CN102159553B - 靶向氧氮自由基药剂 - Google Patents

靶向氧氮自由基药剂 Download PDF

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Publication number
CN102159553B
CN102159553B CN200980136332.XA CN200980136332A CN102159553B CN 102159553 B CN102159553 B CN 102159553B CN 200980136332 A CN200980136332 A CN 200980136332A CN 102159553 B CN102159553 B CN 102159553B
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cells
xjb
compound
solution
compounds
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CN102159553A (zh
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P·温普弗
M·C·弗兰特兹
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University of Pittsburgh
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University of Pittsburgh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/94—Oxygen atom, e.g. piperidine N-oxide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/06—1,3-Thiazines; Hydrogenated 1,3-thiazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN200980136332.XA 2008-07-17 2009-07-17 靶向氧氮自由基药剂 Expired - Fee Related CN102159553B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US8158508P 2008-07-17 2008-07-17
US61/081,585 2008-07-17
US15856909P 2009-03-09 2009-03-09
US61/158,569 2009-03-09
US17857009P 2009-05-15 2009-05-15
US61/178,570 2009-05-15
PCT/US2009/051004 WO2010009405A2 (en) 2008-07-17 2009-07-17 Targeted nitroxide agents

Publications (2)

Publication Number Publication Date
CN102159553A CN102159553A (zh) 2011-08-17
CN102159553B true CN102159553B (zh) 2016-02-17

Family

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CN200980136332.XA Expired - Fee Related CN102159553B (zh) 2008-07-17 2009-07-17 靶向氧氮自由基药剂

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US (8) US8288551B2 (enExample)
EP (1) EP2328875B1 (enExample)
JP (1) JP5719293B2 (enExample)
CN (1) CN102159553B (enExample)
AU (1) AU2009270740B8 (enExample)
CA (1) CA2768183C (enExample)
DK (1) DK2328875T3 (enExample)
ES (1) ES2527958T3 (enExample)
PL (1) PL2328875T3 (enExample)
PT (1) PT2328875E (enExample)
WO (1) WO2010009405A2 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7718603B1 (en) * 2006-01-06 2010-05-18 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Selective targeting agents for mitochondria
WO2010009389A1 (en) * 2008-07-17 2010-01-21 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Use of targeted nitroxide agents in preventing, mitigating and treating radiation injury
WO2010009327A1 (en) 2008-07-17 2010-01-21 University Of Pittsburgh Of The Commonwealth System Of Higher Education Compounds for the treatment of pathologies associated with aging and degenerative disorders
AU2009270740B8 (en) 2008-07-17 2015-07-09 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Targeted nitroxide agents
WO2010141824A2 (en) * 2009-06-05 2010-12-09 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Use of targeted nitroxide agents in bone healing
EP2461747B1 (en) * 2009-08-06 2019-03-06 Peter Theophilos Banos Device for monitoring the effects of cellular stress and damage resulting from radiation exposure
US8778969B2 (en) 2009-11-07 2014-07-15 Peter H Proctor Nitrone, nitroso, and nitroxide spintraps and spin labels and their hydroxylamines
US9217000B2 (en) 2011-02-18 2015-12-22 Univerisyt of Pittsburgh—of the Commonwealth System of Higher Education Targeted nitroxide agents
US9200035B2 (en) 2011-10-21 2015-12-01 University of Pittsburgh—of the Commonwealth System of Higher Education Bifunctional compounds
CN104530424B (zh) * 2014-11-28 2017-03-29 武汉工程大学 异氮杂茚氧化氮自由基改性聚苯胺及其合成方法和用途
US10660851B2 (en) 2015-01-02 2020-05-26 Rxos Medical Polyfunctional radical scavenger hydrogel formulation
CN106267223A (zh) * 2015-05-11 2017-01-04 华东理工大学 一种基于氧自由基的靶向功能材料及其应用
US10450289B2 (en) 2015-06-08 2019-10-22 University of Pittsburgh—of the Commonwealth System of Higher Education Substituted β-lapachones for treating cancer
WO2017004073A1 (en) * 2015-06-29 2017-01-05 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Bisnitroxides
US10028943B2 (en) 2015-07-05 2018-07-24 Peter Herbert Proctor Method for treatment of radiologically-dense breasts
WO2017040537A1 (en) 2015-08-31 2017-03-09 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Compounds for bone healing
US9676738B2 (en) 2015-10-14 2017-06-13 University of Pittsburgh—of the Commonwealth System of Higher Education Antifibrotic effects of oxetanyl sulfoxides
WO2018071761A1 (en) * 2016-10-13 2018-04-19 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Mitochondrially targeted parp inhibitor, and uses thereof
WO2021021699A1 (en) 2019-07-26 2021-02-04 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Targeted nitroxide compounds and their use in treating ferroptosis-related diseases
US12128038B2 (en) 2020-12-29 2024-10-29 University of Pittsburgh—of the Commonwealth System of Higher Education Method of treatment of organic acidemias and other mitochondria defects or deficiencies
CN116789888B (zh) * 2023-05-04 2025-11-18 浙江大学 一种能够减轻器官缺血再灌注损伤的抗自由基聚合物及其制备方法和用途

