JP2011521969A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011521969A5 JP2011521969A5 JP2011511843A JP2011511843A JP2011521969A5 JP 2011521969 A5 JP2011521969 A5 JP 2011521969A5 JP 2011511843 A JP2011511843 A JP 2011511843A JP 2011511843 A JP2011511843 A JP 2011511843A JP 2011521969 A5 JP2011521969 A5 JP 2011521969A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- kinase
- inhibitor
- activin receptor
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 34
- 102000014172 Transforming Growth Factor-beta Type I Receptor Human genes 0.000 claims 13
- 108010011702 Transforming Growth Factor-beta Type I Receptor Proteins 0.000 claims 13
- 239000003112 inhibitor Substances 0.000 claims 13
- 230000015572 biosynthetic process Effects 0.000 claims 4
- 238000001356 surgical procedure Methods 0.000 claims 3
- 230000003796 beauty Effects 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 231100000241 scar Toxicity 0.000 claims 2
- 208000014674 injury Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 230000037390 scarring Effects 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- 230000009772 tissue formation Effects 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5746108P | 2008-05-30 | 2008-05-30 | |
| US61/057,461 | 2008-05-30 | ||
| PCT/US2009/045607 WO2009146408A1 (en) | 2008-05-30 | 2009-05-29 | Methods for using tgf-b receptor inhibitors or activin-like kinase (alk) 5 inhibitors a-83-01 and sb-431542 to treat eye disease and wound healing conditions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011521969A JP2011521969A (ja) | 2011-07-28 |
| JP2011521969A5 true JP2011521969A5 (enExample) | 2011-09-08 |
Family
ID=41377599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011511843A Pending JP2011521969A (ja) | 2008-05-30 | 2009-05-29 | 眼疾患を治療するためのTGF−β受容体阻害剤又はアクチビン様キナーゼ(ALK)5阻害剤、A−83−01及びSB−431542の使用方法及び創傷治療条件 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20100087486A1 (enExample) |
| EP (1) | EP2285380A4 (enExample) |
| JP (1) | JP2011521969A (enExample) |
| CN (1) | CN102083439A (enExample) |
| WO (1) | WO2009146408A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012524073A (ja) * | 2009-04-17 | 2012-10-11 | スムマ ヘルス システムズ エルエルシー | 眼球瘢痕化を抑制するための形質転換成長因子−β受容体阻害剤の使用 |
| WO2012024376A1 (en) * | 2010-08-17 | 2012-02-23 | Allergan, Inc. | Ep2 or ep4 agonists for treating corneal haze |
| MX366336B (es) | 2012-11-02 | 2019-07-05 | Celgene Corp | Antagonistas de activina - actrii y usos para el tratar trastornos oseos y otros. |
| WO2014168264A1 (ja) | 2013-04-12 | 2014-10-16 | 国立大学法人京都大学 | 肺胞上皮前駆細胞の誘導方法 |
| US9822342B2 (en) | 2013-05-14 | 2017-11-21 | Kyoto University | Method of efficiently inducing cardiomyocytes |
| MX386503B (es) | 2013-07-30 | 2025-03-19 | Kyoto Prefectural Public Univ Corp | Medicamentos terapeuticos de matriz extracelular endotelial corneal. |
| JP6378183B2 (ja) | 2013-08-07 | 2018-08-22 | 国立大学法人京都大学 | 膵ホルモン産生細胞の製造法 |
| CN121136933A (zh) | 2013-09-05 | 2025-12-16 | 国立大学法人京都大学 | 由多能干细胞制造产多巴胺神经前体细胞的方法、产多巴胺神经前体细胞、帕金森病治疗剂和试剂盒 |
| PL3064222T3 (pl) * | 2013-10-31 | 2021-04-19 | Kyoto Prefectural Public University Corporation | Lek terapeutyczny zawierający inhibitor sygnału tgf-beta w chorobach związanych z retikulum endoplazmatycznym i śmiercią komórki w śródbłonku rogówki |
| WO2015178431A1 (ja) | 2014-05-21 | 2015-11-26 | 国立大学法人京都大学 | 膵芽細胞の製造方法および膵芽細胞を含む膵疾患治療剤 |
| CN108697793B (zh) | 2015-11-23 | 2023-08-01 | 阿塞勒隆制药公司 | 治疗眼睛疾病的方法 |
