N propionitrile Chemical compound CCC#N FVSKHRXBFJPNKK-UHFFFAOYSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- ICKYUJFKBKOPJT-UHFFFAOYSA-K samarium(3+);tribromide Chemical compound Br[Sm](Br)Br ICKYUJFKBKOPJT-UHFFFAOYSA-K 0.000 description 1
- DDCWGUIPLGMBPO-UHFFFAOYSA-K samarium(3+);trifluoromethanesulfonate Chemical compound [Sm+3].[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F DDCWGUIPLGMBPO-UHFFFAOYSA-K 0.000 description 1
- BHXBZLPMVFUQBQ-UHFFFAOYSA-K samarium(iii) chloride Chemical compound Cl[Sm](Cl)Cl BHXBZLPMVFUQBQ-UHFFFAOYSA-K 0.000 description 1
- APPHYFNIXVIIJR-UHFFFAOYSA-K scandium bromide Chemical compound Br[Sc](Br)Br APPHYFNIXVIIJR-UHFFFAOYSA-K 0.000 description 1
- DVMZCYSFPFUKKE-UHFFFAOYSA-K scandium chloride Chemical compound Cl[Sc](Cl)Cl DVMZCYSFPFUKKE-UHFFFAOYSA-K 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 125000004646 sulfenyl group Chemical group S(*)* 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- PUGUQINMNYINPK-UHFFFAOYSA-N tert-butyl 4-(2-chloroacetyl)piperazine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCN(C(=O)CCl)CC1 PUGUQINMNYINPK-UHFFFAOYSA-N 0.000 description 1
- ROUYFJUVMYHXFJ-UHFFFAOYSA-N tert-butyl 4-oxopiperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(=O)CC1 ROUYFJUVMYHXFJ-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- JMXKSZRRTHPKDL-UHFFFAOYSA-N titanium ethoxide Chemical compound [Ti+4].CC[O-].CC[O-].CC[O-].CC[O-] JMXKSZRRTHPKDL-UHFFFAOYSA-N 0.000 description 1
- XJDNKRIXUMDJCW-UHFFFAOYSA-J titanium tetrachloride Chemical compound Cl[Ti](Cl)(Cl)Cl XJDNKRIXUMDJCW-UHFFFAOYSA-J 0.000 description 1
- AJSTXXYNEIHPMD-UHFFFAOYSA-N triethyl borate Chemical compound CCOB(OCC)OCC AJSTXXYNEIHPMD-UHFFFAOYSA-N 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
- AHZJKOKFZJYCLG-UHFFFAOYSA-K trifluoromethanesulfonate;ytterbium(3+) Chemical compound [Yb+3].[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F AHZJKOKFZJYCLG-UHFFFAOYSA-K 0.000 description 1
- JPJIEXKLJOWQQK-UHFFFAOYSA-K trifluoromethanesulfonate;yttrium(3+) Chemical compound [Y+3].[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F JPJIEXKLJOWQQK-UHFFFAOYSA-K 0.000 description 1
- UAEJRRZPRZCUBE-UHFFFAOYSA-N trimethoxyalumane Chemical compound [Al+3].[O-]C.[O-]C.[O-]C UAEJRRZPRZCUBE-UHFFFAOYSA-N 0.000 description 1
- WRECIMRULFAWHA-UHFFFAOYSA-N trimethyl borate Chemical compound COB(OC)OC WRECIMRULFAWHA-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- CKLHRQNQYIJFFX-UHFFFAOYSA-K ytterbium(III) chloride Chemical compound [Cl-].[Cl-].[Cl-].[Yb+3] CKLHRQNQYIJFFX-UHFFFAOYSA-K 0.000 description 1
- QNLXXQBCQYDKHD-UHFFFAOYSA-K ytterbium(iii) bromide Chemical compound Br[Yb](Br)Br QNLXXQBCQYDKHD-UHFFFAOYSA-K 0.000 description 1
- 229940105965 yttrium bromide Drugs 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
- DUNKXUFBGCUVQW-UHFFFAOYSA-J zirconium tetrachloride Chemical compound Cl[Zr](Cl)(Cl)Cl DUNKXUFBGCUVQW-UHFFFAOYSA-J 0.000 description 1
Abstract
Description
[項1] 下記式(1)
[項3] ルイス酸存在下、反応を行うことを特徴とする項2に記載の製造方法
を提供するものである。
攪拌子を備えた50mlのナス型フラスコを窒素置換した後、これに(S)−トリフルオロメチル tert−ブチルスルフィンイミド(261mg、1.30mmol)、1−メトキシ−3−トリフルオロシリルオキシ−1,3−ブタジエン(360mg、1.95mmol)及びTHF(6.0ml)を仕込み、攪拌しながら−80℃に冷却した後、これにテトライソプロポキシチタン(40.0mg、0.14mol)添加し、同温度で18時間反応を行った。
1H−NMR(400MHz,CDCl3)δppm。
19F−NMR(376MHz,CDCl3)δ−81.95(d,J=7.52Hz)ppm。
Minorδ−80.86(d,J=7.52Hz)ppm。
実施例1と同じ反応装置を用い、(S)−トリフルオロメチル tert−ブチルスルフィンイミドに替えて(R)−トリフルオロメチル tert−ブチルスルフィンイミドを用いた以外実施例1と同じ操作を行い、(6S,1'R)−N−tert−ブチルスルフェニル−2−トリフルオロメチル−2,3−ジヒドロ−4−ピリドンを得た(収率74%、目的物/異性体比=90/10(mol/mol))。
