JP2011509656A5 - - Google Patents
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- Publication number
- JP2011509656A5 JP2011509656A5 JP2010541790A JP2010541790A JP2011509656A5 JP 2011509656 A5 JP2011509656 A5 JP 2011509656A5 JP 2010541790 A JP2010541790 A JP 2010541790A JP 2010541790 A JP2010541790 A JP 2010541790A JP 2011509656 A5 JP2011509656 A5 JP 2011509656A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- cell population
- cell
- tgfb
- fgf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000004027 cell Anatomy 0.000 claims 24
- 238000000034 method Methods 0.000 claims 10
- 210000000963 osteoblast Anatomy 0.000 claims 10
- 210000004663 osteoprogenitor cell Anatomy 0.000 claims 6
- 102000018233 Fibroblast Growth Factor Human genes 0.000 claims 4
- 108050007372 Fibroblast Growth Factor Proteins 0.000 claims 4
- 229940126864 fibroblast growth factor Drugs 0.000 claims 4
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 4
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims 3
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims 3
- 206010061728 Bone lesion Diseases 0.000 claims 3
- 101000635938 Homo sapiens Transforming growth factor beta-1 proprotein Proteins 0.000 claims 3
- 102100030742 Transforming growth factor beta-1 proprotein Human genes 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 102000004067 Osteocalcin Human genes 0.000 claims 2
- 108090000573 Osteocalcin Proteins 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 102100022464 5'-nucleotidase Human genes 0.000 claims 1
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 1
- 102100024210 CD166 antigen Human genes 0.000 claims 1
- 102100025222 CD63 antigen Human genes 0.000 claims 1
- 102100037241 Endoglin Human genes 0.000 claims 1
- 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 claims 1
- 102000003971 Fibroblast Growth Factor 1 Human genes 0.000 claims 1
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 1
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims 1
- 108090000378 Fibroblast growth factor 3 Proteins 0.000 claims 1
- 102100028043 Fibroblast growth factor 3 Human genes 0.000 claims 1
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 1
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 1
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims 1
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 1
- 101000980840 Homo sapiens CD166 antigen Proteins 0.000 claims 1
- 101000934368 Homo sapiens CD63 antigen Proteins 0.000 claims 1
- 101000881679 Homo sapiens Endoglin Proteins 0.000 claims 1
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims 1
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 1
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims 1
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 1
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 1
- 239000000853 adhesive Substances 0.000 claims 1
- 230000001070 adhesive effect Effects 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 210000005087 mononuclear cell Anatomy 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08000458.3 | 2008-01-11 | ||
| EP08000458 | 2008-01-11 | ||
| PCT/EP2009/050209 WO2009087213A1 (en) | 2008-01-11 | 2009-01-09 | Osteogenic differentiation of bone marrow stem cells and mesenchymal stem cells using a combination of growth factors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011509656A JP2011509656A (ja) | 2011-03-31 |
| JP2011509656A5 true JP2011509656A5 (https=) | 2013-02-14 |
| JP5524079B2 JP5524079B2 (ja) | 2014-06-18 |
Family
ID=39415339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010541790A Expired - Fee Related JP5524079B2 (ja) | 2008-01-11 | 2009-01-09 | 成長因子の組合せを使用する骨髄幹細胞及び間葉系幹細胞の骨形成分化 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20100278788A1 (https=) |
| EP (1) | EP2229433B1 (https=) |
| JP (1) | JP5524079B2 (https=) |
| KR (3) | KR20100126680A (https=) |
| CN (2) | CN101945993A (https=) |
| AU (2) | AU2009203682B2 (https=) |
| CA (1) | CA2710571C (https=) |
| DK (1) | DK2229433T3 (https=) |
| ES (1) | ES2650235T3 (https=) |
| NO (1) | NO2229433T3 (https=) |
| PL (1) | PL2229433T3 (https=) |
| PT (1) | PT2229433T (https=) |
| WO (1) | WO2009087213A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104357381A (zh) * | 2008-10-31 | 2015-02-18 | 辛西斯有限责任公司 | 用于活化干细胞的方法和装置 |
