JP2012092341A5 - - Google Patents
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- Publication number
- JP2012092341A5 JP2012092341A5 JP2011255723A JP2011255723A JP2012092341A5 JP 2012092341 A5 JP2012092341 A5 JP 2012092341A5 JP 2011255723 A JP2011255723 A JP 2011255723A JP 2011255723 A JP2011255723 A JP 2011255723A JP 2012092341 A5 JP2012092341 A5 JP 2012092341A5
- Authority
- JP
- Japan
- Prior art keywords
- use according
- conjunctivitis
- compound
- acid
- length
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 5
- 206010010741 Conjunctivitis Diseases 0.000 claims 3
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
- BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 claims 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims 1
- UOQHWNPVNXSDDO-UHFFFAOYSA-N 3-bromoimidazo[1,2-a]pyridine-6-carbonitrile Chemical compound C1=CC(C#N)=CN2C(Br)=CN=C21 UOQHWNPVNXSDDO-UHFFFAOYSA-N 0.000 claims 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical group FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
- 239000004380 Cholic acid Substances 0.000 claims 1
- 229920001287 Chondroitin sulfate Chemical group 0.000 claims 1
- 206010010755 Conjunctivitis viral Diseases 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- 229920002683 Glycosaminoglycan Polymers 0.000 claims 1
- 229920002971 Heparan sulfate Chemical group 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical group OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- 229920001612 Hydroxyethyl starch Polymers 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims 1
- 208000005914 Viral Conjunctivitis Diseases 0.000 claims 1
- 229940068372 acetyl salicylate Drugs 0.000 claims 1
- 229960001138 acetylsalicylic acid Drugs 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 229940050528 albumin Drugs 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 201000007032 bacterial conjunctivitis Diseases 0.000 claims 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 1
- WLNARFZDISHUGS-MIXBDBMTSA-N cholesteryl hemisuccinate Chemical compound C1C=C2C[C@@H](OC(=O)CCC(O)=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 WLNARFZDISHUGS-MIXBDBMTSA-N 0.000 claims 1
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 claims 1
- 235000019416 cholic acid Nutrition 0.000 claims 1
- 229960002471 cholic acid Drugs 0.000 claims 1
- 229940059329 chondroitin sulfate Drugs 0.000 claims 1
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 claims 1
- 229960002086 dextran Drugs 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- JFCQEDHGNNZCLN-UHFFFAOYSA-N glutaric acid Chemical compound OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 229940050526 hydroxyethylstarch Drugs 0.000 claims 1
- 239000002085 irritant Substances 0.000 claims 1
- 231100000021 irritant Toxicity 0.000 claims 1
- 229940099563 lactobionic acid Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 1
- -1 polygelin Polymers 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical group CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/790,182 US7141552B2 (en) | 2000-01-10 | 2004-03-02 | Use of lipid conjugates in the treatment of diseases |
| US10/790,182 | 2004-03-02 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007501901A Division JP2008509229A (ja) | 2004-03-02 | 2005-03-02 | 疾病の治療における脂質複合体の使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012092341A JP2012092341A (ja) | 2012-05-17 |
| JP2012092341A5 true JP2012092341A5 (OSRAM) | 2013-02-07 |
Family
ID=34919723
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007501901A Pending JP2008509229A (ja) | 2004-03-02 | 2005-03-02 | 疾病の治療における脂質複合体の使用 |
| JP2011255723A Pending JP2012092341A (ja) | 2004-03-02 | 2011-11-24 | 疾病の治療における脂質複合体の使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007501901A Pending JP2008509229A (ja) | 2004-03-02 | 2005-03-02 | 疾病の治療における脂質複合体の使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7141552B2 (OSRAM) |
| EP (2) | EP3354318A1 (OSRAM) |
| JP (2) | JP2008509229A (OSRAM) |
| AU (2) | AU2005218545B8 (OSRAM) |
| CA (1) | CA2558416C (OSRAM) |
| IL (1) | IL177847A0 (OSRAM) |
