JP2011519348A5 - - Google Patents
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- JP2011519348A5 JP2011519348A5 JP2010550892A JP2010550892A JP2011519348A5 JP 2011519348 A5 JP2011519348 A5 JP 2011519348A5 JP 2010550892 A JP2010550892 A JP 2010550892A JP 2010550892 A JP2010550892 A JP 2010550892A JP 2011519348 A5 JP2011519348 A5 JP 2011519348A5
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- 0 CC(C)(CCCc1nc(N(*)CCC2)c2cc1C)CC(C)(C)CCC(CC(O)=O)[Al] Chemical compound CC(C)(CCCc1nc(N(*)CCC2)c2cc1C)CC(C)(C)CCC(CC(O)=O)[Al] 0.000 description 2
- VMNAOJIRTPMBEI-UHFFFAOYSA-N CC(C)c1cnc(C)nc1 Chemical compound CC(C)c1cnc(C)nc1 VMNAOJIRTPMBEI-UHFFFAOYSA-N 0.000 description 1
- LMJSFHOWNKPAAW-UHFFFAOYSA-N CCCC(C)c(cn1)ccc1OC Chemical compound CCCC(C)c(cn1)ccc1OC LMJSFHOWNKPAAW-UHFFFAOYSA-N 0.000 description 1
- RFOLHBSBICDYBN-UHFFFAOYSA-N CCc(cc1F)ccc1OC Chemical compound CCc(cc1F)ccc1OC RFOLHBSBICDYBN-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3649508P | 2008-03-14 | 2008-03-14 | |
| US61/036,495 | 2008-03-14 | ||
| PCT/US2009/037114 WO2009114776A2 (en) | 2008-03-14 | 2009-03-13 | Integrin targeting agents and methods of using same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013251107A Division JP2014058556A (ja) | 2008-03-14 | 2013-12-04 | インテグリン標的化剤およびそれらを用いるinvivoおよびinvitroでの画像化方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011519348A JP2011519348A (ja) | 2011-07-07 |
| JP2011519348A5 true JP2011519348A5 (cg-RX-API-DMAC7.html) | 2013-04-11 |
| JP5586485B2 JP5586485B2 (ja) | 2014-09-10 |
Family
ID=40957784
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010550892A Active JP5586485B2 (ja) | 2008-03-14 | 2009-03-13 | インテグリン標的化剤およびそれらを用いるinvivoおよびinvitroでの画像化方法 |
| JP2013251107A Pending JP2014058556A (ja) | 2008-03-14 | 2013-12-04 | インテグリン標的化剤およびそれらを用いるinvivoおよびinvitroでの画像化方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013251107A Pending JP2014058556A (ja) | 2008-03-14 | 2013-12-04 | インテグリン標的化剤およびそれらを用いるinvivoおよびinvitroでの画像化方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US8685370B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2268317B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP5586485B2 (cg-RX-API-DMAC7.html) |
| CN (2) | CN104225613A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2009223235B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2715034C (cg-RX-API-DMAC7.html) |
| DK (1) | DK2268317T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009114776A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2618361T3 (es) | 2005-09-02 | 2017-06-21 | Visen Medical, Inc. | Marcadores colorantes fluorescentes que contienen sulfonamida N,N-disustituida biocompatible |
| US8173819B2 (en) * | 2005-09-02 | 2012-05-08 | Visen Medical, Inc. | Nicotinic and picolinic acid derived near-infrared fluorophores |
| DK1937676T3 (en) | 2005-09-02 | 2017-03-06 | Visen Medical Inc | Biocompatible fluorescent imaging compounds |
| NZ569818A (en) * | 2005-12-16 | 2012-07-27 | Catherine M Shachaf | Diagnostic system for the detection and diagnosis of skin cancer |
| US9913917B2 (en) | 2005-12-22 | 2018-03-13 | Visen Medical, Inc. | Biocompatible fluorescent metal oxide nanoparticles |
