JP2011521969A5 - - Google Patents
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- JP2011521969A5 JP2011521969A5 JP2011511843A JP2011511843A JP2011521969A5 JP 2011521969 A5 JP2011521969 A5 JP 2011521969A5 JP 2011511843 A JP2011511843 A JP 2011511843A JP 2011511843 A JP2011511843 A JP 2011511843A JP 2011521969 A5 JP2011521969 A5 JP 2011521969A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- kinase
- inhibitor
- activin receptor
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5746108P | 2008-05-30 | 2008-05-30 | |
| US61/057,461 | 2008-05-30 | ||
| PCT/US2009/045607 WO2009146408A1 (en) | 2008-05-30 | 2009-05-29 | Methods for using tgf-b receptor inhibitors or activin-like kinase (alk) 5 inhibitors a-83-01 and sb-431542 to treat eye disease and wound healing conditions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011521969A JP2011521969A (ja) | 2011-07-28 |
| JP2011521969A5 true JP2011521969A5 (enExample) | 2011-09-08 |
Family
ID=41377599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011511843A Pending JP2011521969A (ja) | 2008-05-30 | 2009-05-29 | 眼疾患を治療するためのTGF−β受容体阻害剤又はアクチビン様キナーゼ(ALK)5阻害剤、A−83−01及びSB−431542の使用方法及び創傷治療条件 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20100087486A1 (enExample) |
| EP (1) | EP2285380A4 (enExample) |
| JP (1) | JP2011521969A (enExample) |
| CN (1) | CN102083439A (enExample) |
| WO (1) | WO2009146408A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100267731A1 (en) * | 2009-04-17 | 2010-10-21 | Summa Health Systems, LLC | Use of transforming growth factor-b receptor inhibitors to suppress ocular scarring |
| RU2013111281A (ru) * | 2010-08-17 | 2014-09-27 | Аллерган, Инк. | Агонисты ер2 или ер4 для лечения помутнения роговицы |
| RU2018145985A (ru) | 2012-11-02 | 2019-02-18 | Селджин Корпорейшн | Антагонисты активина-actrii и их применение для лечения нарушений костной ткани и других нарушений |
| JP6461787B2 (ja) | 2013-04-12 | 2019-01-30 | 国立大学法人京都大学 | 肺胞上皮前駆細胞の誘導方法 |
| US9822342B2 (en) | 2013-05-14 | 2017-11-21 | Kyoto University | Method of efficiently inducing cardiomyocytes |
| MX386503B (es) | 2013-07-30 | 2025-03-19 | Kyoto Prefectural Public Univ Corp | Medicamentos terapeuticos de matriz extracelular endotelial corneal. |
| WO2015020113A1 (ja) | 2013-08-07 | 2015-02-12 | 国立大学法人京都大学 | 膵ホルモン産生細胞の製造法 |
| EP3042951B1 (en) | 2013-09-05 | 2019-02-20 | Kyoto University | New method for inducing dopamine-producing neural precursor cells |
| CA2927898C (en) | 2013-10-31 | 2021-11-16 | Kyoto Prefectural Public University Corporation | Therapeutic drug for diseases related to endoplasmic reticulum cell death in corneal endothelium |
| US10472610B2 (en) | 2014-05-21 | 2019-11-12 | Kyoto University | Method for generating pancreatic bud cells and therapeutic agent for pancreatic disease containing pancreatic bud cells |
| CA3005975A1 (en) | 2015-11-23 | 2017-06-01 | Acceleron Pharma Inc. | Methods for treating eye disorders |
| US11898163B2 (en) | 2016-04-22 | 2024-02-13 | Kyoto University | Method for producing dopaminergic neuron progenitor cell |
| CN106282092A (zh) * | 2016-09-07 | 2017-01-04 | 山东省眼科研究所 | 一种角膜内皮分离和扩增培养液 |
| CA3064830A1 (en) | 2017-05-25 | 2018-11-29 | Kyoto University | Method for inducing differentiation of intermediate mesodermal cell to renal progenitor cell, and method for inducing differentiation of pluripotent stem cell to renal progenitor cell |
| WO2019160148A1 (ja) | 2018-02-19 | 2019-08-22 | 大日本住友製薬株式会社 | 細胞凝集体、細胞凝集体の混合物及びそれらの製造方法 |
| WO2020022261A1 (ja) | 2018-07-23 | 2020-01-30 | 国立大学法人京都大学 | 新規腎前駆細胞マーカーおよびそれを利用した腎前駆細胞の濃縮方法 |
| CA3140384A1 (en) | 2019-05-15 | 2020-11-19 | Ajinomoto Co., Inc. | Method for purifying neural crest cells or corneal epithelial cells |
| EP3974519A4 (en) | 2019-05-20 | 2023-07-12 | Ajinomoto Co., Inc. | EXPANSION CULTURE METHOD FOR CARTILAGE OR BONE PRECURSOR CELLS |
| US12533383B2 (en) | 2019-09-06 | 2026-01-27 | Keio University | Method for producing cell aggregate including glial progenitor cells |
| EP4043553A4 (en) | 2019-10-01 | 2023-11-22 | Kyoto University | METHOD FOR ISOLATING URETERAL NODLE CELLS |
| CA3175573A1 (en) | 2020-03-19 | 2021-09-23 | Orizuru Therapeutics, Inc. | Cardiomyocyte purification method |