| AU2017254268B2 (en) | 2016-04-22 | 2023-03-16 | Kyoto University | Method for producing dopamine-producing neural precursor cells |
| CN106282092A (zh) * | 2016-09-07 | 2017-01-04 | 山东省眼科研究所 | 一种角膜内皮分离和扩增培养液 |
| KR102594102B1 (ko) | 2017-05-25 | 2023-10-25 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 중간 중배엽 세포로부터 신장 전구 세포로의 분화 유도 방법 및 다능성 줄기세포로부터 신장 전구 세포로의 분화 유도 방법 |
| EP3757208A4 (en) | 2018-02-19 | 2021-12-01 | Sumitomo Dainippon Pharma Co., Ltd. | CELL UNIT, MIXTURE OF CELL UNITS AND METHOD OF MANUFACTURING THEREOF |
| WO2020022261A1 (ja) | 2018-07-23 | 2020-01-30 | 国立大学法人京都大学 | 新規腎前駆細胞マーカーおよびそれを利用した腎前駆細胞の濃縮方法 |
| CA3140384A1 (en) | 2019-05-15 | 2020-11-19 | Ajinomoto Co., Inc. | Method for purifying neural crest cells or corneal epithelial cells |
| JPWO2020235319A1 (enExample) | 2019-05-20 | 2020-11-26 | ||
| WO2021045217A1 (ja) | 2019-09-06 | 2021-03-11 | 学校法人慶應義塾 | グリア前駆細胞を含む細胞凝集体の製造方法 |
| JP7619633B2 (ja) | 2019-10-01 | 2025-01-22 | 国立大学法人京都大学 | 尿管芽先端部細胞の単離方法 |
| JP7785351B2 (ja) | 2020-03-19 | 2025-12-15 | オリヅルセラピューティクス株式会社 | 心筋細胞の精製方法 |
| EP4123015A4 (en) | 2020-03-19 | 2024-05-22 | Orizuru Therapeutics, Inc. | Cardiomyocyte purification method |
| EP4180516A4 (en) | 2020-07-13 | 2024-01-17 | Kyoto University | SKELETON MUSCLE PRECURSOR CELLS AND METHOD FOR PURIFICATION THEREOF, COMPOSITION FOR THE TREATMENT OF MYOGENIC DISEASES AND METHOD FOR PRODUCING SKELETON MUSCLE PRECURSOR CELLS CONTAINING CELL GROUPS |
| JP7798294B2 (ja) | 2021-01-08 | 2026-01-14 | 国立大学法人京都大学 | ネフロン前駆細胞を拡大培養するための培地、ネフロン前駆細胞を拡大培養する方法、腎臓オルガノイドの製造方法 |
| EP4353243A4 (en) | 2021-06-10 | 2025-06-25 | Ajinomoto Co., Inc. | METHOD FOR PRODUCING MESENCHYMAL STEM CELLS |
| JPWO2022265086A1 (enExample) | 2021-06-17 | 2022-12-22 | ||
| EP4372075A4 (en) | 2021-07-15 | 2025-06-11 | Cellfiber Co., Ltd. | Structure and use thereof |
| US20240318142A1 (en) | 2021-08-11 | 2024-09-26 | Kyoto University | Method for producing renal interstitial progenitor cells, erythropoietin-producing cells, and method for producing renin-producing cells |
| JPWO2023149407A1 (enExample) | 2022-02-01 | 2023-08-10 | ||
| CN118679244A (zh) | 2022-02-09 | 2024-09-20 | 住友制药株式会社 | 判定培养液中的细胞在由多能干细胞向中脑底板区域的神经系统细胞的分化中的分化能力的方法 |
| WO2023228908A1 (ja) | 2022-05-23 | 2023-11-30 | 国立大学法人京都大学 | 腎集合管細胞および腎盂上皮細胞の製造方法 |
| JPWO2024070494A1 (enExample) | 2022-09-26 | 2024-04-04 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5470881A (en) * | 1993-09-09 | 1995-11-28 | West Virginia University Research Corporation | Urea ophthalmic ointment and solution |
| US5449671A (en) * | 1993-09-29 | 1995-09-12 | Alcon Laboratories, Inc. | Use of TGF-β3, to prevent or retard fistula closure following glaucoma filtration surgery |
| CA2149528A1 (en) * | 1993-09-29 | 1995-04-06 | Billie M. York | Compositions containing growth factors and antimetabolites |
| JPH08503969A (ja) * | 1993-09-29 | 1996-04-30 | アルコン ラボラトリーズ,インコーポレイテッド | 増殖因子と組織形成抑制剤を含有する組成物 |
| US5486534A (en) * | 1994-07-21 | 1996-01-23 | G. D. Searle & Co. | 3,4-substituted pyrazoles for the treatment of inflammation |
| US6063396A (en) * | 1994-10-26 | 2000-05-16 | Houston Biotechnology Incorporated | Methods and compositions for the modulation of cell proliferation and wound healing |
| US6184226B1 (en) * | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
| WO2003057670A2 (en) * | 2001-12-28 | 2003-07-17 | Guilford Pharmaceuticals Inc. | Indoles as naaladase inhibitors |
