JP2012046483A5 - - Google Patents
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- Publication number
- JP2012046483A5 JP2012046483A5 JP2011126449A JP2011126449A JP2012046483A5 JP 2012046483 A5 JP2012046483 A5 JP 2012046483A5 JP 2011126449 A JP2011126449 A JP 2011126449A JP 2011126449 A JP2011126449 A JP 2011126449A JP 2012046483 A5 JP2012046483 A5 JP 2012046483A5
- Authority
- JP
- Japan
- Prior art keywords
- testosterone
- androgen
- composition
- serum
- levels
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims description 48
- 229960003604 testosterone Drugs 0.000 claims description 25
- 210000002966 serum Anatomy 0.000 claims description 18
- 208000001640 Fibromyalgia Diseases 0.000 claims description 3
- 239000003098 androgen Substances 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- -1 testosterone ester Chemical class 0.000 claims 2
- 150000003515 testosterones Chemical class 0.000 claims 2
- NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 claims 1
- GCKMFJBGXUYNAG-UHFFFAOYSA-N 17alpha-methyltestosterone Natural products C1CC2=CC(=O)CCC2(C)C2C1C1CCC(C)(O)C1(C)CC2 GCKMFJBGXUYNAG-UHFFFAOYSA-N 0.000 claims 1
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 claims 1
- GCKMFJBGXUYNAG-HLXURNFRSA-N Methyltestosterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@](C)(O)[C@@]1(C)CC2 GCKMFJBGXUYNAG-HLXURNFRSA-N 0.000 claims 1
- 230000002411 adverse Effects 0.000 claims 1
- AEMFNILZOJDQLW-QAGGRKNESA-N androst-4-ene-3,17-dione Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 AEMFNILZOJDQLW-QAGGRKNESA-N 0.000 claims 1
- 229960003473 androstanolone Drugs 0.000 claims 1
- 229960005471 androstenedione Drugs 0.000 claims 1
- AEMFNILZOJDQLW-UHFFFAOYSA-N androstenedione Natural products O=C1CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 AEMFNILZOJDQLW-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 229960001566 methyltestosterone Drugs 0.000 claims 1
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims 1
- 230000035946 sexual desire Effects 0.000 claims 1
- 229960000921 testosterone cypionate Drugs 0.000 claims 1
- HPFVBGJFAYZEBE-ZLQWOROUSA-N testosterone cypionate Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(CCC(=O)C=C4CC3)C)CC[C@@]21C)C(=O)CCC1CCCC1 HPFVBGJFAYZEBE-ZLQWOROUSA-N 0.000 claims 1
- 229960003484 testosterone enanthate Drugs 0.000 claims 1
- VOCBWIIFXDYGNZ-IXKNJLPQSA-N testosterone enanthate Chemical group C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CCCCCC)[C@@]1(C)CC2 VOCBWIIFXDYGNZ-IXKNJLPQSA-N 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 238000002657 hormone replacement therapy Methods 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/464,310 US20040259852A1 (en) | 2003-06-18 | 2003-06-18 | Trandsdermal compositions and methods for treatment of fibromyalgia and chronic fatigue syndrome |
| US10/464,310 | 2003-06-18 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006517316A Division JP5717312B2 (ja) | 2003-06-18 | 2004-06-15 | 線維筋痛症候群または慢性疲労症候群の処置のための経皮的組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012046483A JP2012046483A (ja) | 2012-03-08 |
| JP2012046483A5 true JP2012046483A5 (enExample) | 2012-08-30 |
| JP5651540B2 JP5651540B2 (ja) | 2015-01-14 |
Family
ID=33517268
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006517316A Expired - Fee Related JP5717312B2 (ja) | 2003-06-18 | 2004-06-15 | 線維筋痛症候群または慢性疲労症候群の処置のための経皮的組成物および方法 |
| JP2011126449A Expired - Fee Related JP5651540B2 (ja) | 2003-06-18 | 2011-06-06 | 線維筋痛症候群または慢性疲労症候群の処置のための経皮的組成物および方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006517316A Expired - Fee Related JP5717312B2 (ja) | 2003-06-18 | 2004-06-15 | 線維筋痛症候群または慢性疲労症候群の処置のための経皮的組成物および方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US20040259852A1 (enExample) |
| EP (2) | EP1638575A4 (enExample) |
| JP (2) | JP5717312B2 (enExample) |
| AU (2) | AU2004251075B2 (enExample) |
| CA (1) | CA2529575C (enExample) |