1H−NMR(400MHz,CDCl3)δ1.17(s,3H)、2.13(d,1H,J=1.2Hz)、2.14(d,1H,J=3.2Hz)、4.81(d,1H,J=10.4Hz)、5.06−5.13(m,2H)ppm。
19F−NMR(376MHz,CDCl3)δ−81.95(d,J=7.52Hz)ppm。
Minorδ−80.86(d,J=7.52Hz)ppm。
実施例1と同じ反応装置で、(S)−トリフルオロメチル tert−ブチルスルフィンイミド(261mg、1.30mmol)を用い、表1中に示した条件下、反応を行った。結果を表1中に示した。なお、収量、収率、主生成物/異性体の定量は19F−NMRにより行った。
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2011024628A JP5695434B2 (ja) | 2011-02-08 | 2011-02-08 | 光学活性含フッ素2,3−ジヒドロピリドン誘導体及びその製造方法。 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2011024628A JP5695434B2 (ja) | 2011-02-08 | 2011-02-08 | 光学活性含フッ素2,3−ジヒドロピリドン誘導体及びその製造方法。 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2012162493A true JP2012162493A (ja) | 2012-08-30 |
JP5695434B2 JP5695434B2 (ja) | 2015-04-08 |
Family
ID=46842282
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011024628A Active JP5695434B2 (ja) | 2011-02-08 | 2011-02-08 | 光学活性含フッ素2,3−ジヒドロピリドン誘導体及びその製造方法。 |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP5695434B2 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014171937A (ja) * | 2013-03-07 | 2014-09-22 | Osaka City Univ | 不斉アザディールス−アルダー反応用触媒、それを用いた光学活性テトラヒドロピリジン化合物の製造方法 |
-
2011
- 2011-02-08 JP JP2011024628A patent/JP5695434B2/ja active Active
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014171937A (ja) * | 2013-03-07 | 2014-09-22 | Osaka City Univ | 不斉アザディールス−アルダー反応用触媒、それを用いた光学活性テトラヒドロピリジン化合物の製造方法 |
Also Published As
Publication number | Publication date |
---|---|
JP5695434B2 (ja) | 2015-04-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA3175384A1 (en) | Methods and intermediates for preparing therapeutic compounds useful in the treatment of retroviridae viral infection | |
CN102336754B (zh) | 恩替卡韦的合成方法及其中间体化合物 | |
JP7045321B2 (ja) | アミノ酸誘導体のプロドラッグ | |
CN104447443B (zh) | 一种阿普斯特及其中间体的制备方法 | |
CN107188832B (zh) | 一种利用二氧化碳合成含三氟甲基的氨基甲酸酯的方法 | |
CN108069998B (zh) | 一种培南类药物中间体的合成方法 | |
US20230219990A1 (en) | Method for synthesizing c-nucleoside compound | |
CN106674264A (zh) | (2,2,2‑三氟乙氧基)苯硼酸类化合物的合成方法 | |
JP5695434B2 (ja) | 光学活性含フッ素2,3−ジヒドロピリドン誘導体及びその製造方法。 | |
KR20160075816A (ko) | 피리미딘일사이클로펜테인 화합물의 제조 방법 | |
CN104974017B (zh) | (1r,2s)‑2‑(3,4‑二氟苯基)环丙胺·d‑扁桃酸盐的制备方法 | |
JP5918624B2 (ja) | 光学活性含フッ素5,6−ジヒドロピリドン誘導体及びその製造方法 | |
KR20160027536A (ko) | 실로도신 합성에 유용한 중간체의 제조방법 | |
CN109265385B (zh) | 一种手性催化剂的合成工艺 | |
US10562834B2 (en) | Process for preparing substituted crotonic acids | |
CN108727214B (zh) | 一种麻醉剂丁哌卡因杂质的合成方法 | |
Chen et al. | Synthetic studies on (+)-biotin, part 15: A chiral squaramide-mediated enantioselective alcoholysis approach toward the total synthesis of (+)-biotin | |
JP2007222850A (ja) | ディールス・アルダー反応触媒及び不斉環化付加生成物の製造方法 | |
CN112010882A (zh) | 立体选择性制备1,3-双取代环己烷类化合物的方法及应用 | |
CN109942442A (zh) | 一种盐酸达泊西汀有关物质i的制备方法 | |
JP5309680B2 (ja) | フッ素化エステル化合物の製造方法及びその中間体 | |
CN104356156B (zh) | 一种四元环紫杉烷侧链化合物的制备方法 | |
JP7127808B2 (ja) | フルオロアルキル基を含有するイミン類の製造方法 | |
CN106588841B (zh) | 合成2,3-二氢-1-苯并呋喃-4-甲醛的方法 | |
JP2013151452A (ja) | 光学活性トルフルオロメチル基含有イミン誘導体、その製造方法並びにそれを用いたトリフルオロメチル基含有光学活性アミン誘導体の製造方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20140120 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20150203 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20150206 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5695434 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313111 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
S531 | Written request for registration of change of domicile |
Free format text: JAPANESE INTERMEDIATE CODE: R313531 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |