JP2011528555A - 高齢の動物の生活の質を向上させるための方法 - Google Patents
高齢の動物の生活の質を向上させるための方法 Download PDFInfo
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| CN102907561A (zh) * | 2004-12-30 | 2013-02-06 | 希尔氏宠物营养品公司 | 提高老年动物的生活质量的方法 |
| US8252742B2 (en) | 2004-12-30 | 2012-08-28 | Hill's Pet Nutrition, Inc. | Methods for enhancing the quality of life of a senior animal |
| CA2795575C (en) * | 2010-05-12 | 2017-02-28 | Hill's Pet Nutrition, Inc. | Methods for the diagnosis, control and prophylaxis of inflammation and mitigation of inflammatory conditions in canines |
| WO2011143102A1 (en) * | 2010-05-12 | 2011-11-17 | Hill's Pet Nutrition, Inc. | Methods of diagnosis, control and prophylaxis of inflammation and mitigation of inflammatory conditions in felines |
| JP2014502165A (ja) * | 2010-12-20 | 2014-01-30 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 満腹応答を誘導するためのペットフード組成物 |
| WO2012141316A1 (ja) | 2011-04-13 | 2012-10-18 | 味の素株式会社 | 栄養組成物 |
| US20130059028A1 (en) * | 2011-09-01 | 2013-03-07 | Julie Marie Foy | Compositions and Methods for Providing a Life-Stage-Appropriate Animal Diet |
| EP3800271B1 (en) | 2013-11-12 | 2024-10-30 | Hill's Pet Nutrition, Inc. | Improving the level of hydration in a cat |
| AU2015269054A1 (en) * | 2014-06-06 | 2017-01-12 | Berg Llc | Methods of treating a metabolic syndrome by modulating heat shock protein (HSP) 90-beta |
| CN104026404B (zh) * | 2014-06-10 | 2016-02-24 | 贵州省台江县禹洋农业发展有限公司 | 一种老年期犬粮 |
| CN120436205A (zh) | 2015-02-13 | 2025-08-08 | 马斯公司 | 包装宠物食物产品 |
| CN104982668B (zh) * | 2015-07-21 | 2016-08-17 | 广州市优百特饲料科技有限公司 | 一种功能性脂肪粉及其制备方法 |
| GB201522304D0 (en) * | 2015-12-17 | 2016-02-03 | Mars Inc | Food product for reducing muscle breakdown |
| BR112018076320B1 (pt) * | 2016-12-15 | 2023-03-07 | Société des Produits Nestlé S.A. | Composição alimentícia para animais de estimação, seu uso, e método não-terapêutico para aumentar a absorção de aminoácidos em um canino |
| CN110121268B (zh) | 2016-12-27 | 2023-01-31 | 希尔氏宠物营养品公司 | 宠物食品组合物 |
| CA2996780A1 (en) * | 2017-02-28 | 2018-08-28 | Abl Ip Holding Llc | Autonomous electronics platform for light fixtures with integral thermal management properties |
| CN107184598A (zh) * | 2017-04-28 | 2017-09-22 | 深圳市众康动保科技有限公司 | 一种宠物用心脏病复方片剂 |
| GB201721627D0 (en) | 2017-12-21 | 2018-02-07 | Mars Inc | Pet food product |
| EP4586824A1 (en) * | 2022-09-14 | 2025-07-23 | Société des Produits Nestlé S.A. | Compositions and methods utilizing southern ocean mackerel oil for providing health benefits in an animal |
| AU2023351581A1 (en) * | 2022-09-30 | 2025-03-06 | Societe Des Produits Nestle Sa | Methods for providing health benefits in animals |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003529347A (ja) * | 2000-01-25 | 2003-10-07 | ジュヴェノン インコーポレイテッド | 高齢ペット用の栄養補給食品 |
| JP2004519241A (ja) * | 2001-03-09 | 2004-07-02 | ソシエテ デ プロデユイ ネツスル ソシエテ アノニム | 高齢化に伴う生理的障害を改善し寿命を延ばす組成物 |
| WO2006074089A2 (en) * | 2004-12-30 | 2006-07-13 | Hill's Pet Nutrition, Inc. | Methods for enhancing the quality of life of a senior animal |
| WO2007062325A1 (en) * | 2005-11-18 | 2007-05-31 | Hill's Pet Nutrition, Inc. | Methods for reducing the amount of proinflammatory substance in animal tissue or body fluid |
| WO2007088046A2 (en) * | 2006-02-01 | 2007-08-09 | Nestec S.A. | Nutritional system and methods for increasing longevity |
| JP2007524402A (ja) * | 2003-07-03 | 2007-08-30 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | コンパニオン動物における精神活動の加齢劣化を減少させる組成物及び方法 |
| WO2008018043A2 (en) * | 2006-08-09 | 2008-02-14 | The Iams Company | Methods of improving bone health and muscle health |
| JP2008511332A (ja) * | 2004-08-30 | 2008-04-17 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | ゲノムベースのダイエットデザイン |
