JP2011518178A - 病的血管形成および脈管透過性の処置用の組成物および方法 - Google Patents
病的血管形成および脈管透過性の処置用の組成物および方法 Download PDFInfo
- Publication number
- JP2011518178A JP2011518178A JP2011505210A JP2011505210A JP2011518178A JP 2011518178 A JP2011518178 A JP 2011518178A JP 2011505210 A JP2011505210 A JP 2011505210A JP 2011505210 A JP2011505210 A JP 2011505210A JP 2011518178 A JP2011518178 A JP 2011518178A
- Authority
- JP
- Japan
- Prior art keywords
- robo4
- composition
- angiogenesis
- activation
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC(*)(C=CC=C1)C=C1c1nc(*)n[n]1-c(cc1)ccc1NC(C**)=O Chemical compound CC(*)(C=CC=C1)C=C1c1nc(*)n[n]1-c(cc1)ccc1NC(C**)=O 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Marine Sciences & Fisheries (AREA)
- Physical Education & Sports Medicine (AREA)
- Zoology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Reproductive Health (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4558008P | 2008-04-16 | 2008-04-16 | |
| US61/045,580 | 2008-04-16 | ||
| US7388008P | 2008-06-19 | 2008-06-19 | |
| US61/073,880 | 2008-06-19 | ||
| PCT/US2009/040848 WO2009129408A2 (en) | 2008-04-16 | 2009-04-16 | Compositions and methods for treating pathologic angiogenesis and vascular permeability |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011518178A true JP2011518178A (ja) | 2011-06-23 |
| JP2011518178A5 JP2011518178A5 (OSRAM) | 2012-07-26 |
Family
ID=41199735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011505210A Pending JP2011518178A (ja) | 2008-04-16 | 2009-04-16 | 病的血管形成および脈管透過性の処置用の組成物および方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20100222401A1 (OSRAM) |
| EP (1) | EP2262524A4 (OSRAM) |
| JP (1) | JP2011518178A (OSRAM) |
| KR (1) | KR20100133881A (OSRAM) |
| CN (1) | CN101687014A (OSRAM) |
| BR (1) | BRPI0903901A2 (OSRAM) |
| CA (1) | CA2693001A1 (OSRAM) |
| WO (1) | WO2009129408A2 (OSRAM) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017516860A (ja) * | 2014-05-27 | 2017-06-22 | ナビゲン,インコーポレーテッド | Arf6阻害剤並びにそれらの合成方法及び使用 |
| JP2018508528A (ja) * | 2015-03-02 | 2018-03-29 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ イリノイ | 血管新生阻害ペプチド |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010512327A (ja) | 2006-12-11 | 2010-04-22 | ユニヴァーシティー オブ ユタ リサーチ ファウンデーション | 病的血管形成および脈管透過性の処置用の組成物および方法 |
| US8620879B2 (en) * | 2009-10-13 | 2013-12-31 | Google Inc. | Cloud based file storage service |
| US20110087603A1 (en) * | 2009-10-13 | 2011-04-14 | Google Inc. | Cloud based media player and offline media access |
| CN102233134A (zh) * | 2010-04-30 | 2011-11-09 | 中国科学院上海生命科学研究院 | Slit-robo介导的淋巴管形成及其应用 |
| US8399404B2 (en) | 2010-06-15 | 2013-03-19 | The Hospital For Sick Children | Methods and uses for inhibiting platelet coagulation |
| US10561707B2 (en) * | 2013-09-08 | 2020-02-18 | Technion Research And Development Foundation Ltd. | Semaphorin 3C variants, compositions comprising said variants and methods of use thereof in treating eye diseases |
| CN105726534A (zh) * | 2016-02-17 | 2016-07-06 | 上海交通大学医学院附属仁济医院 | SecinH3在制备抑制胃酸分泌药物中的应用 |
| WO2017173327A1 (en) * | 2016-03-31 | 2017-10-05 | The Schepens Eye Research Institute, Inc. | Endomucin inhibitor as an anti-angiogenic agent |
| CN108929383B (zh) * | 2017-05-26 | 2021-10-15 | 阿思科力(苏州)生物科技有限公司 | 重组Slit2D2(C386S)-HSA融合蛋白及其在预防和/或治疗肺部炎症中的应用 |
| US11077422B2 (en) * | 2017-06-16 | 2021-08-03 | Aquablok, Ltd. | Spalling composite particles and methods of using them |
| CN108364289B (zh) * | 2018-03-02 | 2021-05-14 | 成都斯斐德科技有限公司 | Ivoct图像易损斑块自动检测方法 |
| CN108715862A (zh) * | 2018-05-28 | 2018-10-30 | 上海海洋大学 | ddx19基因缺失斑马鱼突变体的制备方法 |
| WO2021077064A1 (en) * | 2019-10-18 | 2021-04-22 | EMULATE, Inc. | Brain-chip modeling neurodegeneration and neuroinflammation in parkinson's disease |
| WO2021184059A1 (en) * | 2020-03-14 | 2021-09-23 | Newsouth Innovations Pty Limited | Treatment methods |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5480975A (en) * | 1994-02-08 | 1996-01-02 | Brigham And Women's Hospital | Induction of vascular endothelial growth factor (VEGF) by transition metals |
| US6372958B1 (en) * | 1999-05-26 | 2002-04-16 | The University Of Utah Research Foundation | Transgenic mouse with endogenous endoglin gene disruption |
| US6960651B2 (en) * | 1999-06-29 | 2005-11-01 | Millennium Pharmaceuticals, Inc. | TANGO 332 polypeptides |
| AU2001283062A1 (en) * | 2000-08-02 | 2002-02-13 | The Johns Hopkins University | Endothelial cell expression patterns |
| US7939497B2 (en) * | 2002-03-08 | 2011-05-10 | Shanghai Institutes For Biological Sciences, Cas | Detection and modulation of slit and roundabount (robo) mediated angiogenesis and uses thereof |
| EP1534318A4 (en) * | 2002-06-27 | 2009-07-01 | Univ Utah Res Found | METHOD AND COMPOSITIONS FOR MANIPULATING GUIDED NAVIGATION OF ENDOTHONE TUBES IN THE ANGIOGENESIS |
| DE102004055998A1 (de) * | 2004-11-19 | 2006-05-24 | Rheinische Friedrich-Wilhelms-Universität Bonn | Niedermolekulare Inhibitoren von Guaninnucleotid-Austauschfaktoren der Cytohesin-Familie |
| DE102006054205A1 (de) * | 2006-11-15 | 2008-05-29 | Rheinische Friedrich-Wilhelms Universität | Verwendung von Cytohesin-Inhibitoren zur chemischen Induktion von Langlebigkeit |
| JP2010512327A (ja) * | 2006-12-11 | 2010-04-22 | ユニヴァーシティー オブ ユタ リサーチ ファウンデーション | 病的血管形成および脈管透過性の処置用の組成物および方法 |
| CN102083452A (zh) * | 2008-12-12 | 2011-06-01 | 犹他大学研究基金会 | 用于促进血管屏障功能和治疗肺纤维化的组合物和方法 |
-
2009
- 2009-04-16 KR KR1020097027516A patent/KR20100133881A/ko not_active Withdrawn
- 2009-04-16 CN CN200980000518A patent/CN101687014A/zh active Pending
- 2009-04-16 JP JP2011505210A patent/JP2011518178A/ja active Pending
- 2009-04-16 EP EP09733521A patent/EP2262524A4/en not_active Withdrawn
- 2009-04-16 CA CA 2693001 patent/CA2693001A1/en not_active Abandoned
- 2009-04-16 BR BRPI0903901A patent/BRPI0903901A2/pt not_active IP Right Cessation
- 2009-04-16 WO PCT/US2009/040848 patent/WO2009129408A2/en not_active Ceased
- 2009-04-16 US US12/667,168 patent/US20100222401A1/en not_active Abandoned
Non-Patent Citations (2)
| Title |
|---|
| JPN6013059253; JONES, C. A. ET AL.: 'Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperper' NAT. MED. , 200803, pages 448 - 453, vol. 14, no. 4 * |
| JPN6013059256; PARK, K. W. ET AL.: 'Robo4 is a vascular-specific receptor that inhibits endothelial migration' DEV. BIOL. , 2003, pages 251 - 267, vol. 261 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017516860A (ja) * | 2014-05-27 | 2017-06-22 | ナビゲン,インコーポレーテッド | Arf6阻害剤並びにそれらの合成方法及び使用 |
| US10849901B2 (en) | 2014-05-27 | 2020-12-01 | Navigen, Inc. | Arf6 inhibitors and methods of synthesis and use thereof |
