JP2011519348A5 - - Google Patents

Download PDF

Info

Publication number
JP2011519348A5
JP2011519348A5 JP2010550892A JP2010550892A JP2011519348A5 JP 2011519348 A5 JP2011519348 A5 JP 2011519348A5 JP 2010550892 A JP2010550892 A JP 2010550892A JP 2010550892 A JP2010550892 A JP 2010550892A JP 2011519348 A5 JP2011519348 A5 JP 2011519348A5
Authority
JP
Japan
Prior art keywords
agent
group
agent according
substituted
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010550892A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011519348A (ja
JP5586485B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2009/037114 external-priority patent/WO2009114776A2/en
Publication of JP2011519348A publication Critical patent/JP2011519348A/ja
Publication of JP2011519348A5 publication Critical patent/JP2011519348A5/ja
Application granted granted Critical
Publication of JP5586485B2 publication Critical patent/JP5586485B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2010550892A 2008-03-14 2009-03-13 インテグリン標的化剤およびそれらを用いるinvivoおよびinvitroでの画像化方法 Active JP5586485B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3649508P 2008-03-14 2008-03-14
US61/036,495 2008-03-14
PCT/US2009/037114 WO2009114776A2 (en) 2008-03-14 2009-03-13 Integrin targeting agents and methods of using same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013251107A Division JP2014058556A (ja) 2008-03-14 2013-12-04 インテグリン標的化剤およびそれらを用いるinvivoおよびinvitroでの画像化方法

Publications (3)

Publication Number Publication Date
JP2011519348A JP2011519348A (ja) 2011-07-07
JP2011519348A5 true JP2011519348A5 (cg-RX-API-DMAC7.html) 2013-04-11
JP5586485B2 JP5586485B2 (ja) 2014-09-10

Family

ID=40957784

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2010550892A Active JP5586485B2 (ja) 2008-03-14 2009-03-13 インテグリン標的化剤およびそれらを用いるinvivoおよびinvitroでの画像化方法
JP2013251107A Pending JP2014058556A (ja) 2008-03-14 2013-12-04 インテグリン標的化剤およびそれらを用いるinvivoおよびinvitroでの画像化方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2013251107A Pending JP2014058556A (ja) 2008-03-14 2013-12-04 インテグリン標的化剤およびそれらを用いるinvivoおよびinvitroでの画像化方法

Country Status (8)

