JP2011528378A5 - - Google Patents
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- Publication number
- JP2011528378A5 JP2011528378A5 JP2011518936A JP2011518936A JP2011528378A5 JP 2011528378 A5 JP2011528378 A5 JP 2011528378A5 JP 2011518936 A JP2011518936 A JP 2011518936A JP 2011518936 A JP2011518936 A JP 2011518936A JP 2011528378 A5 JP2011528378 A5 JP 2011528378A5
- Authority
- JP
- Japan
- Prior art keywords
- linear
- group
- methyl
- branched alkyl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 26
- -1 methyl- Chemical group 0.000 claims 22
- 150000001875 compounds Chemical class 0.000 claims 18
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 13
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 10
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- CINXLCHKHMLIBB-UHFFFAOYSA-N 1-methyl-2-azatricyclo[3.3.1.13,7]decane Chemical compound C1C(C2)CC3CC2NC1(C)C3 CINXLCHKHMLIBB-UHFFFAOYSA-N 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000006289 hydroxybenzyl group Chemical group 0.000 claims 1
- 125000004464 hydroxyphenyl group Chemical group 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 230000002438 mitochondrial effect Effects 0.000 claims 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 0 *C(*C(*)N*)C(*)=O Chemical compound *C(*C(*)N*)C(*)=O 0.000 description 11
- FJFGBJPUYDOZSE-NYMJRDENSA-N CC(C)C[C@@H](/C=C/CC(NC([C@H](CC1C2)C3)[C@@H]2CC3(C)N1O)=O)N Chemical compound CC(C)C[C@@H](/C=C/CC(NC([C@H](CC1C2)C3)[C@@H]2CC3(C)N1O)=O)N FJFGBJPUYDOZSE-NYMJRDENSA-N 0.000 description 1
- XVWPFRPKZMDHKU-MVGZEHJDSA-N CC(C)C[C@@H](/C=C/CC(Nc1cc(C(C)(C)N(C2(C)C)O)c2cc1)=O)N Chemical compound CC(C)C[C@@H](/C=C/CC(Nc1cc(C(C)(C)N(C2(C)C)O)c2cc1)=O)N XVWPFRPKZMDHKU-MVGZEHJDSA-N 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8158508P | 2008-07-17 | 2008-07-17 | |
| US61/081,585 | 2008-07-17 | ||
| US15856909P | 2009-03-09 | 2009-03-09 | |
| US61/158,569 | 2009-03-09 | ||
| US17857009P | 2009-05-15 | 2009-05-15 | |
| US61/178,570 | 2009-05-15 | ||
| PCT/US2009/051004 WO2010009405A2 (en) | 2008-07-17 | 2009-07-17 | Targeted nitroxide agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011528378A JP2011528378A (ja) | 2011-11-17 |
| JP2011528378A5 true JP2011528378A5 (enExample) | 2012-08-30 |
| JP5719293B2 JP5719293B2 (ja) | 2015-05-13 |
Family
ID=41551032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011518936A Expired - Fee Related JP5719293B2 (ja) | 2008-07-17 | 2009-07-17 | 標的化ニトロキシド剤 |
Country Status (11)
| Country | Link |
|---|---|
| US (8) | US8288551B2 (enExample) |
| EP (1) | EP2328875B1 (enExample) |
| JP (1) | JP5719293B2 (enExample) |
| CN (1) | CN102159553B (enExample) |
| AU (1) | AU2009270740B8 (enExample) |
| CA (1) | CA2768183C (enExample) |
| DK (1) | DK2328875T3 (enExample) |
| ES (1) | ES2527958T3 (enExample) |
| PL (1) | PL2328875T3 (enExample) |
| PT (1) | PT2328875E (enExample) |
| WO (1) | WO2010009405A2 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7718603B1 (en) * | 2006-01-06 | 2010-05-18 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Selective targeting agents for mitochondria |
| WO2010009389A1 (en) * | 2008-07-17 | 2010-01-21 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Use of targeted nitroxide agents in preventing, mitigating and treating radiation injury |
| WO2010009327A1 (en) | 2008-07-17 | 2010-01-21 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Compounds for the treatment of pathologies associated with aging and degenerative disorders |
| AU2009270740B8 (en) | 2008-07-17 | 2015-07-09 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Targeted nitroxide agents |
| WO2010141824A2 (en) * | 2009-06-05 | 2010-12-09 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Use of targeted nitroxide agents in bone healing |
| EP2461747B1 (en) * | 2009-08-06 | 2019-03-06 | Peter Theophilos Banos | Device for monitoring the effects of cellular stress and damage resulting from radiation exposure |
| US8778969B2 (en) | 2009-11-07 | 2014-07-15 | Peter H Proctor | Nitrone, nitroso, and nitroxide spintraps and spin labels and their hydroxylamines |
| US9217000B2 (en) | 2011-02-18 | 2015-12-22 | Univerisyt of Pittsburgh—of the Commonwealth System of Higher Education | Targeted nitroxide agents |
| US9200035B2 (en) | 2011-10-21 | 2015-12-01 | University of Pittsburgh—of the Commonwealth System of Higher Education | Bifunctional compounds |
| CN104530424B (zh) * | 2014-11-28 | 2017-03-29 | 武汉工程大学 | 异氮杂茚氧化氮自由基改性聚苯胺及其合成方法和用途 |
