JP2011527181A5 - - Google Patents
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- Publication number
- JP2011527181A5 JP2011527181A5 JP2011516935A JP2011516935A JP2011527181A5 JP 2011527181 A5 JP2011527181 A5 JP 2011527181A5 JP 2011516935 A JP2011516935 A JP 2011516935A JP 2011516935 A JP2011516935 A JP 2011516935A JP 2011527181 A5 JP2011527181 A5 JP 2011527181A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- rha
- plant
- hemagglutinin
- host cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7896308P | 2008-07-08 | 2008-07-08 | |
| US61/078,963 | 2008-07-08 | ||
| PCT/CA2009/000941 WO2010003235A1 (en) | 2008-07-08 | 2009-07-07 | Soluble recombinant influenza antigens |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011527181A JP2011527181A (ja) | 2011-10-27 |
| JP2011527181A5 true JP2011527181A5 (https=) | 2012-08-23 |
| JP5809054B2 JP5809054B2 (ja) | 2015-11-10 |
Family
ID=41506627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011516935A Expired - Fee Related JP5809054B2 (ja) | 2008-07-08 | 2009-07-07 | 可溶性組換えインフルエンザ抗原 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8771703B2 (https=) |
| EP (1) | EP2294202B1 (https=) |
| JP (1) | JP5809054B2 (https=) |
| CN (2) | CN105753948A (https=) |
| AU (1) | AU2009267769B2 (https=) |
| CA (1) | CA2730171C (https=) |
| DK (1) | DK2294202T3 (https=) |
| ES (1) | ES2545607T3 (https=) |
| PT (1) | PT2294202E (https=) |
| WO (1) | WO2010003235A1 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009076778A1 (en) | 2007-11-27 | 2009-06-25 | Medicago Inc. | Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin |
| CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| WO2010117786A1 (en) | 2009-03-30 | 2010-10-14 | Mount Sinai School Of Medicine Of New York University | Influenza virus vaccines and uses thereof |
| HUE039100T2 (hu) | 2009-06-24 | 2018-12-28 | Medicago Inc | Hemagglutinint tartalmazó kimer influenzavírus-jellegû részecskék |
| KR101773431B1 (ko) | 2009-09-22 | 2017-09-12 | 메디카고 인코포레이티드 | 식물-유래 vlp의 제조방법 |
| EP2536425B1 (en) | 2010-02-18 | 2019-06-19 | Icahn School of Medicine at Mount Sinai | Vaccines for use in the prophylaxis and treatment of influenza virus disease |
| CN102939103A (zh) | 2010-03-30 | 2013-02-20 | 西奈山医学院 | 流感病毒疫苗及其应用 |
| EP2595653B1 (en) * | 2010-07-23 | 2017-06-28 | Novavax AB | Influenza vaccine |
| JP2013542928A (ja) * | 2010-09-30 | 2013-11-28 | フランバックス ソチエタ レスポンサビリタ リミテ | ビロソーム粒子の生成 |
| TWI526539B (zh) | 2010-12-22 | 2016-03-21 | 苜蓿股份有限公司 | 植物中生產類病毒顆粒(vlp)的方法及以該方法生產之vlp |
| EP2681232A1 (en) * | 2011-03-02 | 2014-01-08 | Intervet International B.V. | Infectious bronchitis virus (ibv) spike protein as subunit vaccine |
| TWI620816B (zh) | 2011-03-23 | 2018-04-11 | 苜蓿股份有限公司 | 植物衍生蛋白回收方法 |
| EP4241785B1 (en) | 2011-09-20 | 2026-01-28 | Icahn School of Medicine at Mount Sinai | Influenza virus vaccines and uses thereof |
| NZ622731A (en) | 2011-09-30 | 2016-04-29 | Medicago Inc | Increasing virus-like particle yield in plants |
