JP2011518541A5 - - Google Patents
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- Publication number
- JP2011518541A5 JP2011518541A5 JP2010536258A JP2010536258A JP2011518541A5 JP 2011518541 A5 JP2011518541 A5 JP 2011518541A5 JP 2010536258 A JP2010536258 A JP 2010536258A JP 2010536258 A JP2010536258 A JP 2010536258A JP 2011518541 A5 JP2011518541 A5 JP 2011518541A5
- Authority
- JP
- Japan
- Prior art keywords
- c2orf18
- polypeptide
- seq
- nucleotide sequence
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001184 polypeptide Polymers 0.000 claims description 62
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 62
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 62
- 101000637757 Homo sapiens Solute carrier family 35 member F6 Proteins 0.000 claims description 59
- 102100032109 Solute carrier family 35 member F6 Human genes 0.000 claims description 50
- 239000002773 nucleotide Substances 0.000 claims description 45
- 125000003729 nucleotide group Chemical group 0.000 claims description 45
- 239000003795 chemical substances by application Substances 0.000 claims description 42
- 238000000034 method Methods 0.000 claims description 32
- 108091081021 Sense strand Proteins 0.000 claims description 30
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 30
- 230000027455 binding Effects 0.000 claims description 30
- 238000012360 testing method Methods 0.000 claims description 30
- 206010028980 Neoplasm Diseases 0.000 claims description 27
- 201000011510 cancer Diseases 0.000 claims description 27
- 230000000692 anti-sense effect Effects 0.000 claims description 23
- 230000014509 gene expression Effects 0.000 claims description 19
- 108091033319 polynucleotide Proteins 0.000 claims description 14
- 102000040430 polynucleotide Human genes 0.000 claims description 14
- 239000002157 polynucleotide Substances 0.000 claims description 14
- 102100026396 ADP/ATP translocase 2 Human genes 0.000 claims description 12
- 101000718417 Homo sapiens ADP/ATP translocase 2 Proteins 0.000 claims description 12
- 230000002401 inhibitory effect Effects 0.000 claims description 11
- 230000004071 biological effect Effects 0.000 claims description 10
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 9
- 230000009702 cancer cell proliferation Effects 0.000 claims description 9
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 9
- 108020004707 nucleic acids Proteins 0.000 claims description 9
- 102000039446 nucleic acids Human genes 0.000 claims description 9
- 150000007523 nucleic acids Chemical class 0.000 claims description 9
- 201000002528 pancreatic cancer Diseases 0.000 claims description 9
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 9
- 238000012216 screening Methods 0.000 claims description 9
- 230000000295 complement effect Effects 0.000 claims description 8
- 230000000694 effects Effects 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 108700008625 Reporter Genes Proteins 0.000 claims description 5
- 108091027568 Single-stranded nucleotide Proteins 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 239000012472 biological sample Substances 0.000 claims description 4
- 230000010261 cell growth Effects 0.000 claims description 4
- 230000004663 cell proliferation Effects 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 230000001105 regulatory effect Effects 0.000 claims description 4
- 230000002103 transcriptional effect Effects 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims description 3
- 108020004999 messenger RNA Proteins 0.000 claims description 3
- 108020004635 Complementary DNA Proteins 0.000 claims description 2
- 239000000556 agonist Substances 0.000 claims description 2
- 239000005557 antagonist Substances 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 238000001514 detection method Methods 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 238000001574 biopsy Methods 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3603508P | 2008-03-12 | 2008-03-12 | |
| US61/036,035 | 2008-03-12 | ||
| PCT/JP2009/001057 WO2009113295A1 (en) | 2008-03-12 | 2009-03-10 | C2orf18 as target gene for cancer therapy and diagnosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011518541A JP2011518541A (ja) | 2011-06-30 |
| JP2011518541A5 true JP2011518541A5 (enExample) | 2012-04-26 |
Family
ID=41064968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010536258A Pending JP2011518541A (ja) | 2008-03-12 | 2009-03-10 | 癌治療法および癌診断のための標的遺伝子としてのＣ２ｏｒｆ１８ |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20110098339A1 (enExample) |
| EP (1) | EP2262541A4 (enExample) |
| JP (1) | JP2011518541A (enExample) |
| KR (1) | KR20100128326A (enExample) |
| CN (1) | CN102026672A (enExample) |
| BR (1) | BRPI0909310A2 (enExample) |
| CA (1) | CA2718382A1 (enExample) |
| RU (1) | RU2010141742A (enExample) |
| WO (1) | WO2009113295A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101406314B1 (ko) * | 2011-07-19 | 2014-06-12 | 연세대학교 산학협력단 | 췌장암 암 줄기세포 특성에 기초한 췌장암의 치료용 타겟 |
| CN116794325B (zh) * | 2023-06-15 | 2024-05-10 | 中山大学 | 敲低或抑制slc35f6的试剂在制备激活ampk的药物中的应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006110593A2 (en) * | 2005-04-07 | 2006-10-19 | Macrogenics, Inc. | Biological targets for the diagnosis, treatment and prevention of cancer |
| KR20070101610A (ko) * | 2006-04-11 | 2007-10-17 | 주식회사 바이오인프라 | Ａｎｔ２ 유전자의 발현을 억제하는 작은 간섭 ｒｎａ를이용한 암 유전자 치료 및 항암제 내성 극복방법 |
-
2009
- 2009-03-10 JP JP2010536258A patent/JP2011518541A/ja active Pending
- 2009-03-10 KR KR1020107022812A patent/KR20100128326A/ko not_active Withdrawn
- 2009-03-10 RU RU2010141742/10A patent/RU2010141742A/ru not_active Application Discontinuation
- 2009-03-10 CA CA2718382A patent/CA2718382A1/en not_active Abandoned
- 2009-03-10 WO PCT/JP2009/001057 patent/WO2009113295A1/en not_active Ceased
- 2009-03-10 EP EP09718793A patent/EP2262541A4/en not_active Withdrawn
- 2009-03-10 CN CN2009801171940A patent/CN102026672A/zh active Pending
- 2009-03-10 US US12/921,766 patent/US20110098339A1/en not_active Abandoned
- 2009-03-10 BR BRPI0909310A patent/BRPI0909310A2/pt not_active IP Right Cessation
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