| EP2686418A4 (en) | 2011-03-17 | 2015-04-22 | Minerva Biotechnologies Corp | METHOD FOR THE PRODUCTION OF PLURIPOTENTAL STEM CELLS |
| WO2013053722A1 (en) | 2011-10-11 | 2013-04-18 | Bone Therapeutics S.A. | Uses of growth and differentiation factor 8 (gdf-8) |
| EP2768945B1 (en) * | 2011-10-17 | 2022-01-05 | Minerva Biotechnologies Corporation | Media for stem cell proliferation and induction |
| BR112017022656A2 (pt) * | 2015-04-23 | 2018-07-17 | Bone Therapeutics Sa | conservação in vitro de células terapêuticas |
| JP6890138B2 (ja) * | 2016-07-21 | 2021-06-18 | サンバイオ，インコーポレイティド | Ｍｓｃ成長予測因子アッセイ |
| KR102185697B1 (ko) * | 2017-10-20 | 2020-12-03 | 본 테라퓨틱스 소시에테아노님 | 중간엽 줄기 세포의 분화 방법 |
| AU2019345976A1 (en) * | 2018-09-25 | 2021-05-20 | Bone Therapeutics Sa | Methods for differentiating mesenchymal stem cells |
| KR20210076018A (ko) * | 2018-09-25 | 2021-06-23 | 본 테라퓨틱스 소시에테아노님 | 체외 분화 세포의 골형성능을 판정하기 위한 방법 및 용도 |
| CN111357990A (zh) * | 2019-12-26 | 2020-07-03 | 浙江欧谱生物科技有限公司 | 增加骨量的保健食品组合物及其应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5811094A (en) * | 1990-11-16 | 1998-09-22 | Osiris Therapeutics, Inc. | Connective tissue regeneration using human mesenchymal stem cell preparations |
| US5837539A (en) * | 1990-11-16 | 1998-11-17 | Osiris Therapeutics, Inc. | Monoclonal antibodies for human mesenchymal stem cells |
| US5486359A (en) * | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5972703A (en) * | 1994-08-12 | 1999-10-26 | The Regents Of The University Of Michigan | Bone precursor cells: compositions and methods |
| US5736396A (en) * | 1995-01-24 | 1998-04-07 | Case Western Reserve University | Lineage-directed induction of human mesenchymal stem cell differentiation |
| US5827740A (en) * | 1996-07-30 | 1998-10-27 | Osiris Therapeutics, Inc. | Adipogenic differentiation of human mesenchymal stem cells |
| WO1998033515A1 (en) * | 1997-02-05 | 1998-08-06 | Case Western Reserve University | STIMULATORY EFFECTS OF bFGF AND BMP-2 ON OSTEOGENIC DIFFERENTIATION OF MESENCHYMAL STEM CELLS |
| WO2005032344A2 (en) * | 2003-10-02 | 2005-04-14 | The Regents Of The University Of Michigan | Human prostate cancer cell factor(s) that induce stem cell commitment and osteogenesis |
| JP2006346420A (ja) * | 2005-06-13 | 2006-12-28 | Univ Nagoya | 移植材料及び骨質改善剤 |
| WO2007002210A2 (en) * | 2005-06-20 | 2007-01-04 | Bresagen, Inc. | Embryonic stem cell culture compositions and methods of use thereof |
| TW200726474A (en) * | 2005-07-15 | 2007-07-16 | Cognate Therapeutics Inc | The immunophenotype and immunogenicity of human adipose derived cells |
| CA2640794C (en) * | 2006-02-16 | 2015-04-14 | Universite Libre De Bruxelles | A method for osteogenic differentiation of bone marrow stem cells (bmsc) and uses thereof |
-
2008
- 2008-01-01 US US12/811,724 patent/US20100278788A1/en not_active Abandoned
-
2009
- 2009-01-09 KR KR20107017785A patent/KR20100126680A/ko not_active Ceased
- 2009-01-09 AU AU2009203682A patent/AU2009203682B2/en not_active Ceased
- 2009-01-09 ES ES09700353.7T patent/ES2650235T3/es active Active
- 2009-01-09 DK DK09700353.7T patent/DK2229433T3/da active
- 2009-01-09 KR KR1020167008084A patent/KR101920128B1/ko not_active Expired - Fee Related
- 2009-01-09 JP JP2010541790A patent/JP5524079B2/ja not_active Expired - Fee Related
- 2009-01-09 PL PL09700353T patent/PL2229433T3/pl unknown
- 2009-01-09 PT PT97003537T patent/PT2229433T/pt unknown
- 2009-01-09 CN CN2009801051722A patent/CN101945993A/zh active Pending
- 2009-01-09 KR KR1020187021254A patent/KR20180086305A/ko not_active Ceased
- 2009-01-09 CN CN201410427665.0A patent/CN104250633A/zh active Pending
- 2009-01-09 WO PCT/EP2009/050209 patent/WO2009087213A1/en not_active Ceased
- 2009-01-09 EP EP09700353.7A patent/EP2229433B1/en active Active
- 2009-01-09 NO NO09700353A patent/NO2229433T3/no unknown
- 2009-01-09 CA CA2710571A patent/CA2710571C/en active Active
-
2013
- 2013-03-13 US US13/802,602 patent/US20130266544A1/en not_active Abandoned
-
2014
- 2014-07-17 AU AU2014204491A patent/AU2014204491B2/en not_active Ceased
-
2020
- 2020-07-14 US US16/929,042 patent/US20200407688A1/en not_active Abandoned
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