JP2011527330A - スニチニブリンゴ酸塩の結晶形の調製方法 - Google Patents

スニチニブリンゴ酸塩の結晶形の調製方法 Download PDF

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JP2011527330A
JP2011527330A JP2011517242A JP2011517242A JP2011527330A JP 2011527330 A JP2011527330 A JP 2011527330A JP 2011517242 A JP2011517242 A JP 2011517242A JP 2011517242 A JP2011517242 A JP 2011517242A JP 2011527330 A JP2011527330 A JP 2011527330A
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sunitinib
malic acid
dissolved
mixture
sunitinib malate
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Japanese (ja)
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JP2011527330A5 (https=
Inventor
ガイトンデ，アブヘイ
ゴレ，ビナーヤク
チョウダーリ，バラティ
フブリカール，マヘシ
バンソデ，プラカシュ
ファドタレ，スナンダ
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ジェネリクス・（ユーケー）・リミテッド
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Publication of JP2011527330A publication Critical patent/JP2011527330A/ja
Publication of JP2011527330A5 publication Critical patent/JP2011527330A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2011517242A 2008-07-10 2009-07-09 スニチニブリンゴ酸塩の結晶形の調製方法 Pending JP2011527330A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN1193/KOL/2008 2008-07-10
IN1193KO2008 2008-07-10
PCT/GB2009/050818 WO2010004339A1 (en) 2008-07-10 2009-07-09 Processes for the preparation of crystalline forms of sunitinib malate

Publications (2)

Publication Number Publication Date
JP2011527330A true JP2011527330A (ja) 2011-10-27
JP2011527330A5 JP2011527330A5 (https=) 2012-08-23

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ID=41100787

Family Applications (1)

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JP2011517242A Pending JP2011527330A (ja) 2008-07-10 2009-07-09 スニチニブリンゴ酸塩の結晶形の調製方法

Country Status (7)

Country Link
US (1) US20110257237A1 (https=)
EP (1) EP2297138A1 (https=)
JP (1) JP2011527330A (https=)
CN (1) CN102203085A (https=)
AU (1) AU2009269768A1 (https=)
CA (1) CA2730079A1 (https=)
WO (1) WO2010004339A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102197035A (zh) * 2008-08-25 2011-09-21 基因里克斯(英国)有限公司 舒尼替尼的结晶形式及其制备方法
EP2499133A2 (en) * 2009-11-12 2012-09-19 Ranbaxy Laboratories Limited Process for the preparation of crystalline form i of l-malic acid salt of sunitinib
WO2011092664A1 (en) 2010-01-29 2011-08-04 Ranbaxy Laboratories Limited Crystalline forms of l-malic acid salt of sunitinib
ES2709110T3 (es) * 2012-03-23 2019-04-15 Laurus Labs Ltd Un proceso mejorado para la preparación de sunitinib y sus sales de adición de ácido
CA2838587A1 (en) * 2013-10-18 2015-04-18 Hari Babu Matta Pure crystalline form ii of l-malic acid salt of sunitinib and processes for its preparation
CN104693187A (zh) * 2013-12-10 2015-06-10 安杰世纪生物科技（北京）有限公司 一种舒尼替尼L-苹果酸盐晶型λ及其制备方法
CN105085490A (zh) * 2014-05-09 2015-11-25 上海科胜药物研发有限公司 新的舒尼替尼苹果酸盐晶型及其制备方法
CN115057814A (zh) * 2021-12-07 2022-09-16 山东新时代药业有限公司 一种米力农苹果酸盐晶体

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003523340A (ja) * 2000-02-15 2003-08-05 スージェン・インコーポレーテッド ピロール置換２−インドリノン蛋白質キナーゼ阻害剤
JP2005503386A (ja) * 2001-08-15 2005-02-03 ファルマシア アンド アップジョン カンパニー リミティド ライアビリティー カンパニー Ｎ−［２−（ジエチルアミノ）エチル］−５−［（５−フルオロ−１，２−ジヒドロ−２−オキソ−３ｈ−インドール−３−イリデン）メチル］−２，４−ジメチル−１ｈ−ピロール−３−カルボキシアミドのリンゴ酸塩を含む結晶、その製法およびその組成物
JP2006518756A (ja) * 2003-02-24 2006-08-17 スージェン・インコーポレーテッド インドリノン化合物による過度の骨溶解の治療

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1758914A (zh) * 2003-02-24 2006-04-12 苏根公司 用吲哚啉酮化合物治疗过度骨质溶解
EP2220071A2 (en) * 2007-11-21 2010-08-25 Teva Pharmaceutical Industries Ltd. Sunitinib hemi-l-malate, polymorphs and preparation thereof, polymorphs of racemic sunitinib malate, compositins containing sunitinib base and malic acid and preparation thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003523340A (ja) * 2000-02-15 2003-08-05 スージェン・インコーポレーテッド ピロール置換２−インドリノン蛋白質キナーゼ阻害剤
JP2005503386A (ja) * 2001-08-15 2005-02-03 ファルマシア アンド アップジョン カンパニー リミティド ライアビリティー カンパニー Ｎ−［２−（ジエチルアミノ）エチル］−５−［（５−フルオロ−１，２−ジヒドロ−２−オキソ−３ｈ−インドール−３−イリデン）メチル］−２，４−ジメチル−１ｈ−ピロール−３−カルボキシアミドのリンゴ酸塩を含む結晶、その製法およびその組成物
JP2006518756A (ja) * 2003-02-24 2006-08-17 スージェン・インコーポレーテッド インドリノン化合物による過度の骨溶解の治療

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
実験化学講座（続）２ 分離と精製, JPN6012022299, 25 January 1967 (1967-01-25), JP, pages 159 - 178, ISSN: 0002696592 *
新・薬剤学総論（改訂第３版）, vol. 株式会社南江堂, JPN6012025458, 10 April 1987 (1987-04-10), JP, pages 111, ISSN: 0002696591 *
新製剤学, JPN6012022297, 25 April 1984 (1984-04-25), JP, pages 102 - 103, ISSN: 0002696590 *
調剤学−基礎と応用−, JPN6012022295, 20 September 1977 (1977-09-20), JP, pages 142 - 145, ISSN: 0002696589 *

Also Published As

Publication number Publication date
EP2297138A1 (en) 2011-03-23
US20110257237A1 (en) 2011-10-20
CN102203085A (zh) 2011-09-28
AU2009269768A1 (en) 2010-01-14
CA2730079A1 (en) 2010-01-14
WO2010004339A1 (en) 2010-01-14

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