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US5587388A (en) 1992-12-02 1996-12-24 Lucky Limited Irreversible HIV protease inhibitors, intermediates, compositions and processes for the preparation thereof
JP2008533031A (ja) * 2005-03-09 2008-08-21 ニトロメッド インコーポレーティッド アンギオテンシンｉｉアンタゴニストの有機酸化窒素増強塩、組成物および使用法
US20070161544A1 (en) * 2006-01-06 2007-07-12 Peter Wipf Selective targeting agents for mitcochondria
US7528174B2 (en) * 2006-01-06 2009-05-05 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Selective targeting agents for mitochondria
US7718603B1 (en) * 2006-01-06 2010-05-18 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Selective targeting agents for mitochondria
AU2009270740B8 (en) * 2008-07-17 2015-07-09 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Targeted nitroxide agents
WO2010009327A1 (en) * 2008-07-17 2010-01-21 University Of Pittsburgh Of The Commonwealth System Of Higher Education Compounds for the treatment of pathologies associated with aging and degenerative disorders
WO2010009389A1 (en) * 2008-07-17 2010-01-21 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Use of targeted nitroxide agents in preventing, mitigating and treating radiation injury
US20120207687A1 (en) * 2011-01-14 2012-08-16 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Topical formulations of targeted nitroxide agents
US9217000B2 (en) 2011-02-18 2015-12-22 Univerisyt of Pittsburgh—of the Commonwealth System of Higher Education Targeted nitroxide agents

Non-Patent Citations (1)

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Mitochondrial Targeting of Selective Electron Scavengers:Synthesis and Biological Analysis of Hemigramicidin-TEMPO Conjugates;Peter Wipf,et al.,;《J.A.C.S.》;20050819;第127卷(第36期);第12460-12461页 *

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Publication number Publication date
CA2768183A1 (en) 2010-01-21
JP2011528378A (ja) 2011-11-17
WO2010009405A3 (en) 2010-05-14
US20100035869A1 (en) 2010-02-11
EP2328875A4 (en) 2012-03-21
US20180298054A1 (en) 2018-10-18
US9216976B2 (en) 2015-12-22
AU2009270740B8 (en) 2015-07-09
US20200317730A1 (en) 2020-10-08
US9890192B2 (en) 2018-02-13
AU2009270740B2 (en) 2015-01-22
US20230144767A1 (en) 2023-05-11
DK2328875T3 (en) 2015-02-02
HK1157344A1 (zh) 2012-06-29
PL2328875T3 (pl) 2015-04-30
JP5719293B2 (ja) 2015-05-13
US20140378444A1 (en) 2014-12-25
CA2768183C (en) 2018-02-20
EP2328875B1 (en) 2014-10-15
WO2010009405A2 (en) 2010-01-21
EP2328875A2 (en) 2011-06-08
US20160137692A1 (en) 2016-05-19
WO2010009405A9 (en) 2010-03-25
US20130102626A1 (en) 2013-04-25
US8609850B2 (en) 2013-12-17
CN102159553A (zh) 2011-08-17
AU2009270740A1 (en) 2010-01-21
ES2527958T3 (es) 2015-02-02
US10526368B2 (en) 2020-01-07
PT2328875E (pt) 2015-02-04
US8288551B2 (en) 2012-10-16
US20210371460A1 (en) 2021-12-02

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