JP2012136519A5 - - Google Patents
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- Publication number
- JP2012136519A5 JP2012136519A5 JP2012004674A JP2012004674A JP2012136519A5 JP 2012136519 A5 JP2012136519 A5 JP 2012136519A5 JP 2012004674 A JP2012004674 A JP 2012004674A JP 2012004674 A JP2012004674 A JP 2012004674A JP 2012136519 A5 JP2012136519 A5 JP 2012136519A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- domain
- structures
- terminal side
- spacer polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 12
- 229920001184 polypeptide Polymers 0.000 claims 12
- 102000004196 processed proteins & peptides Human genes 0.000 claims 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims 12
- 125000006850 spacer group Chemical group 0.000 claims 12
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 8
- 230000000694 effects Effects 0.000 claims 4
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 3
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 210000003719 b-lymphocyte Anatomy 0.000 claims 3
- 230000004069 differentiation Effects 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012004674A JP5901299B2 (ja) | 2006-03-03 | 2012-01-13 | 生物活性を強化した抗体改変体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006057475 | 2006-03-03 | ||
| JP2006057475 | 2006-03-03 | ||
| JP2012004674A JP5901299B2 (ja) | 2006-03-03 | 2012-01-13 | 生物活性を強化した抗体改変体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008502861A Division JP5598894B2 (ja) | 2006-03-03 | 2007-03-02 | 生物活性を強化した抗体改変体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012136519A JP2012136519A (ja) | 2012-07-19 |
| JP2012136519A5 true JP2012136519A5 (enExample) | 2013-05-30 |
| JP5901299B2 JP5901299B2 (ja) | 2016-04-06 |
Family
ID=38459178
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008502861A Expired - Fee Related JP5598894B2 (ja) | 2006-03-03 | 2007-03-02 | 生物活性を強化した抗体改変体 |
| JP2012004674A Expired - Fee Related JP5901299B2 (ja) | 2006-03-03 | 2012-01-13 | 生物活性を強化した抗体改変体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008502861A Expired - Fee Related JP5598894B2 (ja) | 2006-03-03 | 2007-03-02 | 生物活性を強化した抗体改変体 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20090304715A1 (enExample) |
| EP (2) | EP2610268A1 (enExample) |
| JP (2) | JP5598894B2 (enExample) |
| CA (1) | CA2638804C (enExample) |
| ES (1) | ES2602439T3 (enExample) |
| WO (1) | WO2007100083A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090304715A1 (en) * | 2006-03-03 | 2009-12-10 | Tokyo University Of Science | Modified antibodies with enhanced biological activities |
| MX394440B (es) | 2007-06-01 | 2025-03-24 | Univ Maryland | Agentes de union al receptor de la region constante fc de inmunoglobulina. |
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| US20100143353A1 (en) * | 2008-12-04 | 2010-06-10 | Mosser David M | POLYPEPTIDES COMPRISING Fc FRAGMENTS OF IMMUNOGLOBULIN G (lgG) AND METHODS OF USING THE SAME |
| WO2012002562A1 (en) * | 2010-06-30 | 2012-01-05 | Tokyo University Of Science Educational Foundation Administrative Organization | Modified protein therapeutics |
| TR201906652T4 (tr) | 2010-07-28 | 2019-05-21 | Gliknik Inc | Kademeli multimerize immünoglobülin fc bileşimleri oluşturmak için doğal insan protein fragmanları içeren füzyon proteinleri. |
| KR101572338B1 (ko) | 2011-02-28 | 2015-11-26 | 에프. 호프만-라 로슈 아게 | 1가 항원 결합 단백질 |
| JP5764677B2 (ja) * | 2011-02-28 | 2015-08-19 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 抗原結合タンパク質 |
| CN104718223A (zh) | 2012-08-20 | 2015-06-17 | 格利克尼克股份有限公司 | 具有抗原结合和多价FCγ受体结合活性的分子 |