| JP2018508528A (ja) * | 2015-03-02 | 2018-03-29 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ イリノイ | 血管新生阻害ペプチド |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2262524A4 (en) | 2012-07-11 |
| KR20100133881A (ko) | 2010-12-22 |
| CN101687014A (zh) | 2010-03-31 |
| BRPI0903901A2 (pt) | 2017-05-23 |
| EP2262524A2 (en) | 2010-12-22 |
| WO2009129408A2 (en) | 2009-10-22 |
| WO2009129408A3 (en) | 2009-12-23 |
| US20100222401A1 (en) | 2010-09-02 |
| CA2693001A1 (en) | 2009-10-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011518178A (ja) | 病的血管形成および脈管透過性の処置用の組成物および方法 | |
| US7994130B2 (en) | Compositions and methods for treating ocular pathologic angiogenesis and vascular permeability | |
| Lin et al. | VEGF‐C/VEGFR‐3 axis protects against pressure‐overload induced cardiac dysfunction through regulation of lymphangiogenesis | |
| Kim et al. | IL-37 attenuates lung fibrosis by inducing autophagy and regulating TGF-β1 production in mice | |
| Van Obberghen-Schilling et al. | Fibronectin and tenascin-C: accomplices in vascular morphogenesis during development and tumor growth | |
| Marshall et al. | Dissecting the complement pathway in hepatic injury and regeneration with a novel protective strategy | |
| JP2019536813A (ja) | Saspモジュレータおよび老化アテニュエータを含む組成物、ならびに細胞老化を調節するためのその使用 | |
| KR20110102142A (ko) | 혈관 장벽 기능을 촉진하고 폐 섬유증을 치료하기 위한 조성물 및 방법 | |
| US20050119198A1 (en) | Novel target to inhibit angiogenesis | |
| JP2024156834A (ja) | Cd146と、それをバイオマーカーとして線維症の診断に使用すること及び治療ターゲットとして線維症の治療において使用すること | |
| Grisaru‐Granovsky et al. | PAR1&2 driven placenta EVT invasion act via LRP5/6 as coreceptors | |
| Zhou et al. | Postinfarction healing dynamics in the mechanically unloaded rat left ventricle | |
| US20110086089A1 (en) | Use of p27kip1 for the prevention and treatment of heart failure | |
| US8080252B2 (en) | Compounds and methods of modulating angiogenesis | |
| Hung | Regulation of Muscle Stem Cell Quiescence by Niche Adhesion | |
| Mastej | The Role of KLF4 and KLF2 Crosstalk in Endothelial to Mesenchymal Transition and Pulmonary Fibrosis | |
| EP2068877A2 (en) | Compounds and methods of modulating angiogenesis | |
| Daskalopoulos et al. | Effect of Interventions in WNT Signaling on Healing of Cardiac Injury: A Systematic Review. Cells 2021, 10, 207 | |
| Bracey | Characterization of NLRP3 in the Maintenance of Cardiac Tissue Homeostasis | |
| Beckett | Novel Mechanism and Therapies for Fibrosis | |
| Oas | p120-catenin in vascular development and endothelial adhesion strengthening | |
| Mariotti | Molecular pathophysiology of cholangiopathies: lessons from polycystic and fibropolycystic liver disease | |
| Stewart | Characterising the in vitro and in vivo function of the RhoG effector DOCK4 during angiogenesis and ischemia. | |
| Naugle | Regulation of cardiac fibroblast function via cyclic AMP, collagen I, III, and VI: implications for post-infarction remodeling | |
| HK1139589A (en) | Compositions and methods for treating pathologic angiogenesis and vascular permeability |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120416 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20120416 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120611 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20131203 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20140520 |