| JP2008519838A (ja) * | 2004-11-09 | 2008-06-12 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 遺伝子調節のための酸化防止剤の使用 |
| JP2008521819A (ja) * | 2004-11-24 | 2008-06-26 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 動物における免疫応答を増大させる方法 |
Family Cites Families (162)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2980716A (en) * | 1954-06-11 | 1961-04-18 | Research Corp | Method for preparing 6, 8-dihalooctanoic esters |
| US3202414A (en) | 1962-01-15 | 1965-08-24 | Gen Motors Corp | Vehicle door actuator |
| US3202514A (en) * | 1963-07-15 | 1965-08-24 | Gen Foods Corp | Animal food and method of making the same |
| US6090414A (en) * | 1970-05-20 | 2000-07-18 | Life Science Labs, Inc. | Method and composition to reduce cancer incidence |
| US3946123A (en) * | 1975-03-10 | 1976-03-23 | Star-Kist Foods, Inc. | Canned pet food |
| US4053647A (en) | 1975-12-12 | 1977-10-11 | Samuel Prussin | Pet food product and process of producing such |
| JPS5519090Y2 (enExample) | 1976-06-14 | 1980-05-06 | ||
| AU524005B2 (en) | 1978-07-05 | 1982-08-26 | Jerky Treats Inc. | Meat containing animal biscuit or kibble |
| US4247562A (en) * | 1978-12-21 | 1981-01-27 | The Quaker Oats Company | Moist pet food with blood chunks and a fluid gravy system |
| JPS57132849A (en) | 1981-02-12 | 1982-08-17 | Sanwa Kagaku Kenkyusho:Kk | Preparation of aseptic health feed |
| JPS57132849U (enExample) | 1981-02-14 | 1982-08-19 | ||
| US5004624A (en) * | 1983-03-14 | 1991-04-02 | Star-Kist Foods, Inc. | Semi-moist pet food having free gravy and process for preparation thereof |
| EP0270690B1 (en) * | 1986-06-21 | 1991-05-15 | Dainippon Ink And Chemicals, Inc. | Drug for treatment and prophylaxis of kidney and liver diseases |
| US5030458A (en) * | 1989-11-27 | 1991-07-09 | Shug Austin L | Method for preventing diet-induced carnitine deficiency in domesticated dogs and cats |
| US4997672A (en) * | 1987-03-10 | 1991-03-05 | Virginia Commonwealth University | Salt taste enhancer |
| EP0326034B1 (de) * | 1988-01-28 | 1992-08-26 | Peter Dr. Költringer | Kombinationspräparat zur Behandlung von Nervenzell-und Nervenfasererkrankungen und Verletzungen |
| US6977167B2 (en) * | 1988-09-07 | 2005-12-20 | Martek Biosciences Corporation | Mixtures of omega-3 and omega-6 highly unsaturated fatty acids from euryhaline microorganisms |
| US4997671A (en) * | 1988-09-09 | 1991-03-05 | Nabisco Brands, Inc. | Chewy dog snacks |
| US5114704A (en) * | 1989-05-30 | 1992-05-19 | Nabisco Brands, Inc. | Raw hide having a coating containing an inorganic pyrophosphate |
| JPH03169813A (ja) * | 1989-11-09 | 1991-07-23 | Asta Pharma Ag | 細胞保護作用を有する疼痛及び炎症性疾患及び/又はレトロウイルスに起因する病気の治療用医薬並びにその製法 |
| US6746678B1 (en) * | 1991-02-22 | 2004-06-08 | Howard K. Shapiro | Method of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with medicaments |
| US5419283A (en) * | 1992-04-08 | 1995-05-30 | Ciuffo Gatto S.R.L. | Animal chew toy of starch material and degradable ethylene copolymer |
| US5569670A (en) | 1992-06-05 | 1996-10-29 | Asta Medica Aktiengesellschaft | Combination medications containing alpha-lipoic acid and related |
| US5624896A (en) * | 1992-06-09 | 1997-04-29 | Neorx Corporation | Clearing agents useful in pretargeting methods |
| US5292538A (en) * | 1992-07-22 | 1994-03-08 | Metagenics, Inc. | Improved sustained energy and anabolic composition and method of making |
| DE4235912C2 (de) | 1992-10-23 | 2002-12-05 | Viatris Gmbh | Verfahren zur Herstellung kristalliner Thioctsäure und deren Verwendung |
| JP3347381B2 (ja) * | 1993-01-27 | 2002-11-20 | 協和醗酵工業株式会社 | ペットフード |
| US5532010A (en) * | 1993-05-28 | 1996-07-02 | Nabisco, Inc. | Coated canine biscuits and preparation process |
| US5339771A (en) * | 1993-09-15 | 1994-08-23 | Axelrod Herbert R | Animal chew toy containing animal meal |