| WO (1) | WO2005084307A2 (OSRAM) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7141552B2 (en) * | 2000-01-10 | 2006-11-28 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of diseases |
| US9040078B2 (en) * | 2000-01-10 | 2015-05-26 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of diseases of the nervous system |
| US8076312B2 (en) * | 2000-01-10 | 2011-12-13 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | Use of lipid conjugates in the treatment of disease |
| US20090325876A1 (en) * | 2004-09-29 | 2009-12-31 | Saul Yedgar | Use of lipid conjugates in the treatment of diseases associated with vasculature |
| US7811999B2 (en) * | 2000-01-10 | 2010-10-12 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Use of lipid conjugates in the treatment of diseases |
| US7772196B2 (en) | 2000-01-10 | 2010-08-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of diseases |
| US7608598B2 (en) * | 2000-01-10 | 2009-10-27 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of conjunctivitis |
| US8501701B2 (en) * | 2000-01-10 | 2013-08-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Use of lipid conjugates in the treatment of disease |
| US8916539B2 (en) * | 2000-01-10 | 2014-12-23 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of disease |
| US7893226B2 (en) | 2004-09-29 | 2011-02-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Use of lipid conjugates in the treatment of diseases |
| US20060189569A1 (en) * | 2000-01-10 | 2006-08-24 | Saul Yedgar | Use of lipid conjugates in the treatment of infection |
| US8304395B2 (en) * | 2000-01-10 | 2012-11-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Lipid conjugates in the treatment of disease |
| US20070185052A1 (en) * | 2005-08-03 | 2007-08-09 | Saul Yedgar | Use of lipid conjugates in cystic fibrosis and applications thereof |
| US8883761B2 (en) | 2001-01-10 | 2014-11-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of diseases associated with vasculature |
| JP2008520650A (ja) * | 2004-11-17 | 2008-06-19 | イッサム・リサーチ・ディベロップメント・カンパニー・オブ・ザ・ヘブルー・ユニバーシティ・オブ・エルサレム | 疾患治療における脂質複合体の使用 |
| CN1742623A (zh) * | 2005-07-13 | 2006-03-08 | 凌沛学 | 透明质酸磷脂复合物及其制备方法 |
| DE102005045152A1 (de) | 2005-09-21 | 2007-03-22 | Stremmel, Wolfgang, Prof. Dr. | Verwendung von therapeutisch wirksamen Lipiden nebst Verfahren zur Herstellung von Organ-/Gewebe-spezifischen therapeutisch wirksamen Lipiden |
| US8859524B2 (en) | 2005-11-17 | 2014-10-14 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Lipid conjugates in the treatment of chronic rhinosinusitis |
| US8906882B2 (en) | 2005-11-17 | 2014-12-09 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Lipid conjugates in the treatment of allergic rhinitis |
| WO2010132402A1 (en) | 2009-05-11 | 2010-11-18 | Morria Biopharmaceuticals, Inc | Lipid-polymer conjugates, their preparation and uses thereof |
| US20080183282A1 (en) * | 2006-03-09 | 2008-07-31 | Saul Yedgar | Use of lipid conjugates for the coating of stents and catheters |
| EP2035010B1 (en) | 2006-06-09 | 2012-10-03 | Erasmus University Medical Center Rotterdam | Modulation of the immune system by inositol phospholipids |
| EP2097086A4 (en) * | 2006-11-14 | 2012-01-11 | Yissum Res Dev Co | CONTACT LENS COMPOSITIONS |
| CA2705785A1 (en) * | 2006-11-14 | 2008-05-22 | Saul Yedgar | Use of lipid conjugates in the treatment of diseases or disorders of the eye |
| AR071699A1 (es) * | 2008-05-09 | 2010-07-07 | Kemin Ind Inc | Uso de lisofosfolipidos para tratar la inflamacion. composicion. |
| AP2012006053A0 (en) * | 2009-06-02 | 2012-02-29 | Brian Charles Keller | Pure peg-lipid conjugates. |
| DK2706988T3 (da) | 2011-05-12 | 2020-01-20 | Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd | Liposomer omfattende polymer konjugerede lipider og relateret brug |
| EP2923710A1 (en) * | 2014-03-27 | 2015-09-30 | Universitätsklinikum Heidelberg | Bacterial phospholipase inhibitors as modulator of colonic bacterial flora |
| WO2019147990A1 (en) * | 2018-01-26 | 2019-08-01 | The Regents Of The University Of California | Methods and compositions concerning intestinal permeability |
