JP2011526626A5 - - Google Patents
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- Publication number
- JP2011526626A5 JP2011526626A5 JP2011516323A JP2011516323A JP2011526626A5 JP 2011526626 A5 JP2011526626 A5 JP 2011526626A5 JP 2011516323 A JP2011516323 A JP 2011516323A JP 2011516323 A JP2011516323 A JP 2011516323A JP 2011526626 A5 JP2011526626 A5 JP 2011526626A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- patient
- polypeptide
- actriia
- activin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13336808P | 2008-06-26 | 2008-06-26 | |
| US61/133,368 | 2008-06-26 | ||
| PCT/US2009/003838 WO2009158033A2 (en) | 2008-06-26 | 2009-06-26 | Antagonists of activin-actriia and uses for increasing red blood cell levels |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014022289A Division JP2014088438A (ja) | 2008-06-26 | 2014-02-07 | アクチビン−ActRIIaのアンタゴニストおよび赤血球レベルを高めるためのその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011526626A JP2011526626A (ja) | 2011-10-13 |
| JP2011526626A5 true JP2011526626A5 (enExample) | 2012-08-09 |
| JP5773868B2 JP5773868B2 (ja) | 2015-09-02 |
Family
ID=41445146
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011516323A Active JP5773868B2 (ja) | 2008-06-26 | 2009-06-26 | アクチビン−ActRIIaのアンタゴニストおよび赤血球レベルを高めるためのその使用 |
| JP2014022289A Withdrawn JP2014088438A (ja) | 2008-06-26 | 2014-02-07 | アクチビン−ActRIIaのアンタゴニストおよび赤血球レベルを高めるためのその使用 |
| JP2015145499A Withdrawn JP2015187180A (ja) | 2008-06-26 | 2015-07-23 | アクチビン−ActRIIaのアンタゴニストおよび赤血球レベルを高めるためのその使用 |
| JP2016220297A Withdrawn JP2017036331A (ja) | 2008-06-26 | 2016-11-11 | アクチビン−ActRIIaのアンタゴニストおよび赤血球レベルを高めるためのその使用 |
| JP2018164195A Active JP6643432B2 (ja) | 2008-06-26 | 2018-09-03 | アクチビン−ActRIIaのアンタゴニストおよび赤血球レベルを高めるためのその使用 |
| JP2018164196A Withdrawn JP2018184484A (ja) | 2008-06-26 | 2018-09-03 | アクチビン−ActRIIaのアンタゴニストおよび赤血球レベルを高めるためのその使用 |
| JP2019231523A Withdrawn JP2020041002A (ja) | 2008-06-26 | 2019-12-23 | アクチビン−ActRIIaのアンタゴニストおよび赤血球レベルを高めるためのその使用 |
| JP2021176418A Withdrawn JP2022023184A (ja) | 2008-06-26 | 2021-10-28 | アクチビン-ActRIIaのアンタゴニストおよび赤血球レベルを高めるためのその使用 |
Family Applications After (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014022289A Withdrawn JP2014088438A (ja) | 2008-06-26 | 2014-02-07 | アクチビン−ActRIIaのアンタゴニストおよび赤血球レベルを高めるためのその使用 |
| JP2015145499A Withdrawn JP2015187180A (ja) | 2008-06-26 | 2015-07-23 | アクチビン−ActRIIaのアンタゴニストおよび赤血球レベルを高めるためのその使用 |
| JP2016220297A Withdrawn JP2017036331A (ja) | 2008-06-26 | 2016-11-11 | アクチビン−ActRIIaのアンタゴニストおよび赤血球レベルを高めるためのその使用 |
| JP2018164195A Active JP6643432B2 (ja) | 2008-06-26 | 2018-09-03 | アクチビン−ActRIIaのアンタゴニストおよび赤血球レベルを高めるためのその使用 |
| JP2018164196A Withdrawn JP2018184484A (ja) | 2008-06-26 | 2018-09-03 | アクチビン−ActRIIaのアンタゴニストおよび赤血球レベルを高めるためのその使用 |
| JP2019231523A Withdrawn JP2020041002A (ja) | 2008-06-26 | 2019-12-23 | アクチビン−ActRIIaのアンタゴニストおよび赤血球レベルを高めるためのその使用 |
| JP2021176418A Withdrawn JP2022023184A (ja) | 2008-06-26 | 2021-10-28 | アクチビン-ActRIIaのアンタゴニストおよび赤血球レベルを高めるためのその使用 |
Country Status (10)
| Country | Link |
|---|---|
| EP (4) | EP2318028B1 (enExample) |
