JP2011517451A5 - - Google Patents
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- JP2011517451A5 JP2011517451A5 JP2011502070A JP2011502070A JP2011517451A5 JP 2011517451 A5 JP2011517451 A5 JP 2011517451A5 JP 2011502070 A JP2011502070 A JP 2011502070A JP 2011502070 A JP2011502070 A JP 2011502070A JP 2011517451 A5 JP2011517451 A5 JP 2011517451A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- polymer conjugate
- mice
- individual
- scaffold
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 229920000642 polymer Polymers 0.000 description 4
- 229920001184 polypeptide Polymers 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 3
- 230000033115 angiogenesis Effects 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
Description
「対象」、「個体」、「宿主」および「患者」という用語は、任意の哺乳動物または非哺乳動物の種のメンバーに対して本明細書では互換的に使用される。したがって、対象および患者としてはヒト、非ヒト霊長類、イヌ、ネコ、有蹄動物(例えばウマ、ウシ、ブタ(swine)(例えばブタ(pig)))、トリ、げっ歯類(例えばラット、マウス)および他の対象が挙げられるがそれに限定されない。非ヒト動物モデル、特に哺乳動物、例えば非ヒト霊長類、ネズミ(例えばマウス、ラット)、ウサギなどを実験調査に使用可能である。
別の例として、先に論じたように、対象のポリペプチド-ポリマー抱合体をマトリックスまたはスキャフォールドに付着させることができ、ここでポリペプチド-ポリマー抱合体は細胞結合を与える。対象のポリペプチド-ポリマー抱合体を含み、ポリペプチド-ポリマー抱合体に細胞が結合しているかまたは結合していない、マトリックスまたはスキャフォールドを、細胞移植、組織工学などの文脈で個体に導入することができる。
いくつかの態様では、対象のポリペプチド-ポリマー抱合体は、(例えばポリペプチドが血管新生を誘導するものである場合)、それを必要とする個体において、例えば虚血組織中またはその近傍において、血管新生を誘導することに有用性を見出す。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4055608P | 2008-03-28 | 2008-03-28 | |
| US61/040,556 | 2008-03-28 | ||
| PCT/US2009/038446 WO2009120893A2 (en) | 2008-03-28 | 2009-03-26 | Polypeptide-polymer conjugates and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014251696A Division JP6144249B2 (ja) | 2008-03-28 | 2014-12-12 | ポリペプチド−ポリマー抱合体およびその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011517451A JP2011517451A (ja) | 2011-06-09 |
| JP2011517451A5 true JP2011517451A5 (ja) | 2014-03-20 |
Family
ID=41114732
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011502070A Withdrawn JP2011517451A (ja) | 2008-03-28 | 2009-03-26 | ポリペプチド−ポリマー抱合体およびその使用方法 |
| JP2014251696A Active JP6144249B2 (ja) | 2008-03-28 | 2014-12-12 | ポリペプチド−ポリマー抱合体およびその使用方法 |
| JP2017017249A Pending JP2017122092A (ja) | 2008-03-28 | 2017-02-02 | ポリペプチド−ポリマー抱合体およびその使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014251696A Active JP6144249B2 (ja) | 2008-03-28 | 2014-12-12 | ポリペプチド−ポリマー抱合体およびその使用方法 |
| JP2017017249A Pending JP2017122092A (ja) | 2008-03-28 | 2017-02-02 | ポリペプチド−ポリマー抱合体およびその使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (6) | US9428561B2 (ja) |
| EP (1) | EP2268673B1 (ja) |
| JP (3) | JP2011517451A (ja) |
| KR (1) | KR101694405B1 (ja) |
| CN (1) | CN102046661A (ja) |
| AU (1) | AU2009228217A1 (ja) |
| CA (1) | CA2719250C (ja) |
| ES (1) | ES2656350T3 (ja) |
| WO (1) | WO2009120893A2 (ja) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009228217A1 (en) | 2008-03-28 | 2009-10-01 | The Regents Of The University Of California | Polypeptide-polymer conjugates and methods of use thereof |
| CA2807942C (en) | 2010-08-10 | 2021-07-27 | Ecole Polytechnique Federale De Lausanne | Erythrocyte-binding therapeutics |
| US9517257B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| US9850296B2 (en) | 2010-08-10 | 2017-12-26 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| JP6080777B2 (ja) | 2011-03-17 | 2017-02-22 | コーニング インコーポレイテッド | 細胞培養のための合成被覆 |