| US11390878B2 (en) | 2011-09-30 | 2022-07-19 | Medicago Inc. | Increasing protein yield in plants |
| SG11201504728RA (en) | 2012-12-18 | 2015-07-30 | Icahn School Med Mount Sinai | Influenza virus vaccines and uses thereof |
| US9908930B2 (en) | 2013-03-14 | 2018-03-06 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
| ES2803508T3 (es) | 2013-03-28 | 2021-01-27 | Medicago Inc | Producción de partículas similares al virus de la gripe en plantas |
| US12467058B2 (en) | 2013-03-28 | 2025-11-11 | Aramis Biotechnologies Inc. | Influenza virus-like particle production in plants |
| US10736956B2 (en) | 2015-01-23 | 2020-08-11 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccination regimens |
| TW201731865A (zh) * | 2016-03-15 | 2017-09-16 | 國立清華大學 | 重組h7血凝素及其應用 |
| MX2018015755A (es) | 2016-06-15 | 2019-08-29 | Icahn School Med Mount Sinai | Proteinas de hemaglutinina de virus de influenza y usos de las mismas. |
| US11254733B2 (en) | 2017-04-07 | 2022-02-22 | Icahn School Of Medicine At Mount Sinai | Anti-influenza B virus neuraminidase antibodies and uses thereof |
| US11690907B2 (en) | 2018-06-12 | 2023-07-04 | Kbio Holdings Limited | Vaccines formed by virus and antigen conjugation |
| IL279295B2 (en) * | 2018-06-12 | 2026-03-01 | Kentucky Bioprocessing Inc | Purification and cross-linking of virus and antigen |
| US11529413B2 (en) | 2018-06-12 | 2022-12-20 | Kbio Holdings Limited | Virus and antigen purification and conjugation |
| US11696948B2 (en) | 2018-06-12 | 2023-07-11 | Kbio Holdings Limited | Vaccines formed by virus and antigen conjugation |
| CA3104297A1 (en) | 2018-06-21 | 2019-12-26 | Icahn School Of Medicine At Mount Sinai | Mosaic influenza virus hemagglutinin polypeptides and uses thereof |
| EP3814509A4 (en) | 2018-06-27 | 2022-07-27 | Medicago Inc. | INFLUENCE VIRUS HEMAGGLUTININ MUTANTS |
| US12545718B2 (en) | 2019-04-24 | 2026-02-10 | Icahn School Of Medicine At Mount Sinai | Anti-influenza B virus neuraminidase antibodies and uses thereof |
| KR102647829B1 (ko) * | 2020-04-22 | 2024-03-14 | 포항공과대학교 산학협력단 | 삼량체를 형성하는 코로나-19 바이러스 (COVID-19, Coronavirus Disease 2019)의 재조합 스파이크 단백질 및 식물에서의 상기 재조합 스파이크 단백질의 대량 생산 방법과 이를 기반으로하는 백신조성물 제조 방법 |
| WO2021249013A1 (en) * | 2020-06-10 | 2021-12-16 | Sichuan Clover Biopharmaceuticals, Inc. | Vaccine compositions, methods, and uses thereof |
| CN111662390A (zh) * | 2020-06-17 | 2020-09-15 | 天康生物(上海)有限公司 | 禽流感HA-Fd融合蛋白及其制备方法和疫苗 |
| CN114773487B (zh) * | 2022-05-31 | 2024-07-02 | 湖南大学 | 一种流感病毒和新型冠状病毒融合重组蛋白疫苗免疫原及其制备方法 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0203177A4 (en) | 1984-11-29 | 1987-04-28 | Scripps Clinic Res | POLYPEPTIDES AND ANTIBODIES ASSOCIATED WITH VIRAL GLUCOPROTEINS WITHOUT GLUCOSE. |
| US5232833A (en) * | 1988-09-14 | 1993-08-03 | Stressgen Biotechnologies Corporation | Accumulation of heat shock proteins for evaluating biological damage due to chronic exposure of an organism to sublethal levels of pollutants |