Country Link
US (2) US8685370B2 (cg-RX-API-DMAC7.html)
EP (2) EP2268317B1 (cg-RX-API-DMAC7.html)
JP (2) JP5586485B2 (cg-RX-API-DMAC7.html)
CN (2) CN104225613A (cg-RX-API-DMAC7.html)
AU (1) AU2009223235B2 (cg-RX-API-DMAC7.html)
CA (1) CA2715034C (cg-RX-API-DMAC7.html)
DK (1) DK2268317T3 (cg-RX-API-DMAC7.html)
WO (1) WO2009114776A2 (cg-RX-API-DMAC7.html)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2618361T3 (es) 2005-09-02 2017-06-21 Visen Medical, Inc. Marcadores colorantes fluorescentes que contienen sulfonamida N,N-disustituida biocompatible
US8173819B2 (en) * 2005-09-02 2012-05-08 Visen Medical, Inc. Nicotinic and picolinic acid derived near-infrared fluorophores
DK1937676T3 (en) 2005-09-02 2017-03-06 Visen Medical Inc Biocompatible fluorescent imaging compounds
NZ569818A (en) * 2005-12-16 2012-07-27 Catherine M Shachaf Diagnostic system for the detection and diagnosis of skin cancer
US9913917B2 (en) 2005-12-22 2018-03-13 Visen Medical, Inc. Biocompatible fluorescent metal oxide nanoparticles
WO2008100817A2 (en) * 2007-02-09 2008-08-21 Visen Medical, Inc. Polycyclo dyes and use thereof
WO2008109832A2 (en) * 2007-03-08 2008-09-12 Visen Medical, Inc. Viable near-infrared fluorochrome labeled cells and methods of making and using same
AU2009205950C1 (en) * 2008-01-18 2015-08-06 Visen Medical, Inc. Fluorescent imaging agents
WO2009114776A2 (en) * 2008-03-14 2009-09-17 Visen Medical, Inc. Integrin targeting agents and methods of using same
US8864821B2 (en) * 2008-11-26 2014-10-21 Visen Medical, Inc. Methods and compositions for identifying subjects at risk of developing stent thrombosis
WO2010076334A2 (en) * 2008-12-31 2010-07-08 Centre Leon Berard Intraoperative diagnosis of primary tumors and secondary tumors or metastases
CN106995493B (zh) 2010-02-04 2021-09-24 卫材公司 氯毒素多肽和结合物及其应用
EP3165533B1 (en) * 2010-05-11 2020-04-08 Fred Hutchinson Cancer Research Center Chlorotoxin variants, conjugates and methods for their use
US20110319335A1 (en) 2010-06-23 2011-12-29 Xiaodong Feng Combined administration of integrin receptor antagonists for anti-angiogenic therapy
FR2968999B1 (fr) 2010-12-20 2013-01-04 Guerbet Sa Nanoemulsion de chelate pour irm
JP6122840B2 (ja) 2011-05-09 2017-04-26 ビセン メディカル, インコーポレイテッド 炭酸脱水酵素標的化剤およびそれの使用方法
FR2977892B1 (fr) 2011-07-13 2013-07-26 Servier Lab Nouveaux agents d'imagerie, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2980364B1 (fr) * 2011-09-26 2018-08-31 Guerbet Nanoemulsions et leur utilisation comme agents de contraste
EP2605014A1 (en) * 2011-12-16 2013-06-19 Merck Patent GmbH General strategy for antibody library screening
US8946159B2 (en) 2011-12-22 2015-02-03 California Northstate College Of Pharmacy, Llc Administration of an antagonist of α5β1 for anti-angiogenesis and cancer treatment
WO2013148319A1 (en) 2012-03-30 2013-10-03 Visen Medical, Inc. Bacterial imaging agents and methods of using same
AU2013303233C1 (en) 2012-08-15 2018-08-23 Visen Medical, Inc. Prostate specific antigen agents and methods of using same for prostate cancer imaging
BR112015013525A2 (pt) 2012-12-10 2017-11-14 Hutchinson Fred Cancer Res método para produção de uma proteína de fusão, bem como composição compreendendo uma proteína de fusão
FR3001154B1 (fr) 2013-01-23 2015-06-26 Guerbet Sa Magneto-emulsion vectorisee
US9333270B2 (en) * 2013-03-15 2016-05-10 Purdue Research Foundation Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors
WO2014144702A2 (en) 2013-03-15 2014-09-18 Visen Medical, Inc. 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof
CA2901379C (en) 2013-03-15 2023-05-16 Visen Medical, Inc. Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection
GB201315335D0 (en) 2013-08-29 2013-10-09 Of Singapore Amino diacids containing peptide modifiers
US11559580B1 (en) 2013-09-17 2023-01-24 Blaze Bioscience, Inc. Tissue-homing peptide conjugates and methods of use thereof
CN114805342A (zh) * 2015-02-19 2022-07-29 赛弗卢尔生命科学公司 氟化四氢萘啶基壬酸衍生物及其用途
HK1251512A1 (zh) * 2015-05-11 2019-02-01 佐治亚州立大学研究基金会公司 靶向蛋白造影剂、其制备方法及用途
CA3021011A1 (en) 2016-04-15 2017-10-19 Blaze Bioscience, Inc. Methods of treating breast cancer
CA3026504A1 (en) 2016-06-07 2017-12-14 Nanopharmaceuticals, Llc Non-cleavable polymer conjugated with .alpha..nu..beta.3 integrin thyroid antagonists
CN106243103B (zh) * 2016-07-14 2017-11-03 广西师范大学 萘并[1,2‑h] [1,6]萘啶‑3(4H) ‑酮类化合物及其制备方法和应用
CN107556309B (zh) * 2017-09-11 2020-12-01 浙江永宁药业股份有限公司 多取代四氢萘啶类化合物的药物用途及其制备方法
WO2019056251A1 (zh) * 2017-09-21 2019-03-28 大连理工大学 一组用于氨基/酚羟基标记的同位素标记试剂及其合成方法
US11351137B2 (en) 2018-04-11 2022-06-07 Nanopharmaceuticals Llc Composition and method for dual targeting in treatment of neuroendocrine tumors
US10328043B1 (en) 2018-04-11 2019-06-25 Nanopharmaceuticals, Llc. Composition and method for dual targeting in treatment of neuroendocrine tumors
JOP20200266A1 (ar) * 2018-04-27 2020-10-21 Arrowhead Pharmaceuticals Inc مركبات ترابطية تستهدف إنتجرين واستخداماتها
KR102101561B1 (ko) 2018-07-25 2020-04-20 가톨릭대학교 산학협력단 신생혈관 표적용 조영제 조성물 및 이의 제조방법
KR20210113273A (ko) * 2019-01-09 2021-09-15 애로우헤드 파마슈티컬스 인코포레이티드 HIF-2 알파 (EPAS1)의 발현을 억제하기 위한 RNAi 작용제, 그의 조성물, 및 사용 방법
US10961204B1 (en) 2020-04-29 2021-03-30 Nanopharmaceuticals Llc Composition of scalable thyrointegrin antagonists with improved blood brain barrier penetration and retention into brain tumors
CN113030051B (zh) * 2021-03-17 2023-04-14 四川大学华西医院 一种基于金属离子选择性调控QDs和NMM荧光信号的均相双荧光分析方法及其应用
CN117412772A (zh) * 2021-06-07 2024-01-16 纳米药业有限责任公司 用于双靶向治疗神经内分泌瘤的组合物和方法
US20240409927A1 (en) * 2021-07-07 2024-12-12 Alnylam Pharmaceuticals, Inc. Integrin targeting ligands for ocular delivery of rnai compounds
US11723888B2 (en) 2021-12-09 2023-08-15 Nanopharmaceuticals Llc Polymer conjugated thyrointegrin antagonists

