JP2011530536A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011530536A5 JP2011530536A5 JP2011522288A JP2011522288A JP2011530536A5 JP 2011530536 A5 JP2011530536 A5 JP 2011530536A5 JP 2011522288 A JP2011522288 A JP 2011522288A JP 2011522288 A JP2011522288 A JP 2011522288A JP 2011530536 A5 JP2011530536 A5 JP 2011530536A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- fragment
- seq
- pancreatic cancer
- panin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 17
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 17
- 201000002528 pancreatic cancer Diseases 0.000 claims 17
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 17
- 239000012634 fragment Substances 0.000 claims 15
- 230000002946 anti-pancreatic effect Effects 0.000 claims 11
- 239000000427 antigen Substances 0.000 claims 9
- 102000036639 antigens Human genes 0.000 claims 9
- 108091007433 antigens Proteins 0.000 claims 9
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 8
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 8
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 7
- -1 anthracycline Chemical class 0.000 claims 6
- 239000000032 diagnostic agent Substances 0.000 claims 5
- 229940039227 diagnostic agent Drugs 0.000 claims 5
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 4
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims 4
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 4
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 4
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 4
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 4
- 208000022669 mucinous neoplasm Diseases 0.000 claims 4
- 206010052747 Adenocarcinoma pancreas Diseases 0.000 claims 3
- 102100032528 C-type lectin domain family 11 member A Human genes 0.000 claims 3
- 101710167766 C-type lectin domain family 11 member A Proteins 0.000 claims 3
- 108090000394 Erythropoietin Proteins 0.000 claims 3
- 102000003951 Erythropoietin Human genes 0.000 claims 3
- 206010033645 Pancreatitis Diseases 0.000 claims 3
- 108010041111 Thrombopoietin Proteins 0.000 claims 3
- 102000036693 Thrombopoietin Human genes 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 229940105423 erythropoietin Drugs 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 201000002094 pancreatic adenocarcinoma Diseases 0.000 claims 3
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 3
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 102100029470 Apolipoprotein E Human genes 0.000 claims 2
- 102100031162 Collagen alpha-1(XVIII) chain Human genes 0.000 claims 2
- 108010071942 Colony-Stimulating Factors Proteins 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical class O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- 108010079505 Endostatins Chemical class 0.000 claims 2
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 claims 2
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 claims 2
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 2
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 2
- 102000002812 Heat-Shock Proteins Human genes 0.000 claims 2
- 108010004889 Heat-Shock Proteins Proteins 0.000 claims 2
- 101000595923 Homo sapiens Placenta growth factor Proteins 0.000 claims 2
- 108010000521 Human Growth Hormone Proteins 0.000 claims 2
- 102000002265 Human Growth Hormone Human genes 0.000 claims 2
- 239000000854 Human Growth Hormone Substances 0.000 claims 2
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 2
- 102000006992 Interferon-alpha Human genes 0.000 claims 2
- 108010047761 Interferon-alpha Proteins 0.000 claims 2
- 102000003996 Interferon-beta Human genes 0.000 claims 2
- 108090000467 Interferon-beta Proteins 0.000 claims 2
- 102000008070 Interferon-gamma Human genes 0.000 claims 2
- 108010074328 Interferon-gamma Proteins 0.000 claims 2
- 102000014150 Interferons Human genes 0.000 claims 2
- 108010050904 Interferons Proteins 0.000 claims 2