| JP (8) | JP5773868B2 (enExample) |
| KR (4) | KR20110031951A (enExample) |
| CN (2) | CN107252486B (enExample) |
| AU (4) | AU2009262968A1 (enExample) |
| CA (3) | CA2729054C (enExample) |
| DK (1) | DK2318028T3 (enExample) |
| ES (2) | ES2791699T3 (enExample) |
| NZ (2) | NZ602471A (enExample) |
| WO (2) | WO2009158033A2 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2561048T3 (es) | 2004-07-23 | 2016-02-24 | Acceleron Pharma Inc. | Polipéptidos del receptor ActRII |
| ME00380B (me) | 2005-11-23 | 2011-10-10 | Acceleron Pharma Inc | Amtagonisti aktivin-actriia i primjene za stimulaciju rasta kosti |
| US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
| US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
| US9526759B2 (en) | 2007-02-01 | 2016-12-27 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for treating or preventing breast cancer |
| TW201940502A (zh) | 2007-02-02 | 2019-10-16 | 美商艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
| KR101672156B1 (ko) | 2007-02-09 | 2016-11-02 | 악셀레론 파마 인코포레이티드 | 액티빈-ActRⅡA 길항제 및 암 환자에서 골 생장을 촉진시키기 위한 이의 용도 |
| CN107412734A (zh) | 2007-09-18 | 2017-12-01 | 阿塞勒隆制药公司 | 活化素‑actriia拮抗剂和减少或抑制fsh分泌的用途 |
| LT3750552T (lt) | 2008-08-14 | 2023-06-26 | Acceleron Pharma Inc. | Gdf gaudyklės |
| US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
| CA2749544A1 (en) | 2009-01-13 | 2010-07-22 | Acceleron Pharma Inc. | Methods for increasing adiponectin |
| MX385318B (es) | 2009-06-08 | 2025-03-18 | Acceleron Pharma Inc | Metodos para aumentar adipocitos termogenicos. |
| JP2012529294A (ja) | 2009-06-12 | 2012-11-22 | アクセルロン ファーマ, インコーポレイテッド | 切断型ActRIIB−Fc融合タンパク質 |
| AU2015203400A1 (en) * | 2009-08-13 | 2015-07-16 | Acceleron Pharma Inc. | Combined use of GDF traps and erythropoietin receptor activators to increase red blood cell levels |
| CA2770822C (en) * | 2009-08-13 | 2020-03-24 | Acceleron Pharma Inc. | Combined use of gdf traps and erythropoietin receptor activators to increase red blood cell levels |
| EP2501400B1 (en) | 2009-11-17 | 2017-11-01 | Acceleron Pharma, Inc. | Actriib proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy |
| WO2012064771A1 (en) | 2010-11-08 | 2012-05-18 | Acceleron Pharma, Inc. | Actriia binding agents and uses thereof |
| GR1007832B (el) * | 2011-11-21 | 2013-02-14 | Ιδρυμα Ιατροβιολογικων Ερευνων Ακαδημιας Αθηνων, | Αδρανοποιητες της ακτιβινης και χρηση τους για την θεραπεια ασθενειων που σχετιζονται με παρεκκλινουσα ενεργοποιηση της "αμυντικης αποκρισης του ξενιστη" |
| US9809636B2 (en) | 2012-04-06 | 2017-11-07 | Acceleron Pharma Inc. | Methods for increasing red blood cell levels comprising administering BMP9 |
| JP6401172B2 (ja) * | 2012-10-24 | 2018-10-10 | セルジーン コーポレイション | 貧血の治療方法 |
| RU2018145985A (ru) * | 2012-11-02 | 2019-02-18 | Селджин Корпорейшн | Антагонисты активина-actrii и их применение для лечения нарушений костной ткани и других нарушений |
| WO2014116981A1 (en) | 2013-01-25 | 2014-07-31 | Shire Human Genetic Therapies, Inc. | Follistatin in treating duchenne muscular dystrophy |
