JP2011524856A5 - - Google Patents
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- JP2011524856A5 JP2011524856A5 JP2011507951A JP2011507951A JP2011524856A5 JP 2011524856 A5 JP2011524856 A5 JP 2011524856A5 JP 2011507951 A JP2011507951 A JP 2011507951A JP 2011507951 A JP2011507951 A JP 2011507951A JP 2011524856 A5 JP2011524856 A5 JP 2011524856A5
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- JP
- Japan
- Prior art keywords
- formula
- compound
- group
- mixture
- mixtures
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 69
- 239000000203 mixture Substances 0.000 claims 58
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 27
- 238000000034 method Methods 0.000 claims 19
- 125000003118 aryl group Chemical group 0.000 claims 9
- 125000004665 trialkylsilyl group Chemical group 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 7
- 125000001118 alkylidene group Chemical group 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 230000015572 biosynthetic process Effects 0.000 claims 5
- 238000003786 synthesis reaction Methods 0.000 claims 5
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 3
- 230000002378 acidificating effect Effects 0.000 claims 3
- NHQDETIJWKXCTC-UHFFFAOYSA-N 3-chloroperbenzoic acid Chemical compound OOC(=O)C1=CC=CC(Cl)=C1 NHQDETIJWKXCTC-UHFFFAOYSA-N 0.000 claims 2
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 150000001721 carbon Chemical group 0.000 claims 2
- 230000001590 oxidative effect Effects 0.000 claims 2
- 229930188494 zaragozic acid Natural products 0.000 claims 2
- DFKDOZMCHOGOBR-UHFFFAOYSA-N zaragozic acid A Natural products O1C(C(O)(C(O2)C(O)=O)C(O)=O)(C(O)=O)C(OC(=O)C=CC(C)CC(C)CC)C(O)C21CCC(=C)C(OC(C)=O)C(C)CC1=CC=CC=C1 DFKDOZMCHOGOBR-UHFFFAOYSA-N 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 claims 1
- 238000006359 acetalization reaction Methods 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- -1 alkyl acetal Chemical class 0.000 claims 1
- 238000005906 dihydroxylation reaction Methods 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 150000002373 hemiacetals Chemical class 0.000 claims 1
- 230000003301 hydrolyzing effect Effects 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
- 0 C*[C@](C)([C@@](C)*)[C@@](*)([C@]1*)O[C@](*)(C*)[C@@]1O Chemical compound C*[C@](C)([C@@](C)*)[C@@](*)([C@]1*)O[C@](*)(C*)[C@@]1O 0.000 description 4
- DXKIGSHVJJWLAO-UHFFFAOYSA-N CCCCC(C1)C2=C1CCC2 Chemical compound CCCCC(C1)C2=C1CCC2 DXKIGSHVJJWLAO-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200801303A ES2328213B1 (es) | 2008-05-06 | 2008-05-06 | Procedimiento de obtencion del acido zaragocico y derivados del mismo. |
| ESP200801303 | 2008-05-06 | ||
| PCT/ES2009/070140 WO2009135979A1 (es) | 2008-05-06 | 2009-05-05 | Procedimiento de obtención del ácido zaragócico y derivados del mismo |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011524856A JP2011524856A (ja) | 2011-09-08 |
| JP2011524856A5 true JP2011524856A5 (enExample) | 2012-06-21 |
Family
ID=41226502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011507951A Withdrawn JP2011524856A (ja) | 2008-05-06 | 2009-05-05 | ザラゴジン酸およびその誘導体を得る方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20110207947A1 (enExample) |
| EP (1) | EP2311841A4 (enExample) |
| JP (1) | JP2011524856A (enExample) |
| CN (1) | CN102066383A (enExample) |
| AU (1) | AU2009245669A1 (enExample) |
| ES (1) | ES2328213B1 (enExample) |
| WO (1) | WO2009135979A1 (enExample) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4215048A (en) * | 1979-05-18 | 1980-07-29 | Ortho Pharmaceutical Corporation | Total synthesis of (1RS, 4SR, 5RS)-4-(4,8-dimethyl-5-hydroxy-7-nonenyl)-4-methyl-3,8-dioxabicyclo[3.2.1]octane-1-acetic acid |
| US5262435A (en) | 1992-02-10 | 1993-11-16 | Merck & Co., Inc. | Cholesterol lowering compounds |
| US5302604A (en) * | 1992-03-09 | 1994-04-12 | Merck & Co., Inc. | Cholesterol lowering compounds produced by directed biosynthesis |
| WO1993017557A1 (en) | 1992-03-09 | 1993-09-16 | Merck & Co., Inc. | Cholesterol lowering compounds produced by directed biosynthesis |
| US5283256A (en) * | 1992-07-22 | 1994-02-01 | Merck & Co., Inc. | Cholesterol-lowering agents |
| US5326783A (en) | 1992-08-25 | 1994-07-05 | Merck & Co., Inc. | Cholesterol lowering compounds |
| CN101052621A (zh) * | 2004-09-23 | 2007-10-10 | 辉瑞产品公司 | 4－氨基取代－2－取代－1，2，3，4－四氢喹啉化合物 |
-
2008
- 2008-05-06 ES ES200801303A patent/ES2328213B1/es not_active Expired - Fee Related
-
2009
- 2009-05-05 EP EP09742185A patent/EP2311841A4/en not_active Withdrawn
- 2009-05-05 CN CN2009801239426A patent/CN102066383A/zh active Pending
- 2009-05-05 WO PCT/ES2009/070140 patent/WO2009135979A1/es not_active Ceased
- 2009-05-05 JP JP2011507951A patent/JP2011524856A/ja not_active Withdrawn
- 2009-05-05 AU AU2009245669A patent/AU2009245669A1/en not_active Abandoned
- 2009-05-05 US US12/991,531 patent/US20110207947A1/en not_active Abandoned
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