JP2011529938A - 頭髪および頭皮に薬剤を放出するための被膜形成性の液体製剤 - Google Patents
頭髪および頭皮に薬剤を放出するための被膜形成性の液体製剤 Download PDFInfo
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- JP2011529938A JP2011529938A JP2011521534A JP2011521534A JP2011529938A JP 2011529938 A JP2011529938 A JP 2011529938A JP 2011521534 A JP2011521534 A JP 2011521534A JP 2011521534 A JP2011521534 A JP 2011521534A JP 2011529938 A JP2011529938 A JP 2011529938A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9741—Pteridophyta [ferns]
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A61Q5/00—Preparations for care of the hair
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Abstract
Description
2)エチルアルコール96° 55.00%
3)プロピレングリコール 5.00%
4)ヒドロキシプロピルキトサン 1.00%
5)精製水 38.75%
調製
エチルアルコール、プロピレングリコールおよび水を室温で混合した。次いで、フィナステライドを添加し、清澄な溶液が得られるまで混合した。ヒドロキシプロピルキトサンを最後の成分として添加し、混合物を室温で24時間または溶解するまで撹拌した。
2)エチルアルコール96° 55.00%
3)プロピレングリコール 5.00%
4)ヒドロキシプロピルキトサン 2.00%
5)精製水 37.75%
調製
実施例1に関して記載したのと同じ方法を使用することにより該製剤を調製した。
2)エチルアルコール96° 55.00%
3)プロピレングリコール 5.00%
4)ヒドロキシプロピルキトサン 1.00%
5)精製水 37.00%
調製
実施例1に関して記載したのと同じ方法を使用することにより該製剤を調製した。
2)エチルアルコール96° 55.00%
3)プロピレングリコール 5.00%
4)ヒドロキシプロピルキトサン 2.00%
5)精製水 37.00%
調製
実施例1に関して記載したのと同じ方法を使用することにより該製剤を調製した。
2.精製水 19.25%
3.プロピレングリコール 10.00%
4.イソプロパノール 70.00%
5.キトサン 0.50%
調製
キトサンおよびフィナステライドをプロピレングリコール中に溶解し、次いで、その他の成分を添加し、混合物を溶解するまで撹拌することにより該製剤を調製した。得られた液体は、皮膚表面に強力に付着することができる弾性被膜を形成することができた。
2.エチルアルコール96° 36.50%
3.ジエチレングリコールモノエチルエーテル2 0.50%
4.ヒドロキシプロピルキトサン 1.00%
5.精製水 52.00%
1ビワ葉抽出物CA、2Transcutol(登録商標)P
調製
エチルアルコールおよび水を室温で混合した。次いで、ビワ葉抽出物CAを添加し、清澄な溶液が得られるまで混合した。ジエチレングリコールモノエチルエーテルを添加し、ヒドロキシプロピルキトサンを最後の成分として添加し、混合物を室温で4時間または溶解するまで撹拌した。
2.エチルアルコール96° 36.50%
3.ジエチレングリコールモノエチルエーテル1 0.50%
4.ヒドロキシプロピルキトサン 1.00%
5.精製水 52.00%
1加水分解したジュズダマ抽出物、2Transcutol(登録商標)P
調製
エチルアルコールおよび水を室温で混合した。次いで、加水分解したジュズダマ抽出物を添加し、清澄な溶液が得られるまで混合した。ジエチレングリコールモノエチルエーテルを添加し、ヒドロキシプロピルキトサンを最後の成分として添加し、混合物を室温で4時間または溶解するまで撹拌した。
2)エチルアルコール96° 36.50%
3)ジエチレングリコールモノエチルエーテル2 0.50%
4)キトサン 1.00%
5)精製水 52.00%
1ビワ葉抽出物CA、2Transcutol(登録商標)P
調製
pH3.0の酢酸による酸化後、キトサンを水中に溶解した。次いで、エチルアルコールを添加し、清澄な粘性の溶液を得るまで混合物を撹拌した。この時点で、pHは5.5まで上昇した。
