JP2011528357A - 非細胞毒性二酸化塩素流体 - Google Patents
非細胞毒性二酸化塩素流体 Download PDFInfo
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- JP2011528357A JP2011528357A JP2011518825A JP2011518825A JP2011528357A JP 2011528357 A JP2011528357 A JP 2011528357A JP 2011518825 A JP2011518825 A JP 2011518825A JP 2011518825 A JP2011518825 A JP 2011518825A JP 2011528357 A JP2011528357 A JP 2011528357A
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- chlorine dioxide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B11/00—Oxides or oxyacids of halogens; Salts thereof
- C01B11/02—Oxides of chlorine
- C01B11/022—Chlorine dioxide (ClO2)
- C01B11/023—Preparation from chlorites or chlorates
- C01B11/024—Preparation from chlorites or chlorates from chlorites
Abstract
【選択図】なし
Description
2NaClO2+Cl2(g)→2ClO2(g)+2NaCl [1a]
2NaClO2+HOCl→2ClO2(g)+NaCl+NaOH [1b]
5NaClO2+4HCl→4ClO2(g)+5NaCl+2H2O [1c]
である。
2NaClO3+4HCl→2ClO2+Cl2+2H2O+2NaCl [2a]
2HClO3+H2C2O4→2ClO2+2CO2+2H2O [2b]
2NaClO3+H2SO4+SO2→2ClO2+2NaHSO4 [2c]
が挙げられる。
特に定義されない限り、本明細書に使用される全ての専門および科学用語は、概して、当業者により一般的に理解されるように、同一の意味を有する。概して、本明細書で使用される命名法、および細胞壊死分析、微生物分析、有機および無機化学、および歯科臨床研究における実験手順は、当該分野に周知であり、一般的に利用される。
酸化剤を含む組成物を提供し、薬剤は、組成物が実質的に非細胞毒性である二酸化塩素を含む。いくつかの実施形態において、組成物は、単一酸化剤を含み、薬剤は、二酸化塩素である。いくつかの実施形態において、組成物は、実質的に非刺激性でもある。本組成物は、細胞毒性レベルのオキシ−塩素アニオンを含有する場合があり、また非増粘で粘性が低い場合がある既存技術の二酸化塩素形態から離れる。
実質的に非細胞毒性である組成物は、二酸化塩素、または二酸化塩素(例えば、二酸化塩素形成反応物)を生成するための反応物を含む水性流体である。いくつかの実施形態において、組成物は、組成物に増粘水性流体をもたらす増粘剤成分をさらに含む。別の実施形態において、組成物は、非増粘溶液である。さらに、実質的に非細胞毒性である二酸化塩素組成物を調製するのに有用な前駆体組成物を提供する。いくつかの実施形態において、非細胞毒性である組成物は、非細胞毒性量の第2の酸化成分を含む場合がある。一実施形態において、第2の酸化成分は、過酸化成分である。他の実施形態において、非細胞毒性である組成物は、過酸化成分等の第2の酸化成分を含まない。
哺乳類細胞における二酸化塩素の効果を試験するために、以下の実験を実施した。異なる量の亜塩素酸塩アニオンを含む2系列の試料を調製した。実施例1〜4は、高吸収性ポリアクリレートゲル(ゲルタイプ「S」と標識)を使用した。実施例5〜8は、カルボキシメチルセルロース(CMC)ゲル(ゲルタイプ「C」と標識)を使用した。
2NaClO2+OCl-+H+→2ClO2+NaCl+NaOH 等式4
((S−Tab2顆粒剤質量×顆粒剤中の亜塩素酸ナトリウム質量分率×亜塩素酸ナトリウム中の亜塩素酸塩質量分率×亜塩素酸ナトリウムの基準質量分率)×1000)/最終試料の総質量。S−Tab2顆粒剤で使用された亜塩素酸ナトリウムの質量分率は、0.07である。亜塩素酸ナトリウム中の亜塩素酸塩の質量分率は、0.74である。顆粒剤で使用された亜塩素酸ナトリウム粉末中の実際の亜塩素酸ナトリウムの基準質量分率(すなわち、亜塩素酸ナトリウムの純度)は、0.8である。したがって、例えば、ゲル試料2の1グラム当りのミリグラムのオキシ−塩素アニオンの算出は、
((0.143g×0.07×0.74×0.8)×1000)/30グラム最終試料である。
細胞毒性が、他の場合によっては有害な成分にではなく、オキシ−塩素アニオンにより誘発されることを確証するために、以下の実験が実施された。
実験例1のデータは、オキシ−塩素アニオンの細胞毒性が用量依存であることを示唆する。特定的に、細胞毒性は、1gのゲル当り0.2mg以下の亜塩素酸塩アニオンを有するゲルにおいては観察されないが、細胞毒性は、0.5mg以下の亜塩素酸塩アニオン/グラムを有するゲルにおいて観察された。この実験は、試験される増粘流体組成物の亜塩素酸塩アニオン濃度のより正確な推定を可能にする、亜塩素酸ナトリウム溶液を用いて、亜塩素酸塩アニオンの細胞毒性をさらに検査するために立案された。加えて、漂白剤として10%の過酸化水素を含有する、商業的に入手可能な、市販の過酸化物ベースの歯牙白化製品も評価された。
細胞毒性および増粘流体組成物中のオキシ−塩素アニオン濃度間の関係をさらに検査するために、以下の実験を実施した。
非細胞毒性の二酸化塩素溶液および増粘組成物の抗細菌効力を確認するために、実験が実施された。3つの異なる二酸化塩素濃度の非細胞毒性の二酸化塩素溶液を試験した。異なる手段で調製された、非細胞毒性である二酸化塩素増粘組成物を試験した。