| WO1995013824A1 (en) * | 1993-11-15 | 1995-05-26 | Celtrix Pharmaceuticals, Inc. | Method of treating renal disease by administering igf-i and igfbp-3 |
| CA2147109A1 (en) | 1994-04-18 | 1995-10-19 | Gregory A. Reinhart | Pet food product containing omega-6 and omega-3 fatty acids and process for reducing inflammatory skin responses |
| US7105607B2 (en) * | 1994-04-19 | 2006-09-12 | Applied Elastomerics, Inc. | Tear resistant gels, composites, and articles |
| US6458767B1 (en) | 1994-05-04 | 2002-10-01 | The Uab Research Foundation | Use of peptides inhibitory for thrombospondin dependent TGF-β activation in the treatment of kidney disease |
| DE4427079C2 (de) * | 1994-07-30 | 2002-12-19 | Viatris Gmbh | Verfahren zur Racemisierung von Enantiomeren der alpha-Liponsäure |
| US5976548A (en) | 1994-11-08 | 1999-11-02 | Viva America Marketing, Inc. | Nutritional supplement composition and use |
| US5599835A (en) * | 1994-11-23 | 1997-02-04 | Fischer; Frederick B. | Use of DL-lipoic acid as a medical food in the treatment of diabetes mellitus |
| US5730988A (en) * | 1995-04-20 | 1998-03-24 | Lynntech, Inc. | Nutritional supplements for improving glucose metabolism |
| US6184227B1 (en) * | 1995-07-21 | 2001-02-06 | Savvipharm Inc. | Salts of aminoimidazole carboxamide useful in the prevention and treatment of liver diseases |
| FR2738741B1 (fr) * | 1995-09-19 | 1997-12-05 | Oreal | Composition pour la teinture des fibres keratiniques, contenant un antagoniste de substance p |
| JP3798464B2 (ja) * | 1996-04-09 | 2006-07-19 | 株式会社海洋バイオテクノロジー研究所 | 新規微細藻類及びそれを用いた高度不飽和脂肪酸の製造方法 |
| CA2208392C (en) * | 1996-06-21 | 2002-09-03 | University Of Guelph | Method for enriching docosahexaenoic acid in expressed milk of dairy cattle |
| US5977162A (en) | 1996-09-16 | 1999-11-02 | Seidman; Michael D. | Therapeutic treatment for auditory function |
| ES2565163T3 (es) * | 1996-10-28 | 2016-03-31 | General Mills, Inc. | Imbibición y encapsulación de partículas de liberación controlada y producto encapsulado |
| US5976568A (en) | 1997-02-21 | 1999-11-02 | Medical Doctors' Research Institute, Inc. | Modular system of dietary supplement compositions for optimizing health benefits and methods |
| US6232346B1 (en) * | 1997-03-27 | 2001-05-15 | Michael J. Sole | Composition for improvement of cellular nutrition and mitochondrial energetics |
| US6080788A (en) * | 1997-03-27 | 2000-06-27 | Sole; Michael J. | Composition for improvement of cellular nutrition and mitochondrial energetics |
| US6133323A (en) | 1997-04-09 | 2000-10-17 | The Iams Company | Process for enhancing immune response in animals using β-carotene as a dietary supplement |
| US5851573A (en) | 1997-04-29 | 1998-12-22 | The Iams Company | Pet food composition for large breed puppies and method for promoting proper skeletal growth |
| US6264994B1 (en) * | 1997-05-15 | 2001-07-24 | University Of Washington | Compositions for treating alzheimer's disease and other amyloidoses |
| US5883083A (en) * | 1997-06-09 | 1999-03-16 | Harlmen, Inc. | Dietary supplement for alleviating behavioral problems in canines and reducing seizures in canines and felines |
| US5916912A (en) * | 1997-06-16 | 1999-06-29 | The Regents Of The University Of California | Dietary composition for enhancing metabolism and alleviating oxidative stress |
| DE19726519A1 (de) | 1997-06-23 | 1998-12-24 | Asta Medica Ag | Verfahren zur Herstellung trockener Thioctsäure |
| EP0891719A1 (en) | 1997-07-14 | 1999-01-20 | N.V. Nutricia | Nutritional composition containing methionine |
| US6039952A (en) * | 1997-10-22 | 2000-03-21 | The Iams Company | Composition and method for improving clinical signs in animals with renal disease |
| GB9722361D0 (en) | 1997-10-24 | 1997-12-17 | Pharma Nord Uk Ltd | Pharmaceutical formulation for treating liver disorders |
