JP2011530540A5 - - Google Patents
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- Publication number
- JP2011530540A5 JP2011530540A5 JP2011522346A JP2011522346A JP2011530540A5 JP 2011530540 A5 JP2011530540 A5 JP 2011530540A5 JP 2011522346 A JP2011522346 A JP 2011522346A JP 2011522346 A JP2011522346 A JP 2011522346A JP 2011530540 A5 JP2011530540 A5 JP 2011530540A5
- Authority
- JP
- Japan
- Prior art keywords
- dosage form
- pharmaceutical dosage
- tetrahydrobiopterin
- form according
- metabolic precursor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002552 dosage form Substances 0.000 claims 12
- 230000002503 metabolic effect Effects 0.000 claims 9
- 239000002243 precursor Substances 0.000 claims 9
- FNKQXYHWGSIFBK-RPDRRWSUSA-N sapropterin Chemical compound N1=C(N)NC(=O)C2=C1NC[C@H]([C@@H](O)[C@@H](O)C)N2 FNKQXYHWGSIFBK-RPDRRWSUSA-N 0.000 claims 9
- 229960004617 sapropterin Drugs 0.000 claims 9
- 239000007864 aqueous solution Substances 0.000 claims 6
- 239000003963 antioxidant agent Substances 0.000 claims 5
- 230000003078 antioxidant effect Effects 0.000 claims 4
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 3
- 235000018417 cysteine Nutrition 0.000 claims 3
- -1 sulfhydryl compound Chemical class 0.000 claims 3
- 201000011252 Phenylketonuria Diseases 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 2
- REYLLNRLWCBKCM-YFKPBYRVSA-N (2s)-2-acetamido-4-sulfanylbutanoic acid Chemical compound CC(=O)N[C@H](C(O)=O)CCS REYLLNRLWCBKCM-YFKPBYRVSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 1
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims 1
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 claims 1
- 206010069116 Tetrahydrobiopterin deficiency Diseases 0.000 claims 1
- 229960004308 acetylcysteine Drugs 0.000 claims 1
- 235000008452 baby food Nutrition 0.000 claims 1
- YVKSGVDJQXLXDV-BYPYZUCNSA-N ethyl (2r)-2-amino-3-sulfanylpropanoate Chemical compound CCOC(=O)[C@@H](N)CS YVKSGVDJQXLXDV-BYPYZUCNSA-N 0.000 claims 1
- FTURCWPZLPUMLY-YFKPBYRVSA-N ethyl (2s)-2-amino-4-sulfanylbutanoate Chemical compound CCOC(=O)[C@@H](N)CCS FTURCWPZLPUMLY-YFKPBYRVSA-N 0.000 claims 1
- 229960001913 mecysteine Drugs 0.000 claims 1
- GPBQMUGQGMBCNZ-BYPYZUCNSA-N methyl (2s)-2-amino-4-sulfanylbutanoate Chemical compound COC(=O)[C@@H](N)CCS GPBQMUGQGMBCNZ-BYPYZUCNSA-N 0.000 claims 1
- MCYHPZGUONZRGO-VKHMYHEASA-N methyl L-cysteinate Chemical compound COC(=O)[C@@H](N)CS MCYHPZGUONZRGO-VKHMYHEASA-N 0.000 claims 1
- 235000013336 milk Nutrition 0.000 claims 1
- 239000008267 milk Substances 0.000 claims 1
- 210000004080 milk Anatomy 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ATA1254/2008 | 2008-08-12 | ||
| AT12542008 | 2008-08-12 | ||
| PCT/AT2009/000306 WO2010017570A2 (de) | 2008-08-12 | 2009-08-07 | Pharmazeutische darreichungsform enthaltend tetrahydrobiopterin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011530540A JP2011530540A (ja) | 2011-12-22 |
| JP2011530540A5 true JP2011530540A5 (enExample) | 2012-06-07 |
Family
ID=41111155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011522346A Pending JP2011530540A (ja) | 2008-08-12 | 2009-08-07 | テトラヒドロビオプテリンを含有する医薬剤形 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20110144117A1 (enExample) |
