JP2011521969A5 - - Google Patents
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- Publication number
- JP2011521969A5 JP2011521969A5 JP2011511843A JP2011511843A JP2011521969A5 JP 2011521969 A5 JP2011521969 A5 JP 2011521969A5 JP 2011511843 A JP2011511843 A JP 2011511843A JP 2011511843 A JP2011511843 A JP 2011511843A JP 2011521969 A5 JP2011521969 A5 JP 2011521969A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- kinase
- inhibitor
- activin receptor
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5746108P | 2008-05-30 | 2008-05-30 | |
| US61/057,461 | 2008-05-30 | ||
| PCT/US2009/045607 WO2009146408A1 (en) | 2008-05-30 | 2009-05-29 | Methods for using tgf-b receptor inhibitors or activin-like kinase (alk) 5 inhibitors a-83-01 and sb-431542 to treat eye disease and wound healing conditions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011521969A JP2011521969A (ja) | 2011-07-28 |
| JP2011521969A5 true JP2011521969A5 (enExample) | 2011-09-08 |
Family
ID=41377599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011511843A Pending JP2011521969A (ja) | 2008-05-30 | 2009-05-29 | 眼疾患を治療するためのＴＧＦ−β受容体阻害剤又はアクチビン様キナーゼ（ＡＬＫ）５阻害剤、Ａ−８３−０１及びＳＢ−４３１５４２の使用方法及び創傷治療条件 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20100087486A1 (enExample) |
| EP (1) | EP2285380A4 (enExample) |
| JP (1) | JP2011521969A (enExample) |
| CN (1) | CN102083439A (enExample) |
| WO (1) | WO2009146408A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102695511A (zh) * | 2009-04-17 | 2012-09-26 | 舒玛健康系统有限责任公司 | 抑制眼部瘢痕形成的转化生长因子-β受体抑制剂的用途 |
| BR112013003600A2 (pt) * | 2010-08-17 | 2016-08-16 | Allergan Inc | agonistas ep2 ou ep4 para o tratamento de névoa da córnea |
| US10195249B2 (en) | 2012-11-02 | 2019-02-05 | Celgene Corporation | Activin-ActRII antagonists and uses for treating bone and other disorders |
| JP6461787B2 (ja) | 2013-04-12 | 2019-01-30 | 国立大学法人京都大学 | 肺胞上皮前駆細胞の誘導方法 |
| JP6429280B2 (ja) | 2013-05-14 | 2018-11-28 | 国立大学法人京都大学 | 効率的な心筋細胞の誘導方法 |
| RU2016106641A (ru) | 2013-07-30 | 2017-09-01 | Киото Прифекчурал Паблик Юниверсити Корпорэйшн | Терапевтические средства, направленные на ecm эндотелия роговицы |
| EP3031905A4 (en) | 2013-08-07 | 2017-04-26 | Kyoto University | Method for producing pancreatic hormone-producing cell |
| AU2014316100B2 (en) | 2013-09-05 | 2020-11-05 | Eisai R&D Management Co., Ltd. | New method for inducing dopamine-producing neural precursor cells |
| CA2927898C (en) | 2013-10-31 | 2021-11-16 | Kyoto Prefectural Public University Corporation | Therapeutic drug for diseases related to endoplasmic reticulum cell death in corneal endothelium |
| EP3147353B1 (en) | 2014-05-21 | 2022-03-30 | Kyoto University | Method for producing pancreatic blast cells and pancreatic disease treatment agent containing pancreatic blast cells |
| EP3380121B1 (en) * | 2015-11-23 | 2023-12-20 | Acceleron Pharma Inc. | Actrii antagonist for use in treating eye disorders |
| JP7011260B2 (ja) | 2016-04-22 | 2022-02-10 | 国立大学法人京都大学 | ドーパミン産生神経前駆細胞の製造方法 |
| CN106282092A (zh) * | 2016-09-07 | 2017-01-04 | 山东省眼科研究所 | 一种角膜内皮分离和扩增培养液 |
| EP3633026A4 (en) | 2017-05-25 | 2021-03-10 | Kyoto University | METHOD FOR INDUCING THE DIFFERENTIATION OF A MESODERMAL INTERMEDIATE CELL TO A KIDNEY PRECURSOR CELL AND METHOD FOR INDUCING THE DIFFERENTIATION OF A PLURIPOTENT STEM CELL FROM A KIDNEY PRECURSOR CELL |
| US20200405768A1 (en) | 2018-02-19 | 2020-12-31 | Sumitomo Dainippon Pharma Co., Ltd. | Cell Aggregate, Mixture of Cell Aggregates, and Method for Preparing Same |
| JP7357369B2 (ja) | 2018-07-23 | 2023-10-06 | 国立大学法人京都大学 | 新規腎前駆細胞マーカーおよびそれを利用した腎前駆細胞の濃縮方法 |
| EP3970795A4 (en) | 2019-05-15 | 2023-06-14 | Ajinomoto Co., Inc. | Method for purifying neural crest cells or corneal epithelial cells |
| JPWO2020235319A1 (enExample) | 2019-05-20 | 2020-11-26 | ||
| CN114375328B (zh) | 2019-09-06 | 2024-12-27 | 学校法人庆应义塾 | 包含胶质前体细胞的细胞聚集体的制备方法 |
| EP4043553A4 (en) | 2019-10-01 | 2023-11-22 | Kyoto University | METHOD FOR ISOLATING URETERAL NODLE CELLS |
| BR112022018640A2 (pt) | 2020-03-19 | 2022-11-08 | Orizuru Therapeutics Inc | Métodos para produzir uma população de células compreendendo cardiomiócitos e para purificar cardiomiócitos, população de células contendo cardiomiócitos, e, agente para terapia de transplante de células |
| EP4123016A4 (en) | 2020-03-19 | 2024-06-19 | Orizuru Therapeutics, Inc. | Method for purifying cardiomyocytes |