生菌数試験(Microbiological Examination of Nonsterile Products:Microbial Enumeration Test)に従うDow923の「振とうフラスコ」試験を用いて評価された。つまり、初回の希釈は、脳−心臓滲出培地で行われた。最終希釈は、75mLのリン酸緩衝水で行われた。初期の生物個体数を決定するために、標準的な平板菌数をそれぞれの振とうフラスコ上で実施した。試験物質量(0.75g)を量り、接種された75mLのリン酸緩衝水と共に、別個の減菌使い捨てPBW容器上に配置した。試料の接種レベルは、MRSAおよび緑膿菌において、それぞれ420,000cfu/mLおよび250,000cfu/mLであった。それぞれのフラスコを手首動作振とう機に配置し、1時間、激しく振とうさせた。フラスコを振とう機から外し、試験溶液をペトリ皿に配設した。次いで、標準方法の寒天を添加し、皿をインキュベートした。好気性生菌数/mLを15分、30分、1時間、および24時間で評価した。
局所投与における非細胞毒性である二酸化塩素増粘組成物が創傷治癒に悪影響を及ぼすかを決定するために、動物モデルとしてブタを用いて、以下の実験を実施した。ブタは、1つにはブタの皮膚がヒトの皮膚と多くの特徴を共有するという理由で、頻繁に創傷治癒のモデルとなる。ブタのモデルは、ヒトの創傷の使用目的の候補薬剤の評価において優れたツールであると考えられる。
Claims (17)
- 低刺激性酸化組成物であって、前記組成物は、
二酸化塩素と、
第2の酸化剤と、を含み、
前記第2の酸化剤を含むが二酸化塩素を含まない参照酸化組成物と比較して低刺激性であり、前記参照酸化組成物は、前記酸化組成物と同様の性能効力を有する、組成物。 - 前記第2の酸化剤は、過酸化剤である、請求項1に記載の組成物。
- 前記組成物は、組成物1グラム当り約0.2ミリグラム未満のオキシ−塩素アニオンを含む、請求項1に記載の組成物。
- 前記組成物は、約5〜約2000ppmの二酸化塩素を含む、請求項3に記載の組成物。
- 前記組成物は、約4.5〜約11のpHを有する、請求項4に記載の組成物。
- 増粘剤成分が、天然親水コロイド、半合成親水コロイド、合成親水コロイド、および粘土からなる群から選択される、請求項1に記載の組成物。
- 前記増粘剤成分は、半合成親水コロイドである、請求項6に記載の組成物。
- 前記半合成親水コロイドは、カルボキシメチルセルロースである、請求項7に記載の組成物。
- 前記カルボキシメチルセルロースは、カルボキシメチルセルロースナトリウムである、請求項8に記載の組成物。
- 前記過酸化剤は、過酸化水素である、請求項2に記載の組成物。
- 前記組成物は、約1質量%〜約30質量%の過酸化水素を含む、請求項10に記載の組成物。
- a)二酸化塩素と、
b)過酸化成分と、
c)水性流体と、を含む流体組成物であって、
低刺激性である、流体組成物。 - 前記組成物は、組成物1グラム当り約0.2ミリグラム未満のオキシ−塩素アニオンを含む、請求項12に記載の組成物。
- 前記組成物は、約5〜約2000ppmの二酸化塩素を含む、請求項13に記載の組成物。
- 前記組成物は、約4.5〜約11のpHを有する、請求項14に記載の組成物。
- 過酸化物は、過酸化水素である、請求項12に記載の組成物。
- 前記組成物は、約1質量%〜約30質量%の過酸化水素を含む、請求項16に記載の組成物。
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13501108P | 2008-07-15 | 2008-07-15 | |
US61/135,011 | 2008-07-15 | ||
US10602608P | 2008-10-16 | 2008-10-16 | |
US61/106,026 | 2008-10-16 | ||
US15068509P | 2009-02-06 | 2009-02-06 | |
US61/150,685 | 2009-02-06 | ||
PCT/US2009/050442 WO2010009064A2 (en) | 2008-07-15 | 2009-07-14 | Non-cytotoxic chlorine dioxide fluids |
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JP2011528357A true JP2011528357A (ja) | 2011-11-17 |
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JP2011518824A Pending JP2011528317A (ja) | 2008-07-15 | 2009-07-14 | 非細胞毒性二酸化塩素流体 |
JP2011518825A Pending JP2011528357A (ja) | 2008-07-15 | 2009-07-14 | 非細胞毒性二酸化塩素流体 |
JP2015019937A Pending JP2015120730A (ja) | 2008-07-15 | 2015-02-04 | 非細胞毒性二酸化塩素流体 |
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JP2011518824A Pending JP2011528317A (ja) | 2008-07-15 | 2009-07-14 | 非細胞毒性二酸化塩素流体 |
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US (10) | US8636987B2 (ja) |
EP (6) | EP2313061A2 (ja) |
JP (3) | JP2011528317A (ja) |
KR (2) | KR20110031496A (ja) |
CN (3) | CN102137651A (ja) |
AR (6) | AR073345A1 (ja) |
BR (2) | BRPI0916418A2 (ja) |
CA (2) | CA2730729A1 (ja) |
CL (6) | CL2009001585A1 (ja) |
ES (2) | ES2563654T3 (ja) |
MX (2) | MX2011000536A (ja) |
PL (1) | PL2313065T3 (ja) |
TW (6) | TW201018490A (ja) |
WO (6) | WO2010009119A2 (ja) |
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