| US20230212519A1 (en) | 2020-03-19 | 2023-07-06 | Orizuru Therapeutics, Inc. | Method for purifying cardiomyocytes |
| JP7429294B2 (ja) | 2020-07-13 | 2024-02-07 | 国立大学法人京都大学 | 骨格筋前駆細胞及びその精製方法、筋原性疾患を治療するための組成物、並びに骨格筋前駆細胞を含む細胞群の製造方法 |
| CN116802276A (zh) | 2021-01-08 | 2023-09-22 | 国立大学法人京都大学 | 用于扩增培养肾元祖细胞的培养基、扩增培养肾元祖细胞的方法以及肾脏类器官的制造方法 |
| CA3222761A1 (en) | 2021-06-10 | 2022-12-15 | Ajinomoto Co., Inc. | Method for producing mesenchymal stem cells |
| JPWO2022265086A1 (enExample) | 2021-06-17 | 2022-12-22 | ||
| WO2023286852A1 (ja) | 2021-07-15 | 2023-01-19 | 株式会社セルファイバ | 構造体及びその用途 |
| EP4386083A4 (en) | 2021-08-11 | 2025-11-12 | Univ Kyoto | METHOD FOR PRODUCING RENAL INTERSTITIAL PROGENITOR CELLS, ERYTHROPOIETIN-PRODUCING CELLS AND METHOD FOR PRODUCING RENIIN-PRODUCING CELLS |
| EP4471126A4 (en) | 2022-02-01 | 2026-01-14 | Univ Kyoto | LUNG MESENCHYMAL CELLS AND PROCESS FOR PRODUCING LUNG MESENCHYMAL CELLS |
| WO2023153464A1 (ja) | 2022-02-09 | 2023-08-17 | 住友ファーマ株式会社 | 多能性幹細胞から中脳底板領域の神経系細胞への分化における、培養液中の細胞の分化能を判定する方法 |
| WO2023228908A1 (ja) | 2022-05-23 | 2023-11-30 | 国立大学法人京都大学 | 腎集合管細胞および腎盂上皮細胞の製造方法 |
| CN119948151A (zh) | 2022-09-26 | 2025-05-06 | 国立大学法人京都大学 | 胰腺内胚层细胞的制造方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5470881A (en) * | 1993-09-09 | 1995-11-28 | West Virginia University Research Corporation | Urea ophthalmic ointment and solution |
| JPH08503969A (ja) * | 1993-09-29 | 1996-04-30 | アルコン ラボラトリーズ,インコーポレイテッド | 増殖因子と組織形成抑制剤を含有する組成物 |
| WO1995009003A1 (en) * | 1993-09-29 | 1995-04-06 | Alcon Laboratories, Inc. | Compositions containing growth factors and antimetabolites |
| US5449671A (en) * | 1993-09-29 | 1995-09-12 | Alcon Laboratories, Inc. | Use of TGF-β3, to prevent or retard fistula closure following glaucoma filtration surgery |
| US5486534A (en) * | 1994-07-21 | 1996-01-23 | G. D. Searle & Co. | 3,4-substituted pyrazoles for the treatment of inflammation |
| US6063396A (en) * | 1994-10-26 | 2000-05-16 | Houston Biotechnology Incorporated | Methods and compositions for the modulation of cell proliferation and wound healing |
| US6184226B1 (en) * | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
| WO2003057670A2 (en) * | 2001-12-28 | 2003-07-17 | Guilford Pharmaceuticals Inc. | Indoles as naaladase inhibitors |
| AR039241A1 (es) * | 2002-04-04 | 2005-02-16 | Biogen Inc | Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos |
| EP1581222A2 (en) * | 2003-01-02 | 2005-10-05 | Millennium Pharmaceuticals, Inc. | COMPOSITIONS AND METHODS FOR INHIBITING TGF-&bgr; |
| ATE398125T1 (de) * | 2003-03-12 | 2008-07-15 | Millennium Pharm Inc | Chinazolin-derivate als tgf-beta-inhibitoren |
| US7314939B2 (en) * | 2003-06-17 | 2008-01-01 | Millennium Pharmaceuticals, Inc. | Compositions and methods for inhibiting TGF-β |
| KR100749566B1 (ko) * | 2004-04-21 | 2007-08-16 | 이화여자대학교 산학협력단 | Alk5 및/또는 alk4 억제제로 유효한 2-피리딜이치환된 이미다졸 유도체 |
| US20050256118A1 (en) * | 2004-05-12 | 2005-11-17 | Altenbach Robert J | Bicyclic-substituted amines having cyclic-substituted monocyclic substituents |
| US7098222B2 (en) * | 2004-05-12 | 2006-08-29 | Abbott Laboratories | Bicyclic-substituted amines having cyclic-substituted monocyclic substituents |
| US20060234911A1 (en) * | 2005-03-24 | 2006-10-19 | Hoffmann F M | Method of reversing epithelial mesenchymal transition |
| BRPI0619966A2 (pt) * | 2005-12-16 | 2011-10-25 | Alcon Inc | controle de pressão intra-ocular usando agentes de modulação de alk5 |
| BRPI0714409A2 (pt) * | 2006-07-14 | 2013-03-12 | Novartis Ag | derivados de pirimidina como inibidores de alk-5 |
| US7524640B2 (en) * | 2006-08-06 | 2009-04-28 | Children's Medical Center Corporation | Inhibiting Smad2/3 signaling promotes neurite outgrowth in dorsal root ganglia |
-
2009
- 2009-05-29 WO PCT/US2009/045607 patent/WO2009146408A1/en not_active Ceased
- 2009-05-29 EP EP09755769A patent/EP2285380A4/en not_active Withdrawn
- 2009-05-29 JP JP2011511843A patent/JP2011521969A/ja active Pending
- 2009-05-29 US US12/474,370 patent/US20100087486A1/en not_active Abandoned
- 2009-05-29 CN CN2009801199382A patent/CN102083439A/zh active Pending
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