JP2011523945A5 - - Google Patents
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- Publication number
- JP2011523945A5 JP2011523945A5 JP2011510650A JP2011510650A JP2011523945A5 JP 2011523945 A5 JP2011523945 A5 JP 2011523945A5 JP 2011510650 A JP2011510650 A JP 2011510650A JP 2011510650 A JP2011510650 A JP 2011510650A JP 2011523945 A5 JP2011523945 A5 JP 2011523945A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- group
- unsubstituted
- compound
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- IRYJRGCIQBGHIV-UHFFFAOYSA-N CC(C)(C(N1C)=O)OC1=O Chemical compound CC(C)(C(N1C)=O)OC1=O IRYJRGCIQBGHIV-UHFFFAOYSA-N 0.000 description 1
- 0 CC(N1C)=C(*)SC1=O Chemical compound CC(N1C)=C(*)SC1=O 0.000 description 1
- LVHVTYQPRMNICT-UHFFFAOYSA-N CCOC(C=CN1C)=NC1=O Chemical compound CCOC(C=CN1C)=NC1=O LVHVTYQPRMNICT-UHFFFAOYSA-N 0.000 description 1
- UVTUYTIMHXWMRL-UHFFFAOYSA-N CN(C(SC)=NS1)C1=O Chemical compound CN(C(SC)=NS1)C1=O UVTUYTIMHXWMRL-UHFFFAOYSA-N 0.000 description 1
- DHGBSOMRGXWRSE-UHFFFAOYSA-N CN(C)C(C=CN1C)=NC1=O Chemical compound CN(C)C(C=CN1C)=NC1=O DHGBSOMRGXWRSE-UHFFFAOYSA-N 0.000 description 1
- FNRIYKOFDSKGTF-UHFFFAOYSA-N CN(C=CC(N1CCCC1)=N1)C1=O Chemical compound CN(C=CC(N1CCCC1)=N1)C1=O FNRIYKOFDSKGTF-UHFFFAOYSA-N 0.000 description 1
- QXIHJEWUXUZTHM-UHFFFAOYSA-N CN(C=CC([n]1ncnc1)=N1)C1=O Chemical compound CN(C=CC([n]1ncnc1)=N1)C1=O QXIHJEWUXUZTHM-UHFFFAOYSA-N 0.000 description 1
- CVUKXDYMTQWGBD-UHFFFAOYSA-N CN(CC(N1S)=O)C1=O Chemical compound CN(CC(N1S)=O)C1=O CVUKXDYMTQWGBD-UHFFFAOYSA-N 0.000 description 1
- CYSGHNMQYZDMIA-UHFFFAOYSA-N CN(CCN1C)C1=O Chemical compound CN(CCN1C)C1=O CYSGHNMQYZDMIA-UHFFFAOYSA-N 0.000 description 1
- MTAUWGJDZIAUQM-UHFFFAOYSA-N CN1N=C(C=CC=C2)N2C1=O Chemical compound CN1N=C(C=CC=C2)N2C1=O MTAUWGJDZIAUQM-UHFFFAOYSA-N 0.000 description 1
- IIFFJWZFJVKHFN-UHFFFAOYSA-N CN1NC2C=CC=CC2C1=O Chemical compound CN1NC2C=CC=CC2C1=O IIFFJWZFJVKHFN-UHFFFAOYSA-N 0.000 description 1
- DBJMEBUKQVZWMD-UHFFFAOYSA-N CN1c(cccc2)c2OCC1=O Chemical compound CN1c(cccc2)c2OCC1=O DBJMEBUKQVZWMD-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5443208P | 2008-05-19 | 2008-05-19 | |
| US5443708P | 2008-05-19 | 2008-05-19 | |
| US61/054,437 | 2008-05-19 | ||
| US61/054,432 | 2008-05-19 | ||
| PCT/US2009/044525 WO2009143156A2 (en) | 2008-05-19 | 2009-05-19 | IMIDAZO[1,2-a]PYRIDINE COMPOUNDS |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015090193A Division JP6211556B2 (ja) | 2008-05-19 | 2015-04-27 | イミダゾ［１，２−ａ］ピリジン化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011523945A JP2011523945A (ja) | 2011-08-25 |
| JP2011523945A5 true JP2011523945A5 (enExample) | 2012-07-05 |
| JP5774982B2 JP5774982B2 (ja) | 2015-09-09 |
Family
ID=41031732
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011510650A Expired - Fee Related JP5774982B2 (ja) | 2008-05-19 | 2009-05-19 | イミダゾ［１，２−ａ］ピリジン化合物 |
| JP2015090193A Active JP6211556B2 (ja) | 2008-05-19 | 2015-04-27 | イミダゾ［１，２−ａ］ピリジン化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015090193A Active JP6211556B2 (ja) | 2008-05-19 | 2015-04-27 | イミダゾ［１，２−ａ］ピリジン化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8497278B2 (enExample) |
| EP (1) | EP2300470A2 (enExample) |
| JP (2) | JP5774982B2 (enExample) |
| AU (1) | AU2009249186B2 (enExample) |
| CA (1) | CA2724842A1 (enExample) |
| WO (1) | WO2009143156A2 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2213672A4 (en) * | 2007-10-24 | 2012-05-02 | Nihon Mediphysics Co Ltd | NEW CONNECTION WITH AFFINITY TO AMYLOID |