- 102000015696 Interleukins Human genes 0.000 claims 2
- 108010063738 Interleukins Proteins 0.000 claims 2
- 102000009151 Luteinizing Hormone Human genes 0.000 claims 2
- 108010073521 Luteinizing Hormone Proteins 0.000 claims 2
- 108090000542 Lymphotoxin-alpha Proteins 0.000 claims 2
- 102000004083 Lymphotoxin-alpha Human genes 0.000 claims 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical group CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 2
- 102100035194 Placenta growth factor Human genes 0.000 claims 2
- 102000006382 Ribonucleases Human genes 0.000 claims 2
- 108010083644 Ribonucleases Proteins 0.000 claims 2
- 102000011923 Thyrotropin Human genes 0.000 claims 2
- 108010061174 Thyrotropin Proteins 0.000 claims 2
- 150000001413 amino acids Chemical group 0.000 claims 2
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000002532 enzyme inhibitor Substances 0.000 claims 2
- 229940125532 enzyme inhibitor Drugs 0.000 claims 2
- 229940028334 follicle stimulating hormone Drugs 0.000 claims 2
- 239000003667 hormone antagonist Substances 0.000 claims 2
- 239000002955 immunomodulating agent Substances 0.000 claims 2
- 229940121354 immunomodulator Drugs 0.000 claims 2
- 230000002584 immunomodulator Effects 0.000 claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- 229940079322 interferon Drugs 0.000 claims 2
- 229960003130 interferon gamma Drugs 0.000 claims 2
- 229960001388 interferon-beta Drugs 0.000 claims 2
- 229940040129 luteinizing hormone Drugs 0.000 claims 2
- 239000012074 organic phase Substances 0.000 claims 2
- 210000004923 pancreatic tissue Anatomy 0.000 claims 2
- 230000000861 pro-apoptotic effect Effects 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 239000003053 toxin Substances 0.000 claims 2
- 231100000765 toxin Toxicity 0.000 claims 2
- VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 claims 1
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
- YJGVMLPVUAXIQN-LGWHJFRWSA-N (5s,5ar,8ar,9r)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5h-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one Chemical compound COC1=C(OC)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O)[C@@H]3[C@@H]2C(OC3)=O)=C1 YJGVMLPVUAXIQN-LGWHJFRWSA-N 0.000 claims 1
- FSPQCTGGIANIJZ-UHFFFAOYSA-N 2-[[(3,4-dimethoxyphenyl)-oxomethyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(=O)NC1=C(C(N)=O)C(CCCC2)=C2S1 FSPQCTGGIANIJZ-UHFFFAOYSA-N 0.000 claims 1
- FJHBVJOVLFPMQE-QFIPXVFZSA-N 7-Ethyl-10-Hydroxy-Camptothecin Chemical class C1=C(O)C=C2C(CC)=C(CN3C(C4=C([C@@](C(=O)OC4)(O)CC)C=C33)=O)C3=NC2=C1 FJHBVJOVLFPMQE-QFIPXVFZSA-N 0.000 claims 1
- 108010066676 Abrin Proteins 0.000 claims 1
- 108010059616 Activins Proteins 0.000 claims 1
- 102000005606 Activins Human genes 0.000 claims 1
- 101710092462 Alpha-hemolysin Proteins 0.000 claims 1
- 101710197219 Alpha-toxin Proteins 0.000 claims 1
- 102400000068 Angiostatin Human genes 0.000 claims 1
- 108010079709 Angiostatins Proteins 0.000 claims 1
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical class C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 claims 1
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Chemical class CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims 1
- 102100021809 Chorionic somatomammotropin hormone 1 Human genes 0.000 claims 1
- 102000001189 Cyclic Peptides Human genes 0.000 claims 1
- 108010069514 Cyclic Peptides Proteins 0.000 claims 1
- XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 claims 1
- 102000007260 Deoxyribonuclease I Human genes 0.000 claims 1
- 108010008532 Deoxyribonuclease I Proteins 0.000 claims 1
- 108010053187 Diphtheria Toxin Proteins 0.000 claims 1
- 102000016607 Diphtheria Toxin Human genes 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 108050007372 Fibroblast Growth Factor Proteins 0.000 claims 1
- 102000018233 Fibroblast Growth Factor Human genes 0.000 claims 1
- 108700004714 Gelonium multiflorum GEL Proteins 0.000 claims 1