| US10660851B2 (en) | 2015-01-02 | 2020-05-26 | Rxos Medical | Polyfunctional radical scavenger hydrogel formulation |
| CN106267223A (zh) * | 2015-05-11 | 2017-01-04 | 华东理工大学 | 一种基于氧自由基的靶向功能材料及其应用 |
| US10450289B2 (en) | 2015-06-08 | 2019-10-22 | University of Pittsburgh—of the Commonwealth System of Higher Education | Substituted β-lapachones for treating cancer |
| WO2017004073A1 (en) * | 2015-06-29 | 2017-01-05 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Bisnitroxides |
| US10028943B2 (en) | 2015-07-05 | 2018-07-24 | Peter Herbert Proctor | Method for treatment of radiologically-dense breasts |
| WO2017040537A1 (en) | 2015-08-31 | 2017-03-09 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Compounds for bone healing |
| US9676738B2 (en) | 2015-10-14 | 2017-06-13 | University of Pittsburgh—of the Commonwealth System of Higher Education | Antifibrotic effects of oxetanyl sulfoxides |
| WO2018071761A1 (en) * | 2016-10-13 | 2018-04-19 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Mitochondrially targeted parp inhibitor, and uses thereof |
| WO2021021699A1 (en) | 2019-07-26 | 2021-02-04 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Targeted nitroxide compounds and their use in treating ferroptosis-related diseases |
| US12128038B2 (en) | 2020-12-29 | 2024-10-29 | University of Pittsburgh—of the Commonwealth System of Higher Education | Method of treatment of organic acidemias and other mitochondria defects or deficiencies |
| CN116789888B (zh) * | 2023-05-04 | 2025-11-18 | 浙江大学 | 一种能够减轻器官缺血再灌注损伤的抗自由基聚合物及其制备方法和用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5587388A (en) | 1992-12-02 | 1996-12-24 | Lucky Limited | Irreversible HIV protease inhibitors, intermediates, compositions and processes for the preparation thereof |
| JP2008533031A (ja) * | 2005-03-09 | 2008-08-21 | ニトロメッド インコーポレーティッド | アンギオテンシンｉｉアンタゴニストの有機酸化窒素増強塩、組成物および使用法 |
| US20070161544A1 (en) * | 2006-01-06 | 2007-07-12 | Peter Wipf | Selective targeting agents for mitcochondria |
| US7528174B2 (en) * | 2006-01-06 | 2009-05-05 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Selective targeting agents for mitochondria |
| US7718603B1 (en) * | 2006-01-06 | 2010-05-18 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Selective targeting agents for mitochondria |
| AU2009270740B8 (en) * | 2008-07-17 | 2015-07-09 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Targeted nitroxide agents |
| WO2010009327A1 (en) * | 2008-07-17 | 2010-01-21 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Compounds for the treatment of pathologies associated with aging and degenerative disorders |
| WO2010009389A1 (en) * | 2008-07-17 | 2010-01-21 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Use of targeted nitroxide agents in preventing, mitigating and treating radiation injury |
| US20120207687A1 (en) * | 2011-01-14 | 2012-08-16 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Topical formulations of targeted nitroxide agents |
| US9217000B2 (en) | 2011-02-18 | 2015-12-22 | Univerisyt of Pittsburgh—of the Commonwealth System of Higher Education | Targeted nitroxide agents |
-
2009
- 2009-07-17 AU AU2009270740A patent/AU2009270740B8/en not_active Ceased
- 2009-07-17 ES ES09798808.3T patent/ES2527958T3/es active Active
- 2009-07-17 EP EP09798808.3A patent/EP2328875B1/en active Active
- 2009-07-17 CN CN200980136332.XA patent/CN102159553B/zh not_active Expired - Fee Related
- 2009-07-17 PL PL09798808T patent/PL2328875T3/pl unknown
- 2009-07-17 JP JP2011518936A patent/JP5719293B2/ja not_active Expired - Fee Related
- 2009-07-17 DK DK09798808.3T patent/DK2328875T3/en active
- 2009-07-17 WO PCT/US2009/051004 patent/WO2010009405A2/en not_active Ceased
- 2009-07-17 US US12/505,294 patent/US8288551B2/en active Active
- 2009-07-17 CA CA2768183A patent/CA2768183C/en active Active
- 2009-07-17 PT PT97988083T patent/PT2328875E/pt unknown
-
2012
- 2012-09-14 US US13/620,029 patent/US8609850B2/en active Active
-
2013
- 2013-11-22 US US14/088,233 patent/US9216976B2/en active Active
-
2015
- 2015-11-17 US US14/943,965 patent/US9890192B2/en active Active
-
2017
- 2017-12-27 US US15/855,598 patent/US10526368B2/en active Active
-
2019
- 2019-11-20 US US16/689,930 patent/US20200317730A1/en not_active Abandoned
-
2021
- 2021-01-14 US US17/149,565 patent/US20210371460A1/en not_active Abandoned
-
2023
- 2023-01-05 US US18/093,704 patent/US20230144767A1/en not_active Abandoned
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