2.牽引抵抗力(UNI EN ISO2062:1997に従った)
3.分光測光法(CIE、国際照明委員会(Commission Internationale de l'Eclairage)に従って輝きを測定した)
4.3D Hirox KH−770の2100倍および350倍でのデジタル3Dビデオ顕微鏡法
結果は以下の通りであった。処理した束は、12%高い平均体積、分光測光法により測定すると6%高い輝きおよび対照束より11%高い牽引抵抗力を示した。デジタルビデオ顕微鏡法では、処理した頭髪がより滑らかで角質がより規則的な外観を有しているように見えた。
Claims (16)
- (a)キトサン、キトサン誘導体またはそれらの生理学的に許容される塩と、
(b)5−アルファ還元酵素阻害剤、抗アンドロゲンホルモン、カリウムチャネルアゴニスト、アミノ酸、植物抽出物および酸化防止剤から選択される少なくとも1種の医薬または化粧品活性成分と、
(c)少なくとも1種の揮発性溶媒と、
を含有することを特徴とする、頭皮および/または頭髪の症状および/または疾患の治療および/または予防用組成物。 - 成分a)は、前記組成物の総重量に対して0.1から10%、好ましくは0.2から5%、より好ましくは0.25から2.0%の量で存在することを特徴とする請求項1に記載の組成物。
- 成分a)は、水溶性キトサン誘導体またはそれらの塩であることを特徴とする前記請求項1または2に記載の組成物。
- 前記水溶性キトサン誘導体は、ヒドロキシアルキル−キトサンであることを特徴とする請求項3に記載の組成物。
- 前記ヒドロキシアルキル−キトサンは、ヒドロキシプロピル−キトサンであることを特徴とする請求項4に記載の組成物。
- 成分b)は、前記組成物の総重量に対して0.001から25%、好ましくは0.2から10%、より好ましくは0.4から5.0%の量で存在することを特徴とする前記請求項1〜5のいずれか一項に記載の組成物。
- 前記5−アルファ還元酵素阻害剤は、フィナステライド、デュタステライド、アゼライン酸、ベータシトステロール、亜鉛、ビタミンB6から選択され、前記抗アンドロゲンホルモンは、スピロノラクトン、酢酸シプロテロン、フルタミド、ケトコナゾール、エストロゲンおよびそれらの塩から選択され、前記カリウムチャネルアゴニストはミノキシジルであり、前記アミノ酸は、L−システイン、N−アセチルシステイン、L−シスチン、L−メチオニン、ジメチルスルホン、L−タウリンから選択され、および/または前記植物抽出物は、ノコギリパルメット、アロエベラ、スギナ、キビ、アフリカプルーン、セイヨウイラクサ、ジュズダマ、ビワの抽出物から選択されることを特徴とする前記請求項1〜6のいずれか一項に記載の組成物。
- 成分c)は、前記組成物の総重量に対して25%から90%、好ましくは30%から85%、より好ましくは35%から80%の量で存在することを特徴とする前記請求項1〜7のいずれか一項に記載の組成物。
- 成分c)は、好ましくはエタノールまたはイソプロパノールから選択される低級アルカノールであることを特徴とする前記請求項1〜8のいずれか一項に記載の組成物。
- 水を含むことを特徴とする前記請求項1〜9のいずれか一項に記載の組成物。
- 通常の賦形剤および/またはアジュバントを含むことを特徴とする前記請求項1〜10のいずれか一項に記載の組成物。
- 液体、好ましくは溶液、エマルジョン、懸濁液またはコロイドであることを特徴とする前記請求項1〜11のいずれか一項に記載の組成物。
- 噴霧により塗布されることを特徴とする前記請求項1〜12のいずれか一項に記載の組成物。
- 前記頭皮および/または頭髪の症状および/または疾患は、抜け毛、禿頭症、脱毛症、アンドロゲン性脱毛症および/または頭髪の脆弱化から選択されることを特徴とする前記請求項1〜13のいずれか一項に記載の組成物。
- 好ましくはジエチレングリコールモノエチルエーテルまたはマイクロカプセルから選択される少なくとも1種の浸透力を改良する系をさらに含有することを特徴とする前記請求項1〜14のいずれか一項に記載の組成物。
- 前記頭皮および/または頭髪の症状および/または疾患の治療および/または予防は、前記組成物をヒトの頭皮および/または頭髪に塗布することにより達成されることを特徴とする前記請求項1〜15のいずれか一項に記載の組成物。
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PCT/EP2009/059807 WO2010015556A1 (en) | 2008-08-04 | 2009-07-29 | Film-forming liquid formulations for drug release to hair and scalp |
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