- 102000003886 Glycoproteins Human genes 0.000 claims 1
- 108090000288 Glycoproteins Proteins 0.000 claims 1
- 108010086677 Gonadotropins Proteins 0.000 claims 1
- 102000006771 Gonadotropins Human genes 0.000 claims 1
- 101000853002 Homo sapiens Interleukin-25 Proteins 0.000 claims 1
- 101001128431 Homo sapiens Myeloid-derived growth factor Proteins 0.000 claims 1
- 102000002746 Inhibins Human genes 0.000 claims 1
- 108010004250 Inhibins Proteins 0.000 claims 1
- 102000004877 Insulin Human genes 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- 102000014429 Insulin-like growth factor Human genes 0.000 claims 1
- 102100037852 Insulin-like growth factor I Human genes 0.000 claims 1
- 108010002352 Interleukin-1 Proteins 0.000 claims 1
- 102000000589 Interleukin-1 Human genes 0.000 claims 1
- 108090000174 Interleukin-10 Proteins 0.000 claims 1
- 108090000177 Interleukin-11 Proteins 0.000 claims 1
- 108010065805 Interleukin-12 Proteins 0.000 claims 1
- 108090000176 Interleukin-13 Proteins 0.000 claims 1
- 108050003558 Interleukin-17 Proteins 0.000 claims 1
- 102000013691 Interleukin-17 Human genes 0.000 claims 1
- 102000003810 Interleukin-18 Human genes 0.000 claims 1
- 108090000171 Interleukin-18 Proteins 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 102100030703 Interleukin-22 Human genes 0.000 claims 1
- 108010002386 Interleukin-3 Proteins 0.000 claims 1
- 108090000978 Interleukin-4 Proteins 0.000 claims 1
- 108010002616 Interleukin-5 Proteins 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 108010002586 Interleukin-7 Proteins 0.000 claims 1
- 108090001007 Interleukin-8 Proteins 0.000 claims 1
- 108010002335 Interleukin-9 Proteins 0.000 claims 1
- 206010073365 Intraductal papillary mucinous carcinoma of pancreas Diseases 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- 102000016267 Leptin Human genes 0.000 claims 1
- 108010092277 Leptin Proteins 0.000 claims 1
- 102100032352 Leukemia inhibitory factor Human genes 0.000 claims 1
- 108090000581 Leukemia inhibitory factor Proteins 0.000 claims 1
- 102100026632 Mimecan Human genes 0.000 claims 1
- 102100031789 Myeloid-derived growth factor Human genes 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 101800002327 Osteoinductive factor Proteins 0.000 claims 1
- 229930012538 Paclitaxel Chemical class 0.000 claims 1
- 102000003982 Parathyroid hormone Human genes 0.000 claims 1
- 108090000445 Parathyroid hormone Proteins 0.000 claims 1
- 101710124951 Phospholipase C Proteins 0.000 claims 1
- 108010003044 Placental Lactogen Proteins 0.000 claims 1
- 239000000381 Placental Lactogen Substances 0.000 claims 1
- 108010076181 Proinsulin Proteins 0.000 claims 1
- 108010057464 Prolactin Proteins 0.000 claims 1
- 102000003946 Prolactin Human genes 0.000 claims 1
- 241000589516 Pseudomonas Species 0.000 claims 1
- 101000762949 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) Exotoxin A Proteins 0.000 claims 1
- 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 claims 1
- 101710151245 Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 claims 1
- 108090000103 Relaxin Proteins 0.000 claims 1
- 102000003743 Relaxin Human genes 0.000 claims 1
- 108010039491 Ricin Proteins 0.000 claims 1
- 108010084592 Saporins Proteins 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 229940123237 Taxane Drugs 0.000 claims 1
- 102000002938 Thrombospondin Human genes 0.000 claims 1
- 108060008245 Thrombospondin Proteins 0.000 claims 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 1
- 101800004564 Transforming growth factor alpha Proteins 0.000 claims 1
- 102400001320 Transforming growth factor alpha Human genes 0.000 claims 1
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 1
- 102100039037 Vascular endothelial growth factor A Human genes 0.000 claims 1
- 229940122803 Vinca alkaloid Drugs 0.000 claims 1
- 239000000488 activin Substances 0.000 claims 1
- 108010035879 albumin-bilirubin complex Proteins 0.000 claims 1
- 150000008052 alkyl sulfonates Chemical class 0.000 claims 1
- 239000002168 alkylating agent Substances 0.000 claims 1
- 229940100198 alkylating agent Drugs 0.000 claims 1
- 239000002776 alpha toxin Substances 0.000 claims 1
- 229940121369 angiogenesis inhibitor Drugs 0.000 claims 1
- 229940045799 anthracyclines and related substance Drugs 0.000 claims 1
- 230000000340 anti-metabolite Effects 0.000 claims 1
- 229940100197 antimetabolite Drugs 0.000 claims 1
- 239000002256 antimetabolite Substances 0.000 claims 1
- 239000003080 antimitotic agent Substances 0.000 claims 1
- 239000000074 antisense oligonucleotide Substances 0.000 claims 1
- 238000012230 antisense oligonucleotides Methods 0.000 claims 1
- FZCSTZYAHCUGEM-UHFFFAOYSA-N aspergillomarasmine B Natural products OC(=O)CNC(C(O)=O)CNC(C(O)=O)CC(O)=O FZCSTZYAHCUGEM-UHFFFAOYSA-N 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 108010006025 bovine growth hormone Proteins 0.000 claims 1
- 229940127093 camptothecin Drugs 0.000 claims 1
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000003246 corticosteroid Chemical class 0.000 claims 1
- 229940111134 coxibs Drugs 0.000 claims 1
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 claims 1
- 208000012106 cystic neoplasm Diseases 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims 1
- 229960004679 doxorubicin Drugs 0.000 claims 1
- 239000002158 endotoxin Substances 0.000 claims 1
- YJGVMLPVUAXIQN-UHFFFAOYSA-N epipodophyllotoxin Natural products COC1=C(OC)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YJGVMLPVUAXIQN-UHFFFAOYSA-N 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- 229940126864 fibroblast growth factor Drugs 0.000 claims 1
- 150000002224 folic acids Chemical class 0.000 claims 1
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 1
- 229960005277 gemcitabine Drugs 0.000 claims 1
- 239000002622 gonadotropin Substances 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 230000003394 haemopoietic effect Effects 0.000 claims 1
- 239000003276 histone deacetylase inhibitor Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 239000000893 inhibin Substances 0.000 claims 1
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 claims 1
- 229940125396 insulin Drugs 0.000 claims 1
- 102000006495 integrins Human genes 0.000 claims 1
- 108010044426 integrins Proteins 0.000 claims 1
- 108010074108 interleukin-21 Proteins 0.000 claims 1
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims 1
- 229940124302 mTOR inhibitor Drugs 0.000 claims 1
- 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 claims 1
- HAWPXGHAZFHHAD-UHFFFAOYSA-N mechlorethamine Chemical class ClCCN(C)CCCl HAWPXGHAZFHHAD-UHFFFAOYSA-N 0.000 claims 1
- 229960004961 mechlorethamine Drugs 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- HDZGCSFEDULWCS-UHFFFAOYSA-N monomethylhydrazine Chemical class CNN HDZGCSFEDULWCS-UHFFFAOYSA-N 0.000 claims 1
- OSTGTTZJOCZWJG-UHFFFAOYSA-N nitrosourea Chemical compound NC(=O)N=NO OSTGTTZJOCZWJG-UHFFFAOYSA-N 0.000 claims 1
- 229960001592 paclitaxel Drugs 0.000 claims 1
- 201000004754 pancreatic intraductal papillary-mucinous neoplasm Diseases 0.000 claims 1
- 229960001319 parathyroid hormone Drugs 0.000 claims 1
- 239000000199 parathyroid hormone Substances 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- 108700028325 pokeweed antiviral Proteins 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 229940097325 prolactin Drugs 0.000 claims 1
- 108010087851 prorelaxin Proteins 0.000 claims 1
- 150000003180 prostaglandins Chemical class 0.000 claims 1
- 150000003212 purines Chemical class 0.000 claims 1
- 150000003230 pyrimidines Chemical class 0.000 claims 1
- 239000002924 silencing RNA Substances 0.000 claims 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical class O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 1
- 229940034208 thyroxine Drugs 0.000 claims 1
