JP2011529500A5 - - Google Patents
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- JP2011529500A5 JP2011529500A5 JP2011521224A JP2011521224A JP2011529500A5 JP 2011529500 A5 JP2011529500 A5 JP 2011529500A5 JP 2011521224 A JP2011521224 A JP 2011521224A JP 2011521224 A JP2011521224 A JP 2011521224A JP 2011529500 A5 JP2011529500 A5 JP 2011529500A5
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- Prior art keywords
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- haloalkyl
- alkyl
- halogen
- substituted
- Prior art date
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- 229910052736 halogen Inorganic materials 0.000 claims 38
- 150000002367 halogens Chemical class 0.000 claims 38
- 125000001424 substituent group Chemical group 0.000 claims 35
- 125000001188 haloalkyl group Chemical group 0.000 claims 29
- 239000008194 pharmaceutical composition Substances 0.000 claims 28
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 27
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 26
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 25
- -1 cyano, hydroxy Chemical group 0.000 claims 24
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 23
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 18
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 claims 18
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 18
- 125000000217 alkyl group Chemical group 0.000 claims 17
- 125000004093 cyano group Chemical group *C#N 0.000 claims 17
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 16
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 15
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 13
- 125000003118 aryl group Chemical group 0.000 claims 13
- 125000003545 alkoxy group Chemical group 0.000 claims 11
- 125000005093 alkyl carbonyl alkyl group Chemical group 0.000 claims 11
- 125000004994 halo alkoxy alkyl group Chemical group 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 9
- 239000011780 sodium chloride Substances 0.000 claims 9
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 8
- 125000000278 alkyl amino alkyl group Chemical group 0.000 claims 8
- 125000004103 aminoalkyl group Chemical group 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 claims 8
- 125000004971 nitroalkyl group Chemical group 0.000 claims 8
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 7
- 125000001931 aliphatic group Chemical group 0.000 claims 7
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 claims 7
- 125000003107 substituted aryl group Chemical group 0.000 claims 7
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 6
- 125000004432 carbon atoms Chemical group C* 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 125000005243 carbonyl alkyl group Chemical group 0.000 claims 5
- 125000004663 dialkyl amino group Chemical group 0.000 claims 5
- 125000003282 alkyl amino group Chemical group 0.000 claims 4
- 125000004433 nitrogen atoms Chemical group N* 0.000 claims 4
- 125000002947 alkylene group Chemical group 0.000 claims 3
- 125000002785 azepinyl group Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000003386 piperidinyl group Chemical group 0.000 claims 3
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 2
- 125000006832 (C1-C10) alkylene group Chemical group 0.000 claims 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 125000002393 azetidinyl group Chemical group 0.000 claims 2
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 2
- 125000004438 haloalkoxy group Chemical group 0.000 claims 2
- 125000002757 morpholinyl group Chemical group 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004193 piperazinyl group Chemical group 0.000 claims 2
- 206010018372 Glomerulonephritis membranous Diseases 0.000 claims 1
- 206010018378 Glomerulonephritis rapidly progressive Diseases 0.000 claims 1
- 208000005777 Lupus Nephritis Diseases 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000005122 aminoalkylamino group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 125000004429 atoms Chemical group 0.000 claims 1
- 239000003892 ceramide glucosyltransferase inhibitor Substances 0.000 claims 1
- 201000005637 crescentic glomerulonephritis Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 230000001434 glomerular Effects 0.000 claims 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 201000008350 membranous glomerulonephritis Diseases 0.000 claims 1
- 231100000855 membranous nephropathy Toxicity 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 230000002062 proliferating Effects 0.000 claims 1
- 201000008171 proliferative glomerulonephritis Diseases 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13721408P | 2008-07-28 | 2008-07-28 | |
| US61/137,214 | 2008-07-28 | ||
