JP2011519847A5 - - Google Patents
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- Publication number
- JP2011519847A5 JP2011519847A5 JP2011506772A JP2011506772A JP2011519847A5 JP 2011519847 A5 JP2011519847 A5 JP 2011519847A5 JP 2011506772 A JP2011506772 A JP 2011506772A JP 2011506772 A JP2011506772 A JP 2011506772A JP 2011519847 A5 JP2011519847 A5 JP 2011519847A5
- Authority
- JP
- Japan
- Prior art keywords
- support
- product
- antigen
- cell
- immunostimulant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 36
- 239000000427 antigen Substances 0.000 claims 27
- 102000036639 antigens Human genes 0.000 claims 27
- 108091007433 antigens Proteins 0.000 claims 27
- 230000003308 immunostimulating effect Effects 0.000 claims 20
- 210000003719 b-lymphocyte Anatomy 0.000 claims 16
- 229960001438 immunostimulant agent Drugs 0.000 claims 16
- 239000003022 immunostimulating agent Substances 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 13
- 210000004027 cell Anatomy 0.000 claims 9
- 239000003795 chemical substances by application Substances 0.000 claims 9
- 238000004519 manufacturing process Methods 0.000 claims 9
- 230000001404 mediated effect Effects 0.000 claims 6
- 230000028993 immune response Effects 0.000 claims 5
- 239000002245 particle Substances 0.000 claims 5
- 238000002360 preparation method Methods 0.000 claims 5
- 108010001441 Phosphopeptides Proteins 0.000 claims 4
- 230000002708 enhancing effect Effects 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 210000002966 serum Anatomy 0.000 claims 4
- 208000023275 Autoimmune disease Diseases 0.000 claims 3
- 208000035473 Communicable disease Diseases 0.000 claims 3
- 206010020751 Hypersensitivity Diseases 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 239000000556 agonist Substances 0.000 claims 3
- 230000007815 allergy Effects 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 3
- 230000003844 B-cell-activation Effects 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 210000004443 dendritic cell Anatomy 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 150000002632 lipids Chemical group 0.000 claims 2
- 239000002502 liposome Substances 0.000 claims 2
- 210000004698 lymphocyte Anatomy 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000000638 stimulation Effects 0.000 claims 2
- VQFKFAKEUMHBLV-BYSUZVQFSA-N 1-O-(alpha-D-galactosyl)-N-hexacosanoylphytosphingosine Chemical group CCCCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@H]([C@H](O)[C@H](O)CCCCCCCCCCCCCC)CO[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQFKFAKEUMHBLV-BYSUZVQFSA-N 0.000 claims 1
- HOMYIYLRRDTKAA-UHFFFAOYSA-N 2-hydroxy-N-[3-hydroxy-1-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctadeca-4,8-dien-2-yl]hexadecanamide Chemical compound CCCCCCCCCCCCCCC(O)C(=O)NC(C(O)C=CCCC=CCCCCCCCCC)COC1OC(CO)C(O)C(O)C1O HOMYIYLRRDTKAA-UHFFFAOYSA-N 0.000 claims 1
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 claims 1
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims 1
- 101150013553 CD40 gene Proteins 0.000 claims 1
- 229940046168 CpG oligodeoxynucleotide Drugs 0.000 claims 1
- UNXHWFMMPAWVPI-QWWZWVQMSA-N D-threitol Chemical compound OC[C@@H](O)[C@H](O)CO UNXHWFMMPAWVPI-QWWZWVQMSA-N 0.000 claims 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims 1
- 229930186217 Glycolipid Natural products 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 230000020411 cell activation Effects 0.000 claims 1
- 230000036755 cellular response Effects 0.000 claims 1
