JP2011523642A5 - - Google Patents

Info

Publication number

JP2011523642A5

JP2011523642A5 JP2011509995A JP2011509995A JP2011523642A5 JP 2011523642 A5 JP2011523642 A5 JP 2011523642A5 JP 2011509995 A JP2011509995 A JP 2011509995A JP 2011509995 A JP2011509995 A JP 2011509995A JP 2011523642 A5 JP2011523642 A5 JP 2011523642A5

Authority

JP

Japan

Prior art keywords

seq

expression vector

replicase

adjuvant

vaccine composition

Prior art date

2009-05-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 108010026228 mRNA guanylyltransferase Proteins 0.000 claims description 54
• 239000013604 expression vector Substances 0.000 claims description 41
• 241000710929 Alphavirus Species 0.000 claims description 35
• 230000035772 mutation Effects 0.000 claims description 27
• 239000002671 adjuvant Substances 0.000 claims description 24
• 229960005486 vaccine Drugs 0.000 claims description 23
• 108090000623 proteins and genes Proteins 0.000 claims description 11
• 102000004169 proteins and genes Human genes 0.000 claims description 11
• 239000013598 vector Substances 0.000 claims description 11
• 108091028043 Nucleic acid sequence Proteins 0.000 claims description 9
• 101800000980 Protease nsP2 Proteins 0.000 claims description 9
• 210000000987 immune system Anatomy 0.000 claims description 9
• 239000000427 antigen Substances 0.000 claims description 8
• 102000036639 antigens Human genes 0.000 claims description 8
• 108091007433 antigens Proteins 0.000 claims description 8
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 7
• 239000003814 drug Substances 0.000 claims description 7
• 108020004414 DNA Proteins 0.000 claims description 6
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 5
• 230000004568 DNA-binding Effects 0.000 claims description 4
• 108060004795 Methyltransferase Proteins 0.000 claims description 4
• 241000710961 Semliki Forest virus Species 0.000 claims description 4
• 201000010099 disease Diseases 0.000 claims description 4
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
• 150000007523 nucleic acids Chemical group 0.000 claims description 4
• 230000003612 virological effect Effects 0.000 claims description 4
• 229940023143 protein vaccine Drugs 0.000 claims description 3
• 208000035143 Bacterial infection Diseases 0.000 claims description 2
• 208000035473 Communicable disease Diseases 0.000 claims description 2
• 241000388186 Deltapapillomavirus 4 Species 0.000 claims description 2
• 101710125507 Integrase/recombinase Proteins 0.000 claims description 2
• 206010028980 Neoplasm Diseases 0.000 claims description 2
• 201000011510 cancer Diseases 0.000 claims description 2
• 208000015181 infectious disease Diseases 0.000 claims description 2
• 210000004962 mammalian cell Anatomy 0.000 claims description 2
• 230000010076 replication Effects 0.000 claims description 2
• 101710172711 Structural protein Proteins 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 208000022362 bacterial infectious disease Diseases 0.000 claims 1
• 230000001105 regulatory effect Effects 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 description 5
• 230000000694 effects Effects 0.000 description 1
• 230000028993 immune response Effects 0.000 description 1
• 238000000034 method Methods 0.000 description 1
• 108020004707 nucleic acids Proteins 0.000 description 1
• 102000039446 nucleic acids Human genes 0.000 description 1
• 230000002265 prevention Effects 0.000 description 1