| ATE142883T1 (de) * | 1991-03-28 | 1996-10-15 | Rooperol Na Nv | Zusammensetzungen von phytosterolen mit phytosterolinen als immunmodulatoren |
| US5762939A (en) * | 1993-09-13 | 1998-06-09 | Mg-Pmc, Llc | Method for producing influenza hemagglutinin multivalent vaccines using baculovirus |
| GB9409768D0 (en) | 1994-05-16 | 1994-07-06 | Medical Res Council | Trimerising polypeptides |
| WO1998056906A1 (en) | 1997-06-11 | 1998-12-17 | Thoegersen Hans Christian | Trimerising module |
| US20010006950A1 (en) * | 1998-02-11 | 2001-07-05 | Juha Punnonen | Genetic vaccine vector engineering |
| US6489537B1 (en) * | 1998-08-07 | 2002-12-03 | The Trustees Of The University Of Pennsylvania | Phytochelatin synthases and uses therefor |
| IL141312A0 (en) | 1998-08-11 | 2002-03-10 | Biosource Tech Inc | Method for recovering proteins from the interstitial fluid of plant tissues |
| US6392121B1 (en) * | 1998-10-07 | 2002-05-21 | Boyce Thompson Institute For Plant Research | Gemini virus vectors for gene expression in plants |
| FR2791358B1 (fr) | 1999-03-22 | 2003-05-16 | Meristem Therapeutics | Promoteurs chimeriques d'expression, cassettes d'expression, plasmides, vecteurs, plantes et semences transgeniques les contenant et leurs methodes d'obtention |
| US7125978B1 (en) * | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
| CA2435000C (en) | 2001-01-18 | 2014-03-25 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Oligomeric complexes of chimeric proteins with enhanced immunogenic potential |
| KR101113432B1 (ko) * | 2002-02-13 | 2012-02-29 | 위스콘신 얼럼나이 리서어치 화운데이션 | 인플루엔자 바이러스 벡터의 패키징을 위한 신호 |
| US20040121465A1 (en) | 2002-02-14 | 2004-06-24 | Novavax, Inc. | Optimization of gene sequences of virus-like particles for expression in insect cells |
| CN1665934B (zh) * | 2002-03-19 | 2010-05-26 | 国际植物研究所 | GNTIII(UDP-N乙酰葡萄糖胺:β-D-甘露糖苷β(1,4)-N-乙酰葡萄糖胺基-转移酶III)在植物中的表达 |
| ES2224792B1 (es) * | 2002-06-28 | 2007-02-16 | Era Plantech, S.L. | Produccion de peptidos y proteinas por acumulacion de cuerpos proteicos derivados de reticulos endoplasmico en plantas. |
| BRPI0410342A (pt) | 2003-05-05 | 2006-06-20 | Dow Agrosciences Llc | composições imunoprofiláticas e terapêuticas estáveis derivadas de células vegetais transgênicas e processos para produção |
| KR20060035596A (ko) | 2003-05-05 | 2006-04-26 | 보이스 톰슨 인스터튜트 포 플랜트 리서치 | 외래유전자도입 식물로부터 유래된 면역보호성 조성물을제조하기 위한 벡터와 세포 |
| US7566458B2 (en) * | 2003-06-16 | 2009-07-28 | Medimmune, Llc | Influenza hemagglutinin and neuraminidase variants |
| US8592197B2 (en) | 2003-07-11 | 2013-11-26 | Novavax, Inc. | Functional influenza virus-like particles (VLPs) |
| ES2662118T3 (es) | 2005-04-29 | 2018-04-05 | University Of Cape Town | Expresión de proteínas virales en las plantas |
| CA2615658A1 (en) | 2005-07-19 | 2007-01-25 | Dow Global Technolgies Inc. | Recombinant flu vaccines |
| AU2006279323B2 (en) * | 2005-08-16 | 2013-08-01 | Merck Sharp & Dohme Corp. | Influenza recombinant subunit vaccine |
| KR101359723B1 (ko) | 2005-10-18 | 2014-02-05 | 노바백스, 인코포레이티드 | 기능성 인플루엔자 바이러스 유사 입자들 |