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4647447A (en) 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US5268486A (en) 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
US5627027A (en) 1986-04-18 1997-05-06 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US5569587A (en) 1986-04-18 1996-10-29 Carnegie Mellon University Method for labeling and detecting materials employing luminescent arysulfonate cyanine dyes
US4981977A (en) 1989-06-09 1991-01-01 Carnegie-Mellon University Intermediate for and fluorescent cyanine dyes containing carboxylic acid groups
US5808044A (en) 1993-01-22 1998-09-15 Pharmacia Biotech Inc. Indocarbocyanine and benzindocarbocyanine phosphoramidites
US6127134A (en) 1995-04-20 2000-10-03 Carnegie Mellon University Difference gel electrophoresis using matched multiple dyes
US6008373A (en) 1995-06-07 1999-12-28 Carnegie Mellon University Fluorescent labeling complexes with large stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer
IT1276833B1 (it) 1995-10-09 1997-11-03 Sorin Biomedica Cardio Spa Coloranti fluorescenti della famiglia della solfo benz e indocianina
US6004536A (en) 1995-11-14 1999-12-21 Molecular Probes, Inc. Lipophilic cyanine dyes with enchanced aqueous solubilty
WO1997040104A1 (en) 1996-04-19 1997-10-30 Amersham Pharmacia Biotech Uk Limited Squarate dyes and their use in fluorescent sequencing method
US5877310A (en) 1997-04-25 1999-03-02 Carnegie Mellon University Glycoconjugated fluorescent labeling reagents
ES2243016T3 (es) 1997-12-17 2005-11-16 MERCK & CO., INC. Antagonistas de receptores de integrinas.
US6048861A (en) 1997-12-17 2000-04-11 Merck & Co., Inc. Integrin receptor antagonists
EE200000362A (et) 1997-12-17 2001-12-17 Merck & Co., Inc. Integriini retseptori antagonistid, farmatseutiline kompositsioon ja selle valmistamismeetod
US6133445A (en) 1997-12-17 2000-10-17 Carnegie Mellon University Rigidized trimethine cyanine dyes
US6017926A (en) 1997-12-17 2000-01-25 Merck & Co., Inc. Integrin receptor antagonists
AU3386399A (en) 1998-04-08 1999-10-25 Ewald A. Terpetschnig Luminescent compounds
US6002003A (en) 1998-04-14 1999-12-14 Beckman Instruments, Inc. Cyanine dye activating group with improved coupling selectivity
US6592847B1 (en) 1998-05-14 2003-07-15 The General Hospital Corporation Intramolecularly-quenched near infrared flourescent probes
EP1491591B1 (en) 1999-07-02 2009-07-01 Visen Medical, Inc. New fluorescence cyanine labels containing a sulfamido linker arm
WO2001021624A1 (en) 1999-09-20 2001-03-29 Fuji Photo Film Co., Ltd. Compounds for fluorescence labeling
WO2002022616A2 (en) 2000-09-14 2002-03-21 Merck & Co., Inc. Alpha v integrin receptor antagonists
US6615063B1 (en) 2000-11-27 2003-09-02 The General Hospital Corporation Fluorescence-mediated molecular tomography
EP1221465A1 (en) 2001-01-03 2002-07-10 Innosense S.r.l. Symmetric, monofunctionalised polymethine dyes labelling reagents
US7439319B2 (en) 2001-09-14 2008-10-21 Burnham Institute For Medical Research Selective substrates for matrix metalloproteinases
WO2003079015A1 (en) 2002-03-11 2003-09-25 Visen Medical, Inc. Optical imaging probes
EP2410315B1 (en) 2002-06-04 2020-04-01 Visen Medical, Inc. Imaging volumes with arbitrary geometries in contact and non-contact tomography
US20040224986A1 (en) * 2002-08-16 2004-11-11 Bart De Corte Piperidinyl targeting compounds that selectively bind integrins
RU2393167C2 (ru) 2004-06-16 2010-06-27 Джи-И Хелткер АС Пептидные соединения
AR059224A1 (es) * 2006-01-31 2008-03-19 Jerini Ag Compuestos para la inhibicion de integrinas y uso de estas
WO2009114776A2 (en) * 2008-03-14 2009-09-17 Visen Medical, Inc. Integrin targeting agents and methods of using same