- 229940106189 ceramide Drugs 0.000 claims 1
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 230000005847 immunogenicity Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 210000000581 natural killer T-cell Anatomy 0.000 claims 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims 1
- 229940046166 oligodeoxynucleotide Drugs 0.000 claims 1
- 150000003019 phosphosphingolipids Chemical group 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 230000009466 transformation Effects 0.000 claims 1
- 230000001131 transforming effect Effects 0.000 claims 1
- 238000002255 vaccination Methods 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4981408P | 2008-05-02 | 2008-05-02 | |
| US61/049,814 | 2008-05-02 | ||
| PCT/GB2009/001111 WO2009133378A2 (en) | 2008-05-02 | 2009-05-05 | Products and methods for stimulating an immune response |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014160906A Division JP2015028023A (ja) | 2008-05-02 | 2014-08-07 | 免疫応答を刺激するための作製物および方法 |
| JP2014160907A Division JP5853068B2 (ja) | 2008-05-02 | 2014-08-07 | 免疫応答を刺激するための作製物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011519847A JP2011519847A (ja) | 2011-07-14 |
| JP2011519847A5 true JP2011519847A5 (https=) | 2012-06-07 |
| JP5721620B2 JP5721620B2 (ja) | 2015-05-20 |
Family
ID=40888253
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011506772A Expired - Fee Related JP5721620B2 (ja) | 2008-05-02 | 2009-05-05 | 免疫応答を刺激するための作製物および方法 |
| JP2014160906A Pending JP2015028023A (ja) | 2008-05-02 | 2014-08-07 | 免疫応答を刺激するための作製物および方法 |
| JP2014160907A Expired - Fee Related JP5853068B2 (ja) | 2008-05-02 | 2014-08-07 | 免疫応答を刺激するための作製物および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014160906A Pending JP2015028023A (ja) | 2008-05-02 | 2014-08-07 | 免疫応答を刺激するための作製物および方法 |
| JP2014160907A Expired - Fee Related JP5853068B2 (ja) | 2008-05-02 | 2014-08-07 | 免疫応答を刺激するための作製物および方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20110280930A1 (https=) |
| EP (3) | EP2711021B1 (https=) |
| JP (3) | JP5721620B2 (https=) |
| CN (1) | CN102170903B (https=) |
| AU (1) | AU2009241645B2 (https=) |
| CA (1) | CA2723226A1 (https=) |
| ES (1) | ES2570973T3 (https=) |
| WO (1) | WO2009133378A2 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2711021B1 (en) * | 2008-05-02 | 2016-03-09 | BliNK Therapeutics Limited | Products and methods for stimulating an immune response |
| WO2012088414A1 (en) * | 2010-12-23 | 2012-06-28 | Ludwig Institute For Cancer Research Ltd. | Liposomal formulation of nonglycosidic ceramides and uses thereof |
| US9675561B2 (en) | 2011-04-28 | 2017-06-13 | President And Fellows Of Harvard College | Injectable cryogel vaccine devices and methods of use thereof |
| EP2714017B1 (en) | 2011-06-02 | 2018-08-01 | The Regents of The University of California | Membrane encapsulated nanoparticles and method of use |
| TW201442739A (zh) * | 2013-02-27 | 2014-11-16 | Riken | 過敏疾病治療藥 |
| GB2514591A (en) | 2013-05-30 | 2014-12-03 | Mologen Ag | Predictive biomarker for cancer therapy |
| EP3024936B1 (en) | 2013-07-25 | 2019-09-04 | Exicure, Inc. | Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use |
| WO2015021390A2 (en) | 2013-08-08 | 2015-02-12 | The Regents Of The University Of California | Nanoparticles leverage biological membranes to target pathogens for disease treatment and diagnosis |
| US20170000875A1 (en) * | 2013-12-02 | 2017-01-05 | Arytha Biosciences, Llc | Toxoid preparation and uses thereof |