| US6365623B1 (en) * | 1997-11-17 | 2002-04-02 | Nicholas V. Perricone | Treatment of acne using lipoic acid |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| DE19810336A1 (de) | 1998-03-11 | 1999-09-23 | Asta Medica Ag | Alpha-Liponsäure mit neuartiger Modifikation |
| US6117477A (en) * | 1998-03-18 | 2000-09-12 | Kal Kan Foods, Inc. | Multicomponent food product and methods of making and using the same |
| US6306430B1 (en) * | 1998-04-16 | 2001-10-23 | The Iams Company | Process for decreasing adiposity using vitamin a as a dietary supplement |
| RU2131677C1 (ru) | 1998-05-05 | 1999-06-20 | Научно-производственная фирма "Аквазинэль" | Кормовая добавка "биовитос" |
| US6492325B1 (en) | 1998-05-22 | 2002-12-10 | Boys Town National Research Hospital | Use of α1β1 integrin receptor inhibitors and TGF-β1 inhibitors in the treatment of kidney disease |
| US6197340B1 (en) * | 1998-05-28 | 2001-03-06 | Medical Research Institute | Controlled release lipoic acid |
| JP2000014392A (ja) * | 1998-07-07 | 2000-01-18 | Ikeda Shokken Kk | 高度不飽和脂肪酸含有グリセリドの製造方法 |
| DE19834608A1 (de) * | 1998-07-31 | 2000-02-03 | Basf Ag | Kristallmodifikation der Liponsäure |
| US6136339A (en) | 1998-08-21 | 2000-10-24 | Gardiner; Paul T. | Food supplements and methods comprising lipoic acid and creatine |
| IT1302307B1 (it) * | 1998-09-01 | 2000-09-05 | Sigma Tau Healthscience Spa | Composizione ad attivita' antiossidante ed atta a migliorarel'utilizzazione metabolica del glucosio, comprendente acetil |
| US6203825B1 (en) | 1998-09-02 | 2001-03-20 | Heska Corporation | Method and composition to protect an obligate carnivore from a disease of abnormal carbohydrate metabolism |
| FR2786100B1 (fr) | 1998-11-24 | 2002-03-01 | Aventis Laboratoire | Nouvelle application therapeutique de la nicergoline |
| AUPP784398A0 (en) * | 1998-12-21 | 1999-01-21 | Monash University | Kidney disease detection and treatment |
| US20040029175A1 (en) * | 1998-12-21 | 2004-02-12 | Comper Wayne D. | Method for kidney disease detection |
| AU1674400A (en) * | 1998-12-21 | 2000-07-12 | Monash University | Kidney disease detection and treatment |
| US6284786B1 (en) * | 1999-02-16 | 2001-09-04 | The Center For The Improvement Of Human Functioning, Int'l., Inc. | Treatment of cancer using lipoic acid in combination with ascorbic acid |
| US6238708B1 (en) | 1999-02-23 | 2001-05-29 | The Iams Company | Composition and process for controlling glucose metabolism in companion animals by dietary starch |
| AUPP887399A0 (en) | 1999-02-24 | 1999-03-25 | Bartlett Grain Pty Ltd | Animal feed formulae for the nutritional enrichment of foodstuffs |
| PT1033364E (pt) * | 1999-03-01 | 2005-07-29 | Pfizer Prod Inc | Ciano com acidos oxamicos e derivados como ligandos de receptores de tiroide |
| IT1306130B1 (it) | 1999-04-16 | 2001-05-30 | Sigma Tau Healthscience Spa | Composizione comprendente una carnitina e glutatione, atta adaumentare l'assorbimento del glutatione sinergizzandone gli effetti. |
| DE60022024T3 (de) | 1999-05-27 | 2012-10-11 | The Iams Company | Verfahren zur herstellung von produkt zur erhöhung der immunantwort in haustieren mit verwendung einer kombination von antioxidantien |
| US6365211B1 (en) * | 1999-06-18 | 2002-04-02 | The Procter & Gamble Co. | Cooking aid with reduced foaming |
| JP4098927B2 (ja) * | 1999-08-03 | 2008-06-11 | 花王株式会社 | 油脂組成物 |
| US6479069B1 (en) | 1999-09-23 | 2002-11-12 | Juvenon, Inc. | Nutritional supplement for increased energy and stamina |
| US6426362B1 (en) * | 1999-10-08 | 2002-07-30 | Galileo Laboratories, Inc. | Formulations of tocopherols and methods of making and using them |
| AU781718B2 (en) * | 1999-11-02 | 2005-06-09 | Depomed, Inc. | Pharmacological inducement of the fed mode for enhanced drug administration to the stomach |
