JP2011528332A5 - - Google Patents

Info

Publication number

JP2011528332A5

JP2011528332A5 JP2011517954A JP2011517954A JP2011528332A5 JP 2011528332 A5 JP2011528332 A5 JP 2011528332A5 JP 2011517954 A JP2011517954 A JP 2011517954A JP 2011517954 A JP2011517954 A JP 2011517954A JP 2011528332 A5 JP2011528332 A5 JP 2011528332A5

Authority

JP

Japan

Prior art keywords

human beta

beta defensin

composition

seq

body weight

Prior art date

2009-07-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000203 mixture Substances 0.000 claims 8
• 101001033280 Homo sapiens Cytokine receptor common subunit beta Proteins 0.000 claims 5
• 102000055647 human CSF2RB Human genes 0.000 claims 5
• 102000000541 Defensins Human genes 0.000 claims 4
• 108010002069 Defensins Proteins 0.000 claims 4
• 230000037396 body weight Effects 0.000 claims 4
• 101000884714 Homo sapiens Beta-defensin 4A Proteins 0.000 claims 3
• 102000049262 human DEFB4A Human genes 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 2
• 201000004624 Dermatitis Diseases 0.000 claims 2
• 125000003275 alpha amino acid group Chemical group 0.000 claims 2
• 208000027866 inflammatory disease Diseases 0.000 claims 2
• 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
• 201000004384 Alopecia Diseases 0.000 claims 1
• 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
• 201000001320 Atherosclerosis Diseases 0.000 claims 1
• 208000023328 Basedow disease Diseases 0.000 claims 1
• 208000009137 Behcet syndrome Diseases 0.000 claims 1
• 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
• 206010010744 Conjunctivitis allergic Diseases 0.000 claims 1
• 206010012438 Dermatitis atopic Diseases 0.000 claims 1
• 206010018364 Glomerulonephritis Diseases 0.000 claims 1
• 208000015023 Graves' disease Diseases 0.000 claims 1
• 101000952040 Homo sapiens Beta-defensin 1 Proteins 0.000 claims 1
• 101000912247 Homo sapiens Beta-defensin 103 Proteins 0.000 claims 1
• 208000003456 Juvenile Arthritis Diseases 0.000 claims 1
• 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 1
• 201000004681 Psoriasis Diseases 0.000 claims 1
• 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
• 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
• 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 1
• 206010039710 Scleroderma Diseases 0.000 claims 1
• 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
• 201000009594 Systemic Scleroderma Diseases 0.000 claims 1
• 206010042953 Systemic sclerosis Diseases 0.000 claims 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
• 206010046851 Uveitis Diseases 0.000 claims 1
• 206010047115 Vasculitis Diseases 0.000 claims 1
• 230000001154 acute effect Effects 0.000 claims 1
• 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 1
• 208000002205 allergic conjunctivitis Diseases 0.000 claims 1
• 230000000172 allergic effect Effects 0.000 claims 1
• 231100000360 alopecia Toxicity 0.000 claims 1
• 208000006673 asthma Diseases 0.000 claims 1
• 208000024998 atopic conjunctivitis Diseases 0.000 claims 1
• 201000008937 atopic dermatitis Diseases 0.000 claims 1
• 208000010668 atopic eczema Diseases 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 102000046975 human DEFB1 Human genes 0.000 claims 1
• 102000055779 human DEFB103A Human genes 0.000 claims 1
• 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims 1
• 206010025135 lupus erythematosus Diseases 0.000 claims 1
• 201000006417 multiple sclerosis Diseases 0.000 claims 1
• 206010028417 myasthenia gravis Diseases 0.000 claims 1
• 201000008482 osteoarthritis Diseases 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
• 206010039083 rhinitis Diseases 0.000 claims 1
• 201000000306 sarcoidosis Diseases 0.000 claims 1