| WO2008100817A2 (en) * | 2007-02-09 | 2008-08-21 | Visen Medical, Inc. | Polycyclo dyes and use thereof |
| WO2008109832A2 (en) * | 2007-03-08 | 2008-09-12 | Visen Medical, Inc. | Viable near-infrared fluorochrome labeled cells and methods of making and using same |
| AU2009205950C1 (en) * | 2008-01-18 | 2015-08-06 | Visen Medical, Inc. | Fluorescent imaging agents |
| WO2009114776A2 (en) * | 2008-03-14 | 2009-09-17 | Visen Medical, Inc. | Integrin targeting agents and methods of using same |
| US8864821B2 (en) * | 2008-11-26 | 2014-10-21 | Visen Medical, Inc. | Methods and compositions for identifying subjects at risk of developing stent thrombosis |
| WO2010076334A2 (en) * | 2008-12-31 | 2010-07-08 | Centre Leon Berard | Intraoperative diagnosis of primary tumors and secondary tumors or metastases |
| CN106995493B (zh) | 2010-02-04 | 2021-09-24 | 卫材公司 | 氯毒素多肽和结合物及其应用 |
| EP3165533B1 (en) * | 2010-05-11 | 2020-04-08 | Fred Hutchinson Cancer Research Center | Chlorotoxin variants, conjugates and methods for their use |
| US20110319335A1 (en) | 2010-06-23 | 2011-12-29 | Xiaodong Feng | Combined administration of integrin receptor antagonists for anti-angiogenic therapy |
| FR2968999B1 (fr) | 2010-12-20 | 2013-01-04 | Guerbet Sa | Nanoemulsion de chelate pour irm |
| JP6122840B2 (ja) | 2011-05-09 | 2017-04-26 | ビセン メディカル, インコーポレイテッド | 炭酸脱水酵素標的化剤およびそれの使用方法 |
| FR2977892B1 (fr) | 2011-07-13 | 2013-07-26 | Servier Lab | Nouveaux agents d'imagerie, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2980364B1 (fr) * | 2011-09-26 | 2018-08-31 | Guerbet | Nanoemulsions et leur utilisation comme agents de contraste |
| EP2605014A1 (en) * | 2011-12-16 | 2013-06-19 | Merck Patent GmbH | General strategy for antibody library screening |
| US8946159B2 (en) | 2011-12-22 | 2015-02-03 | California Northstate College Of Pharmacy, Llc | Administration of an antagonist of α5β1 for anti-angiogenesis and cancer treatment |
| WO2013148319A1 (en) | 2012-03-30 | 2013-10-03 | Visen Medical, Inc. | Bacterial imaging agents and methods of using same |
| AU2013303233C1 (en) | 2012-08-15 | 2018-08-23 | Visen Medical, Inc. | Prostate specific antigen agents and methods of using same for prostate cancer imaging |
| BR112015013525A2 (pt) | 2012-12-10 | 2017-11-14 | Hutchinson Fred Cancer Res | método para produção de uma proteína de fusão, bem como composição compreendendo uma proteína de fusão |
| FR3001154B1 (fr) | 2013-01-23 | 2015-06-26 | Guerbet Sa | Magneto-emulsion vectorisee |
| US9333270B2 (en) * | 2013-03-15 | 2016-05-10 | Purdue Research Foundation | Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors |
| WO2014144702A2 (en) | 2013-03-15 | 2014-09-18 | Visen Medical, Inc. | 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof |
| CA2901379C (en) | 2013-03-15 | 2023-05-16 | Visen Medical, Inc. | Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection |
| GB201315335D0 (en) | 2013-08-29 | 2013-10-09 | Of Singapore | Amino diacids containing peptide modifiers |
| US11559580B1 (en) | 2013-09-17 | 2023-01-24 | Blaze Bioscience, Inc. | Tissue-homing peptide conjugates and methods of use thereof |
| CN114805342A (zh) * | 2015-02-19 | 2022-07-29 | 赛弗卢尔生命科学公司 | 氟化四氢萘啶基壬酸衍生物及其用途 |
