DK2268317T3 - Integrin-targeteringssubstanser og in vivo- og in vitro-billeddannelsesmetoder som anvender samme - Google Patents

Integrin-targeteringssubstanser og in vivo- og in vitro-billeddannelsesmetoder som anvender samme Download PDF

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Publication number
DK2268317T3
DK2268317T3 DK09720423.4T DK09720423T DK2268317T3 DK 2268317 T3 DK2268317 T3 DK 2268317T3 DK 09720423 T DK09720423 T DK 09720423T DK 2268317 T3 DK2268317 T3 DK 2268317T3
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Prior art keywords
vivo
same
imaging methods
integrin targeting
vitro imaging
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DK09720423.4T
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Danish (da)
English (en)
Inventor
Milind Rajopadhye
Bohumil Bednar
Le T Duong
Paul J Coleman
Guojie Ho
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Visen Medical Inc
Merck Sharp & Dohme
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
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    • A61K49/0052—Small organic molecules
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    • A61K49/0017—Fluorescence in vivo
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    • A61K49/0056—Peptides, proteins, polyamino acids
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    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
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    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
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    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
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    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
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    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
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    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
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    • C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
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    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
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    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/086—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer

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DK09720423.4T 2008-03-14 2009-03-13 Integrin-targeteringssubstanser og in vivo- og in vitro-billeddannelsesmetoder som anvender samme DK2268317T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3649508P 2008-03-14 2008-03-14
PCT/US2009/037114 WO2009114776A2 (en) 2008-03-14 2009-03-13 Integrin targeting agents and methods of using same

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DK2268317T3 true DK2268317T3 (da) 2020-05-25

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US (2) US8685370B2 (cg-RX-API-DMAC7.html)
EP (2) EP2268317B1 (cg-RX-API-DMAC7.html)
JP (2) JP5586485B2 (cg-RX-API-DMAC7.html)
CN (2) CN104225613A (cg-RX-API-DMAC7.html)
AU (1) AU2009223235B2 (cg-RX-API-DMAC7.html)
CA (1) CA2715034C (cg-RX-API-DMAC7.html)
DK (1) DK2268317T3 (cg-RX-API-DMAC7.html)
WO (1) WO2009114776A2 (cg-RX-API-DMAC7.html)

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CN104225613A (zh) 2014-12-24
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US20140170066A1 (en) 2014-06-19
US8685370B2 (en) 2014-04-01
US9694089B2 (en) 2017-07-04
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CA2715034C (en) 2016-12-06
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AU2009223235B2 (en) 2014-09-11
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CN102026671A (zh) 2011-04-20
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