ATE491451T1 - N-(5-adamantane-1-yl-methoxy- pentyl)desoxynojirimycin oder eines pharmazeutischen salzes davon zur verwendung bei der behandlung der insulinresistenz - Google Patents
N-(5-adamantane-1-yl-methoxy- pentyl)desoxynojirimycin oder eines pharmazeutischen salzes davon zur verwendung bei der behandlung der insulinresistenzInfo
- Publication number
- ATE491451T1 ATE491451T1 AT04793684T AT04793684T ATE491451T1 AT E491451 T1 ATE491451 T1 AT E491451T1 AT 04793684 T AT04793684 T AT 04793684T AT 04793684 T AT04793684 T AT 04793684T AT E491451 T1 ATE491451 T1 AT E491451T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- insulin resistance
- desoxynojirimycin
- adamantane
- pentyl
- Prior art date
Links
- 206010022489 Insulin Resistance Diseases 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 title abstract 2
- 208000031888 Mycoses Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 206010033307 Overweight Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- LXBIFEVIBLOUGU-JGWLITMVSA-N duvoglustat Chemical class OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O LXBIFEVIBLOUGU-JGWLITMVSA-N 0.000 abstract 1
- 208000000069 hyperpigmentation Diseases 0.000 abstract 1
- 230000003810 hyperpigmentation Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03078396 | 2003-10-29 | ||
| EP04076936 | 2004-07-06 | ||
| PCT/NL2004/000760 WO2005039578A2 (en) | 2003-10-29 | 2004-10-29 | Use of a deoxynojirimycin derivative or a pharmaceutically salt thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE491451T1 true ATE491451T1 (de) | 2011-01-15 |
Family
ID=34524734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04793684T ATE491451T1 (de) | 2003-10-29 | 2004-10-29 | N-(5-adamantane-1-yl-methoxy- pentyl)desoxynojirimycin oder eines pharmazeutischen salzes davon zur verwendung bei der behandlung der insulinresistenz |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7662838B2 (de) |
| EP (1) | EP1680112B1 (de) |
| JP (1) | JP2007509925A (de) |
| AT (1) | ATE491451T1 (de) |
| AU (1) | AU2004283631A1 (de) |
| CA (1) | CA2544086A1 (de) |
| DE (1) | DE602004030604D1 (de) |
| IL (1) | IL175259A0 (de) |
| PL (1) | PL1680112T3 (de) |
| PT (1) | PT1680112E (de) |
| WO (1) | WO2005039578A2 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1528056A1 (de) * | 2003-10-29 | 2005-05-04 | Academisch Ziekenhuis bij de Universiteit van Amsterdam | Deoxynojirimycin Derivate und ihre Verwendung als Glukosesylceramidase-Inhibitoren |
| US20060025449A1 (en) * | 2004-03-25 | 2006-02-02 | United Therapeutics | Use of N-substituted imino sugars for appetite suppression |
| CA2586761A1 (en) | 2004-11-10 | 2006-05-18 | Genzyme Corporation | Methods of treating diabetes mellitus |
| FR2887549B1 (fr) * | 2005-06-23 | 2009-07-10 | Centre Nat Rech Scient | Nouveaux composes de la famille des iminosucres, leurs utilisations, notamment pour le traitement de maladies lysosomales, ainsi que leur procede de preparation |
| EP2032134B1 (de) | 2006-05-09 | 2015-06-24 | Genzyme Corporation | Verfahren zur behandlung von krankhafter fettleber durch hemmung der glucosphingolipid-synthese |
| GB0614098D0 (en) * | 2006-07-15 | 2006-08-23 | Mnl Pharma Ltd | Immune response variegation with imino sugars |
| JP2008104399A (ja) * | 2006-10-25 | 2008-05-08 | Spirulina Biological Lab Ltd | 糖尿病予防食品 |
| US8304447B2 (en) | 2007-05-31 | 2012-11-06 | Genzyme Corporation | 2-acylaminopropoanol-type glucosylceramide synthase inhibitors |