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 claims 1
- AYNNSCRYTDRFCP-UHFFFAOYSA-N triazene Chemical compound NN=N AYNNSCRYTDRFCP-UHFFFAOYSA-N 0.000 claims 1
- 239000013638 trimer Substances 0.000 claims 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 claims 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 claims 1
- 150000003672 ureas Chemical class 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8746308P | 2008-08-08 | 2008-08-08 | |
| US61/087,463 | 2008-08-08 | ||
| US12/343,655 US7993626B2 (en) | 2007-01-11 | 2008-12-24 | Methods and compositions for F-18 labeling of proteins, peptides and other molecules |
| US12/343,655 | 2008-12-24 | ||
| US14422709P | 2009-01-13 | 2009-01-13 | |
| US61/144,227 | 2009-01-13 | ||
| US12/418,877 US7906118B2 (en) | 2005-04-06 | 2009-04-06 | Modular method to prepare tetrameric cytokines with improved pharmacokinetics by the dock-and-lock (DNL) technology |
| US12/418,877 | 2009-04-06 | ||
| PCT/US2009/053192 WO2010017500A2 (en) | 2008-08-08 | 2009-08-07 | Anti-pancreatic cancer antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015009665A Division JP2015110618A (ja) | 2008-08-08 | 2015-01-21 | 抗膵癌抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011530536A JP2011530536A (ja) | 2011-12-22 |
| JP2011530536A5 true JP2011530536A5 (cg-RX-API-DMAC7.html) | 2012-08-23 |
| JP5919604B2 JP5919604B2 (ja) | 2016-05-18 |
Family
ID=41664221
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011522288A Expired - Fee Related JP5919604B2 (ja) | 2008-08-08 | 2009-08-07 | 抗膵癌抗体 |
| JP2015009665A Pending JP2015110618A (ja) | 2008-08-08 | 2015-01-21 | 抗膵癌抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015009665A Pending JP2015110618A (ja) | 2008-08-08 | 2015-01-21 | 抗膵癌抗体 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP2331134A4 (cg-RX-API-DMAC7.html) |
| JP (2) | JP5919604B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN102137681B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2009279503B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2731438C (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010017500A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8481041B2 (en) | 2005-04-06 | 2013-07-09 | Ibc Pharmaceuticals, Inc. | Dock-and-lock (DNL) constructs for human immunodeficiency virus (HIV) therapy |
| BR112012028006A2 (pt) * | 2010-05-07 | 2016-08-02 | Hoffmann La Roche | método de imuno-histoquímica (ihq), uso de um domínio de ligação, kit e domínio de ligação terapeuticamente ativo |
| AU2011323354B2 (en) * | 2010-11-03 | 2014-07-31 | Ibc Pharmaceuticals, Inc. | Dock-and-lock (DNL) constructs for human immunodeficiency virus (HIV) therapy |
| CA2814962A1 (en) * | 2010-12-02 | 2012-06-07 | Immunomedics, Inc. | In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents |
| CN102485753A (zh) * | 2010-12-03 | 2012-06-06 | 上海杰隆生物工程股份有限公司 | 具有人血管内皮生长因子结合活性的人源重链可变区 |
| ES2643392T3 (es) * | 2011-11-15 | 2017-11-22 | Quincy Bioscience Llc | Apoaecuorina para reducir lesiones neuronales debidas a isquemia |
| CA2884313C (en) * | 2012-12-13 | 2023-01-03 | Immunomedics, Inc. | Dosages of immunoconjugates of antibodies and sn-38 for improved efficacy and decreased toxicity |
| EP2981829A4 (en) * | 2013-04-01 | 2016-10-26 | Immunomedics Inc | ANTI-MUCIN ANTIBODY FOR THE EARLY RECOGNITION AND TREATMENT OF PANCREATIC CANCER |
| CN107252485A (zh) * | 2013-04-03 | 2017-10-17 | Ibc药品公司 | 用于诱导对疾病的免疫应答的组合疗法 |
| EP3015864A4 (en) * | 2013-06-14 | 2017-01-18 | Universidad de Granada | Biomarkers for the diagnosis and the response to treatment of pancreatic cancer |
| KR20150129932A (ko) * | 2014-05-12 | 2015-11-23 | 연세대학교 산학협력단 | 보체인자 b 단백질에 특이적으로 결합하는 항체를 포함하는 췌장암 진단용 키트 |
| EP3160499A4 (en) * | 2014-06-30 | 2018-03-14 | Immunomedics, Inc. | Antibodies reactive with an epitope located in the n-terminal region of muc5ac comprising cysteine-rich subdomain 2 (cys2) |