| WO2012140650A2 (en) * | 2011-04-12 | 2012-10-18 | Hepacore Ltd. | Conjugates of carboxy polysaccharides with fibroblast growth factors and variants thereof |
| CN102552980B (zh) * | 2012-01-11 | 2013-10-30 | 中南大学湘雅三医院 | 黏附特异性多肽序列聚己内酯多元醇-磷酸三钙支架 |
| EP2981556A4 (en) | 2013-04-02 | 2016-11-30 | Univ California | HYALURONIC ACID BIOPOLYMERS ETHYLSULFONATED AND METHODS OF USE |
| CN103232561B (zh) * | 2013-04-10 | 2018-07-13 | 上海大学 | 选择亲和性多肽分子刷及其制备方法 |
| WO2015006141A1 (en) * | 2013-07-08 | 2015-01-15 | The Regents Of The University Of California | Carboxymethylcellulose-peptide conjugates and methods for using the same |
| US10046056B2 (en) | 2014-02-21 | 2018-08-14 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| US10946079B2 (en) | 2014-02-21 | 2021-03-16 | Ecole Polytechnique Federale De Lausanne | Glycotargeting therapeutics |
| US10953101B2 (en) | 2014-02-21 | 2021-03-23 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| MX2016010835A (es) | 2014-02-21 | 2017-07-11 | Anokion Sa | Terapeuticos dirigidos a la glucosa. |
| CN103865085B (zh) * | 2014-03-04 | 2016-04-27 | 山东理工大学 | 一种聚三亚甲基碳酸酯与聚乙烯吡咯烷酮改进聚肽膜亲水性的方法 |
| JP6959912B2 (ja) | 2015-09-23 | 2021-11-05 | ジェネンテック， インコーポレイテッド | 抗ｖｅｇｆ抗体の最適化変異体 |
| CA3022905A1 (en) | 2015-12-09 | 2017-06-15 | The Regents Of The University Of California | Methods of treating an ocular disease or disorder |
| WO2017136427A1 (en) * | 2016-02-02 | 2017-08-10 | The Regents Of The University Of California | Hydrogel for endogenous neuroprogenitor cell recruitment |
| CA3055985A1 (en) | 2017-03-22 | 2018-09-27 | Genentech, Inc. | Hydrogel cross-linked hyaluronic acid prodrug compositions and methods |
| EP3638296A1 (en) | 2017-06-16 | 2020-04-22 | The University Of Chicago | Compositions and methods for inducing immune tolerance |
| AU2019232001A1 (en) * | 2018-03-09 | 2020-10-22 | Valitor, Inc. | Multivalent peptide conjugates for sustained intra-articular treatment of joint inflammation |
| CN109503708A (zh) * | 2018-11-22 | 2019-03-22 | 浙江海洋大学 | 一种牛磺酸修饰的新型巨乌贼明胶多功能肽的制备方法 |
| CN109354600B (zh) * | 2018-11-29 | 2021-08-10 | 浙江海洋大学 | 一种牛磺酸修饰的新型阿拉斯加鳕鱼多功能肽的制备方法 |
| JP2020169141A (ja) * | 2019-04-04 | 2020-10-15 | 株式会社日立製作所 | 樹脂との密着性に優れたペプチドならびにそれを用いた生体適合機能材料 |
| MX2022000037A (es) * | 2019-07-01 | 2022-05-18 | Valitor Inc | Enlazadores hidrofilicos para conjugados de peptidos multivalentes. |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US5162218A (en) | 1988-11-18 | 1992-11-10 | The Regents Of The University Of California | Conjugated polypeptides and methods for their preparation |
| US7122636B1 (en) | 1997-02-21 | 2006-10-17 | Genentech, Inc. | Antibody fragment-polymer conjugates and uses of same |
| US6781030B1 (en) | 1998-11-02 | 2004-08-24 | Trustee Of Tufts College, Ballou Hall | Methods for cloning mammals using telophase oocytes |
| EP1025861A1 (de) | 1999-02-04 | 2000-08-09 | Roche Diagnostics GmbH | Pharmazeutische Zusammensetzung von hydrophob modifizierten Hedgehog-Proteinen und deren Verwendung |
| AU782493B2 (en) * | 1999-06-01 | 2005-08-04 | Curis, Inc. | Polymer conjugates of hedgehog proteins and uses |