| MX388380B (es) * | 2014-04-18 | 2025-03-19 | Acceleron Pharma Inc | Composiciones para usarse en el incremento de los niveles de glóbulos rojos y el tratamiento de enfermedad de células falciformes. |
| CN106795224B (zh) * | 2014-06-04 | 2021-05-18 | 阿塞勒隆制药公司 | 用促滤泡素抑制素多肽治疗病症的方法和组合物 |
| TN2016000553A1 (en) | 2014-06-13 | 2018-04-04 | Acceleron Pharma Inc | Methods and compositions for treating ulcers |
| MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
| DK3227675T3 (da) | 2014-12-03 | 2023-05-30 | Celgene Corp | Activin-actrii-antagonister og anvendelser til behandling af myelodysplastisk syndrom |
| MD3280727T2 (ro) * | 2015-04-06 | 2021-06-30 | Acceleron Pharma Inc | Proteine de fuziune ale receptorului de tip I și de tip II cu un singur braț și utilizările acestora |
| DK3286206T3 (da) | 2015-04-22 | 2021-05-03 | Biogen Ma Inc | Hidtil ukendte hybride actriib-ligand-trap-proteiner til behandling af muskelsvindsygdomme |
| CA3005975A1 (en) | 2015-11-23 | 2017-06-01 | Acceleron Pharma Inc. | Methods for treating eye disorders |
| US20170306027A1 (en) | 2016-04-06 | 2017-10-26 | Acceleron Pharma Inc. | Alk7 antagonists and uses thereof |
| EA201990226A1 (ru) | 2016-07-27 | 2019-08-30 | Акселерон Фарма Инк. | Способы и композиции для лечения миелофиброза |
| JP7280182B2 (ja) | 2016-10-05 | 2023-05-23 | アクセルロン ファーマ インコーポレイテッド | バリアントActRIIBタンパク質およびその使用 |
| JOP20190085A1 (ar) | 2016-10-20 | 2019-04-17 | Biogen Ma Inc | طرق علاج الضمور العضلي ومرض العظام باستخدام بروتينات احتجاز مركب ترابطي actriib هجين حديثة |
| WO2018089715A1 (en) * | 2016-11-10 | 2018-05-17 | Keros Therapeutics, Inc. | Activin receptor type iia variants and methods of use thereof |
| KR20250059538A (ko) | 2017-11-09 | 2025-05-02 | 케로스 테라퓨틱스, 인크. | 액티빈 수용체 유형 iia 변이체 및 그의 사용 방법 |
| JP7510875B2 (ja) | 2018-01-12 | 2024-07-04 | ケロス セラピューティクス インコーポレイテッド | アクチビンiib型受容体変異体および同変異体を含む医薬組成物 |
| KR20250133994A (ko) * | 2018-05-09 | 2025-09-09 | 케로스 테라퓨틱스, 인크. | 액티빈 수용체 유형 iia 변이체 및 그의 사용 방법 |
| WO2020100993A1 (ja) | 2018-11-15 | 2020-05-22 | 三菱ケミカル株式会社 | 改変型アクチビンa |
| KR20220049568A (ko) * | 2019-08-22 | 2022-04-21 | 더 리전츠 오브 더 유니버시티 오브 캘리포니아 | 엔젤만 증후군의 치료를 위한 ube3a |
| KR20230004515A (ko) | 2020-03-20 | 2023-01-06 | 케로스 테라퓨틱스, 인크. | 액티빈 수용체 유형 ii 키메라 및 이의 사용 방법 |
| EP4121088A4 (en) | 2020-03-20 | 2024-07-03 | Keros Therapeutics, Inc. | Methods of using activin receptor type iib variants |
| CN119529092A (zh) * | 2021-09-03 | 2025-02-28 | 来凯医药科技(上海)有限公司 | 抗acvr2a抗体及其用途 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1265208A (en) | 1915-09-07 | 1918-05-07 | Edward C Kahn | Liquid-fuel burner. |
| US5080891A (en) | 1987-08-03 | 1992-01-14 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5198346A (en) | 1989-01-06 | 1993-03-30 | Protein Engineering Corp. | Generation and selection of novel DNA-binding proteins and polypeptides |
| US5096815A (en) | 1989-01-06 | 1992-03-17 | Protein Engineering Corporation | Generation and selection of novel dna-binding proteins and polypeptides |