| HK1251512A1 (zh) * | 2015-05-11 | 2019-02-01 | 佐治亚州立大学研究基金会公司 | 靶向蛋白造影剂、其制备方法及用途 |
| CA3021011A1 (en) | 2016-04-15 | 2017-10-19 | Blaze Bioscience, Inc. | Methods of treating breast cancer |
| CA3026504A1 (en) | 2016-06-07 | 2017-12-14 | Nanopharmaceuticals, Llc | Non-cleavable polymer conjugated with .alpha..nu..beta.3 integrin thyroid antagonists |
| CN106243103B (zh) * | 2016-07-14 | 2017-11-03 | 广西师范大学 | 萘并[1,2‑h] [1,6]萘啶‑3(4H) ‑酮类化合物及其制备方法和应用 |
| CN107556309B (zh) * | 2017-09-11 | 2020-12-01 | 浙江永宁药业股份有限公司 | 多取代四氢萘啶类化合物的药物用途及其制备方法 |
| WO2019056251A1 (zh) * | 2017-09-21 | 2019-03-28 | 大连理工大学 | 一组用于氨基/酚羟基标记的同位素标记试剂及其合成方法 |
| US11351137B2 (en) | 2018-04-11 | 2022-06-07 | Nanopharmaceuticals Llc | Composition and method for dual targeting in treatment of neuroendocrine tumors |
| US10328043B1 (en) | 2018-04-11 | 2019-06-25 | Nanopharmaceuticals, Llc. | Composition and method for dual targeting in treatment of neuroendocrine tumors |
| JOP20200266A1 (ar) * | 2018-04-27 | 2020-10-21 | Arrowhead Pharmaceuticals Inc | مركبات ترابطية تستهدف إنتجرين واستخداماتها |
| KR102101561B1 (ko) | 2018-07-25 | 2020-04-20 | 가톨릭대학교 산학협력단 | 신생혈관 표적용 조영제 조성물 및 이의 제조방법 |
| KR20210113273A (ko) * | 2019-01-09 | 2021-09-15 | 애로우헤드 파마슈티컬스 인코포레이티드 | HIF-2 알파 (EPAS1)의 발현을 억제하기 위한 RNAi 작용제, 그의 조성물, 및 사용 방법 |
| US10961204B1 (en) | 2020-04-29 | 2021-03-30 | Nanopharmaceuticals Llc | Composition of scalable thyrointegrin antagonists with improved blood brain barrier penetration and retention into brain tumors |
| CN113030051B (zh) * | 2021-03-17 | 2023-04-14 | 四川大学华西医院 | 一种基于金属离子选择性调控QDs和NMM荧光信号的均相双荧光分析方法及其应用 |
| CN117412772A (zh) * | 2021-06-07 | 2024-01-16 | 纳米药业有限责任公司 | 用于双靶向治疗神经内分泌瘤的组合物和方法 |
| US20240409927A1 (en) * | 2021-07-07 | 2024-12-12 | Alnylam Pharmaceuticals, Inc. | Integrin targeting ligands for ocular delivery of rnai compounds |
| US11723888B2 (en) | 2021-12-09 | 2023-08-15 | Nanopharmaceuticals Llc | Polymer conjugated thyrointegrin antagonists |
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| US4647447A (en) | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
| US5268486A (en) | 1986-04-18 | 1993-12-07 | Carnegie-Mellon Unversity | Method for labeling and detecting materials employing arylsulfonate cyanine dyes |
| US5627027A (en) | 1986-04-18 | 1997-05-06 | Carnegie Mellon University | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods |
| US5569587A (en) | 1986-04-18 | 1996-10-29 | Carnegie Mellon University | Method for labeling and detecting materials employing luminescent arysulfonate cyanine dyes |
| US4981977A (en) | 1989-06-09 | 1991-01-01 | Carnegie-Mellon University | Intermediate for and fluorescent cyanine dyes containing carboxylic acid groups |
| US5808044A (en) | 1993-01-22 | 1998-09-15 | Pharmacia Biotech Inc. | Indocarbocyanine and benzindocarbocyanine phosphoramidites |
| US6127134A (en) | 1995-04-20 | 2000-10-03 | Carnegie Mellon University | Difference gel electrophoresis using matched multiple dyes |
| US6008373A (en) | 1995-06-07 | 1999-12-28 | Carnegie Mellon University | Fluorescent labeling complexes with large stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer |
| IT1276833B1 (it) | 1995-10-09 | 1997-11-03 | Sorin Biomedica Cardio Spa | Coloranti fluorescenti della famiglia della solfo benz e indocianina |