| CA2899052A1 (en) | 2013-01-28 | 2014-07-31 | Evec Inc. | Human antibody specific to human metapneumovirus, or antigen-binding fragment thereof |
| US10519194B2 (en) | 2013-07-12 | 2019-12-31 | Merck Patent Gmbh | Removal of fragments from a sample containing a target protein using activated carbon |
| EP3227328B1 (en) | 2014-12-05 | 2022-10-05 | Merck Patent GmbH | Domain-exchanged antibody |
| DK3325011T6 (da) | 2015-07-24 | 2023-05-15 | Gliknik Inc | Fusionsproteiner af humane proteinfragmenter til fremstilling af ordnede multimeriserede immunoglobulin Fc-sammensætninger med forstærket komplementbinding |
| EP3328427B1 (en) | 2015-07-27 | 2024-05-29 | The General Hospital Corporation | Antibody derivatives with conditionally enabled effector function |
| US11034775B2 (en) | 2016-06-07 | 2021-06-15 | Gliknik Inc. | Cysteine-optimized stradomers |
| CA3043261A1 (en) | 2016-12-09 | 2018-06-14 | Gliknik Inc. | Manufacturing optimization of gl-2045, a multimerizing stradomer |
| CA3043251A1 (en) | 2016-12-09 | 2018-06-14 | Gliknik Inc. | Methods of treating inflammatory disorders with multivalent fc compounds |
| WO2018129397A1 (en) * | 2017-01-06 | 2018-07-12 | Momenta Pharmaceuticals, Inc. | Compositions and methods related to engineered fc-antigen binding domain constructs |
| BR112021000391A2 (pt) * | 2018-07-11 | 2021-04-06 | Momenta Pharmaceuticals, Inc. | Composições e métodos relacionados a construtos do domínio de ligação fc-antígeno manipulado direcionado a ccr4 |
| EP4471147A4 (en) | 2022-01-28 | 2026-01-07 | Evec Inc | Human neutralizing antibody directed against SARS-CoV-2 extending to variant strains, and its antigen-binding fragment |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8824869D0 (en) | 1988-10-24 | 1988-11-30 | Stevenson G T | Synthetic antibody |
| DE3908834A1 (de) | 1989-03-17 | 1990-09-20 | Hollingsworth Gmbh | Vorrichtung zur ausscheidung von verunreinigungen eines faserverbandes an einer karde |
| AU2002250293B2 (en) * | 2001-03-09 | 2007-10-11 | Arnason, Barry G. Mr | Polymeric immunoglobulin fusion proteins that target low-affinity FCGammaReceptors |
| EP2298805A3 (en) * | 2002-09-27 | 2011-04-13 | Xencor, Inc. | Optimized Fc variants and methods for their generation |
| WO2005077981A2 (en) * | 2003-12-22 | 2005-08-25 | Xencor, Inc. | Fc POLYPEPTIDES WITH NOVEL Fc LIGAND BINDING SITES |
| ES2330860T3 (es) * | 2004-01-22 | 2009-12-16 | Merck Patent Gmbh | Anticuerpos anticancerosos con fijacion del complemento reducida. |
| WO2006085967A2 (en) * | 2004-07-09 | 2006-08-17 | Xencor, Inc. | OPTIMIZED ANTI-CD20 MONOCONAL ANTIBODIES HAVING Fc VARIANTS |
| US20090304715A1 (en) * | 2006-03-03 | 2009-12-10 | Tokyo University Of Science | Modified antibodies with enhanced biological activities |
-
2007
- 2007-03-02 US US12/281,437 patent/US20090304715A1/en not_active Abandoned
- 2007-03-02 EP EP13001539.9A patent/EP2610268A1/en not_active Withdrawn
- 2007-03-02 WO PCT/JP2007/054018 patent/WO2007100083A1/ja not_active Ceased
- 2007-03-02 ES ES07737666.3T patent/ES2602439T3/es active Active
- 2007-03-02 CA CA2638804A patent/CA2638804C/en not_active Expired - Fee Related
- 2007-03-02 JP JP2008502861A patent/JP5598894B2/ja not_active Expired - Fee Related
- 2007-03-02 EP EP07737666.3A patent/EP2006305B1/en not_active Not-in-force
-
2012
- 2012-01-13 JP JP2012004674A patent/JP5901299B2/ja not_active Expired - Fee Related
-
2019
- 2019-08-12 US US16/538,482 patent/US20190367630A1/en not_active Abandoned
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