| PCT/US2009/051864 WO2010014554A1 (en) | 2008-07-28 | 2009-07-27 | Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015056011A Division JP6038213B2 (ja) | 2008-07-28 | 2015-03-19 | 虚脱性糸球体症および他の糸球体疾患の処置のためのグルコシルセラミドシンターゼ阻害 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011529500A JP2011529500A (ja) | 2011-12-08 |
| JP2011529500A5 true JP2011529500A5 (US07794700-20100914-C00152.png) | 2012-07-19 |
Family
ID=41110511
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011521224A Pending JP2011529500A (ja) | 2008-07-28 | 2009-07-27 | 虚脱性糸球体症および他の糸球体疾患の処置のためのグルコシルセラミドシンターゼ阻害 |
| JP2015056011A Expired - Fee Related JP6038213B2 (ja) | 2008-07-28 | 2015-03-19 | 虚脱性糸球体症および他の糸球体疾患の処置のためのグルコシルセラミドシンターゼ阻害 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015056011A Expired - Fee Related JP6038213B2 (ja) | 2008-07-28 | 2015-03-19 | 虚脱性糸球体症および他の糸球体疾患の処置のためのグルコシルセラミドシンターゼ阻害 |
Country Status (5)
Families Citing this family (23)
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|---|---|---|---|---|
| BRPI0517701A8 (pt) | 2004-11-10 | 2018-01-23 | Genzyme Corp | métodos de tratamento de diabetes mellitus |
| PL2032134T3 (pl) | 2006-05-09 | 2015-11-30 | Genzyme Corp | Sposoby leczenia stłuszczeniowej choroby wątroby obejmujące hamowanie syntezy glikosfingolipidów |
| WO2008150486A2 (en) | 2007-05-31 | 2008-12-11 | Genzyme Corporation | 2-acylaminopropoanol-type glucosylceramide synthase inhibitors |
| SG184721A1 (en) * | 2007-10-05 | 2012-10-30 | Genzyme Corp | Method of treating polycystic kidney diseases with ceramide derivatives |
| US8389517B2 (en) | 2008-07-28 | 2013-03-05 | Genzyme Corporation | Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease |
| WO2010039256A1 (en) | 2008-10-03 | 2010-04-08 | Genzyme Corporation | 2-acylaminopropoanol-type glucosylceramide synthase inhibitors |
| EP3673906A1 (en) | 2011-03-18 | 2020-07-01 | Genzyme Corporation | Glucosylceramide synthase inhibitors |
| JP6254088B2 (ja) | 2011-10-17 | 2017-12-27 | バイオセリックス， インコーポレイテッド | 置換ビアリールアルキルアミド |
| US8961959B2 (en) * | 2011-10-17 | 2015-02-24 | The Regents Of The University Of Michigan | Glucosylceramide synthase inhibitors and therapeutic methods using the same |
| JOP20130273B1 (ar) | 2012-09-11 | 2021-08-17 | Genzyme Corp | مثبطات انزيم (سينثاز) غلوكوسيل سيراميد |
| EP2968268B1 (en) | 2013-03-15 | 2020-07-29 | Concert Pharmaceuticals Inc. | Inhibitors of the enzyme udp-glucose: n-acyl-sphingosine glucosyltransferase |
| MX2016003486A (es) * | 2013-09-20 | 2016-06-28 | Biomarin Pharm Inc | Inhibidores de glucosilceramida sintasa para el tratamiento de enfermedades. |
| NZ719028A (en) * | 2013-10-29 | 2021-12-24 | Biomarin Pharm Inc | N-(1-hydroxy-3-(pyrrolidinyl)propan-2-yl)pyrrolidine-3-carboxamide derivatives as glucosylceramide synthase inhibitors |
| JP6749923B2 (ja) | 2015-02-02 | 2020-09-02 | ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン | グルコシルセラミドシンターゼ阻害剤及びそれを使用した治療方法 |
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| EP3728265A1 (en) | 2017-12-21 | 2020-10-28 | BIAL - BioTech Investments, Inc. | Crystalline substituted cyclohexyl pyrazolo[1,5-a]pyrimidinyl carboxamide compound and therapeutic uses thereof |
| US11760741B2 (en) * | 2018-05-02 | 2023-09-19 | Kashiv Biosciences, Llc | Pro-drugs of eliglustat |
| WO2020193746A1 (en) | 2019-03-28 | 2020-10-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the survival of patients suffering from melanoma |
| JP2022553107A (ja) | 2019-10-23 | 2022-12-21 | ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン | グルコシルセラミドシンターゼ阻害剤およびそれを使用する治療方法 |
| KR20210059632A (ko) | 2019-11-15 | 2021-05-25 | 주식회사유한양행 | 신규의 2,3-다이하이드로-1h-인덴 또는 2,3-다이하이드로벤조퓨란 모이어티를 갖는 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법, 및 이를 포함하는 약학 조성물 |
| EP4142878B1 (en) | 2020-04-28 | 2024-06-26 | The Regents of The University of Michigan | Pyridine inhibitors of glucosylceramide synthase and therapeutic methods using the same |
| AU2021311131A1 (en) | 2020-07-24 | 2023-03-23 | Genzyme Corporation | Pharmaceutical compositions comprising venglustat |
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-
2009
- 2009-07-27 US US13/055,036 patent/US8389517B2/en active Active
- 2009-07-27 EP EP09790852.9A patent/EP2320886B1/en active Active
- 2009-07-27 JP JP2011521224A patent/JP2011529500A/ja active Pending
- 2009-07-27 WO PCT/US2009/051864 patent/WO2010014554A1/en active Application Filing
- 2009-07-27 CA CA2731685A patent/CA2731685A1/en not_active Abandoned
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2013
- 2013-02-07 US US13/762,102 patent/US8729075B2/en not_active Expired - Fee Related
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2014
- 2014-04-17 US US14/255,634 patent/US9481671B2/en active Active
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2015
- 2015-03-19 JP JP2015056011A patent/JP6038213B2/ja not_active Expired - Fee Related