| WO1992004913A1 (en) * | 1990-09-13 | 1992-04-02 | Children's Hospital Medical Center Of Northern California | Method for increasing red blood cell production by treatment with activin or activin-related peptides |
| US5677196A (en) | 1993-05-18 | 1997-10-14 | University Of Utah Research Foundation | Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays |
| US5525490A (en) | 1994-03-29 | 1996-06-11 | Onyx Pharmaceuticals, Inc. | Reverse two-hybrid method |
| US5814565A (en) | 1995-02-23 | 1998-09-29 | University Of Utah Research Foundation | Integrated optic waveguide immunosensor |
| ATE352638T1 (de) | 1995-04-11 | 2007-02-15 | Gen Hospital Corp | REVERSE ßTWO-HYBRIDß-SYSTEME |
| US6231880B1 (en) * | 1997-05-30 | 2001-05-15 | Susan P. Perrine | Compositions and administration of compositions for the treatment of blood disorders |
| AU8921698A (en) | 1997-08-29 | 1999-03-16 | Human Genome Sciences, Inc. | Follistatin-3 |
| US6953662B2 (en) * | 1997-08-29 | 2005-10-11 | Human Genome Sciences, Inc. | Follistatin-3 |
| US6468543B1 (en) * | 1999-05-03 | 2002-10-22 | Zymogenetics, Inc. | Methods for promoting growth of bone using ZVEGF4 |
| JP2004526419A (ja) | 2000-10-16 | 2004-09-02 | フィロス インク. | 抗体模倣物および他の結合タンパク質のためのタンパク質骨格 |
| WO2002088171A2 (en) | 2001-04-26 | 2002-11-07 | Avidia Research Institute | Combinatorial libraries of monomer domains |
| US7074901B2 (en) * | 2001-05-25 | 2006-07-11 | Serono Genetics Institute S.A. | Isolated human vCOL16A1 polypeptide and fragments thereof |
| US6855344B2 (en) * | 2001-07-17 | 2005-02-15 | Integrated Chinese Medicine Holdings, Ltd. | Compositions and methods for prostate and kidney health and disorders, an herbal preparation |
| US20040223966A1 (en) * | 2002-10-25 | 2004-11-11 | Wolfman Neil M. | ActRIIB fusion polypeptides and uses therefor |
| WO2005028517A2 (en) * | 2003-05-09 | 2005-03-31 | The General Hospital Corporation | SOLUBLE TGF-β TYPE III RECEPTOR FUSION PROTEINS |
| WO2005025601A1 (en) | 2003-09-15 | 2005-03-24 | Monash University | Follistatin isoforms and uses thereof |
| JP4688483B2 (ja) | 2004-04-15 | 2011-05-25 | 株式会社テクノネットワーク四国 | フォリスタチン変異体ポリペプチド |
| ES2561048T3 (es) * | 2004-07-23 | 2016-02-24 | Acceleron Pharma Inc. | Polipéptidos del receptor ActRII |
| US20060034831A1 (en) * | 2004-08-12 | 2006-02-16 | Wyeth | Combination therapy for diabetes, obesity and cardiovascular diseases using GDF-8 inhibitors |
| US20060234299A1 (en) | 2004-11-16 | 2006-10-19 | Avidia Research Institute | Protein scaffolds and uses thereof |
| ME00380B (me) | 2005-11-23 | 2011-10-10 | Acceleron Pharma Inc | Amtagonisti aktivin-actriia i primjene za stimulaciju rasta kosti |
| WO2007133653A2 (en) * | 2006-05-09 | 2007-11-22 | Hemaquest Pharmaceuticals, Inc. | Methods for treating blood disorders |
| ES2386651T3 (es) * | 2006-07-13 | 2012-08-24 | Basf Se | Masas termoplásticas conteniendo ligante para la elaboración de cuerpos moldeados metálicos |
| EP2484352B1 (en) * | 2006-07-21 | 2014-07-09 | Lyne Laboratories, Inc. | Liquid compositions of calcium acetate |