| WO (1) | WO2005000236A2 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6251691B1 (en) | 1996-04-25 | 2001-06-26 | Bioarray Solutions, Llc | Light-controlled electrokinetic assembly of particles near surfaces |
| US9709559B2 (en) | 2000-06-21 | 2017-07-18 | Bioarray Solutions, Ltd. | Multianalyte molecular analysis using application-specific random particle arrays |
| US7262063B2 (en) | 2001-06-21 | 2007-08-28 | Bio Array Solutions, Ltd. | Directed assembly of functional heterostructures |
| ES2712173T3 (es) | 2001-10-15 | 2019-05-09 | Bioarray Solutions Ltd | Análisis multiplexado de loci polimórficos mediante consulta simultánea y detección mediada por enzimas |
| WO2004047007A1 (en) | 2002-11-15 | 2004-06-03 | Bioarray Solutions, Ltd. | Analysis, secure access to, and transmission of array images |
| US8883769B2 (en) * | 2003-06-18 | 2014-11-11 | White Mountain Pharma, Inc. | Methods for the treatment of fibromyalgia and chronic fatigue syndrome |
| US9511079B2 (en) | 2003-06-18 | 2016-12-06 | White Mountain Pharma, Inc. | Methods for the treatment of fibromyalgia and chronic fatigue syndrome |
| US20040259852A1 (en) * | 2003-06-18 | 2004-12-23 | White Hillary D. | Trandsdermal compositions and methods for treatment of fibromyalgia and chronic fatigue syndrome |
| PT1664722E (pt) | 2003-09-22 | 2011-12-28 | Bioarray Solutions Ltd | Polielectrólito imobilizado à superfície com grupos funcionais múltiplos capazes de se ligarem covalentemente às biomoléculas |
| EP1692298A4 (en) | 2003-10-28 | 2008-08-13 | Bioarray Solutions Ltd | OPTIMIZATION OF GENE EXPRESSION ANALYSIS USING IMMOBILIZED CATCHES |
| US8784869B2 (en) | 2003-11-11 | 2014-07-22 | Mattern Pharma Ag | Controlled release delivery system for nasal applications and methods of treatment |
| ES2258694T3 (es) | 2003-11-11 | 2006-09-01 | Mattern, Udo | Sistema de administracion de liberacion controlada de hormonas sexuales para aplicaciones nasales. |
| CN101027061B (zh) | 2004-05-11 | 2014-03-12 | 情感智能有限责任公司 | 药物制剂及其在治疗女性性功能障碍中的应用 |
| US7848889B2 (en) | 2004-08-02 | 2010-12-07 | Bioarray Solutions, Ltd. | Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification |
| EP1790343A1 (en) | 2005-11-11 | 2007-05-30 | Emotional Brain B.V. | Pharmaceuticals formulations and uses thereof in the treatment of female sexual dysfunction |
| DK2068825T3 (da) | 2006-10-04 | 2011-05-16 | M & P Patent Ag | Kontrolleret frisætningstilførselssystem til nasal påføring af neurotransmittere |
| EP1925307A1 (en) | 2006-11-03 | 2008-05-28 | Emotional Brain B.V. | Use of 3-alpha-androstanediol in the treatment of sexual dysfunction |
| CA2643529C (en) * | 2008-11-06 | 2019-05-21 | Kenneth W. Adams | Method and composition for enhancement of male erectile function |
| US9642862B2 (en) | 2010-11-18 | 2017-05-09 | White Mountain Pharma, Inc. | Methods for treating chronic or unresolvable pain and/or increasing the pain threshold in a subject and pharmaceutical compositions for use therein |
| US20130040923A1 (en) | 2011-05-13 | 2013-02-14 | Trimel Pharmaceuticals Corporation | Intranasal lower dosage strength testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder |
| US20130045958A1 (en) | 2011-05-13 | 2013-02-21 | Trimel Pharmaceuticals Corporation | Intranasal 0.15% and 0.24% testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder |
| US9757388B2 (en) | 2011-05-13 | 2017-09-12 | Acerus Pharmaceuticals Srl | Intranasal methods of treating women for anorgasmia with 0.6% and 0.72% testosterone gels |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| EP2782584B1 (en) | 2011-11-23 | 2021-06-09 | TherapeuticsMD, Inc. | Natural combination hormone replacement formulations and therapies |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11744838B2 (en) | 2013-03-15 | 2023-09-05 | Acerus Biopharma Inc. | Methods of treating hypogonadism with transnasal testosterone bio-adhesive gel formulations in male with allergic rhinitis, and methods for preventing an allergic rhinitis event |
