RU2011109210A - Лекарственная форма, содержащая тетрагидробиоптерин - Google Patents
Лекарственная форма, содержащая тетрагидробиоптерин Download PDFInfo
- Publication number
- RU2011109210A RU2011109210A RU2011109210/15A RU2011109210A RU2011109210A RU 2011109210 A RU2011109210 A RU 2011109210A RU 2011109210/15 A RU2011109210/15 A RU 2011109210/15A RU 2011109210 A RU2011109210 A RU 2011109210A RU 2011109210 A RU2011109210 A RU 2011109210A
- Authority
- RU
- Russia
- Prior art keywords
- dosage form
- tetrahydrobiopterin
- form according
- metabolic precursor
- aqueous solution
- Prior art date
Links
- FNKQXYHWGSIFBK-RPDRRWSUSA-N sapropterin Chemical compound N1=C(N)NC(=O)C2=C1NC[C@H]([C@@H](O)[C@@H](O)C)N2 FNKQXYHWGSIFBK-RPDRRWSUSA-N 0.000 title claims abstract 15
- 229960004617 sapropterin Drugs 0.000 title claims abstract 15
- 239000002552 dosage form Substances 0.000 claims abstract 17
- 230000002503 metabolic effect Effects 0.000 claims abstract 13
- 239000002243 precursor Substances 0.000 claims abstract 13
- 239000007864 aqueous solution Substances 0.000 claims abstract 9
- -1 sulfhydryl compound Chemical class 0.000 claims abstract 9
- 239000003963 antioxidant agent Substances 0.000 claims abstract 8
- 230000003078 antioxidant effect Effects 0.000 claims abstract 8
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims abstract 7
- 235000018417 cysteine Nutrition 0.000 claims abstract 7
- 239000012895 dilution Substances 0.000 claims abstract 3
- 238000010790 dilution Methods 0.000 claims abstract 3
- REYLLNRLWCBKCM-YFKPBYRVSA-N (2s)-2-acetamido-4-sulfanylbutanoic acid Chemical compound CC(=O)N[C@H](C(O)=O)CCS REYLLNRLWCBKCM-YFKPBYRVSA-N 0.000 claims abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims abstract 2
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims abstract 2
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 claims abstract 2
- 229960004308 acetylcysteine Drugs 0.000 claims abstract 2
- YVKSGVDJQXLXDV-BYPYZUCNSA-N ethyl (2r)-2-amino-3-sulfanylpropanoate Chemical compound CCOC(=O)[C@@H](N)CS YVKSGVDJQXLXDV-BYPYZUCNSA-N 0.000 claims abstract 2
- FTURCWPZLPUMLY-YFKPBYRVSA-N ethyl (2s)-2-amino-4-sulfanylbutanoate Chemical compound CCOC(=O)[C@@H](N)CCS FTURCWPZLPUMLY-YFKPBYRVSA-N 0.000 claims abstract 2
- GPBQMUGQGMBCNZ-BYPYZUCNSA-N methyl (2s)-2-amino-4-sulfanylbutanoate Chemical compound COC(=O)[C@@H](N)CCS GPBQMUGQGMBCNZ-BYPYZUCNSA-N 0.000 claims abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims abstract 2
- 150000003839 salts Chemical group 0.000 claims abstract 2
- 125000003396 thiol group Chemical group [H]S* 0.000 claims abstract 2
- 201000011252 Phenylketonuria Diseases 0.000 claims 1
- 235000008452 baby food Nutrition 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 235000013336 milk Nutrition 0.000 claims 1
- 239000008267 milk Substances 0.000 claims 1
- 210000004080 milk Anatomy 0.000 claims 1
- 230000002035 prolonged effect Effects 0.000 claims 1
- 230000000717 retained effect Effects 0.000 claims 1
- 230000006641 stabilisation Effects 0.000 claims 1
- 238000011105 stabilization Methods 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ATA1254/2008 | 2008-08-12 | ||
| AT12542008 | 2008-08-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2011109210A true RU2011109210A (ru) | 2012-09-20 |
Family
ID=41111155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2011109210/15A RU2011109210A (ru) | 2008-08-12 | 2009-08-07 | Лекарственная форма, содержащая тетрагидробиоптерин |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20110144117A1 (enExample) |