| CN110183779B (zh) * | 2019-06-06 | 2021-08-24 | 宁波一舟塑胶有限公司 | 羧甲基纤维素铈作为阻燃剂在高分子聚合物材料中的应用 |
| WO2022195579A1 (en) * | 2021-03-15 | 2022-09-22 | Saul Yedgar | Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory diseases |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL84252A (en) * | 1987-10-23 | 1994-02-27 | Yissum Res Dev Co | Phospholipase inhibiting compositions |
| CA2058940C (en) * | 1989-06-23 | 2000-05-09 | Helen Loughrey | Targeted liposomes and methods for liposome-protein coupling |
| JPH0482893A (ja) * | 1990-07-23 | 1992-03-16 | Fuji Photo Film Co Ltd | ペプチド誘導リン脂質化合物およびそれを用いたポリペブチドリポソームの製造方法 |
| JP2997018B2 (ja) * | 1990-07-24 | 2000-01-11 | 生化学工業株式会社 | 燐脂質又は脂質結合グリコサミノグリカン |
| US5464942A (en) * | 1990-07-24 | 1995-11-07 | Seikagaku Kogyo Kabushiki Kaisha | Phospholipid- or lipid-linked glycosaminoglycan and process for producing the same |
| US6022866A (en) * | 1991-07-03 | 2000-02-08 | Hyal Pharmaceutical Corporation | Use of hyaluronic acid and forms to prevent arterial restenosis |
| WO1993008191A1 (en) * | 1991-10-15 | 1993-04-29 | Warner-Lambert Company | Azabicyclo oxime and amine cholinergic agents and methods of treatment |
| JP3714683B2 (ja) * | 1992-07-30 | 2005-11-09 | 生化学工業株式会社 | 抗リウマチ剤 |
| US6043231A (en) * | 1993-03-02 | 2000-03-28 | The Research Foundation Of State Univ. Of New York | Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines |
| EP0952841A4 (en) * | 1994-08-05 | 2000-11-02 | Molecular Structural Biotechno | DIRECTED BIOMOLECULAR COMPLEXES |
| JPH11501636A (ja) | 1995-03-09 | 1999-02-09 | ノボ ノルディスク アクティーゼルスカブ | 医薬組成物 |
| BR9608012A (pt) * | 1995-04-20 | 1999-01-05 | Searle & Co | Agentes de amidino cíclicos úteis como inbidores da sintase do óxido nítrico |
| US6033645A (en) * | 1996-06-19 | 2000-03-07 | Unger; Evan C. | Methods for diagnostic imaging by regulating the administration rate of a contrast agent |
| KR19990028383A (ko) | 1995-06-26 | 1999-04-15 | 지 더블유 페이스 | 신규한 보조제 조성물 및 이것을 함유한 백신 제제 |
| US5785975A (en) * | 1995-06-26 | 1998-07-28 | Research Triangle Pharmaceuticals | Adjuvant compositions and vaccine formulations comprising same |
| JPH0930970A (ja) * | 1995-07-19 | 1997-02-04 | Taisho Pharmaceut Co Ltd | 抗菌剤 |
| JP3942205B2 (ja) | 1995-07-24 | 2007-07-11 | 生化学工業株式会社 | 神経疾患の治療剤 |
| US6071532A (en) * | 1996-10-15 | 2000-06-06 | Emory University | Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof |
| WO1998051285A2 (en) * | 1997-05-15 | 1998-11-19 | Genzyme Corporation | Cationic amphiphile formulations |
| US6162787A (en) * | 1999-04-02 | 2000-12-19 | Immudyne, Inc. | Methods for treating arthritis using collagen type II, glucosamine chondroitin sulfate, and compositions |
| EP1046394A3 (en) * | 1999-04-19 | 2001-10-10 | ImaRx Pharmaceutical Corp. | Novel compositions useful for delivering compounds into a cell |
| US7101859B2 (en) * | 2000-01-10 | 2006-09-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of diseases |
| US7141552B2 (en) * | 2000-01-10 | 2006-11-28 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of diseases |
| EP2845596A3 (en) * | 2000-01-10 | 2015-07-15 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Use of lipid conjugates in the treatment of disease |
| EP1289565B1 (en) * | 2000-06-02 | 2015-04-22 | Bracco Suisse SA | Compounds for targeting endothelial cells |
-
2004
- 2004-03-02 US US10/790,182 patent/US7141552B2/en not_active Expired - Fee Related
-
2005
- 2005-03-02 EP EP17206166.5A patent/EP3354318A1/en not_active Ceased
- 2005-03-02 EP EP05724186A patent/EP1758595A4/en not_active Withdrawn
- 2005-03-02 CA CA2558416A patent/CA2558416C/en not_active Expired - Lifetime
- 2005-03-02 JP JP2007501901A patent/JP2008509229A/ja active Pending
- 2005-03-02 AU AU2005218545A patent/AU2005218545B8/en not_active Ceased
- 2005-03-02 WO PCT/US2005/006591 patent/WO2005084307A2/en not_active Ceased
-
2006
- 2006-08-31 IL IL177847A patent/IL177847A0/en unknown
-
2011
- 2011-03-15 AU AU2011201154A patent/AU2011201154B2/en not_active Ceased
- 2011-11-24 JP JP2011255723A patent/JP2012092341A/ja active Pending
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