| WO2001032168A1 (en) * | 1999-11-03 | 2001-05-10 | Juvenon, Inc. | Method of treating benign forgetfulness |
| NL1013817C2 (nl) * | 1999-12-10 | 2001-06-12 | Stork Mps Bv | Coagulatieoplossing voor het laten coaguleren van een collageen. |
| US6379727B1 (en) * | 1999-12-29 | 2002-04-30 | John F. Addy | Flavoring system for pet foods |
| US20030060503A1 (en) * | 2000-01-25 | 2003-03-27 | Juvenon, Inc. | Nutritional supplements for mature pets |
| MXPA02007466A (es) * | 2000-02-01 | 2004-02-26 | Muscletech Res And Dev Inc | Suplemento alimenticio a base de acido alfa-lipoico para incrementar la masa muscular escas y la fuerza. |
| EG22407A (en) * | 2000-02-17 | 2003-01-29 | Iams Company | Method for improving bone modeling and chondrocyte functioning in growing canines |
| PE20011109A1 (es) | 2000-03-22 | 2001-11-27 | Nestle Sa | Alimento para mascotas dentalmente beneficioso y su metodo de fabricacion |
| JP4487376B2 (ja) * | 2000-03-31 | 2010-06-23 | 味の素株式会社 | 腎疾患治療剤 |
| EP1155627A1 (en) | 2000-05-18 | 2001-11-21 | Belovo Eggs & Egg Products | Eggs with balanced lipid composition |
| US6436463B1 (en) * | 2000-06-26 | 2002-08-20 | Hill's Pet Nutrition, Inc. | Pet food composition and method |
| JP2004505645A (ja) | 2000-08-10 | 2004-02-26 | レネッセン リミテッド ライアビリティ カンパニー | ハイオイルコーンから得られるコーン油及びコーンミールを含む製品 |
| US20020044988A1 (en) | 2000-08-22 | 2002-04-18 | Fuchs Eileen C. | Nutritional composition and method for improving protein deposition |
| WO2002019839A1 (en) * | 2000-09-07 | 2002-03-14 | University Of Maryland Biotechnology Institute | Use of arachidonic acid for enhanced culturing of fish larvae and broodstock |
| US6784159B2 (en) * | 2000-09-29 | 2004-08-31 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture | Triterpene saponins from soybeans for treating kidney disease |
| US6277842B1 (en) * | 2000-10-17 | 2001-08-21 | James Alexander Carthron | Dietary supplemental method for fat and weight reduction |
| US20020052402A1 (en) * | 2000-10-31 | 2002-05-02 | Colgate-Palmolive Company | Composition and method |
| US8669282B2 (en) * | 2000-10-31 | 2014-03-11 | Hill's Pet Nutrition, Inc. | Companion animal compositions including lipoic acid and methods of use thereof |
| US20020076469A1 (en) * | 2000-10-31 | 2002-06-20 | Colgate-Palmolive Company | Composition and method |
| US20090156658A1 (en) * | 2000-10-31 | 2009-06-18 | Hill's Pet Nutrition, Inc. | Antioxidant-Containing Food Composition For Use In Inhibiting Histamine Pathways In Companion Animals |
| US20020115710A1 (en) * | 2000-10-31 | 2002-08-22 | Zicker Steven Curtis | Composition and method |
| US20020076470A1 (en) * | 2000-10-31 | 2002-06-20 | Colgate-Palmolive Company | Composition and method |
| US8592479B2 (en) * | 2000-10-31 | 2013-11-26 | Hill's Pet Nutrition, Inc. | Antioxidant-containing food composition for use in enhancing antiviral immunity in companion animals |
| WO2002052951A1 (en) * | 2000-12-29 | 2002-07-11 | Martin Francis Gannon | An animal food product |
| US7001610B2 (en) | 2001-04-23 | 2006-02-21 | Omeganutrel Inc. | Food supplement and use thereof for elevating levels of essential fatty acids in livestock and products therefrom |
| AU2002303744B2 (en) * | 2001-05-14 | 2008-04-17 | Dsm Ip Assets B.V. | A method of improving the flavor, tenderness and overall consumer acceptability of poultry meat |
| US6596762B2 (en) * | 2001-05-17 | 2003-07-22 | The Regents Of The University Of Colorado | Antioxidant compositions and use for treatment of hepatic steatosis and steatohepatitis |
| US6596768B2 (en) * | 2001-05-22 | 2003-07-22 | Church & Dwight Co., Inc. | Unsaturated lipid-enriched feedstock for ruminants |
| US6902739B2 (en) * | 2001-07-23 | 2005-06-07 | Nutracea | Methods for treating joint inflammation, pain, and loss of mobility |
| GB0119052D0 (en) * | 2001-08-03 | 2001-09-26 | Mars Uk Ltd | Foodstuff |
