JP2011521652A5 - - Google Patents

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Publication number
JP2011521652A5
JP2011521652A5 JP2011511949A JP2011511949A JP2011521652A5 JP 2011521652 A5 JP2011521652 A5 JP 2011521652A5 JP 2011511949 A JP2011511949 A JP 2011511949A JP 2011511949 A JP2011511949 A JP 2011511949A JP 2011521652 A5 JP2011521652 A5 JP 2011521652A5
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JP
Japan
Prior art keywords
ana
rna
chemically modified
modified sirna
sense
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP2011511949A
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English (en)
Japanese (ja)
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JP2011521652A (ja
JP5684116B2 (ja
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Publication date
Priority claimed from CA002635187A external-priority patent/CA2635187A1/en
Priority claimed from PCT/CA2008/002259 external-priority patent/WO2009076775A1/en
Application filed filed Critical
Publication of JP2011521652A publication Critical patent/JP2011521652A/ja
Publication of JP2011521652A5 publication Critical patent/JP2011521652A5/ja
Application granted granted Critical
Publication of JP5684116B2 publication Critical patent/JP5684116B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2011511949A 2008-06-05 2009-06-05 Ｄｎａ様ヌクレオチドおよびｒｎａ様ヌクレオチドを含むオリゴヌクレオチド二重鎖およびその使用 Active JP5684116B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US5918608P 2008-06-05 2008-06-05
US61/059,186 2008-06-05
CA002635187A CA2635187A1 (en) 2008-06-05 2008-06-17 Oligonucleotide duplexes and uses thereof
CA2,635,187 2008-06-17
CAPCT/CA2008/002259 2008-12-19
PCT/CA2008/002259 WO2009076775A1 (en) 2007-12-19 2008-12-19 Immune response modulation and uses thereof
PCT/CA2009/000789 WO2009146556A1 (en) 2008-06-05 2009-06-05 Oligonucleotide duplexes comprising dna-like and rna-like nucleotides and uses thereof

Publications (3)

Publication Number Publication Date
JP2011521652A JP2011521652A (ja) 2011-07-28
JP2011521652A5 true JP2011521652A5 (enExample) 2014-08-28
JP5684116B2 JP5684116B2 (ja) 2015-03-11

Family

ID=41397419

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011511949A Active JP5684116B2 (ja) 2008-06-05 2009-06-05 Ｄｎａ様ヌクレオチドおよびｒｎａ様ヌクレオチドを含むオリゴヌクレオチド二重鎖およびその使用

Country Status (6)

Country Link
US (2) US9090649B2 (enExample)
EP (1) EP2294195B1 (enExample)
JP (1) JP5684116B2 (enExample)
CA (2) CA2635187A1 (enExample)
ES (1) ES2643576T3 (enExample)
WO (1) WO2009146556A1 (enExample)

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WO2008017473A2 (en) 2006-08-08 2008-02-14 Gunther Hartmann Structure and use of 5' phosphate oligonucleotides
JP5689413B2 (ja) 2008-05-21 2015-03-25 ライニッシュ フリードリッヒ−ウィルヘルムズ−ユニバーシタット ボン 平滑末端を有する５’三リン酸オリゴヌクレオチドおよびその使用
CA2635187A1 (en) 2008-06-05 2009-12-05 The Royal Institution For The Advancement Of Learning/Mcgill University Oligonucleotide duplexes and uses thereof
US9920317B2 (en) 2010-11-12 2018-03-20 The General Hospital Corporation Polycomb-associated non-coding RNAs
EP2638163B1 (en) 2010-11-12 2017-05-17 The General Hospital Corporation Polycomb-associated non-coding rnas
EP2508530A1 (en) 2011-03-28 2012-10-10 Rheinische Friedrich-Wilhelms-Universität Bonn Purification of triphosphorylated oligonucleotides using capture tags
HK1200484A1 (zh) 2011-09-14 2015-08-07 Translate Bio Ma, Inc. 多聚寡核苷酸化合物
US10174323B2 (en) 2012-05-16 2019-01-08 The General Hospital Corporation Compositions and methods for modulating ATP2A2 expression
AU2013262700A1 (en) 2012-05-16 2015-01-22 Rana Therapeutics, Inc. Compositions and methods for modulating hemoglobin gene family expression
US10058623B2 (en) 2012-05-16 2018-08-28 Translate Bio Ma, Inc. Compositions and methods for modulating UTRN expression
EP2850186B1 (en) 2012-05-16 2018-12-19 Translate Bio MA, Inc. Compositions and methods for modulating smn gene family expression
US10837014B2 (en) 2012-05-16 2020-11-17 Translate Bio Ma, Inc. Compositions and methods for modulating SMN gene family expression
CA2873779A1 (en) 2012-05-16 2013-11-21 Rana Therapeutics Inc. Compositions and methods for modulating mecp2 expression
WO2014043544A1 (en) 2012-09-14 2014-03-20 Rana Therapeutics, Inc. Multimeric oligonucleotide compounds
EP2712870A1 (en) 2012-09-27 2014-04-02 Rheinische Friedrich-Wilhelms-Universität Bonn Novel RIG-I ligands and methods for producing them
EP3052632A4 (en) 2013-10-04 2017-03-29 Rana Therapeutics, Inc. Compositions and methods for treating amyotrophic lateral sclerosis
US10858650B2 (en) 2014-10-30 2020-12-08 The General Hospital Corporation Methods for modulating ATRX-dependent gene repression
WO2016130943A1 (en) 2015-02-13 2016-08-18 Rana Therapeutics, Inc. Hybrid oligonucleotides and uses thereof
EP3271460A4 (en) 2015-03-17 2019-03-13 The General Hospital Corporation RNA INTERACTOM OF POLYCOMB REPRESSIVE COMPLEX 1 (PRC1)
US20230159922A1 (en) * 2019-08-15 2023-05-25 Ionis Pharmaceuticals, Inc. Modified oligomeric compounds and uses thereof

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US5703055A (en) * 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5539082A (en) * 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
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CA2635187A1 (en) 2008-06-05 2009-12-05 The Royal Institution For The Advancement Of Learning/Mcgill University Oligonucleotide duplexes and uses thereof

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