| CA2778949C (en) | 2009-10-30 | 2018-02-27 | Janssen Pharmaceutica Nv | Imidazo[1,2-b]pyridazine derivatives and their use as pde10 inhibitors |
| CN110483499A (zh) | 2009-11-05 | 2019-11-22 | 圣母大学 | 咪唑并[1,2-a]吡啶类化合物及其合成及使用方法 |
| AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
| CA2800618C (en) * | 2010-05-26 | 2018-08-28 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
| US20140221354A1 (en) * | 2011-03-31 | 2014-08-07 | Emblem Technology Transfer Gmbh | IMIDAZO [1,2-a]PYRIDINE COMPOUNDS FOR USE IN THERAPY |
| BR112013033375B1 (pt) | 2011-06-27 | 2022-05-10 | Janssen Pharmaceutica N.V | Derivados de 1-aril-4-metil-[1,2,4]triazolo[4,3-a]quinoxa-lina, seu uso, composição farmacêutica que os compreende, processo de preparação dos mesmos, solução estéril e composto intermediário |
| MX2014014308A (es) * | 2012-05-30 | 2015-02-12 | Hoffmann La Roche | Pirrolidino heterociclos. |
| RU2657540C2 (ru) | 2012-06-26 | 2018-06-14 | Янссен Фармацевтика Нв | Комбинации, содержащие ингибиторы pde 2, такие как 1-арил-4-метил-[1,2,4]триазоло[4,3-а]хиноксалиновые соединения, и ингибиторы pde 10, для применения в лечении неврологических или метаболических расстройств |
| EP2869822B1 (en) | 2012-07-09 | 2016-09-14 | Janssen Pharmaceutica, N.V. | Inhibitors of phosphodiesterase 10 enzyme |
| WO2014187922A1 (en) | 2013-05-24 | 2014-11-27 | Iomet Pharma Ltd. | Slc2a transporter inhibitors |
| US10919888B2 (en) | 2015-09-17 | 2021-02-16 | University Of Notre Dame Du Lac | Benzyl amine-containing heterocyclic compounds and compositions useful against mycobacterial infection |
| DK3153506T3 (en) * | 2015-10-07 | 2018-03-26 | Sanko Tekstil Isletmeleri San Ve Tic As | ISOXAZOLES, PROCEDURE FOR THEIR PREPARATION AND APPLICATIONS THEREOF |
| ES2928164T3 (es) | 2015-10-19 | 2022-11-15 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| MD3377488T2 (ro) | 2015-11-19 | 2023-02-28 | Incyte Corp | Compuși heterociclici ca imunomodulatori |
| MX2018007040A (es) | 2015-12-10 | 2018-08-15 | Bayer Pharma AG | Derivados de 2-fenil-3-(piperazinometil) imidazo[1,2-a] piridina como bloqueadores de los canales task-1 y task-2 para el tratamiento de trastornos respiratorios relacionados con el sueño. |
| CN108699084A (zh) | 2015-12-10 | 2018-10-23 | 拜耳制药股份公司 | 取代全氢吡咯并[3,4-c]吡咯衍生物及其用途 |
| MA44075A (fr) | 2015-12-17 | 2021-05-19 | Incyte Corp | Dérivés de n-phényl-pyridine-2-carboxamide et leur utilisation en tant que modulateurs des interactions protéine/protéine pd-1/pd-l1 |
| MY199705A (en) | 2015-12-22 | 2023-11-20 | Incyte Corp | Heterocyclic compounds as immunomodulators |
| WO2017192961A1 (en) | 2016-05-06 | 2017-11-09 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| WO2017205464A1 (en) | 2016-05-26 | 2017-11-30 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| KR102685249B1 (ko) | 2016-06-20 | 2024-07-17 | 인사이트 코포레이션 | 면역조절제로서의 복소환식 화합물 |
| MA45669A (fr) | 2016-07-14 | 2019-05-22 | Incyte Corp | Composés hétérocycliques utilisés comme immunomodulateurs |
| JOP20190005A1 (ar) * | 2016-07-20 | 2019-01-20 | Bayer Ag | مركبات ديازاهيترو ثنائية الحلقة مستبدلة واستخداماتها |
| CN106279123B (zh) * | 2016-08-15 | 2018-09-04 | 郑州大学 | 3-(苯磺酰甲基)咪唑并杂环类化合物及其合成方法 |
| WO2018044783A1 (en) | 2016-08-29 | 2018-03-08 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| EA039175B1 (ru) * | 2016-12-14 | 2021-12-14 | Байер Акциенгезельшафт | Замещенные диазагетеробициклические соединения, способ их получения и их применение |