| US6923960B2 (en) * | 2001-10-03 | 2005-08-02 | Vsl Pharmaceuticals Inc. | Antioxidant combination composition and use thereof |
| GB0129864D0 (en) | 2001-12-13 | 2002-02-06 | Danisco | Animal feed |
| US20030190343A1 (en) * | 2002-03-05 | 2003-10-09 | Pfizer Inc. | Palatable pharmaceutical compositions for companion animals |
| ES2355890T3 (es) * | 2002-04-05 | 2011-04-01 | Societe des Produits Nestlé S.A. | Composiciones y métodos para promocionar la asimilación de lípidos en los animales domésticos. |
| US20030194478A1 (en) | 2002-04-12 | 2003-10-16 | Davenport Gary Mitchell | Dietary methods for canine performance enhancement |
| US6733793B2 (en) | 2002-06-04 | 2004-05-11 | Metaproteomics, Llc | Oral composition with insulin-like activities and methods of use |
| US6572899B1 (en) * | 2002-07-03 | 2003-06-03 | Vitacost.Com, Inc. | Memory loss treatment formulation |
| WO2004018598A1 (ja) | 2002-08-07 | 2004-03-04 | Kao Corporation | 油脂組成物 |
| JP2004141130A (ja) | 2002-08-28 | 2004-05-20 | Mars Inc | 特定の犬種に専用のドッグフード |
| EP2384750A1 (en) | 2002-09-27 | 2011-11-09 | Martek Biosciences Corporation | Improved Glycemic Control for Prediabetes and/or Diabetes Type II using Docohexaenoic Acid |
| US6974841B1 (en) | 2002-09-27 | 2005-12-13 | Rapisarda Family Irrevocable Trust | Pet anti-aging wellness supplement |
| US8841344B2 (en) * | 2002-10-03 | 2014-09-23 | Hill's Pet Nutrition, Inc. | Method of using omega-3 fatty acids |
| JP3813585B2 (ja) * | 2003-01-23 | 2006-08-23 | 花王株式会社 | ジグリセリドの製造方法 |
| RU2221456C1 (ru) | 2003-03-11 | 2004-01-20 | Общество с ограниченной ответственностью "Арсентех" | Биологически активное вещество, биологически активная добавка к пище, фармацевтический препарат, биологически активная добавка для кормления животных, ветеринарный препарат, удобрение, активатор микробиологических процессов, пероральное питание, парфюмерно-косметическое средство, гигиеническое средство, молочный продукт, кондитерское изделие, хлебобулочное изделие, масло-жировой продукт, соус, алкогольный напиток, безалкогольный напиток, рыбный продукт, мясной продукт, макаронные изделия, жевательная резинка, пиво |
| WO2004100773A2 (en) * | 2003-05-13 | 2004-11-25 | The Regents Of The University Of Colorado | Diagnostic and therapeutic treatments related to mitochondrial disorders |
| US7202270B2 (en) * | 2003-06-20 | 2007-04-10 | Sami Labs Limited | Convenient stable non-hygroscopic crystalline solid forms of racemic and chiral LA-plus salts: process for their manufacture and uses |
| US8633247B2 (en) * | 2003-08-11 | 2014-01-21 | Hill's Pet Nutrition, Inc. | Method for decreasing cartilage damage in dogs |
| JP4699901B2 (ja) | 2003-09-02 | 2011-06-15 | ジェレックスインターナショナル株式会社 | 体脂肪代謝機能と燃焼エネルギーの活用機能とを備えているダイエット用添加物質 |
| US7078064B2 (en) * | 2003-12-03 | 2006-07-18 | George Zabrecky | Compositions and methods useful for treating and preventing chronic liver disease, chronic HCV infection and non-alcoholic steatohepatitis |
| ITMI20040069A1 (it) * | 2004-01-21 | 2004-04-21 | Tiberio Bruzzese | Uso di composizioni di acidi grassi n-3 ad elevata concentrazione per il trattamento di disturbi del sistema nervoso centrale |
| US20050249787A1 (en) | 2004-04-16 | 2005-11-10 | Nestec Sa | Methods and compositions for reducing oxidative stress in an animal |
| US20050266051A1 (en) | 2004-05-27 | 2005-12-01 | The Procter & Gamble Company | Pet food compositions and methods |
| US20060002985A1 (en) * | 2004-07-02 | 2006-01-05 | Zicker Steven C | Compositions and methods for decreasing age-related deterioration in mental activities in companion animals |
| US20090176864A1 (en) * | 2004-11-24 | 2009-07-09 | Hill's Pet Nutrition, Inc. | Methods For Improving Hepatic and Immune Function In An Animal |