| EP (1) | EP2309983B1 (enExample) |
| JP (1) | JP2011530540A (enExample) |
| ES (1) | ES2736730T3 (enExample) |
| PL (1) | PL2309983T3 (enExample) |
| RU (1) | RU2011109210A (enExample) |
| TR (1) | TR201910287T4 (enExample) |
| WO (1) | WO2010017570A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20140108281A (ko) * | 2013-01-10 | 2014-09-05 | 뉴트리셔널 테라퓨틱스, 인크. | 건강 유지 및 급성 및 만성 장애의 치료를 위한 지질 보조제를 함유하는 츄어블 웨이퍼 |
| ES2586945T3 (es) * | 2014-03-31 | 2016-10-19 | Vasopharm Gmbh | Composiciones farmacéuticas sólidas que comprenden derivados de biopterina y usos de dichas composiciones |
| CN110312721A (zh) | 2016-11-29 | 2019-10-08 | 显莎制药公司 | 墨蝶呤的多晶型物 |
| WO2018102315A1 (en) * | 2016-11-29 | 2018-06-07 | Censa Pharmaceuticals Inc. | Polymoprhs of sepiapterin and salts thereof |
| MX2020002271A (es) * | 2017-09-01 | 2020-10-05 | Ptc Therapeutics Mp Inc | Composiciones farmaceuticas que comprenden sepiapterina y sus usos de las mismas. |
| CA3102105A1 (en) | 2018-05-30 | 2019-12-05 | Ptc Therapeutics Mp, Inc. | Compositions and methods for increasing tetrahydrobiopterin plasma exposure |
| JP7778477B2 (ja) | 2018-05-30 | 2025-12-02 | ピーティーシー セラピューティクス エムピー，インコーポレイテッド | セピアプテリンの薬学的に許容される塩 |
| JP7502197B2 (ja) | 2018-05-30 | 2024-06-18 | ピーティーシー セラピューティクス エムピー，インコーポレイテッド | セピアプテリン血漿曝露を増加させるための方法 |
| JP7553906B2 (ja) * | 2018-11-01 | 2024-09-19 | 宏 一瀬 | Ｓｐｒをコードするポリヌクレオチドを含む組換えベクター、及びそれを含む組成物 |
| LT4009978T (lt) | 2019-08-05 | 2024-11-25 | Ptc Therapeutics Mp, Inc. | Sepiapterino ir jo metabolitų panaudojimas spinduliuotės poveikio gydymui |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61277618A (ja) * | 1985-06-04 | 1986-12-08 | Suntory Ltd | 自閉症治療剤 |
| JP2588191B2 (ja) * | 1987-04-24 | 1997-03-05 | サントリー株式会社 | 悪性腫瘍および重症ウイルス感染症に伴う神経症状を改善するための治療剤 |
| DE10260263A1 (de) * | 2002-12-20 | 2004-07-15 | Biocrates Life Sciences Gmbh | Verwendung von Tetrahydrobiopterinderivaten zur Behandlung und Ernährung von Patienten mit Aminosäurestoffwechselstörungen |
| US20080207624A1 (en) * | 2004-05-11 | 2008-08-28 | Osamu Sugita | Therapeutic Agent for Bh4-Responsive Hyperphenylalaninemia |
| CN101132776A (zh) * | 2004-11-17 | 2008-02-27 | 生物马林药物股份有限公司 | 稳定的四氢生物喋呤片剂制剂 |
| US20060188492A1 (en) * | 2005-01-13 | 2006-08-24 | Chronorx Llc, An Alaska Limited Liability Company | Topical management of ocular and periocular conditions |
| JP2008540486A (ja) * | 2005-05-11 | 2008-11-20 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｐｄｅ４インヒビター及びテトラヒドロビオプテリン誘導体との組合せ物 |
| KR20160065998A (ko) * | 2007-04-11 | 2016-06-09 | 바이오마린 파머수티컬 인크. | 테트라하이드로바이오프테린 투여 방법, 관련 조성물 및 측정 방법 |
-
2009
- 2009-08-07 WO PCT/AT2009/000306 patent/WO2010017570A2/de not_active Ceased
- 2009-08-07 US US13/058,625 patent/US20110144117A1/en not_active Abandoned
- 2009-08-07 PL PL09775591T patent/PL2309983T3/pl unknown
- 2009-08-07 EP EP09775591.2A patent/EP2309983B1/de active Active
- 2009-08-07 JP JP2011522346A patent/JP2011530540A/ja active Pending
- 2009-08-07 TR TR2019/10287T patent/TR201910287T4/tr unknown
- 2009-08-07 ES ES09775591T patent/ES2736730T3/es active Active
- 2009-08-07 RU RU2011109210/15A patent/RU2011109210A/ru not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US20110144117A1 (en) | 2011-06-16 |
| EP2309983B1 (de) | 2019-04-24 |
| TR201910287T4 (tr) | 2019-07-22 |
| ES2736730T3 (es) | 2020-01-07 |
| WO2010017570A3 (de) | 2010-08-05 |
| PL2309983T3 (pl) | 2019-09-30 |
| JP2011530540A (ja) | 2011-12-22 |
| WO2010017570A2 (de) | 2010-02-18 |
| EP2309983A2 (de) | 2011-04-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20131015 |