| EP3558989B1 (en) | 2016-12-22 | 2021-04-14 | Incyte Corporation | Triazolo[1,5-a]pyridine derivatives as immunomodulators |
| CA3047991A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Bicyclic heteroaromatic compounds as immunomodulators |
| PE20191532A1 (es) | 2016-12-22 | 2019-10-23 | Incyte Corp | Compuestos heterociclicos como inmunomoduladores |
| EP3558973B1 (en) | 2016-12-22 | 2021-09-15 | Incyte Corporation | Pyridine derivatives as immunomodulators |
| WO2018119224A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Tetrahydro imidazo[4,5-c]pyridine derivatives as pd-l1 internalization inducers |
| CN107163039A (zh) * | 2017-05-11 | 2017-09-15 | 浙江工业大学 | 一种6‑甲基‑2‑对甲苯基咪唑并[1,2‑a]吡啶‑3‑甲醛的制备方法 |
| JOP20190284A1 (ar) | 2017-06-14 | 2019-12-11 | Bayer Pharma AG | مركبات إيميدازوبيريميدين مستبدلة بديازا ثنائي الحلقة واستخدامها للمعالجة من اضطرابات التنفس |
| WO2018227427A1 (en) | 2017-06-14 | 2018-12-20 | Bayer Aktiengesellschaft | Substituted bridged diazepane derivatives and use thereof |
| RS64055B1 (sr) | 2018-03-30 | 2023-04-28 | Incyte Corp | Heterociklična jedinjenja kao imunomodulatori |
| MD3790877T2 (ro) | 2018-05-11 | 2023-08-31 | Incyte Corp | Derivați de tetrahidro-imidazo[4,5-c]piridină în calitate de imunomodulatori PD-L1 |
| AU2019286312B2 (en) * | 2018-06-13 | 2023-08-17 | F. Hoffmann-La Roche Ag | New isoxazolyl ether derivatives as GABA A alpha5 PAM |
| CN110964020B (zh) * | 2018-09-28 | 2022-06-14 | 中国科学院大连化学物理研究所 | 一种制备3’,4’-二氢螺[吲哚啉-3,2’-吡咯]化合物的方法 |
| AU2019416589B2 (en) * | 2018-12-29 | 2023-04-06 | Wuhan Ll Science And Technology Development Co., Ltd. | Heterocyclic compound intermediate, preparation method therefor and application thereof |
| JP7665593B2 (ja) | 2019-08-09 | 2025-04-21 | インサイト・コーポレイション | Ｐｄ－１／ｐｄ－ｌ１阻害剤の塩 |
| AR120109A1 (es) | 2019-09-30 | 2022-02-02 | Incyte Corp | Compuestos de pirido[3,2-d]pirimidina como inmunomoduladores |
| PE20230407A1 (es) | 2019-11-11 | 2023-03-07 | Incyte Corp | Sales y formas cristalinas de un inhibidor de pd-1/pd-l1 |
| CN114380819B (zh) * | 2020-10-22 | 2024-08-23 | 鲁南制药集团股份有限公司 | 一种唑吡坦中间体化合物 |
| TW202233616A (zh) | 2020-11-06 | 2022-09-01 | 美商英塞特公司 | 用於製備ｐｄ－１／ｐｄ－ｌ１抑制劑以及其鹽及結晶形式之方法 |
| WO2022099018A1 (en) | 2020-11-06 | 2022-05-12 | Incyte Corporation | Process of preparing a pd-1/pd-l1 inhibitor |
| WO2022099075A1 (en) | 2020-11-06 | 2022-05-12 | Incyte Corporation | Crystalline form of a pd-1/pd-l1 inhibitor |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB991589A (en) * | 1963-04-30 | 1965-05-12 | Selvi & C Lab Bioterapico | Novel [1,2-ª‡]imidazopyridines and a process for the manufacture thereof |
| US3489755A (en) * | 1966-08-03 | 1970-01-13 | Pfizer & Co C | Imidazo (1,2-b) pyridazines |
| US4242513A (en) * | 1979-03-05 | 1980-12-30 | Appleton Papers Inc. | Lactone compounds containing a heterocyclic radical |
| GB8305245D0 (en) * | 1983-02-25 | 1983-03-30 | Fujisawa Pharmaceutical Co | Imidazo-heterocyclic compounds |
| FR2568880B1 (fr) * | 1984-08-07 | 1986-12-12 | Synthelabo | Derives d'acylaminomethyl-3 imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique |
| ES2032455T3 (es) * | 1986-01-22 | 1993-02-16 | Synthelabo | Procedimiento para preparar derivados de 3-acilaminometil-imidazo (-1,2-a)piridinas. |
