JP2011523037A5 - - Google Patents
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- Publication number
- JP2011523037A5 JP2011523037A5 JP2011507535A JP2011507535A JP2011523037A5 JP 2011523037 A5 JP2011523037 A5 JP 2011523037A5 JP 2011507535 A JP2011507535 A JP 2011507535A JP 2011507535 A JP2011507535 A JP 2011507535A JP 2011523037 A5 JP2011523037 A5 JP 2011523037A5
- Authority
- JP
- Japan
- Prior art keywords
- antagonist
- level
- sample
- sle
- lupus erythematosus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 15
- 239000012472 biological sample Substances 0.000 claims description 6
- 238000011282 treatment Methods 0.000 claims description 6
- 210000002966 serum Anatomy 0.000 claims description 4
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 12
- 239000005557 antagonist Substances 0.000 claims 11
- 102000016605 B-Cell Activating Factor Human genes 0.000 claims 5
- 108010028006 B-Cell Activating Factor Proteins 0.000 claims 5
- 239000013068 control sample Substances 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 239000000523 sample Substances 0.000 claims 3
- 238000003018 immunoassay Methods 0.000 claims 1
- 239000013610 patient sample Substances 0.000 claims 1
- 238000011269 treatment regimen Methods 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000001363 autoimmune Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4970608P | 2008-05-01 | 2008-05-01 | |
| US61/049,706 | 2008-05-01 | ||
| PCT/US2009/041089 WO2009134633A1 (en) | 2008-05-01 | 2009-04-20 | Levels of blys/april heterotrimers in serum and use in diagnostic methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011523037A JP2011523037A (ja) | 2011-08-04 |
| JP2011523037A5 true JP2011523037A5 (https=) | 2014-04-03 |
| JP5902478B2 JP5902478B2 (ja) | 2016-04-13 |
Family
ID=40791678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011507535A Active JP5902478B2 (ja) | 2008-05-01 | 2009-04-20 | 血清中のＢＬｙＳ／ＡＰＲＩＬヘテロ三量体レベルおよび診断方法における使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20090274711A1 (https=) |
| EP (1) | EP2291657B1 (https=) |
| JP (1) | JP5902478B2 (https=) |
| AU (1) | AU2009241442B2 (https=) |
| CA (1) | CA2720651C (https=) |
| DK (1) | DK2291657T3 (https=) |
| ES (1) | ES2578526T3 (https=) |
| HU (1) | HUE028784T2 (https=) |
| PL (1) | PL2291657T3 (https=) |
| PT (1) | PT2291657T (https=) |
| SI (1) | SI2291657T1 (https=) |
| WO (1) | WO2009134633A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8003335B2 (en) | 2008-04-30 | 2011-08-23 | Universite Paris-SUD11 | Levels of APRIL in serum and use in diagnostic methods |
| CA2867444C (en) | 2012-03-16 | 2021-04-13 | University Health Network | Compositions containing soluble toso protein and uses thereof |
| FI3380522T3 (fi) | 2015-11-25 | 2024-01-16 | Visterra Inc | Vasta-ainemolekyylejä april-proteiinille ja niiden käyttöjä |
| JP7749319B2 (ja) | 2017-10-10 | 2025-10-06 | アルパイン イミューン サイエンシズ インコーポレイテッド | Ｃｔｌａ－４変異型免疫調節タンパク質およびそれらの使用 |
| EP4146684A2 (en) | 2020-05-08 | 2023-03-15 | Alpine Immune Sciences, Inc. | April and baff inhibitory immunomodulatory proteins with and without a t cell inhibitory protein and methods of use thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10041402A1 (de) | 2000-08-23 | 2002-03-14 | Morphochem Ag | Neue Verbindungen, die Faktor Xa-Aktivität inhibieren |
| PT2281843T (pt) | 2000-06-16 | 2017-01-02 | Human Genome Sciences Inc | Anticorpos que se ligam imunoespecificamente a blys |
| BRPI0209933B8 (pt) * | 2001-05-24 | 2021-05-25 | Zymogenetics Inc | proteína de fusão, e, molécula de ácido nucleico |
| EP1401870A4 (en) * | 2001-05-24 | 2006-04-19 | Human Genome Sciences | ANTIBODIES AGAINST TUMOR NECROSIS FACTOR DELTA (APRIL) |
| WO2003040307A2 (en) * | 2001-07-27 | 2003-05-15 | Human Genome Sciences, Inc. | Heteromultimeric tnf ligand family members |
| CA2465268A1 (en) | 2001-10-24 | 2003-05-01 | National Jewish Medical And Research Center | Three-dimensional structures of tall-1 and its cognate receptors and modified proteins and methods related thereto |
| JP2007526220A (ja) | 2003-06-05 | 2007-09-13 | ジェネンテック・インコーポレーテッド | Ｂ細胞疾患の併用療法 |
| EP1960525B1 (en) * | 2005-09-09 | 2013-04-24 | Zymogenetics, Inc. | Method for preparing trimeric proteins |
| WO2007142667A2 (en) * | 2005-10-13 | 2007-12-13 | Human Genome Sciences, Inc. | Treatment of patients with autoantibody positive disease |
| MY150687A (en) * | 2006-07-21 | 2014-02-28 | Femalon S P R L | Assay and kit for predicting implantation success in assisted fertilisation |
| US8003335B2 (en) | 2008-04-30 | 2011-08-23 | Universite Paris-SUD11 | Levels of APRIL in serum and use in diagnostic methods |
-
2009
- 2009-04-20 HU HUE09739435A patent/HUE028784T2/en unknown
- 2009-04-20 PT PT97394357T patent/PT2291657T/pt unknown
- 2009-04-20 JP JP2011507535A patent/JP5902478B2/ja active Active
- 2009-04-20 EP EP09739435.7A patent/EP2291657B1/en active Active
- 2009-04-20 ES ES09739435.7T patent/ES2578526T3/es active Active
- 2009-04-20 AU AU2009241442A patent/AU2009241442B2/en not_active Ceased
- 2009-04-20 CA CA2720651A patent/CA2720651C/en active Active
- 2009-04-20 SI SI200931441A patent/SI2291657T1/sl unknown
- 2009-04-20 WO PCT/US2009/041089 patent/WO2009134633A1/en not_active Ceased
- 2009-04-20 DK DK09739435.7T patent/DK2291657T3/en active
- 2009-04-20 PL PL09739435.7T patent/PL2291657T3/pl unknown
- 2009-04-22 US US12/428,146 patent/US20090274711A1/en not_active Abandoned
-
2013
- 2013-08-21 US US13/972,186 patent/US9146242B2/en active Active
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