DK2229433T3 - Osteogen differentiering af knoglemarvsstamceller og mesenkymale stamceller under anvendelse af en kombination af vækstfaktorer - Google Patents

Osteogen differentiering af knoglemarvsstamceller og mesenkymale stamceller under anvendelse af en kombination af vækstfaktorer

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Publication number
DK2229433T3
DK2229433T3 DK09700353.7T DK09700353T DK2229433T3 DK 2229433 T3 DK2229433 T3 DK 2229433T3 DK 09700353 T DK09700353 T DK 09700353T DK 2229433 T3 DK2229433 T3 DK 2229433T3
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DK
Denmark
Prior art keywords
stem cells
mesenkymal
differentizing
osteogen
combination
Prior art date
Application number
DK09700353.7T
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Danish (da)
English (en)
Inventor
Enrico Bastianelli
Xavier Pesesse
Cindy Badoer
Original Assignee
Bone Therapeutics Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bone Therapeutics Sa filed Critical Bone Therapeutics Sa
Application granted granted Critical
Publication of DK2229433T3 publication Critical patent/DK2229433T3/da

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0664—Dental pulp stem cells, Dental follicle stem cells
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
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    • C12N5/0662—Stem cells
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    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
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    • C12N5/0688—Cells from the lungs or the respiratory tract
    • C12N5/0689—Stem cells; Progenitors
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells

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DK09700353.7T 2008-01-11 2009-01-09 Osteogen differentiering af knoglemarvsstamceller og mesenkymale stamceller under anvendelse af en kombination af vækstfaktorer DK2229433T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08000458 2008-01-11
PCT/EP2009/050209 WO2009087213A1 (en) 2008-01-11 2009-01-09 Osteogenic differentiation of bone marrow stem cells and mesenchymal stem cells using a combination of growth factors

Publications (1)

Publication Number Publication Date
DK2229433T3 true DK2229433T3 (da) 2017-11-13

Family

ID=39415339

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DK09700353.7T DK2229433T3 (da) 2008-01-11 2009-01-09 Osteogen differentiering af knoglemarvsstamceller og mesenkymale stamceller under anvendelse af en kombination af vækstfaktorer

Country Status (13)

Country Link
US (3) US20100278788A1 (https=)
EP (1) EP2229433B1 (https=)
JP (1) JP5524079B2 (https=)
KR (3) KR20100126680A (https=)
CN (2) CN101945993A (https=)
AU (2) AU2009203682B2 (https=)
CA (1) CA2710571C (https=)
DK (1) DK2229433T3 (https=)
ES (1) ES2650235T3 (https=)
NO (1) NO2229433T3 (https=)
PL (1) PL2229433T3 (https=)
PT (1) PT2229433T (https=)
WO (1) WO2009087213A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104357381A (zh) * 2008-10-31 2015-02-18 辛西斯有限责任公司 用于活化干细胞的方法和装置
EP2686418A4 (en) 2011-03-17 2015-04-22 Minerva Biotechnologies Corp METHOD FOR THE PRODUCTION OF PLURIPOTENTAL STEM CELLS
WO2013053722A1 (en) 2011-10-11 2013-04-18 Bone Therapeutics S.A. Uses of growth and differentiation factor 8 (gdf-8)
EP2768945B1 (en) * 2011-10-17 2022-01-05 Minerva Biotechnologies Corporation Media for stem cell proliferation and induction
BR112017022656A2 (pt) * 2015-04-23 2018-07-17 Bone Therapeutics Sa conservação in vitro de células terapêuticas
JP6890138B2 (ja) * 2016-07-21 2021-06-18 サンバイオ，インコーポレイティド Ｍｓｃ成長予測因子アッセイ
KR102185697B1 (ko) * 2017-10-20 2020-12-03 본 테라퓨틱스 소시에테아노님 중간엽 줄기 세포의 분화 방법
AU2019345976A1 (en) * 2018-09-25 2021-05-20 Bone Therapeutics Sa Methods for differentiating mesenchymal stem cells
KR20210076018A (ko) * 2018-09-25 2021-06-23 본 테라퓨틱스 소시에테아노님 체외 분화 세포의 골형성능을 판정하기 위한 방법 및 용도
CN111357990A (zh) * 2019-12-26 2020-07-03 浙江欧谱生物科技有限公司 增加骨量的保健食品组合物及其应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811094A (en) * 1990-11-16 1998-09-22 Osiris Therapeutics, Inc. Connective tissue regeneration using human mesenchymal stem cell preparations
US5837539A (en) * 1990-11-16 1998-11-17 Osiris Therapeutics, Inc. Monoclonal antibodies for human mesenchymal stem cells
US5486359A (en) * 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5972703A (en) * 1994-08-12 1999-10-26 The Regents Of The University Of Michigan Bone precursor cells: compositions and methods
US5736396A (en) * 1995-01-24 1998-04-07 Case Western Reserve University Lineage-directed induction of human mesenchymal stem cell differentiation
US5827740A (en) * 1996-07-30 1998-10-27 Osiris Therapeutics, Inc. Adipogenic differentiation of human mesenchymal stem cells
WO1998033515A1 (en) * 1997-02-05 1998-08-06 Case Western Reserve University STIMULATORY EFFECTS OF bFGF AND BMP-2 ON OSTEOGENIC DIFFERENTIATION OF MESENCHYMAL STEM CELLS
WO2005032344A2 (en) * 2003-10-02 2005-04-14 The Regents Of The University Of Michigan Human prostate cancer cell factor(s) that induce stem cell commitment and osteogenesis
JP2006346420A (ja) * 2005-06-13 2006-12-28 Univ Nagoya 移植材料及び骨質改善剤
WO2007002210A2 (en) * 2005-06-20 2007-01-04 Bresagen, Inc. Embryonic stem cell culture compositions and methods of use thereof
TW200726474A (en) * 2005-07-15 2007-07-16 Cognate Therapeutics Inc The immunophenotype and immunogenicity of human adipose derived cells
CA2640794C (en) * 2006-02-16 2015-04-14 Universite Libre De Bruxelles A method for osteogenic differentiation of bone marrow stem cells (bmsc) and uses thereof

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Publication number Publication date
CA2710571A1 (en) 2009-07-16
US20200407688A1 (en) 2020-12-31
EP2229433B1 (en) 2017-09-20
JP5524079B2 (ja) 2014-06-18
KR20160039699A (ko) 2016-04-11
JP2011509656A (ja) 2011-03-31
US20130266544A1 (en) 2013-10-10
KR20180086305A (ko) 2018-07-30
AU2014204491B2 (en) 2016-03-24
AU2014204491A1 (en) 2014-08-07
KR20100126680A (ko) 2010-12-02
ES2650235T3 (es) 2018-01-17
US20100278788A1 (en) 2010-11-04
PT2229433T (pt) 2017-12-12
CA2710571C (en) 2017-11-07
NO2229433T3 (https=) 2018-02-17
CN104250633A (zh) 2014-12-31
CN101945993A (zh) 2011-01-12
AU2009203682A1 (en) 2009-07-16
PL2229433T3 (pl) 2018-01-31
WO2009087213A1 (en) 2009-07-16
EP2229433A1 (en) 2010-09-22
KR101920128B1 (ko) 2018-11-19
AU2009203682B2 (en) 2014-07-03

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