| US20230256024A1 (en) | 2020-07-13 | 2023-08-17 | Kyoto University | Skeletal muscle precursor cells and method for purifying same, composition for treating myogenic diseases, and method for producing cell group containing skeletal muscle precursor cells |
| US20240010989A1 (en) | 2021-01-08 | 2024-01-11 | Kyoto University | Medium for culturing and expanding nephron progenitor cells, method for culturing and expanding nephron progenitor cells, and method for producing renal organoids |
| EP4353243A4 (en) | 2021-06-10 | 2025-06-25 | Ajinomoto Co., Inc. | METHOD FOR PRODUCING MESENCHYMAL STEM CELLS |
| JPWO2022265086A1 (enExample) | 2021-06-17 | 2022-12-22 | ||
| WO2023286852A1 (ja) | 2021-07-15 | 2023-01-19 | 株式会社セルファイバ | 構造体及びその用途 |
| EP4386083A4 (en) | 2021-08-11 | 2025-11-12 | Univ Kyoto | METHOD FOR PRODUCING RENAL INTERSTITIAL PROGENITOR CELLS, ERYTHROPOIETIN-PRODUCING CELLS AND METHOD FOR PRODUCING RENIIN-PRODUCING CELLS |
| US20250163385A1 (en) | 2022-02-01 | 2025-05-22 | Kyoto University | Method for producing lung mesenchymal cells and lung mesenchymal cells |
| CN118679244A (zh) | 2022-02-09 | 2024-09-20 | 住友制药株式会社 | 判定培养液中的细胞在由多能干细胞向中脑底板区域的神经系统细胞的分化中的分化能力的方法 |
| EP4530344A1 (en) | 2022-05-23 | 2025-04-02 | Kyoto University | Production method for renal collecting duct cells and pelvic epithelial cells |
| US20260097083A1 (en) | 2022-09-26 | 2026-04-09 | Kyoto University | Method for producing pancreatic endoderm cells |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5470881A (en) * | 1993-09-09 | 1995-11-28 | West Virginia University Research Corporation | Urea ophthalmic ointment and solution |
| WO1995009003A1 (en) * | 1993-09-29 | 1995-04-06 | Alcon Laboratories, Inc. | Compositions containing growth factors and antimetabolites |
| US5449671A (en) * | 1993-09-29 | 1995-09-12 | Alcon Laboratories, Inc. | Use of TGF-β3, to prevent or retard fistula closure following glaucoma filtration surgery |
| CA2149657A1 (en) * | 1993-09-29 | 1995-04-06 | Billie M. York | Compositions containing growth factors and antiplastic agents |
| US5486534A (en) * | 1994-07-21 | 1996-01-23 | G. D. Searle & Co. | 3,4-substituted pyrazoles for the treatment of inflammation |
| US6063396A (en) * | 1994-10-26 | 2000-05-16 | Houston Biotechnology Incorporated | Methods and compositions for the modulation of cell proliferation and wound healing |
| US6184226B1 (en) * | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
| AU2002357003A1 (en) * | 2001-12-28 | 2003-07-24 | Guilford Pharmaceuticals Inc. | Indoles as naaladase inhibitors |
| AR039241A1 (es) * | 2002-04-04 | 2005-02-16 | Biogen Inc | Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos |
| AU2003300099A1 (en) * | 2003-01-02 | 2004-07-29 | Millennium Pharmaceuticals, Inc. | COMPOSITIONS AND METHODS FOR INHIBITING TGF-Beta |
| DE602004014347D1 (de) * | 2003-03-12 | 2008-07-24 | Millennium Pharm Inc | Chinazolin-derivate als tgf-beta-inhibitoren |
| ES2389258T3 (es) * | 2003-06-17 | 2012-10-24 | Millennium Pharmaceuticals, Inc. | Composiciones y métodos para inhibir TGF-s |
| KR100749566B1 (ko) * | 2004-04-21 | 2007-08-16 | 이화여자대학교 산학협력단 | Ａｌｋ5 및/또는 ａｌｋ4 억제제로 유효한 2-피리딜이치환된 이미다졸 유도체 |
| US20050256118A1 (en) * | 2004-05-12 | 2005-11-17 | Altenbach Robert J | Bicyclic-substituted amines having cyclic-substituted monocyclic substituents |
| US7098222B2 (en) * | 2004-05-12 | 2006-08-29 | Abbott Laboratories | Bicyclic-substituted amines having cyclic-substituted monocyclic substituents |
| US20060234911A1 (en) * | 2005-03-24 | 2006-10-19 | Hoffmann F M | Method of reversing epithelial mesenchymal transition |
| CN101330914A (zh) * | 2005-12-16 | 2008-12-24 | 爱尔康公司 | 使用alk5调节剂控制眼内压 |
| PL2044056T3 (pl) * | 2006-07-14 | 2013-01-31 | Novartis Ag | Pochodne pirymidyny jako inhibitory ALK-5 |
| US7524640B2 (en) * | 2006-08-06 | 2009-04-28 | Children's Medical Center Corporation | Inhibiting Smad2/3 signaling promotes neurite outgrowth in dorsal root ganglia |
-
2009
- 2009-05-29 US US12/474,370 patent/US20100087486A1/en not_active Abandoned
- 2009-05-29 EP EP09755769A patent/EP2285380A4/en not_active Withdrawn
- 2009-05-29 WO PCT/US2009/045607 patent/WO2009146408A1/en not_active Ceased
- 2009-05-29 CN CN2009801199382A patent/CN102083439A/zh active Pending
- 2009-05-29 JP JP2011511843A patent/JP2011521969A/ja active Pending
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