| CN106163504B (zh) | 2014-03-20 | 2021-02-09 | 加利福尼亚大学董事会 | 水凝胶毒素-吸收或结合纳米颗粒 |
| EP3137105A4 (en) | 2014-04-30 | 2017-12-27 | President and Fellows of Harvard College | Combination vaccine devices and methods of killing cancer cells |
| TR201908550T4 (tr) * | 2014-06-04 | 2019-07-22 | Exicure Inc | Profilaktik veya terapötik uygulamalar için lipozomal sferik nükleik asitler tarafından immün modülatörlerin çok değerlikli teslimi. |
| WO2016164705A1 (en) * | 2015-04-10 | 2016-10-13 | Omar Abdel-Rahman Ali | Immune cell trapping devices and methods for making and using the same |
| WO2016176041A1 (en) | 2015-04-29 | 2016-11-03 | The Regents Of The University Of California | Detoxification using nanoparticles |
| JP2018516996A (ja) * | 2015-06-10 | 2018-06-28 | ウニヴェルズィテート・デ・ザールラントＵｎｉｖｅｒｓｉｔａｅｔ Ｄｅｓ Ｓａａｒｌａｎｄｅｓ | Ｂ細胞悪性腫瘍を処置するための手段および方法 |
| US11752238B2 (en) | 2016-02-06 | 2023-09-12 | President And Fellows Of Harvard College | Recapitulating the hematopoietic niche to reconstitute immunity |
| WO2017211314A1 (en) | 2016-06-08 | 2017-12-14 | Kei International Limited | Method for detecting presence of mycobacterial material in sample using immobilised mannosyl phosphoketide antigen |
| NL2017204B1 (en) | 2016-06-08 | 2017-12-18 | Kei International Ltd | Solid substrate comprising antigens immobilised thereto, biosensor comprising said solid substrate and method for detecting the presence of mycobacterial material in a sample |
| CN109789092A (zh) | 2016-07-13 | 2019-05-21 | 哈佛学院院长等 | 抗原呈递细胞模拟支架及其制备和使用方法 |
| IL264557B2 (en) | 2016-08-02 | 2024-01-01 | Harvard College | Biological agents for regulating immune responses |
| US20190365657A1 (en) * | 2016-08-17 | 2019-12-05 | Orbis Health Solutions, Llc | Tumor-targeting bead vectors and methods of using the same |
| WO2019032862A1 (en) * | 2017-08-10 | 2019-02-14 | Dana-Farber Cancer Institute, Inc. | CELLS EXPRESSING LMP1 AND METHODS OF USE |
| NL2021443B1 (en) | 2018-08-08 | 2020-02-20 | Kei International Ltd | Synthetic antigens for tuberculosis detection |
| WO2020061129A1 (en) | 2018-09-19 | 2020-03-26 | President And Fellows Of Harvard College | Compositions and methods for labeling and modulation of cells in vitro and in vivo |
| EP3650466A1 (en) * | 2018-11-12 | 2020-05-13 | Consejo Superior De Investigaciones Científicas | In vitro production of high affinity monoclonal antibodies |
| CN111229023B (zh) * | 2018-11-29 | 2022-01-28 | 内蒙古东盛硅藻土科技创新产业园有限公司 | 一种化学降解添加剂 |
| WO2021061837A1 (en) | 2019-09-23 | 2021-04-01 | President And Fellows Of Harvard College | Biomaterial-based antigen free vaccine and the use thereof |
| CN112300987B (zh) * | 2020-10-16 | 2022-04-29 | 中国农业大学 | 单个浆细胞的筛选方法及其在小分子单克隆抗体制备中的应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK590288D0 (da) | 1988-10-24 | 1988-10-24 | Symbicom Ab | Kemiske forbindelser |
| DK0506868T4 (da) | 1989-12-22 | 2004-04-26 | Mikrogen Molekularbiol Entw | Immunologisk aktive proteiner fra Borrelia burgdorferi, tilhørende testkits og vaccine |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| FI933580A7 (fi) | 1991-02-15 | 1993-10-13 | Uab Research Foundation | Pneumokokkiproteiinin rakennegeeni |
| US6113914A (en) | 1991-08-15 | 2000-09-05 | Smithkline Beecham Biologicals (S.A.) | Osp A proteins of Borrelia burgdorferi subgroups, encoding genes and vaccines |
| ES2194010T3 (es) | 1991-10-22 | 2003-11-16 | Symbicom Ab | Mejoras en el diagnostico y profilaxis de la borrelia burgdorferi. |