| JP5785355B2 (ja) * | 2004-11-24 | 2015-09-30 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 動物における生体異物物質の肝臓クリアランスを改良する方法 |
| US8168161B2 (en) | 2004-12-22 | 2012-05-01 | Hill's Pet Nutrition, Inc. | Method to promote oral health in companion animals |
| AU2005322015B2 (en) * | 2004-12-29 | 2010-02-25 | Hill's Pet Nutrition, Inc. | Methods for inhibiting a decline in learning and/or memory in animals |
| US8647660B2 (en) * | 2004-12-29 | 2014-02-11 | Hill's Pet Nutrition, Inc. | Combination of limited nutrients and enhanced dietary antioxidants to impart improved kidney health |
| US8252742B2 (en) | 2004-12-30 | 2012-08-28 | Hill's Pet Nutrition, Inc. | Methods for enhancing the quality of life of a senior animal |
| JP5743373B2 (ja) * | 2004-12-30 | 2015-07-01 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | ネコ食餌用の組成物 |
| US7700139B2 (en) * | 2004-12-30 | 2010-04-20 | Commonwealth Scientific And Industrial Research Organization | Method and means for improving bowel health |
| CA2598525A1 (en) * | 2005-02-22 | 2006-08-31 | Mochida Pharmaceutical Co., Ltd. | Nerve regeneration promoting agent |
| JP2008540394A (ja) * | 2005-05-04 | 2008-11-20 | プロノヴァ バイオファーマ ノルゲ アクティーゼルスカブ | 脂肪酸組成物、即ち、dha誘導体の医薬としての使用 |
| BRPI0612841A2 (pt) | 2005-06-29 | 2012-10-09 | Hills Pet Nutrition Inc | composição, métodos para prevenir ou tratar doença inflamatória e para produzir uma composição de ração, kit, meio para comunicar informação ou instruções, e, método para inibir ou prevenir liberação de mediadores pró-inflamatórios |
| RU2402919C2 (ru) * | 2005-07-14 | 2010-11-10 | Хилл'С Пет Ньютришн, Инк. | Способ продления жизни животных |
| CA2619042C (en) * | 2005-08-17 | 2011-03-15 | Hill's Pet Nutrition, Inc. | Methods and compositions for the prevention and treatment of kidney disease |
| PL2333076T3 (pl) * | 2005-09-20 | 2015-08-31 | Simplot Co J R | Żywność o niskiej zawartości akrylamidu |
| EP1951067B1 (en) * | 2005-11-10 | 2017-07-26 | Hill's Pet Nutrition, Inc. | Compositions and methods for improving skin health and pelage quality |
| DE602006008985D1 (de) * | 2005-12-16 | 2009-10-15 | Nutricia Nv | Zusammensetzung enthaltend oligosaccharide als lösliche ballaststoffe zur verwendung gegen muskelschwund |
| CA2634139C (en) * | 2005-12-20 | 2015-06-23 | Cenestra, Llc. | Omega 3 fatty acid formulations |
| US9265745B2 (en) * | 2005-12-21 | 2016-02-23 | Brudy Technology S.L. | Use of DHA, EPA or DHA-derived EPA for treating a pathology associated with cellular oxidative damage |
| FR2903860B1 (fr) * | 2006-07-21 | 2010-12-31 | Royal Canin Sa | Aliment sec pour reduire l'appetit des chiens |
| US7282225B1 (en) | 2006-09-27 | 2007-10-16 | Occular Technologies, Inc. | Composition and methods for improving retinal health |
| MX2009004144A (es) * | 2006-10-20 | 2009-12-18 | Dow Global Technologies Inc | Prevencion o reduccion de tension oxidante o de lesion celular oxidantes mediante la administracion de un derivado de celulosa insoluble en agua. |
| WO2008151131A1 (en) | 2007-06-04 | 2008-12-11 | Mane, Inc. | Palatability enhancing compositions and foods for pets, and methods regarding the same |
| CA2691691C (en) | 2007-06-20 | 2013-09-24 | Seth J. Baum | Compositions and methods of treating chronic kidney disease |
| US20080317884A1 (en) | 2007-06-22 | 2008-12-25 | Jewell Dennis E | Enhancing Disease Resistance In An Animal |
| WO2009067530A1 (en) * | 2007-11-20 | 2009-05-28 | Albion International Inc. | Increased protein or energy digestion resulting from inclusion of metal amino acid chelates in animal feed |
| CN101909632A (zh) | 2008-01-04 | 2010-12-08 | 雀巢产品技术援助有限公司 | 包含不饱和脂肪酸和一氧化氮释放化合物的组合物及其用于增强认知和相关功能的用途 |
| JP2011528556A (ja) * | 2008-07-18 | 2011-11-24 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 高齢の動物の生活の質を向上させるための方法 |
-
2008