Similar Documents

Publication Publication Date Title
JP2011519348A5 (cg-RX-API-DMAC7.html)
US9694089B2 (en) Integrin targeting agents and in-vivo and in-vitro imaging methods using the same
EP1973575B1 (en) Biocompatible fluorescent metal oxide nanoparticles
US9375493B2 (en) Bacterial imaging agents and methods of using same
CN101528267A (zh) 用于检测前列腺癌的造影剂
CN110204478A (zh) 碳酸酐酶靶向剂及其使用方法
BRPI1006246A2 (pt) "kit para imagem médica marcada e/ou terapias, sonda efetora e método"
JP5500875B2 (ja) 新規化合物、該新規化合物を用いたプローブ及び該新規化合物もしくは該プローブを用いた蛍光イメージング用造影剤
JP2015532641A5 (cg-RX-API-DMAC7.html)
CN111447955A (zh) 99mTc-替马诺塞和相关的分子构建体用于鉴定和诊断恶性肿瘤和用于监测治疗性抗肿瘤干预的用途
US9655980B2 (en) Theranostic platform for targeted cancer therapy and drug delivery monitoring
Gambino et al. RGD-peptide functionalization affects the In vivo diffusion of a responsive Trimeric MRI contrast agent through interactions with Integrins
Liu et al. Molecular imaging of cell-based cancer immunotherapy
JP7538117B2 (ja) 腫瘍アシドーシス画像化のためのデュアルモダリティupsナノプローブ
Hettie et al. Off-peak near-infrared-II (NIR-II) bioimaging of an immunoconjugate having peak fluorescence emission in the NIR-I spectral region for improving tumor margin delineation
US9044505B2 (en) Multimeric biotinidase resistant multimodality probes
JP2008509921A (ja) 内皮特異的な生体内伝達のターゲティング剤としての熱ショックタンパク質
US12144872B1 (en) Modified nanodelivery system and method for enhanced in vivo medical and preclinical imaging
CN116284223A (zh) 一种整合素受体靶向多肽衍生物及分子探针与应用
Lahkar et al. Image-guided Biodistribution and pharmacokinetic studies of theranostics
JP2009512700A5 (cg-RX-API-DMAC7.html)
CN118806935A (zh) 靶向弹性蛋白的血管造影剂