JP2012051888A5 - - Google Patents
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- Publication number
- JP2012051888A5 JP2012051888A5 JP2011191990A JP2011191990A JP2012051888A5 JP 2012051888 A5 JP2012051888 A5 JP 2012051888A5 JP 2011191990 A JP2011191990 A JP 2011191990A JP 2011191990 A JP2011191990 A JP 2011191990A JP 2012051888 A5 JP2012051888 A5 JP 2012051888A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- lateral sclerosis
- amyotrophic lateral
- agent according
- gene mutation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003795 chemical substances by application Substances 0.000 claims 4
- GWEHVDNNLFDJLR-HSGWXFLFSA-N 1,3-diphenylurea Chemical class C=1C=CC=CC=1N[11C](=O)NC1=CC=CC=C1 GWEHVDNNLFDJLR-HSGWXFLFSA-N 0.000 claims 2
- 206010064571 Gene mutation Diseases 0.000 claims 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
- 208000019995 familial amyotrophic lateral sclerosis Diseases 0.000 claims 2
- 101150062190 sod1 gene Proteins 0.000 claims 2
- MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 claims 1
- 239000005511 L01XE05 - Sorafenib Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229960003787 sorafenib Drugs 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37955810P | 2010-09-02 | 2010-09-02 | |
| US61/379,558 | 2010-09-02 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012051888A JP2012051888A (ja) | 2012-03-15 |
| JP2012051888A5 true JP2012051888A5 (enExample) | 2014-10-16 |
| JP5835729B2 JP5835729B2 (ja) | 2015-12-24 |
Family
ID=45773059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011191990A Expired - Fee Related JP5835729B2 (ja) | 2010-09-02 | 2011-09-02 | 筋萎縮性側索硬化症の予防および治療用医薬組成物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9856210B2 (enExample) |
| EP (1) | EP2611437B1 (enExample) |
| JP (1) | JP5835729B2 (enExample) |
| WO (1) | WO2012029994A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2977449B1 (en) | 2013-03-21 | 2020-02-26 | Kyoto University | Pluripotent stem cell for neuronal differentiation induction |
| CN104045598B (zh) * | 2014-05-29 | 2017-02-15 | 烟台大学 | 一种含芳胺结构的硫脲类化合物及其制备方法和应用 |
| MX2017006216A (es) | 2014-11-14 | 2018-08-29 | Voyager Therapeutics Inc | Composiciones y métodos para tratar la esclerosis lateral amiotrófica (ela). |
| US20180000771A1 (en) | 2015-01-13 | 2018-01-04 | Kyoto University | Agent for preventing and/or treating amyotrophic lateral sclerosis |
| AU2018261790B2 (en) | 2017-05-05 | 2024-10-03 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (ALS) |
| US11434502B2 (en) | 2017-10-16 | 2022-09-06 | Voyager Therapeutics, Inc. | Treatment of amyotrophic lateral sclerosis (ALS) |
| WO2021075476A1 (ja) | 2019-10-18 | 2021-04-22 | 武田薬品工業株式会社 | 複素環化合物 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2688138B1 (fr) | 1992-03-06 | 1995-05-05 | Rhone Poulenc Rorer Sa | Application de l'amino-2 trifluoromethoxy-6 benzothiazole pour obtenir un medicament destine au traitement de la sclerose laterale amyotrophique. |
| ATE538794T1 (de) | 1999-01-13 | 2012-01-15 | Bayer Healthcare Llc | Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer |
| US7235576B1 (en) | 2001-01-12 | 2007-06-26 | Bayer Pharmaceuticals Corporation | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| US20030236287A1 (en) | 2002-05-03 | 2003-12-25 | Piotrowski David W. | Positive allosteric modulators of the nicotinic acetylcholine receptor |
| US8227643B2 (en) | 2002-05-31 | 2012-07-24 | Proteotech, Inc. | Sirtuin 1 and the treatment of neurodegenerative diseases |
| CA2561639A1 (en) | 2004-03-29 | 2005-10-06 | Neurosearch A/S | Novel urea derivatives and their medical use |
| AU2005274852B2 (en) * | 2004-07-19 | 2011-12-08 | The Johns Hopkins University | FLT3 inhibitors for immune suppression |
| US8329408B2 (en) * | 2005-10-31 | 2012-12-11 | Bayer Healthcare Llc | Methods for prognosis and monitoring cancer therapy |
| KR101420740B1 (ko) | 2005-12-13 | 2014-07-17 | 교또 다이가꾸 | 핵초기화 인자 |
| GB0606429D0 (en) * | 2006-03-30 | 2006-05-10 | Novartis Ag | Organic compounds |
| CN101415409B (zh) * | 2006-04-05 | 2012-12-05 | 诺瓦提斯公司 | 用于治疗癌症的治疗剂的组合 |
| GB0609378D0 (en) * | 2006-05-11 | 2006-06-21 | Novartis Ag | Organic compounds |
| WO2008031835A2 (en) | 2006-09-13 | 2008-03-20 | Novartis Ag | Method of treating autoimmune diseases using vegf-pathway inhibitors |
| WO2008136976A2 (en) * | 2007-04-30 | 2008-11-13 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| JP2010522163A (ja) * | 2007-03-20 | 2010-07-01 | キュリス，インコーポレイテッド | 亜鉛結合部位を含むＲａｆキナーゼインヒビター |
| EP2137296A2 (en) | 2007-03-23 | 2009-12-30 | Wisconsin Alumni Research Foundation | Somatic cell reprogramming |
| US20090004213A1 (en) * | 2007-03-26 | 2009-01-01 | Immatics Biotechnologies Gmbh | Combination therapy using active immunotherapy |
| WO2008133884A2 (en) * | 2007-04-23 | 2008-11-06 | Combinatorx, Incorporated | Methods and compositions for the treatment of neurodegenerative disorders |
| CA2694983A1 (en) * | 2007-07-17 | 2009-01-22 | Combinatorx, Incorporated | Treatments of b-cell proliferative disorders |
| KR20110050649A (ko) | 2008-08-15 | 2011-05-16 | 보드 오브 리전츠 더 유니버시티 오브 텍사스 시스템 | 신경퇴화성 질환의 치료를 위한 치료제로서의 1,4-벤즈옥사진 화합물 및 그의 유도체 |
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2011
- 2011-09-02 JP JP2011191990A patent/JP5835729B2/ja not_active Expired - Fee Related
- 2011-09-02 WO PCT/JP2011/070538 patent/WO2012029994A1/en not_active Ceased
- 2011-09-02 EP EP11822002.9A patent/EP2611437B1/en not_active Not-in-force
- 2011-09-02 US US13/820,420 patent/US9856210B2/en active Active