JP2011520434A5 - - Google Patents
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- JP2011520434A5 JP2011520434A5 JP2011507925A JP2011507925A JP2011520434A5 JP 2011520434 A5 JP2011520434 A5 JP 2011520434A5 JP 2011507925 A JP2011507925 A JP 2011507925A JP 2011507925 A JP2011507925 A JP 2011507925A JP 2011520434 A5 JP2011520434 A5 JP 2011520434A5
- Authority
- JP
- Japan
- Prior art keywords
- msc
- cells
- fgf
- csf
- exposing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims 12
- 102100037241 Endoglin Human genes 0.000 claims 9
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 9
- 101000881679 Homo sapiens Endoglin Proteins 0.000 claims 9
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 9
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims 7
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 6
- 210000005009 osteogenic cell Anatomy 0.000 claims 6
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims 5
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims 5
- 210000001185 bone marrow Anatomy 0.000 claims 5
- 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 claims 4
- 102000003971 Fibroblast Growth Factor 1 Human genes 0.000 claims 4
- 108090000378 Fibroblast growth factor 3 Proteins 0.000 claims 4
- 102100028043 Fibroblast growth factor 3 Human genes 0.000 claims 4
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 4
- 102100022464 5'-nucleotidase Human genes 0.000 claims 3
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 3
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 3
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims 3
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims 3
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims 3
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 3
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 3
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 3
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 3
- 102000003390 tumor necrosis factor Human genes 0.000 claims 3
- 108010047303 von Willebrand Factor Proteins 0.000 claims 3
- 102100036537 von Willebrand factor Human genes 0.000 claims 3
- 229960001134 von willebrand factor Drugs 0.000 claims 3
- 108010048154 Angiopoietin-1 Proteins 0.000 claims 2
- 102000009088 Angiopoietin-1 Human genes 0.000 claims 2
- 108010048036 Angiopoietin-2 Proteins 0.000 claims 2
- 102000009075 Angiopoietin-2 Human genes 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 108090000394 Erythropoietin Proteins 0.000 claims 2
- 102000003951 Erythropoietin Human genes 0.000 claims 2
- 102100039619 Granulocyte colony-stimulating factor Human genes 0.000 claims 2
- 101000746367 Homo sapiens Granulocyte colony-stimulating factor Proteins 0.000 claims 2
- 102100037850 Interferon gamma Human genes 0.000 claims 2
- 108010074328 Interferon-gamma Proteins 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 229940105423 erythropoietin Drugs 0.000 claims 2
- 230000003394 haemopoietic effect Effects 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 2
- 108010050904 Interferons Proteins 0.000 claims 1
- 102000014150 Interferons Human genes 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000002798 bone marrow cell Anatomy 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 210000003714 granulocyte Anatomy 0.000 claims 1
- 229940079322 interferon Drugs 0.000 claims 1
- 210000002540 macrophage Anatomy 0.000 claims 1
- 210000001616 monocyte Anatomy 0.000 claims 1
- 230000002188 osteogenic effect Effects 0.000 claims 1
- 230000001023 pro-angiogenic effect Effects 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08155764 | 2008-05-07 | ||
| EP08155764.7 | 2008-05-07 | ||