| KR20160085917A (ko) | 2007-10-05 | 2016-07-18 | 젠자임 코포레이션 | 세라마이드 유도체로 다낭성 신장질환을 치료하는 방법 |
| WO2010014554A1 (en) | 2008-07-28 | 2010-02-04 | Genzyme Corporation | Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease |
| US8309593B2 (en) | 2008-10-03 | 2012-11-13 | Genzyme Corporation | 2-acylaminopropoanol-type glucosylceramide synthase inhibitors |
| CA2793276A1 (en) * | 2009-03-27 | 2010-09-30 | Zacharon Pharmaceuticals, Inc. | Ganglioside biosynthesis modulators |
| US20140227371A1 (en) * | 2011-07-13 | 2014-08-14 | Alan David Heath | Edible composition |
| KR20150128899A (ko) * | 2013-03-15 | 2015-11-18 | 유니터 바이롤로지, 엘엘씨 | 항박테리아 화합물 |
| WO2022227287A1 (zh) * | 2021-04-25 | 2022-11-03 | 中南大学 | Dnj及其衍生物在制备预防和/或治疗肺动脉高压药物中的应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2504000B2 (ja) | 1986-09-02 | 1996-06-05 | 日本新薬株式会社 | グルコシルモラノリン誘導体 |
| WO1998002161A1 (en) | 1996-07-15 | 1998-01-22 | Universiteit Van Amsterdam | Deoxynojirimycin derivatives and their uses as glucosylceramidase inhibitors |
| BR9902585A (pt) * | 1999-02-11 | 2000-09-26 | Claudio Cerqueira Lopes | Um novo processo de sìntese de aza-açúcares com atividade biológica |
| GB0100889D0 (en) | 2001-01-12 | 2001-02-21 | Oxford Glycosciences Uk Ltd | Compounds |
| US6235737B1 (en) | 2000-01-25 | 2001-05-22 | Peter Styczynski | Reduction of hair growth |
| US20040204379A1 (en) | 2000-06-19 | 2004-10-14 | Cheng Seng H. | Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases |
| CZ2004564A3 (cs) * | 2001-10-15 | 2005-03-16 | Genentech, Inc. | Prostředky pro léčení a diagnózu stavů inzulinové rezistence |
| EP1528056A1 (de) * | 2003-10-29 | 2005-05-04 | Academisch Ziekenhuis bij de Universiteit van Amsterdam | Deoxynojirimycin Derivate und ihre Verwendung als Glukosesylceramidase-Inhibitoren |
| WO2005063706A1 (en) | 2003-12-23 | 2005-07-14 | Macrozyme Dnm B.V. | Synthesis of nojirimycins |
| EP3782655A1 (de) | 2005-05-17 | 2021-02-24 | Amicus Therapeutics, Inc. | Verfahren zur behandlung der pompe-krankheit unter verwendung von 1-deoxynojirimycin und derivaten |
-
2004
- 2004-10-29 AT AT04793684T patent/ATE491451T1/de not_active IP Right Cessation
- 2004-10-29 JP JP2006537908A patent/JP2007509925A/ja active Pending
- 2004-10-29 DE DE602004030604T patent/DE602004030604D1/de not_active Expired - Lifetime
- 2004-10-29 AU AU2004283631A patent/AU2004283631A1/en not_active Abandoned
- 2004-10-29 EP EP04793684A patent/EP1680112B1/de not_active Expired - Lifetime
- 2004-10-29 WO PCT/NL2004/000760 patent/WO2005039578A2/en not_active Ceased
- 2004-10-29 PT PT04793684T patent/PT1680112E/pt unknown
- 2004-10-29 PL PL04793684T patent/PL1680112T3/pl unknown
- 2004-10-29 US US10/595,584 patent/US7662838B2/en not_active Expired - Lifetime
- 2004-10-29 CA CA002544086A patent/CA2544086A1/en not_active Abandoned
-
2006
- 2006-04-27 IL IL175259A patent/IL175259A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT1680112E (pt) | 2011-03-24 |
| EP1680112B1 (de) | 2010-12-15 |
| CA2544086A1 (en) | 2005-05-06 |
| US20070135487A1 (en) | 2007-06-14 |
| PL1680112T3 (pl) | 2011-05-31 |
| US7662838B2 (en) | 2010-02-16 |
| JP2007509925A (ja) | 2007-04-19 |
| WO2005039578A2 (en) | 2005-05-06 |
| IL175259A0 (en) | 2006-09-05 |
| DE602004030604D1 (de) | 2011-01-27 |
| WO2005039578A3 (en) | 2005-09-29 |
| AU2004283631A1 (en) | 2005-05-06 |
| EP1680112A2 (de) | 2006-07-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |