JP2011527915A - 大量出血を停止および漏出を封止するための医療用接着剤 - Google Patents

大量出血を停止および漏出を封止するための医療用接着剤 Download PDF

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Publication number
JP2011527915A
JP2011527915A JP2011517778A JP2011517778A JP2011527915A JP 2011527915 A JP2011527915 A JP 2011527915A JP 2011517778 A JP2011517778 A JP 2011517778A JP 2011517778 A JP2011517778 A JP 2011517778A JP 2011527915 A JP2011527915 A JP 2011527915A
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JP
Japan
Prior art keywords
component
tissue
functional
isocyanate
polyol
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JP2011517778A
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Japanese (ja)
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JP2011527915A5 (https=
Inventor
ハイケ・ヘックロート
ブルクハルト・ケーラー
ゼバスティアン・デーア
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Covestro Deutschland AG
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Bayer MaterialScience AG
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Publication of JP2011527915A publication Critical patent/JP2011527915A/ja
Publication of JP2011527915A5 publication Critical patent/JP2011527915A5/ja
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
    • A61L24/0094—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/04—Surgical instruments, devices or methods for suturing wounds; Holders or packages for needles or suture materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06—At least partially resorbable materials
    • A61L17/10—At least partially resorbable materials containing macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/08—Processes
    • C08G18/089—Reaction retarding agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/08—Processes
    • C08G18/10—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/48—Polyethers
    • C08G18/4833—Polyethers containing oxyethylene units
    • C08G18/4837—Polyethers containing oxyethylene units and other oxyalkylene units
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L75/00—Compositions of polyureas or polyurethanes; Compositions of derivatives of such polymers
    • C08L75/04—Polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J175/00—Adhesives based on polyureas or polyurethanes; Adhesives based on derivatives of such polymers
    • C09J175/04—Polyurethanes
    • C09J175/12—Polyurethanes from compounds containing nitrogen and active hydrogen, the nitrogen atom not being part of an isocyanate group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Polymers & Plastics (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Composite Materials (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Adhesives Or Adhesive Processes (AREA)
JP2011517778A 2008-07-17 2009-07-04 大量出血を停止および漏出を封止するための医療用接着剤 Withdrawn JP2011527915A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08012901A EP2145634A1 (de) 2008-07-17 2008-07-17 Medizinische Klebstoffe zur Stillung schwerwiegender Blutungen und Abdichtung von Leckagen
EP08012901.8 2008-07-17
PCT/EP2009/004833 WO2010006714A2 (de) 2008-07-17 2009-07-04 Medizinische klebstoffe zur stillung schwerwiegender blutungen und abdichtung von leckagen

Publications (2)

Publication Number Publication Date
JP2011527915A true JP2011527915A (ja) 2011-11-10
JP2011527915A5 JP2011527915A5 (https=) 2012-08-16

Family

ID=39877989

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011517778A Withdrawn JP2011527915A (ja) 2008-07-17 2009-07-04 大量出血を停止および漏出を封止するための医療用接着剤

Country Status (13)

Country Link
US (4) US9764058B2 (https=)
EP (2) EP2145634A1 (https=)
JP (1) JP2011527915A (https=)
KR (1) KR20110052573A (https=)
CN (1) CN102089015A (https=)
AU (1) AU2009270521A1 (https=)
BR (1) BRPI0916192A2 (https=)
CA (1) CA2730850A1 (https=)
DK (1) DK2307063T3 (https=)
ES (1) ES2533077T3 (https=)
RU (1) RU2011105724A (https=)
TW (1) TW201016248A (https=)
WO (1) WO2010006714A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015509090A (ja) * 2012-01-09 2015-03-26 メディカル・アドヒーシブ・レボリューション・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＭｅｄｉｃａｌ Ａｄｈｅｓｉｖｅ Ｒｅｖｏｌｕｔｉｏｎ ＧｍｂＨ 修飾ベータ−アミノ酸エステル（アスパラギン酸エステル）硬化剤およびポリ尿素組織接着剤におけるその使用
JP2019151728A (ja) * 2018-03-02 2019-09-12 東洋紡株式会社 ポリカルボン酸誘導体
JP2024501314A (ja) * 2020-12-23 2024-01-11 ピーターズ サージカル Ｎｃｏ末端ウレタンプレプロポリマーを含む止血性の組織接着剤組成物

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2145634A1 (de) * 2008-07-17 2010-01-20 Bayer MaterialScience AG Medizinische Klebstoffe zur Stillung schwerwiegender Blutungen und Abdichtung von Leckagen
DE102010019504A1 (de) 2010-05-06 2011-11-10 Bayer Materialscience Ag Polyisocyanatprepolymere und deren Verwendung
WO2012013673A1 (de) 2010-07-29 2012-02-02 Bayer Materialscience Ag Bioabbaubarer gewebekleber
PL2673311T3 (pl) 2011-02-09 2015-02-27 Bayer Materialscience Ag Kleje tkankowe na bazie trójfunkcjonalnych asparginianów
WO2012107375A1 (de) 2011-02-09 2012-08-16 Bayer Materialscience Ag Gewebekleber auf basis stickstoffmodifizierter aspartate
WO2012107376A1 (de) 2011-02-09 2012-08-16 Bayer Materialscience Ag Gewebekleber auf basis aminosubstituierter triacetale
EP2699615B1 (de) 2011-04-19 2015-06-17 Medical Adhesive Revolution GmbH Medizinischer klebstoff zur stillung von blutungen
WO2012143358A1 (de) * 2011-04-19 2012-10-26 Bayer Materialscience Ag Gewebekleber mit beschleunigter aushärtung
EP2543395A1 (de) * 2011-07-04 2013-01-09 Bayer MaterialScience AG Schichtaufbau zum Verschließen von Gewebeleckagen
ES2694826T3 (es) * 2011-12-20 2018-12-27 Adhesys Medical Gmbh Prepolímero con funcionalidad isocianato para un adhesivo de tejidos biodegradable
EP2695900B1 (en) * 2012-08-06 2019-03-20 Novachem Industriale S.r.l. Process for preparing a two-component polyurethane adhesive system
KR20170134572A (ko) 2015-04-06 2017-12-06 쓰리엠 이노베이티브 프로퍼티즈 컴파니 제거가능한 필름 형성 겔 조성물 및 이의 적용 방법
WO2019241484A1 (en) 2018-06-14 2019-12-19 Ecolab Usa Inc. Carboxy alkyl-ester anti-agglomerants for the control of natural gas hydrates
EP3698723A1 (de) 2019-02-20 2020-08-26 Adhesys Medical GmbH Applikator für einen zwei-komponenten gewebekleber
WO2022013345A1 (de) 2020-07-17 2022-01-20 Adhesys Medical Gmbh Kit aus einem zwei-komponenten gewebekleber und einer textilen struktur zur stärkung des bindegewebes nach einer operation sowie dessen verwendung
DE102021102484A1 (de) 2021-02-03 2022-08-04 Adhesys Medical Gmbh Kit für die Gefäßanastomose aus einem zwei-Komponenten Gewebekleber und einer Gefäßprothese sowie dessen Verwendung
DE102021106358A1 (de) 2021-03-16 2022-09-22 Adhesys Medical Gmbh Gewebekleber in Form eines Zweikomponenten-Klebstoffs zur Verwendung bei der Pankreasanastomose im Rahmen der Pankreasresektion
EP4104870A1 (de) 2021-06-15 2022-12-21 Adhesys Medical GmbH Gewebekleber in form eines zweikomponenten-klebstoffs zur verwendung als bakterielle barriere bei der wundbehandlung, insbesondere nach chirurgischen eingriffen
CN114053474A (zh) * 2021-11-24 2022-02-18 华南理工大学 一种具备止血功能的医用胶粘剂及其使用方法
EP4591856A1 (en) 2023-03-28 2025-07-30 POSTECH Research and Business Development Foundation Polymer nanoparticles of metabolites and use thereof

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US4740534A (en) * 1985-08-30 1988-04-26 Sanyo Chemical Industries, Ltd. Surgical adhesive
ES2062188T3 (es) * 1989-06-23 1994-12-16 Bayer Ag Procedimiento para la elaboracion de revestimientos.
US5243012A (en) 1992-06-10 1993-09-07 Miles Inc. Polyurea coating compositions having improved pot lives
WO1998054224A1 (en) * 1997-05-28 1998-12-03 Tapic International Co., Ltd. Collagen gel
US6355829B2 (en) * 1999-09-02 2002-03-12 Bayer Corporation Aspartate-terminated urea/urethane prepolymers and their use in coating compositions
DE10246708A1 (de) * 2002-10-07 2004-04-15 Bayer Ag Zweikomponenten-Systeme für die Herstellung elastischer Beschichtungen
US20050129733A1 (en) * 2003-12-09 2005-06-16 Milbocker Michael T. Surgical adhesive and uses therefore
US8044234B2 (en) * 2005-05-05 2011-10-25 Tyco Healthcare Group Lp Bioabsorbable surgical composition
ES2669059T3 (es) * 2005-07-28 2018-05-23 Bioptigen, Inc. Sistema de formación de imagen de tomografía de coherencia óptica en el dominio de la frecuencia
WO2007127198A2 (en) * 2006-04-24 2007-11-08 Incept, Llc Protein crosslinkers, crosslinking methods and applications thereof
EP2011808A1 (de) * 2007-07-03 2009-01-07 Bayer MaterialScience AG Medizinische Klebstoffe für die Chirurgie
EP2095832A1 (de) * 2008-02-28 2009-09-02 Bayer MaterialScience AG Polyharnstoff-Systeme und deren Anwendung als postoperative Adhäsionsbarrieren, Filme und Verbundteile.
EP2145634A1 (de) * 2008-07-17 2010-01-20 Bayer MaterialScience AG Medizinische Klebstoffe zur Stillung schwerwiegender Blutungen und Abdichtung von Leckagen
EP2275466A1 (de) * 2009-07-16 2011-01-19 Bayer MaterialScience AG Polyharnstoff-basierter Gewebekleber
WO2012107375A1 (de) * 2011-02-09 2012-08-16 Bayer Materialscience Ag Gewebekleber auf basis stickstoffmodifizierter aspartate

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015509090A (ja) * 2012-01-09 2015-03-26 メディカル・アドヒーシブ・レボリューション・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＭｅｄｉｃａｌ Ａｄｈｅｓｉｖｅ Ｒｅｖｏｌｕｔｉｏｎ ＧｍｂＨ 修飾ベータ−アミノ酸エステル（アスパラギン酸エステル）硬化剤およびポリ尿素組織接着剤におけるその使用
JP2017047203A (ja) * 2012-01-09 2017-03-09 アドヒーシス・メディカル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＡｄｈｅｓｙｓ Ｍｅｄｉｃａｌ ＧｍｂＨ 修飾ベータ−アミノ酸エステル（アスパラギン酸エステル）硬化剤およびポリ尿素組織接着剤におけるその使用
JP2019151728A (ja) * 2018-03-02 2019-09-12 東洋紡株式会社 ポリカルボン酸誘導体
JP7155544B2 (ja) 2018-03-02 2022-10-19 東洋紡株式会社 ポリカルボン酸誘導体
JP2024501314A (ja) * 2020-12-23 2024-01-11 ピーターズ サージカル Ｎｃｏ末端ウレタンプレプロポリマーを含む止血性の組織接着剤組成物

Also Published As

Publication number Publication date
EP2307063B1 (de) 2014-12-31
KR20110052573A (ko) 2011-05-18
BRPI0916192A2 (pt) 2018-05-29
US10391198B2 (en) 2019-08-27
CA2730850A1 (en) 2010-01-21
US10117963B2 (en) 2018-11-06
AU2009270521A1 (en) 2010-01-21
EP2307063A2 (de) 2011-04-13
US20190030206A1 (en) 2019-01-31
US20110123479A1 (en) 2011-05-26
US20200046875A1 (en) 2020-02-13
US20170326268A1 (en) 2017-11-16
TW201016248A (en) 2010-05-01
US9764058B2 (en) 2017-09-19
RU2011105724A (ru) 2012-08-27
WO2010006714A3 (de) 2010-09-30
EP2145634A1 (de) 2010-01-20
US10722609B2 (en) 2020-07-28
WO2010006714A2 (de) 2010-01-21
CN102089015A (zh) 2011-06-08
DK2307063T3 (en) 2015-04-07
ES2533077T3 (es) 2015-04-07

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