| EP (1) | EP2309983B1 (enExample) |
| JP (1) | JP2011530540A (enExample) |
| ES (1) | ES2736730T3 (enExample) |
| PL (1) | PL2309983T3 (enExample) |
| RU (1) | RU2011109210A (enExample) |
| TR (1) | TR201910287T4 (enExample) |
| WO (1) | WO2010017570A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20140108281A (ko) * | 2013-01-10 | 2014-09-05 | 뉴트리셔널 테라퓨틱스, 인크. | 건강 유지 및 급성 및 만성 장애의 치료를 위한 지질 보조제를 함유하는 츄어블 웨이퍼 |
| ES2586945T3 (es) * | 2014-03-31 | 2016-10-19 | Vasopharm Gmbh | Composiciones farmacéuticas sólidas que comprenden derivados de biopterina y usos de dichas composiciones |
| CN110312721A (zh) | 2016-11-29 | 2019-10-08 | 显莎制药公司 | 墨蝶呤的多晶型物 |
| WO2018102315A1 (en) * | 2016-11-29 | 2018-06-07 | Censa Pharmaceuticals Inc. | Polymoprhs of sepiapterin and salts thereof |
| MX2020002271A (es) * | 2017-09-01 | 2020-10-05 | Ptc Therapeutics Mp Inc | Composiciones farmaceuticas que comprenden sepiapterina y sus usos de las mismas. |
| CA3102105A1 (en) | 2018-05-30 | 2019-12-05 | Ptc Therapeutics Mp, Inc. | Compositions and methods for increasing tetrahydrobiopterin plasma exposure |
| JP7778477B2 (ja) | 2018-05-30 | 2025-12-02 | ピーティーシー セラピューティクス エムピー，インコーポレイテッド | セピアプテリンの薬学的に許容される塩 |
| JP7502197B2 (ja) | 2018-05-30 | 2024-06-18 | ピーティーシー セラピューティクス エムピー，インコーポレイテッド | セピアプテリン血漿曝露を増加させるための方法 |
| JP7553906B2 (ja) * | 2018-11-01 | 2024-09-19 | 宏 一瀬 | Ｓｐｒをコードするポリヌクレオチドを含む組換えベクター、及びそれを含む組成物 |
| LT4009978T (lt) | 2019-08-05 | 2024-11-25 | Ptc Therapeutics Mp, Inc. | Sepiapterino ir jo metabolitų panaudojimas spinduliuotės poveikio gydymui |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61277618A (ja) * | 1985-06-04 | 1986-12-08 | Suntory Ltd | 自閉症治療剤 |
| JP2588191B2 (ja) * | 1987-04-24 | 1997-03-05 | サントリー株式会社 | 悪性腫瘍および重症ウイルス感染症に伴う神経症状を改善するための治療剤 |
| DE10260263A1 (de) * | 2002-12-20 | 2004-07-15 | Biocrates Life Sciences Gmbh | Verwendung von Tetrahydrobiopterinderivaten zur Behandlung und Ernährung von Patienten mit Aminosäurestoffwechselstörungen |
| US20080207624A1 (en) * | 2004-05-11 | 2008-08-28 | Osamu Sugita | Therapeutic Agent for Bh4-Responsive Hyperphenylalaninemia |
| CN101132776A (zh) * | 2004-11-17 | 2008-02-27 | 生物马林药物股份有限公司 | 稳定的四氢生物喋呤片剂制剂 |
| US20060188492A1 (en) * | 2005-01-13 | 2006-08-24 | Chronorx Llc, An Alaska Limited Liability Company | Topical management of ocular and periocular conditions |
| JP2008540486A (ja) * | 2005-05-11 | 2008-11-20 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｐｄｅ４インヒビター及びテトラヒドロビオプテリン誘導体との組合せ物 |
| KR20160065998A (ko) * | 2007-04-11 | 2016-06-09 | 바이오마린 파머수티컬 인크. | 테트라하이드로바이오프테린 투여 방법, 관련 조성물 및 측정 방법 |
-
2009
- 2009-08-07 WO PCT/AT2009/000306 patent/WO2010017570A2/de not_active Ceased
- 2009-08-07 US US13/058,625 patent/US20110144117A1/en not_active Abandoned
- 2009-08-07 PL PL09775591T patent/PL2309983T3/pl unknown
- 2009-08-07 EP EP09775591.2A patent/EP2309983B1/de active Active
- 2009-08-07 JP JP2011522346A patent/JP2011530540A/ja active Pending
- 2009-08-07 TR TR2019/10287T patent/TR201910287T4/tr unknown
- 2009-08-07 ES ES09775591T patent/ES2736730T3/es active Active
- 2009-08-07 RU RU2011109210/15A patent/RU2011109210A/ru not_active Application Discontinuation
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