| KR20160045547A (ko) * | 2014-10-17 | 2016-04-27 | 에스케이텔레콤 주식회사 | 췌장암 진단용 조성물 및 이를 이용한 췌장암 진단방법 |
| CN104974988B (zh) * | 2015-07-31 | 2016-08-24 | 南京麦科林生物医药科技有限公司 | 抗胰腺癌单克隆抗体及其应用 |
| CA3094719A1 (en) * | 2018-04-05 | 2019-10-10 | Tarveda Therapeutics, Inc. | Hsp90-targeting conjugates and formulations thereof |
| KR20210073515A (ko) | 2018-09-10 | 2021-06-18 | 콜드스프링하버러보러토리 | 췌장염을 치료하는 방법 |
| MX2022004582A (es) * | 2019-10-18 | 2022-07-21 | Nihon Mediphysics Co Ltd | Anticuerpo humanizado marcado con ri. |
| IL303002A (en) * | 2020-12-16 | 2023-07-01 | Alpha Tau Medical Ltd | Diffusing Alpha-emitters Radiation Therapy with Enhanced Beta Treatment |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6357596A (ja) * | 1986-08-29 | 1988-03-12 | Nisshin Flour Milling Co Ltd | モノクロ−ナル抗体、その製法およびそれからなる肝疾患診断剤 |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US7214786B2 (en) * | 2000-12-14 | 2007-05-08 | Kovalic David K | Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement |
| EP1519958B1 (en) * | 2002-06-14 | 2014-10-15 | Immunomedics, Inc. | Humanized monoclonal antibody hpam4 |
| AU2006232310B9 (en) * | 2005-04-06 | 2011-07-21 | Ibc Pharmaceuticals, Inc. | Improved stably tethered structures of defined compositions with multiple functions or binding specificities |
| CA2916671C (en) * | 2007-01-17 | 2018-01-09 | Immunomedics, Inc. | Polymeric carriers of therapeutic agents and recognition moieties for antibody-based targeting of disease sites |
-
2009
- 2009-08-07 AU AU2009279503A patent/AU2009279503B2/en not_active Ceased
- 2009-08-07 JP JP2011522288A patent/JP5919604B2/ja not_active Expired - Fee Related
- 2009-08-07 EP EP09805623.7A patent/EP2331134A4/en not_active Withdrawn
- 2009-08-07 CA CA2731438A patent/CA2731438C/en not_active Expired - Fee Related
- 2009-08-07 CN CN200980134258.8A patent/CN102137681B/zh not_active Expired - Fee Related
- 2009-08-07 WO PCT/US2009/053192 patent/WO2010017500A2/en not_active Ceased
-
2015
- 2015-01-21 JP JP2015009665A patent/JP2015110618A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011530536A5 (cg-RX-API-DMAC7.html) | ||
| ES2994774T3 (en) | Methods for preventing or treating allergy by administering an il-4r antagonist | |
| TWI856945B (zh) | 用抗tslp抗體治療氣喘 | |
| US20200399384A1 (en) | Method of treating diseases using an il-17 receptor antibody formulation | |
| US8846002B2 (en) | Anti-CD74 immunoconjugates and methods of use | |
| JP2020188775A (ja) | プロラクチン受容体結合タンパク質およびそれらの使用 | |
| KR101927118B1 (ko) | Ｇｄ２ 양성암의 치료 방법 | |
| ES2547689T3 (es) | Composiciones y métodos para el tratamiento de enfermedades y trastornos asociados con la señalización de citocinas que implican anticuerpos que se unen a IL-22 y a IL-22R | |
| RU2005100777A (ru) | Моноклональное антитело рам4 и его применение для диагностики и лечения рака поджелудочной железы | |
| JP2008520551A5 (cg-RX-API-DMAC7.html) | ||
| JP2006502698A5 (cg-RX-API-DMAC7.html) | ||
| JP6596014B2 (ja) | 爪および頭皮乾癬の治療方法 | |
| AU2023210647A1 (en) | Antibodies Neutralizing GM-CSF For Use In The Treatment Of Rheumatoid Arthritis Or As Analgesics | |
| JPWO2018191479A5 (cg-RX-API-DMAC7.html) | ||
| JP2015511225A (ja) | 抗体を有するインターフェロンλでの標的化は抗腫瘍および抗ウイルス活性を大きく増強する | |
| US20210000949A1 (en) | Methods for treating or preventing asthma by administering an il-33 antagonist | |
| Amini-Vaughan et al. | Therapeutic strategies for harnessing human eosinophils in allergic inflammation, hypereosinophilic disorders, and cancer | |
| JP2019537617A5 (cg-RX-API-DMAC7.html) | ||
| TW201718021A (zh) | 包含金屬奈米粒子、連接物及抗體之複合物 | |
| KR20220002899A (ko) | 항-psma/cd3 항체로 전립선암을 치료하는 방법 | |
| WO2021249445A1 (zh) | 抗il-17a抗体药物组合物及其用途 | |
| KR20160072268A (ko) | 항-efna4 항체-약물 접합체 | |
| KR20220002900A (ko) | 항-psma/cd3 항체로 신장암을 치료하는 방법 | |
| US20210230265A1 (en) | Methods for treating copd by administering an il-33 antagonist | |
| Desai et al. | Biologics in asthma: emerging biologics |