| US6004536A (en) | 1995-11-14 | 1999-12-21 | Molecular Probes, Inc. | Lipophilic cyanine dyes with enchanced aqueous solubilty |
| WO1997040104A1 (en) | 1996-04-19 | 1997-10-30 | Amersham Pharmacia Biotech Uk Limited | Squarate dyes and their use in fluorescent sequencing method |
| US5877310A (en) | 1997-04-25 | 1999-03-02 | Carnegie Mellon University | Glycoconjugated fluorescent labeling reagents |
| ES2243016T3 (es) | 1997-12-17 | 2005-11-16 | MERCK & CO., INC. | Antagonistas de receptores de integrinas. |
| US6048861A (en) | 1997-12-17 | 2000-04-11 | Merck & Co., Inc. | Integrin receptor antagonists |
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| US6133445A (en) | 1997-12-17 | 2000-10-17 | Carnegie Mellon University | Rigidized trimethine cyanine dyes |
| US6017926A (en) | 1997-12-17 | 2000-01-25 | Merck & Co., Inc. | Integrin receptor antagonists |
| AU3386399A (en) | 1998-04-08 | 1999-10-25 | Ewald A. Terpetschnig | Luminescent compounds |
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| US6592847B1 (en) | 1998-05-14 | 2003-07-15 | The General Hospital Corporation | Intramolecularly-quenched near infrared flourescent probes |
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| WO2001021624A1 (en) | 1999-09-20 | 2001-03-29 | Fuji Photo Film Co., Ltd. | Compounds for fluorescence labeling |
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| US6615063B1 (en) | 2000-11-27 | 2003-09-02 | The General Hospital Corporation | Fluorescence-mediated molecular tomography |
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| WO2003079015A1 (en) | 2002-03-11 | 2003-09-25 | Visen Medical, Inc. | Optical imaging probes |
| EP2410315B1 (en) | 2002-06-04 | 2020-04-01 | Visen Medical, Inc. | Imaging volumes with arbitrary geometries in contact and non-contact tomography |
| US20040224986A1 (en) * | 2002-08-16 | 2004-11-11 | Bart De Corte | Piperidinyl targeting compounds that selectively bind integrins |
| RU2393167C2 (ru) | 2004-06-16 | 2010-06-27 | Джи-И Хелткер АС | Пептидные соединения |
| AR059224A1 (es) * | 2006-01-31 | 2008-03-19 | Jerini Ag | Compuestos para la inhibicion de integrinas y uso de estas |
| WO2009114776A2 (en) * | 2008-03-14 | 2009-09-17 | Visen Medical, Inc. | Integrin targeting agents and methods of using same |
-
2009
- 2009-03-13 WO PCT/US2009/037114 patent/WO2009114776A2/en not_active Ceased
- 2009-03-13 JP JP2010550892A patent/JP5586485B2/ja active Active
- 2009-03-13 CN CN201410387744.3A patent/CN104225613A/zh active Pending
- 2009-03-13 CA CA2715034A patent/CA2715034C/en active Active
- 2009-03-13 CN CN200980115127.5A patent/CN102026671B/zh active Active
- 2009-03-13 DK DK09720423.4T patent/DK2268317T3/da active
- 2009-03-13 EP EP09720423.4A patent/EP2268317B1/en active Active
- 2009-03-13 AU AU2009223235A patent/AU2009223235B2/en active Active
- 2009-03-13 US US12/922,594 patent/US8685370B2/en active Active
- 2009-03-13 EP EP19217516.4A patent/EP3673922A1/en active Pending
-
2013
- 2013-12-04 JP JP2013251107A patent/JP2014058556A/ja active Pending
-
2014
- 2014-02-24 US US14/188,162 patent/US9694089B2/en active Active
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