| WO2008030367A2 (en) | 2006-09-01 | 2008-03-13 | The General Hospital Corporation | Selective myostatin inhibitors |
| US7547781B2 (en) * | 2006-09-11 | 2009-06-16 | Curis, Inc. | Quinazoline based EGFR inhibitors containing a zinc binding moiety |
| CN104524548A (zh) * | 2006-12-18 | 2015-04-22 | 阿塞勒隆制药公司 | 活化素-actrii拮抗剂及在提高红细胞水平中的用途 |
| TW201940502A (zh) | 2007-02-02 | 2019-10-16 | 美商艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
| KR101672156B1 (ko) | 2007-02-09 | 2016-11-02 | 악셀레론 파마 인코포레이티드 | 액티빈-ActRⅡA 길항제 및 암 환자에서 골 생장을 촉진시키기 위한 이의 용도 |
| CN107412734A (zh) * | 2007-09-18 | 2017-12-01 | 阿塞勒隆制药公司 | 活化素‑actriia拮抗剂和减少或抑制fsh分泌的用途 |
| DE102008016742B4 (de) * | 2008-03-31 | 2010-01-14 | Thyssenkrupp Presta Ag | Lenksäule für ein Kraftfahrzeug |
-
2009
- 2009-06-26 CN CN201710403739.0A patent/CN107252486B/zh active Active
- 2009-06-26 KR KR1020117001139A patent/KR20110031951A/ko not_active Withdrawn
- 2009-06-26 ES ES09770571T patent/ES2791699T3/es active Active
- 2009-06-26 EP EP09770571.9A patent/EP2318028B1/en active Active
- 2009-06-26 WO PCT/US2009/003838 patent/WO2009158033A2/en not_active Ceased
- 2009-06-26 KR KR1020217011646A patent/KR20210047374A/ko not_active Ceased
- 2009-06-26 CN CN200980133280.0A patent/CN102131515B/zh active Active
- 2009-06-26 AU AU2009262968A patent/AU2009262968A1/en not_active Abandoned
- 2009-06-26 CA CA2729054A patent/CA2729054C/en active Active
- 2009-06-26 EP EP20195139.9A patent/EP3804746A1/en not_active Withdrawn
- 2009-06-26 KR KR1020197012336A patent/KR20190049912A/ko not_active Ceased
- 2009-06-26 WO PCT/US2009/003808 patent/WO2009158015A2/en not_active Ceased
- 2009-06-26 DK DK09770571.9T patent/DK2318028T3/da active
- 2009-06-26 NZ NZ602471A patent/NZ602471A/en unknown
- 2009-06-26 CA CA3049354A patent/CA3049354A1/en not_active Abandoned
- 2009-06-26 EP EP09770553.7A patent/EP2303917B1/en active Active
- 2009-06-26 EP EP19191414.2A patent/EP3620795A1/en not_active Withdrawn
- 2009-06-26 CA CA2729098A patent/CA2729098C/en active Active
- 2009-06-26 ES ES09770553T patent/ES2852699T3/es active Active
- 2009-06-26 KR KR1020177008278A patent/KR102024444B1/ko active Active
- 2009-06-26 JP JP2011516323A patent/JP5773868B2/ja active Active
- 2009-06-26 NZ NZ590326A patent/NZ590326A/xx unknown
-
2014
- 2014-02-07 JP JP2014022289A patent/JP2014088438A/ja not_active Withdrawn
-
2015
- 2015-07-23 JP JP2015145499A patent/JP2015187180A/ja not_active Withdrawn
-
2016
- 2016-05-12 AU AU2016203098A patent/AU2016203098B2/en active Active
- 2016-11-11 JP JP2016220297A patent/JP2017036331A/ja not_active Withdrawn
-
2018
- 2018-06-08 AU AU2018204105A patent/AU2018204105A1/en not_active Abandoned
- 2018-09-03 JP JP2018164195A patent/JP6643432B2/ja active Active
- 2018-09-03 JP JP2018164196A patent/JP2018184484A/ja not_active Withdrawn
-
2019
- 2019-12-23 JP JP2019231523A patent/JP2020041002A/ja not_active Withdrawn
-
2020
- 2020-08-17 AU AU2020220046A patent/AU2020220046A1/en not_active Abandoned
-
2021
- 2021-10-28 JP JP2021176418A patent/JP2022023184A/ja not_active Withdrawn
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