JP2011529906A - ベタレイン組成物およびそれらの使用 - Google Patents
ベタレイン組成物およびそれらの使用 Download PDFInfo
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- JP2011529906A JP2011529906A JP2011521337A JP2011521337A JP2011529906A JP 2011529906 A JP2011529906 A JP 2011529906A JP 2011521337 A JP2011521337 A JP 2011521337A JP 2011521337 A JP2011521337 A JP 2011521337A JP 2011529906 A JP2011529906 A JP 2011529906A
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Abstract
Description
発明の分野は、ヒトの状態を治療する組成物および方法であり、特に、骨関節症、ざ瘡、アレルギー状態、副鼻腔炎および接触皮膚炎の治療のためのベタレイン含有組成物に関する。本明細書において考慮される組成物および方法も、非カフェイン刺激剤としてのベタレイン含有組成物の使用に関する。
骨関節症(OA)は、極めて一般的な状態であり、米国の人口の約80%が65歳までにはX線によるOAの証拠を有すると予想される。骨関節症は、罹患した関節に隣接する組織の疼痛および腫脹を頻繁に伴う関節軟骨の損失により特徴付けられ、次に多くの場合にその関節に関連する筋肉の局所性または領域性の萎縮を引き起こす。OAは同一の基礎原因を有さないが、OAは、一次または変形性OAとも呼ばれ、一方、二次OAは、多様な障害または疾患(例えば、糖尿病、局所傷害または感染、関節不安定症など)により典型的に誘起される。対照的に、リウマチ様関節炎(RA)は、免疫系が罹患関節を攻撃し、著しい炎症をもたらし、続いて組織変性をもたらす、慢性で全身性の自己免疫障害である。
本発明は、ビート由来組成物およびそのような組成物が多様な状態、特に、骨関節症、ざ瘡、接触皮膚炎、副鼻腔炎および/またはアレルギーに関連する状態の治療に使用される方法を対象とする。より好ましくは、考慮される組成物および方法は、ベタレインが豊富であり、未加工ビート液汁と比較して糖含有量が低減している。
本発明者たちは、ベタレイン含有調製物、特に多様な赤ビート調製物が、特定の状態、特に、骨関節症、副鼻腔炎、接触皮膚炎、ざ瘡、アレルギー状態、喘息、覚醒状態の低減、体力の低減、身体持久力の低減および/または気分障害に伴う1つ以上の症状を低減するのに適していることを発見した。
抽出の例示的方法
Claims (20)
- ヒト消費用の生成物中に一定量のベタレインを提供すること(前記量は、生成物が推奨投与量およびスケジュールで摂取される場合に、状態に伴う少なくとも1つの症状を低減するのに有効であり、
状態は、骨関節症、副鼻腔炎、接触皮膚炎、ざ瘡、アレルギー状態、覚醒状態の低減、体力の低減、身体持久力の低減および気分障害からなる群より選択される。);ならびに
状態に伴う少なくとも1つの症状を低減するために、生成物を推奨投与量およびスケジュールで経口投与するようにヒトに指示すること
を含む、ヒト消費用の生成物を提供する方法。 - 状態が骨関節症である、請求項1の方法。
- 状態が、副鼻腔炎、接触皮膚炎またはアレルギー状態である、請求項1の方法。
- 状態がざ瘡である、請求項1の方法。
- 状態が、覚醒状態の低減、体力の低減、身体持久力の低減または気分障害である、請求項1の方法。
- 一定量のベタレインが赤ビートから調製される、請求項1の方法。
- 一定量のベタレインが、少なくとも2重量%の濃度の総ベタレインを含む固体調製物として生成物に含まれる、請求項1の方法。
- 固体調製物が、少なくとも2重量%の総ベタレイン濃度およびベタレインと糖の比が少なくとも0.3で化学的に異なる複数のベタレインを含む、請求項7の方法。
- 固体調製物が、少なくとも10重量%の総ベタレイン濃度の化学的に異なる複数のベタレインを含み、少なくとも1.0のベタレインと糖の比を有する、請求項7の方法。
- 投与量およびスケジュールが、組成物の総1日摂取量が10mgから50mgの総ベタレインを提供するように選択される、請求項1の方法。
- 生成物が、栄養補給剤として配合され、ならびに補給剤が、1000mg未満の補給剤の1日用量において10から250mgの総ベタレインを提供するように配合される、請求項1の方法。
- 骨関節症に伴う少なくとも1つの症状を低減するのに有効な投与量およびスケジュールでベタレインを、治療を必要とするヒトに投与する工程を含む、骨関節症を治療する方法。
- 投与量およびスケジュールが、ベタレインの総1日摂取量が10mgから50mgであるように選択される、請求項12の方法。
- ベタレインが、植物材料から単離された組成物に存在し、ならびに組成物が、少なくとも1.0のベタレインと糖の比を有する、請求項13の方法。
- 栄養補助刺激剤が推奨投与量およびスケジュールで摂取される場合、覚醒状態、体力、身体持久力および気分の少なくとも1つを増加するのに有効な量でベタレインを栄養補助刺激剤に提供すること;ならびに
覚醒状態、体力、身体持久力および気分の少なくとも1つを増加するために、推奨投与量およびスケジュールで刺激剤を経口投与するようにヒトに指示すること
を含む、栄養補助刺激剤を提供する方法。 - 投与量およびスケジュールが、刺激剤の総1日摂取量が10mgから50mgのベタレインを提供するように選択される、請求項15の方法。
- ベタレインが、植物材料から単離された、少なくとも1.0のベタレインと糖の比を有する組成物における刺激剤に添加される、請求項16の方法。
- 骨関節症、副鼻腔炎、接触皮膚炎、ざ瘡、アレルギー状態、覚醒状態の低減、体力の低減、身体持久力の低減および気分障害からなる群より選択される状態の治療のための経口投与組成物の製造における、ベタレイン含有調製物の使用。
- ベタレイン含有調製物が、少なくとも5重量%のベタレイン濃度を有する乾燥調製物である、請求項18の使用。
- ベタレインが、1投与単位あたり少なくとも15mgの量で調製物に含まれる、請求項18の使用。
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