| PCT/EP2009/055549 WO2009135905A2 (en) | 2008-05-07 | 2009-05-07 | Novel mesenchymal stem cells and bone-forming cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016244344A Division JP2017099386A (ja) | 2008-05-07 | 2016-12-16 | 新規の間葉系幹細胞及び骨形成性細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011520434A JP2011520434A (ja) | 2011-07-21 |
| JP2011520434A5 true JP2011520434A5 (https=) | 2013-05-09 |
| JP6097479B2 JP6097479B2 (ja) | 2017-03-15 |
Family
ID=39769308
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011507925A Expired - Fee Related JP6097479B2 (ja) | 2008-05-07 | 2009-05-07 | 新規の間葉系幹細胞及び骨形成性細胞 |
| JP2016244344A Pending JP2017099386A (ja) | 2008-05-07 | 2016-12-16 | 新規の間葉系幹細胞及び骨形成性細胞 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016244344A Pending JP2017099386A (ja) | 2008-05-07 | 2016-12-16 | 新規の間葉系幹細胞及び骨形成性細胞 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US9371515B2 (https=) |
| EP (1) | EP2291516B1 (https=) |
| JP (2) | JP6097479B2 (https=) |
| KR (2) | KR20160065213A (https=) |
| CN (1) | CN102016008A (https=) |
| AU (1) | AU2009245751B2 (https=) |
| BE (1) | BE1018748A3 (https=) |
| CA (1) | CA2722625A1 (https=) |
| WO (1) | WO2009135905A2 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6097479B2 (ja) * | 2008-05-07 | 2017-03-15 | ボーン セラピューティクス エス．アー． | 新規の間葉系幹細胞及び骨形成性細胞 |
| US9192695B2 (en) | 2008-11-20 | 2015-11-24 | Allosource | Allografts combined with tissue derived stem cells for bone healing |
| JP2013528208A (ja) * | 2010-06-11 | 2013-07-08 | ユニバーシティ−インダストリー コーオペレーション グループ オブ キョン ヒ ユニバーシティ | サブスタンスｐを用いた骨形成剤及びその製造方法 |
| SI2785359T1 (sl) * | 2011-11-30 | 2018-11-30 | Astellas Institute For Regenerative Medicine | Mezenhimske stromalne celice in uporabe povezane z njimi |
| US8961956B2 (en) | 2011-11-30 | 2015-02-24 | Ocata Therapeutics, Inc. | Mesenchymal stromal cells and uses related thereto |
| HK1208054A1 (en) | 2012-07-12 | 2016-02-19 | 爱姆斯坦生物技术公司 | Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof |
| CN102827807B (zh) * | 2012-09-19 | 2014-04-16 | 北京京蒙高科干细胞技术有限公司 | 一种间充质干细胞无血清培养基 |
| WO2014113704A2 (en) * | 2013-01-18 | 2014-07-24 | Escape Therapeutics, Inc. | Enhanced differentiation of mesenchymal stem cells |
| CA2899713C (en) | 2013-03-15 | 2022-07-19 | Allosource | Cell repopulated collagen matrix for soft tissue repair and regeneration |
| KR101528305B1 (ko) * | 2013-06-25 | 2015-06-11 | 사회복지법인 삼성생명공익재단 | 중간엽 줄기세포로부터 유래된, 내피세포의 특성을 포함하는 신규한 줄기세포 |
| PT3083944T (pt) * | 2013-12-19 | 2021-02-17 | Univ Liege | Células estaminais derivadas de músculo de mamífero |
| US11433163B2 (en) * | 2014-04-10 | 2022-09-06 | Bonus Therapeutics Ltd. | Bone repair compositions |
| US11174461B2 (en) | 2016-03-16 | 2021-11-16 | Cynata Therapeutics Limited | Colony forming medium and use thereof |
| US11452796B2 (en) | 2017-06-30 | 2022-09-27 | Allosource | Cellular bone grafts, and methods of manufacture and use |
| BE1026600B1 (fr) * | 2018-09-25 | 2020-12-07 | Bone Therapeutics Sa | Procedes et utilisations pour determiner le potentiel osteogenique de cellules differenciees in vitro |
| AU2022391267A1 (en) * | 2021-11-18 | 2024-06-27 | National University Corporation Tokyo Medical And Dental University | Cell population comprising mesenchymal stem cells, cell sheet, and method for producing a cell sheet |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5837539A (en) | 1990-11-16 | 1998-11-17 | Osiris Therapeutics, Inc. | Monoclonal antibodies for human mesenchymal stem cells |
| US5811094A (en) | 1990-11-16 | 1998-09-22 | Osiris Therapeutics, Inc. | Connective tissue regeneration using human mesenchymal stem cell preparations |
| AU681879B2 (en) | 1993-03-29 | 1997-09-11 | Zymogenetics Inc. | Oesteoblast growth stimulating compostion containing PDGF and vitamin D |