| AR100562A1 (es) | 2014-05-22 | 2016-10-12 | Therapeuticsmd Inc | Composición farmacéutica de estradiol y progesterona para terapia de reemplazo hormonal |
| KR20170040209A (ko) | 2014-07-29 | 2017-04-12 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 경피 크림 |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| WO2017173044A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd Inc. | Steroid hormone compositions in medium chain oils |
| KR20180126582A (ko) | 2016-04-01 | 2018-11-27 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 스테로이드 호르몬 약제학적 조성물 |
| WO2020263989A1 (en) | 2019-06-24 | 2020-12-30 | University Of Iowa Research Foundation | Jnk inhibitors as anticancer agents |
| US11904006B2 (en) | 2019-12-11 | 2024-02-20 | University Of Iowa Research Foundation | Poly(diaminosulfide) particle-based vaccine |
| US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
| WO2022271951A1 (en) | 2021-06-23 | 2022-12-29 | University Of Iowa Research Foundation | Sustained release formulations comprising a selective androgen receptor modulator |
| AU2023314508A1 (en) * | 2022-07-29 | 2024-11-14 | University Of Rochester | Methods for improving muscle mass, strength, or function with a combination of testosterone and growth hormone |
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| US5206008A (en) | 1991-04-15 | 1993-04-27 | Virginia Commonwealth University | Enhancement of immune response |
| US5676968A (en) | 1991-10-31 | 1997-10-14 | Schering Aktiengesellschaft | Transdermal therapeutic systems with crystallization inhibitors |
| US5656606A (en) * | 1995-02-17 | 1997-08-12 | Merck & Co., Inc. | Camphor compounds promote release of growth hormone |
| US6923983B2 (en) | 1996-02-19 | 2005-08-02 | Acrux Dds Pty Ltd | Transdermal delivery of hormones |
| AUPN814496A0 (en) | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
| DE19619045C1 (de) | 1996-05-02 | 1997-11-13 | Jenapharm Gmbh | Verwendung von Kombinationspräparaten zur Behandlung hypogonadaler Männer sowie Männern mit Hypophysenerkrankungen |
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| US20030139384A1 (en) | 2000-08-30 | 2003-07-24 | Dudley Robert E. | Method for treating erectile dysfunction and increasing libido in men |
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| KR20080016552A (ko) | 2005-04-13 | 2008-02-21 | 유니메드 파마슈티칼스, 인크. | 여성의 테스토스테론 및 관련된 스테로이드의 농도를증가시키는 방법 |
| US8492369B2 (en) * | 2010-04-12 | 2013-07-23 | Clarus Therapeutics Inc | Oral testosterone ester formulations and methods of treating testosterone deficiency comprising same |
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| KR20130114229A (ko) | 2005-06-03 | 2013-10-16 | 애크럭스 디디에스 피티와이 리미티드 | 경피 약물 전달 방법 및 조성물 |
| US20080261937A1 (en) * | 2007-03-23 | 2008-10-23 | Dudley Robert E | Pharmaceutical compositions and method for treating pediatric hypogonadism |
| US9642862B2 (en) * | 2010-11-18 | 2017-05-09 | White Mountain Pharma, Inc. | Methods for treating chronic or unresolvable pain and/or increasing the pain threshold in a subject and pharmaceutical compositions for use therein |
-
2003
- 2003-06-18 US US10/464,310 patent/US20040259852A1/en not_active Abandoned
-
2004
- 2004-06-15 JP JP2006517316A patent/JP5717312B2/ja not_active Expired - Fee Related
- 2004-06-15 EP EP04776655A patent/EP1638575A4/en not_active Withdrawn
- 2004-06-15 AU AU2004251075A patent/AU2004251075B2/en not_active Ceased
- 2004-06-15 EP EP08154166.6A patent/EP2000143B1/en not_active Expired - Lifetime
- 2004-06-15 CA CA2529575A patent/CA2529575C/en not_active Expired - Fee Related
- 2004-06-15 WO PCT/US2004/019201 patent/WO2005000236A2/en not_active Ceased
-
2005
- 2005-12-16 US US11/303,813 patent/US7799769B2/en not_active Expired - Fee Related
-
2010
- 2010-07-15 US US12/837,310 patent/US8999963B2/en not_active Expired - Fee Related
-
2011
- 2011-03-02 AU AU2011200914A patent/AU2011200914B2/en not_active Ceased
- 2011-06-06 JP JP2011126449A patent/JP5651540B2/ja not_active Expired - Fee Related
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