| WO1989001333A1 (en) * | 1987-08-07 | 1989-02-23 | The Australian National University | IMIDAZO[1,2-b]PYRIDAZINES |
| IN179789B (enExample) * | 1992-02-10 | 1997-12-06 | Council Scient Ind Res | |
| FR2714907B1 (fr) * | 1994-01-07 | 1996-03-29 | Union Pharma Scient Appl | Nouveaux dérivés de l'Adénosine, leurs procédés de préparation, compositions pharmaceutiques les contenant. |
| JPH09176165A (ja) * | 1995-12-25 | 1997-07-08 | Nippon Nohyaku Co Ltd | イミダゾ［１，２−ａ］ピリジン誘導体、その製法およびその用途 |
| AU2001270297A1 (en) * | 2000-06-30 | 2002-01-14 | Neurogen Corporation | 2-phenylimidazo(1,2-a)pyridine derivatives: a new class of gaba brain receptor ligands |
| DE10040016A1 (de) * | 2000-08-16 | 2002-02-28 | Boehringer Ingelheim Pharma | Neue beta-Amyloid Inhibitoren, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| US6514969B2 (en) * | 2000-08-16 | 2003-02-04 | Boehringer Ingelheim Pharma Kg | β-amyloid inhibitors, processes for preparing them, and their use in pharmaceutical compositions |
| SE0100567D0 (sv) * | 2001-02-20 | 2001-02-20 | Astrazeneca Ab | Compounds |
| US7148353B2 (en) * | 2003-10-28 | 2006-12-12 | Sepracor Inc. | Imidazo[1,2-a] pyridine anxiolytics |
| EP1713784A1 (en) | 2004-02-12 | 2006-10-25 | Neurogen Corporation | Imidazo-pyridazines, triazolo-pyridazines and related benzodiazepine receptor ligands |
| CN101065377B (zh) | 2004-11-11 | 2011-07-27 | 菲尔若国际公司 | 咪唑并[1,2-a]吡啶化合物、组合物、与其有关的应用和方法 |
| US7666880B2 (en) * | 2005-03-21 | 2010-02-23 | S*Bio Pte Ltd. | Imidazo[1,2-A]pyridine derivatives: preparation and pharmaceutical applications |
| MX2007011710A (es) * | 2005-03-21 | 2007-11-20 | S Bio Pte Ltd | Derivados de imidazo[1,2-a]piridina, preparacion y aplicaciones farmaceuticas. |
| JP2008542323A (ja) | 2005-06-01 | 2008-11-27 | ユセベ ファルマ ソシエテ アノニム | ２−オキソ−１−ピロリジン誘導体、その製造方法及びその使用 |
| EP1909910A1 (en) * | 2005-08-04 | 2008-04-16 | Sirtris Pharmaceuticals, Inc. | Benzimidazole derivatives as sirtuin modulators |
| EP1959959B1 (en) * | 2005-12-06 | 2013-04-10 | Merck Sharp & Dohme Corp. | Morpholine carboxamide prokineticin receptor antagonists |
| EP1845098A1 (en) * | 2006-03-29 | 2007-10-17 | Ferrer Internacional, S.A. | Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands |
| AU2007288124B2 (en) * | 2006-08-24 | 2013-04-04 | Australian Nuclear Science & Technology Organisation | Fluorinated ligands for targeting peripheral benzodiazepine receptors |
| MY146474A (en) * | 2006-11-06 | 2012-08-15 | Supergen Inc | Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors |
| EP1974729A1 (en) | 2007-03-28 | 2008-10-01 | Santhera Pharmaceuticals (Schweiz) AG | Substituted imidazopyridine derivates as melanocortin- 4 receptor antagonists |
| US8642660B2 (en) * | 2007-12-21 | 2014-02-04 | The University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
-
2009
- 2009-05-19 EP EP09751384A patent/EP2300470A2/en not_active Ceased
- 2009-05-19 CA CA2724842A patent/CA2724842A1/en not_active Abandoned
- 2009-05-19 AU AU2009249186A patent/AU2009249186B2/en not_active Ceased
- 2009-05-19 JP JP2011510650A patent/JP5774982B2/ja not_active Expired - Fee Related
- 2009-05-19 US US12/993,679 patent/US8497278B2/en not_active Expired - Fee Related
- 2009-05-19 WO PCT/US2009/044525 patent/WO2009143156A2/en not_active Ceased
-
2013
- 2013-06-24 US US13/925,108 patent/US20130289013A1/en not_active Abandoned
-
2015
- 2015-04-27 JP JP2015090193A patent/JP6211556B2/ja active Active
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