| US5972703A (en) | 1994-08-12 | 1999-10-26 | The Regents Of The University Of Michigan | Bone precursor cells: compositions and methods |
| US5736396A (en) | 1995-01-24 | 1998-04-07 | Case Western Reserve University | Lineage-directed induction of human mesenchymal stem cell differentiation |
| US5827740A (en) | 1996-07-30 | 1998-10-27 | Osiris Therapeutics, Inc. | Adipogenic differentiation of human mesenchymal stem cells |
| WO2000007639A1 (en) | 1998-08-07 | 2000-02-17 | Tissue Engineering, Inc. | Bone precursor compositions |
| EP1099754A1 (en) * | 1999-11-10 | 2001-05-16 | Universiteit Leiden | Mesenchymal stem cells and/or progenitor cells, their isolation and use |
| US20030032034A1 (en) * | 2001-03-05 | 2003-02-13 | Tang Y. Tom | Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides |
| DE10158680B4 (de) * | 2001-11-30 | 2004-04-08 | Universitätsklinikum Hamburg-Eppendorf | Verfahren zur ex vivo-Expansion und -Differenzierung von multipotenten Stammzellen |
| US20050019910A1 (en) * | 2001-12-13 | 2005-01-27 | Mutsumi Takagi | Human cell culture medium and culture method |
| US7470538B2 (en) | 2002-12-05 | 2008-12-30 | Case Western Reserve University | Cell-based therapies for ischemia |
| WO2005007799A2 (en) * | 2003-07-17 | 2005-01-27 | Gamida-Cell Ltd. | Methods for ex-vivo expanding stem/progenitor cells |
| WO2005035738A1 (en) * | 2003-10-07 | 2005-04-21 | Biomaster Inc. | Cell differentiation of adipose-derived precursor cells |
| JP2005287479A (ja) | 2004-03-31 | 2005-10-20 | Kazuhisa Maeda | 組織幹細胞採取方法及びそれを利用した装置 |
| WO2006062989A1 (en) * | 2004-12-07 | 2006-06-15 | Bacterin International, Inc. | Three-dimensional cell culsture system |
| JP2006230316A (ja) * | 2005-02-25 | 2006-09-07 | Japan Health Science Foundation | 瘢痕のない創傷治癒能を有する細胞およびその調製方法 |
| WO2006134951A1 (ja) * | 2005-06-13 | 2006-12-21 | Biomaster, Inc. | 脂肪由来幹細胞の長期培養増殖法 |
| WO2007044418A2 (en) * | 2005-10-06 | 2007-04-19 | Moscatello David K | Cell culture media, kits and methods of use |
| CZ301148B6 (cs) * | 2006-01-25 | 2009-11-18 | Univerzita Karlova V Praze | Zpusob pestování lidských mezenchymových kmenových bunek, zejména pro lécbu nehojících se fraktur, a bioreaktor k provádení tohoto zpusobu |
| CA2640794C (en) * | 2006-02-16 | 2015-04-14 | Universite Libre De Bruxelles | A method for osteogenic differentiation of bone marrow stem cells (bmsc) and uses thereof |
| JP5155530B2 (ja) * | 2006-07-25 | 2013-03-06 | 株式会社カネカ | 成体幹細胞分離・培養システム |
| WO2008018190A1 (en) * | 2006-08-09 | 2008-02-14 | Biomaster, Inc. | Fat-derived neural crest cells |
| JP6097479B2 (ja) * | 2008-05-07 | 2017-03-15 | ボーン セラピューティクス エス．アー． | 新規の間葉系幹細胞及び骨形成性細胞 |
-
2009
- 2009-05-07 JP JP2011507925A patent/JP6097479B2/ja not_active Expired - Fee Related
- 2009-05-07 KR KR1020167013649A patent/KR20160065213A/ko not_active Ceased
- 2009-05-07 BE BE2009/0286A patent/BE1018748A3/fr not_active IP Right Cessation
- 2009-05-07 US US12/991,120 patent/US9371515B2/en active Active
- 2009-05-07 CN CN2009801164561A patent/CN102016008A/zh active Pending
- 2009-05-07 WO PCT/EP2009/055549 patent/WO2009135905A2/en not_active Ceased
- 2009-05-07 KR KR20107027373A patent/KR20110013450A/ko not_active Ceased
- 2009-05-07 CA CA 2722625 patent/CA2722625A1/en not_active Abandoned
- 2009-05-07 EP EP09742123.4A patent/EP2291516B1/en active Active
- 2009-05-07 AU AU2009245751A patent/AU2009245751B2/en not_active Ceased
-
2013
- 2013-03-12 US US13/797,179 patent/US20140093480A1/en not_active Abandoned
-
2016
- 2016-12-16 JP JP2016244344A patent/JP2017099386A/ja active Pending
-
2017
- 2017-05-07 US US15/588,693 patent/US20170290859A1/en not_active Abandoned
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