| AR039241A1 (es) * | 2002-04-04 | 2005-02-16 | Biogen Inc | Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos |
| AU2003300099A1 (en) * | 2003-01-02 | 2004-07-29 | Millennium Pharmaceuticals, Inc. | COMPOSITIONS AND METHODS FOR INHIBITING TGF-Beta |
| DE602004014347D1 (de) * | 2003-03-12 | 2008-07-24 | Millennium Pharm Inc | Chinazolin-derivate als tgf-beta-inhibitoren |
| EP1633718B1 (en) * | 2003-06-17 | 2012-06-06 | Millennium Pharmaceuticals, Inc. | COMPOSITIONS AND METHODS FOR INHIBITING TGF-s |
| KR100749566B1 (ko) * | 2004-04-21 | 2007-08-16 | 이화여자대학교 산학협력단 | Alk5 및/또는 alk4 억제제로 유효한 2-피리딜이치환된 이미다졸 유도체 |
| US7098222B2 (en) * | 2004-05-12 | 2006-08-29 | Abbott Laboratories | Bicyclic-substituted amines having cyclic-substituted monocyclic substituents |
| US20050256118A1 (en) * | 2004-05-12 | 2005-11-17 | Altenbach Robert J | Bicyclic-substituted amines having cyclic-substituted monocyclic substituents |
| US20060234911A1 (en) * | 2005-03-24 | 2006-10-19 | Hoffmann F M | Method of reversing epithelial mesenchymal transition |
| CN101330914A (zh) * | 2005-12-16 | 2008-12-24 | 爱尔康公司 | 使用alk5调节剂控制眼内压 |
| US7989458B2 (en) * | 2006-07-14 | 2011-08-02 | Novartis Ag | Pyrimidine derivatives as alk-5 inhibitors |
| US7524640B2 (en) * | 2006-08-06 | 2009-04-28 | Children's Medical Center Corporation | Inhibiting Smad2/3 signaling promotes neurite outgrowth in dorsal root ganglia |
-
2009
- 2009-05-29 JP JP2011511843A patent/JP2011521969A/ja active Pending
- 2009-05-29 EP EP09755769A patent/EP2285380A4/en not_active Withdrawn
- 2009-05-29 US US12/474,370 patent/US20100087486A1/en not_active Abandoned
- 2009-05-29 CN CN2009801199382A patent/CN102083439A/zh active Pending
- 2009-05-29 WO PCT/US2009/045607 patent/WO2009146408A1/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011521969A5 (enExample) | ||
| JP2009280627A5 (enExample) | ||
| DK2729123T3 (en) | Cannabinoidreceptorbindende funds and formations and methods | |
| CN102821791B (zh) | 透皮递送贴剂 | |
| CA2796575C (en) | Dermal pharmaceutical compositions of 1-methyl-2',6'-pipecoloxylidide and method of use | |
| JP2009102342A5 (enExample) | ||
| IL260579A (en) | Diagnosis, prevention and treatment of joint diseases | |
| WO2007102241A1 (ja) | 外用の医薬組成物 | |
| JP2014518266A5 (enExample) | ||
| HRP20120254T1 (hr) | Pripravak za produljenu lokalnu anesteziju koji sadrži saib | |
| CN104379139A (zh) | 贴附剂 | |
| TW201004617A (en) | Anti-inflammatory analgesic agent for external use | |
| JP2011516460A5 (enExample) | ||
| TW201141524A (en) | Stabilized ophthalmic galactomannan formulations | |
| CA2717948A1 (en) | 5imidazoquinolines and pyrimidine derivatives as potent modulators of vegf-driven angiogenic processes | |
| MX2010009395A (es) | Agonistas de receptores muscarinicos, composiciones, metodos de tratamiento de los mismos, y procesos para preparacion de los mismos. | |
| WO2009109654A3 (en) | 1-benzyl-3-hydr0xymethylindaz0le derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cxcr1 and p40 | |
| CN105997951A (zh) | 一种包含卡巴拉汀的透皮给药系统及制备方法 | |
| JP2012508256A5 (enExample) | ||
| CA2785851A1 (en) | Therapeutic agent (y - 39983 ) for corneal endothelial dysfunction | |
| RU2013130026A (ru) | Смеси карнозина и гиалуроновой кислоты и их применение | |
| JP2009532373A5 (enExample) | ||
| JP2014510156A5 (enExample) | ||
| JP2012526099A5 (enExample) | ||
| JP2011512362A5 (enExample) |