| BRPI0707733B1 (pt) | 2006-02-13 | 2019-12-31 | Ibio, Inc. | antígeno isolado, composição de vacina, uso da referida composição e método para produção de uma proteína de antígeno |
| AR060565A1 (es) | 2006-04-21 | 2008-06-25 | Dow Agrosciences Llc | Vacuna para la gripe aviaria y metodos de uso |
| WO2007130327A2 (en) | 2006-05-01 | 2007-11-15 | Technovax, Inc. | Influenza virus-like particle (vlp) compositions |
| WO2008054540A2 (en) * | 2006-05-18 | 2008-05-08 | Pharmexa Inc. | Inducing immune responses to influenza virus using polypeptide and nucleic acid compositions |
| US20070286873A1 (en) * | 2006-05-23 | 2007-12-13 | Williams John V | Recombinant Influenza H5 Hemagluttinin Protein And Nucleic Acid Coding Therefor |
| DK2155880T3 (en) | 2007-06-15 | 2016-12-05 | Medicago Inc | Modification of glycoproteinproduktion i plants |
| WO2009076778A1 (en) * | 2007-11-27 | 2009-06-25 | Medicago Inc. | Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin |
| CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| WO2009026397A2 (en) * | 2007-08-20 | 2009-02-26 | Fraunhofer Usa, Inc. | Prophylactic and therapeutic influenza vaccines, antigens, compositions, and methods |
| GB0800272D0 (en) | 2008-01-08 | 2008-02-13 | Plant Bioscience Ltd | Protein expression systems |
| SG187500A1 (en) | 2008-01-21 | 2013-02-28 | Medicago Inc | Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin |
| DE102008009491B4 (de) | 2008-02-15 | 2010-02-04 | Rainer Brenner | Vorrichtung zur Sicherung von Waren |
| NZ590351A (en) * | 2008-07-18 | 2012-11-30 | Medicago Inc | HA1 domain totally or partially free of N-linked glycosylation operatively linked to a regulatory region |
| CA2736796A1 (en) | 2008-08-27 | 2010-03-04 | Arizona Board Of Regents For And On Behalf Of Arizona State University | A dna replicon system for high-level rapid production of vaccines and monoclonal antibody therapeutics in plants |
| WO2010077712A1 (en) | 2008-12-09 | 2010-07-08 | Novavax, Inc. | Bovine respiratory syncytial virus virus-like particle (vlps) |
| HUE039100T2 (hu) * | 2009-06-24 | 2018-12-28 | Medicago Inc | Hemagglutinint tartalmazó kimer influenzavírus-jellegû részecskék |
-
2009
- 2009-07-07 AU AU2009267769A patent/AU2009267769B2/en not_active Ceased
- 2009-07-07 CA CA2730171A patent/CA2730171C/en active Active
- 2009-07-07 CN CN201610265015.XA patent/CN105753948A/zh active Pending
- 2009-07-07 ES ES09793751.0T patent/ES2545607T3/es active Active
- 2009-07-07 JP JP2011516935A patent/JP5809054B2/ja not_active Expired - Fee Related
- 2009-07-07 CN CN200980126670.5A patent/CN102089432A/zh active Pending
- 2009-07-07 DK DK09793751.0T patent/DK2294202T3/en active
- 2009-07-07 EP EP09793751.0A patent/EP2294202B1/en active Active
- 2009-07-07 WO PCT/CA2009/000941 patent/WO2010003235A1/en not_active Ceased
- 2009-07-07 PT PT97937510T patent/PT2294202E/pt unknown
- 2009-07-07 US US13/001,111 patent/US8771703B2/en active Active
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