- 2008-07-18 US US12/176,331 patent/US8252742B2/en active Active
-
2009
- 2009-07-20 RU RU2011106036/10A patent/RU2513698C2/ru not_active IP Right Cessation
- 2009-07-20 CN CN201410049648.8A patent/CN103766663A/zh active Pending
- 2009-07-20 AU AU2009270702A patent/AU2009270702B2/en not_active Ceased
- 2009-07-20 BR BRPI0915979A patent/BRPI0915979A8/pt not_active Application Discontinuation
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- 2009-07-20 EP EP09790624A patent/EP2315533A1/en not_active Ceased
- 2009-07-20 CA CA2731069A patent/CA2731069C/en not_active Expired - Fee Related
- 2009-07-20 WO PCT/US2009/051114 patent/WO2010009458A1/en not_active Ceased
- 2009-07-20 JP JP2011518956A patent/JP2011528555A/ja active Pending
- 2009-07-20 EP EP16174970.0A patent/EP3155904B1/en active Active
-
2011
- 2011-02-17 ZA ZA2011/01282A patent/ZA201101282B/en unknown
-
2012
- 2012-07-24 US US13/556,925 patent/US8669211B2/en active Active
-
2013
- 2013-09-24 US US14/035,287 patent/US8759283B2/en active Active
-
2014
- 2014-12-18 JP JP2014255730A patent/JP6178302B2/ja active Active
Patent Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003529347A (ja) * | 2000-01-25 | 2003-10-07 | ジュヴェノン インコーポレイテッド | 高齢ペット用の栄養補給食品 |
| JP2004519241A (ja) * | 2001-03-09 | 2004-07-02 | ソシエテ デ プロデユイ ネツスル ソシエテ アノニム | 高齢化に伴う生理的障害を改善し寿命を延ばす組成物 |
| JP2007524402A (ja) * | 2003-07-03 | 2007-08-30 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | コンパニオン動物における精神活動の加齢劣化を減少させる組成物及び方法 |
| JP2008511332A (ja) * | 2004-08-30 | 2008-04-17 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | ゲノムベースのダイエットデザイン |
| JP2008519838A (ja) * | 2004-11-09 | 2008-06-12 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 遺伝子調節のための酸化防止剤の使用 |
| JP2008521819A (ja) * | 2004-11-24 | 2008-06-26 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 動物における免疫応答を増大させる方法 |
| WO2006074089A2 (en) * | 2004-12-30 | 2006-07-13 | Hill's Pet Nutrition, Inc. | Methods for enhancing the quality of life of a senior animal |
| WO2007062325A1 (en) * | 2005-11-18 | 2007-05-31 | Hill's Pet Nutrition, Inc. | Methods for reducing the amount of proinflammatory substance in animal tissue or body fluid |
| JP2009519899A (ja) * | 2005-11-18 | 2009-05-21 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 動物の組織または体液中の炎症性物質の量を減少させるための方法 |
| WO2007088046A2 (en) * | 2006-02-01 | 2007-08-09 | Nestec S.A. | Nutritional system and methods for increasing longevity |
| JP2009536148A (ja) * | 2006-02-01 | 2009-10-08 | ネステク ソシエテ アノニム | 寿命を伸長するための栄養システム及び方法 |
| WO2008018043A2 (en) * | 2006-08-09 | 2008-02-14 | The Iams Company | Methods of improving bone health and muscle health |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017159741A1 (ja) * | 2016-03-16 | 2017-09-21 | 味の素株式会社 | 行動体力向上剤 |
| JPWO2017159741A1 (ja) * | 2016-03-16 | 2019-01-31 | 味の素株式会社 | 行動体力向上剤 |
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| US8759283B2 (en) | 2014-06-24 |
| US8252742B2 (en) | 2012-08-28 |
| BRPI0915979A8 (pt) | 2017-10-10 |
| US20090111877A1 (en) | 2009-04-30 |
| EP3155904A3 (en) | 2017-06-28 |
| CA2731069C (en) | 2015-10-27 |
| CA2731069A1 (en) | 2010-01-21 |
| AU2009270702A1 (en) | 2010-01-21 |
| US20140018528A1 (en) | 2014-01-16 |
| ZA201101282B (en) | 2014-07-30 |
| CN103766663A (zh) | 2014-05-07 |
| US8669211B2 (en) | 2014-03-11 |
| BRPI0915979A2 (pt) | 2015-08-11 |
| US20120289430A1 (en) | 2012-11-15 |
| EP3155904A2 (en) | 2017-04-19 |
| RU2513698C2 (ru) | 2014-04-20 |
| CN102186359A (zh) | 2011-09-14 |
| EP2315533A1 (en) | 2011-05-04 |
| CN102186359B (zh) | 2016-03-23 |
| WO2010009458A1 (en) | 2010-01-21 |
| JP2015077139A (ja) | 2015-04-23 |
| AU2009270702B2 (en) | 2012-11-15 |
| RU2011106036A (ru) | 2012-08-27 |
| EP3155904B1 (en) | 2024-09-18 |
| JP6178302B2 (ja) | 2017-08-09 |
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