JP2012090563A5 - - Google Patents
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- Publication number
- JP2012090563A5 JP2012090563A5 JP2010240426A JP2010240426A JP2012090563A5 JP 2012090563 A5 JP2012090563 A5 JP 2012090563A5 JP 2010240426 A JP2010240426 A JP 2010240426A JP 2010240426 A JP2010240426 A JP 2010240426A JP 2012090563 A5 JP2012090563 A5 JP 2012090563A5
- Authority
- JP
- Japan
- Prior art keywords
- glucose
- substrate specificity
- reactivity
- wild
- specific activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 14
- 239000008103 glucose Substances 0.000 description 14
- 239000000758 substrate Substances 0.000 description 13
- 230000009257 reactivity Effects 0.000 description 10
- 230000000694 effects Effects 0.000 description 6
- 102000004190 Enzymes Human genes 0.000 description 5
- 108090000790 Enzymes Proteins 0.000 description 5
- 150000001720 carbohydrates Chemical class 0.000 description 4
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 3
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 3
- 230000035772 mutation Effects 0.000 description 3
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 150000008163 sugars Chemical class 0.000 description 2
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010240426A JP5824205B2 (ja) | 2010-10-27 | 2010-10-27 | 変異グルコース脱水素酵素 |
| US13/282,243 US20120107903A1 (en) | 2010-10-27 | 2011-10-26 | Mutant Glucose Dehydrogenase |
| EP11186943.4A EP2447358B1 (en) | 2010-10-27 | 2011-10-27 | Mutant glucose dehydrogenase |
| CN201110404251.2A CN102453702B (zh) | 2010-10-27 | 2011-10-27 | 变异葡萄糖脱氢酶 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010240426A JP5824205B2 (ja) | 2010-10-27 | 2010-10-27 | 変異グルコース脱水素酵素 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012090563A JP2012090563A (ja) | 2012-05-17 |
| JP2012090563A5 true JP2012090563A5 (enExample) | 2013-11-21 |
| JP5824205B2 JP5824205B2 (ja) | 2015-11-25 |
Family
ID=44862726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010240426A Active JP5824205B2 (ja) | 2010-10-27 | 2010-10-27 | 変異グルコース脱水素酵素 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20120107903A1 (enExample) |
| EP (1) | EP2447358B1 (enExample) |
| JP (1) | JP5824205B2 (enExample) |
| CN (1) | CN102453702B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107532152A (zh) * | 2014-12-04 | 2018-01-02 | 智慧酶生物医药有限公司 | 用于测量血糖水平的组合物和方法 |
| WO2016087937A2 (en) * | 2014-12-04 | 2016-06-09 | Smartzyme Innovation Ltd. | Compositions and methods for measuring blood glucose levels |
| CN108368489A (zh) * | 2015-07-23 | 2018-08-03 | 智慧酶生物医药有限公司 | 用于测量血液葡萄糖水平的组合物和方法 |
| JP6783108B2 (ja) * | 2015-10-15 | 2020-11-11 | アークレイ株式会社 | 酵素電極 |
| EP3156791A1 (en) * | 2015-10-15 | 2017-04-19 | ARKRAY, Inc. | Enzyme electrode |
| CN105331590B (zh) * | 2015-10-29 | 2020-02-28 | 英科隆生物技术（杭州）有限公司 | 葡萄糖特异性改善的可溶性吡咯喹啉醌依赖性葡萄糖脱氢酶突变体、聚核苷酸及其应用 |
| JP6856344B2 (ja) * | 2015-10-29 | 2021-04-07 | アークレイ株式会社 | 変異グルコース脱水素酵素およびその利用 |
| EP3249050B1 (en) | 2016-05-23 | 2019-01-23 | ARKRAY, Inc. | Enzyme electrode and biosensor using the same |
| JP7339723B2 (ja) * | 2017-07-04 | 2023-09-06 | アークレイ株式会社 | 変異型シトクロムタンパク質およびその利用 |
| CN109425643B (zh) | 2017-08-25 | 2022-10-25 | 爱科来株式会社 | 基于酶电化学阻抗测量法的新型生物传感技术 |
| CN108486027A (zh) * | 2018-04-04 | 2018-09-04 | 江南大学 | 一种fad为辅基的葡萄糖脱氢酶的生产、纯化方法 |
| CN110514704B (zh) | 2018-05-22 | 2024-02-13 | 爱科来株式会社 | 新型生物传感方法 |
| US11293921B2 (en) | 2018-10-03 | 2022-04-05 | Arkray, Inc. | Direct electron transfer-type oxidoreductase-modified molecular recognition element |
| EP4067483A1 (en) | 2021-03-29 | 2022-10-05 | The University of North Carolina at Chapel Hill | Mutant glucose dehydrogenase having improved thermal stability, and use thereof |
| US20220306996A1 (en) * | 2021-03-29 | 2022-09-29 | The University Of North Carolina At Chapel Hill | Mutant Glucose Dehydrogenase Having Improved Thermal Stability, and Use Thereof |
| CN113186175B (zh) * | 2021-06-04 | 2023-08-04 | 翌圣生物科技(上海)股份有限公司 | 突变型Taq DNA聚合酶、编码DNA序列、重组载体、重组表达细胞及其应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4107386B2 (ja) | 2000-10-31 | 2008-06-25 | 広司 早出 | 新規グルコース脱水素酵素及び該脱水素酵素の製造方法 |
| WO2003091430A1 (fr) | 2002-04-26 | 2003-11-06 | Koji Sode | SOUS-UNITE ss DE LA GLUCOSE DESHYDROGENASE ET ADN LA CODANT |
| AU2003246245B2 (en) * | 2002-07-04 | 2008-09-18 | Ultizyme International Ltd. | Glucose dehydrogenase |
| US7803592B2 (en) * | 2004-04-23 | 2010-09-28 | Arkray, Inc. | Mutant glucose dehydrogenase |
| ATE520771T1 (de) * | 2005-06-20 | 2011-09-15 | Arkray Inc | Mutierte glucose-dehydrogenase |
-
2010
- 2010-10-27 JP JP2010240426A patent/JP5824205B2/ja active Active
-
2011
- 2011-10-26 US US13/282,243 patent/US20120107903A1/en not_active Abandoned
- 2011-10-27 CN CN201110404251.2A patent/CN102453702B/zh active Active
- 2011-10-27 EP EP11186943.4A patent/EP2447358B1/en active Active
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