| US5776427A (en) | 1992-03-05 | 1998-07-07 | Board Of Regents, The University Of Texas System | Methods for targeting the vasculature of solid tumors |
| US6004763A (en) * | 1992-09-11 | 1999-12-21 | Institut Pasteur | Antigen-carrying microparticles and their use in the induction of humoral or cellular responses |
| FR2695563B1 (fr) * | 1992-09-11 | 1994-12-02 | Pasteur Institut | Microparticules portant des antigènes et leur utilisation pour l'induction de réponses humorales ou cellulaires. |
| EP0773993A4 (en) | 1994-08-19 | 2000-07-05 | Gen Hospital Corp | PORCINE CELLS TREATED BY GENETIC ENGINEERING |
| EP1434859A2 (en) | 2001-07-25 | 2004-07-07 | New York University | Use of glycosylceramides as adjuvants for vaccines against infections and cancer |
| DE10164309A1 (de) * | 2001-12-28 | 2003-07-10 | Fraunhofer Ges Forschung | Verbesserte strukturiert-funktionale Bindematrices für Biomoleküle |
| CN100455600C (zh) * | 2002-08-14 | 2009-01-28 | 阿维迪斯公司 | 包含支架,佐剂和抗原的异源多聚体化合物及其用途 |
| AU2004215125B2 (en) | 2003-02-26 | 2011-01-06 | Institute For Research In Biomedicine | Monoclonal antibody production by EBV transformation of B cells |
| US20050175583A1 (en) * | 2003-12-02 | 2005-08-11 | Lawrence Tamarkin | Methods and compositions for the production of monoclonal antibodies |
| EP1767216B1 (en) | 2004-06-11 | 2012-07-11 | Riken | Drug having regulatory cell ligand contained in liposome |
| JP4987704B2 (ja) * | 2004-07-07 | 2012-07-25 | スタテンス セールム インスティトゥート | 糖脂質を用いた、脂質系アジュバント製剤を安定化する組成物及び方法 |
| EP1793863B1 (en) * | 2004-10-01 | 2017-04-12 | Midatech Ltd. | Nanoparticles comprising antigens and adjuvants capable of stimulating t helper cells |
| US20080138431A1 (en) * | 2005-03-02 | 2008-06-12 | James Edward Eyles | Pharmaceutical Composition |
| BRPI0617687A2 (pt) | 2005-10-25 | 2011-08-02 | Ludwig Inst Cancer Res | composto, método para proteger um indivìduo mamìfero contra, ou tratar, um vìrus, infecção microbiana, parasita, uma doença auto-imune, cáncer, alergia ou asma, e, composição farmacêutica |
| WO2007051004A2 (en) | 2005-10-28 | 2007-05-03 | The Brigham And Women's Hospital, Inc. | Conjugate vaccines for non-proteinaceous antigens |
| US20070231344A1 (en) | 2005-10-28 | 2007-10-04 | The Brigham And Women's Hospital, Inc. | Conjugate vaccines for non-proteinaceous antigens |
| EP2711021B1 (en) * | 2008-05-02 | 2016-03-09 | BliNK Therapeutics Limited | Products and methods for stimulating an immune response |
| JP5782775B2 (ja) | 2011-03-29 | 2015-09-24 | ソニー株式会社 | 情報表示装置および情報表示方法、並びにプログラム |
-
2009
- 2009-05-05 EP EP13189439.6A patent/EP2711021B1/en not_active Not-in-force
- 2009-05-05 EP EP09738408A patent/EP2288381A2/en not_active Withdrawn
- 2009-05-05 WO PCT/GB2009/001111 patent/WO2009133378A2/en not_active Ceased
- 2009-05-05 JP JP2011506772A patent/JP5721620B2/ja not_active Expired - Fee Related
- 2009-05-05 CA CA2723226A patent/CA2723226A1/en not_active Abandoned
- 2009-05-05 ES ES13189439T patent/ES2570973T3/es active Active
- 2009-05-05 US US12/736,706 patent/US20110280930A1/en not_active Abandoned
- 2009-05-05 CN CN200980125581.9A patent/CN102170903B/zh not_active Expired - Fee Related
- 2009-05-05 AU AU2009241645A patent/AU2009241645B2/en not_active Ceased
- 2009-05-05 EP EP13189438.8A patent/EP2711020B1/en not_active Not-in-force
-
2014
- 2014-08-07 JP JP2014160906A patent/JP2015028023A/ja active Pending
- 2014-08-07 JP JP2014160907A patent/JP5853068B2/ja not_active Expired - Fee Related
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