| US20030236214A1 (en) * | 1999-06-09 | 2003-12-25 | Wolff Jon A. | Charge reversal of polyion complexes and treatment of peripheral occlusive disease |
| US9522217B2 (en) * | 2000-03-15 | 2016-12-20 | Orbusneich Medical, Inc. | Medical device with coating for capturing genetically-altered cells and methods for using same |
| US20040248801A1 (en) * | 2000-03-21 | 2004-12-09 | Kiessling Laura L. | Methods and reagents for regulation of cellular responses in biological systems |
| US20030003048A1 (en) * | 2001-04-26 | 2003-01-02 | Chun Li | Diagnostic imaging compositions, their methods of synthesis and use |
| US6908963B2 (en) | 2001-10-09 | 2005-06-21 | Nektar Therapeutics Al, Corporation | Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith |
| WO2003033521A1 (en) | 2001-10-16 | 2003-04-24 | Massachusetts Institute Of Technology | Inppressor trna system in mammalian cells for the introduction of unnatural amino acids in polypeptides. |
| KR100508369B1 (ko) * | 2001-10-31 | 2005-08-17 | 주식회사 바이오폴리메드 | 펩타이드 스페이서를 갖는 생체적합성 고분자 |
| US20070026518A1 (en) * | 2005-03-29 | 2007-02-01 | The Regents Of The University Of California | Controlling stem cell destiny with tunable matrices |
| MXPA05000186A (es) | 2002-07-03 | 2005-08-17 | Pericor Science Inc | Composiciones de acido hialuronico y metodos de uso. |
| US20040116348A1 (en) * | 2002-09-23 | 2004-06-17 | Ying Chau | Polymer-linker-drug conjugates for targeted drug delivery |
| CA2521784C (en) * | 2003-04-08 | 2012-03-27 | Yeda Research And Development Co. Ltd. | Reversible pegylated drugs |
| WO2005054860A1 (en) | 2003-12-01 | 2005-06-16 | Dako Denmark A/S | Methods and compositions for immuno-histochemical detection |
| US20050260153A1 (en) | 2004-04-13 | 2005-11-24 | Pericles Calias | Facilitation of iontophoresis using charged moieties |
| US8591885B2 (en) | 2004-04-30 | 2013-11-26 | Allergan, Inc. | Carbonic anhydrase inhibitor sustained release intraocular drug delivery systems |
| CA2705785A1 (en) | 2006-11-14 | 2008-05-22 | Saul Yedgar | Use of lipid conjugates in the treatment of diseases or disorders of the eye |
| US11078262B2 (en) | 2007-04-30 | 2021-08-03 | Allergan, Inc. | High viscosity macromolecular compositions for treating ocular conditions |
| WO2009048280A2 (en) * | 2007-10-09 | 2009-04-16 | Postech Academy-Industry Foundation | Long acting hyaluronic acid - peptide conjugate |
| AU2009228217A1 (en) | 2008-03-28 | 2009-10-01 | The Regents Of The University Of California | Polypeptide-polymer conjugates and methods of use thereof |
| US8759322B2 (en) | 2008-11-05 | 2014-06-24 | National University Corporation Tokyo Medical And Dental University | Hyaluronic acid derivative and pharmaceutical composition thereof |
| IT1399351B1 (it) | 2009-06-16 | 2013-04-16 | Fidia Farmaceutici | Procedimento per la sintesi di coniugati di glicosamminoglicani (gag) con molecole biologicamente attive, coniugati polimerici e usi relativi |
| US20120282211A1 (en) | 2009-11-24 | 2012-11-08 | Carnegie Mellon University | Antibodies and conjugates for modulators of angiogenesis |
| KR101309566B1 (ko) | 2010-12-10 | 2013-09-17 | 포항공과대학교 산학협력단 | 히알루론산-단백질 컨쥬게이트 및 이의 제조 방법 |
| WO2012140650A2 (en) | 2011-04-12 | 2012-10-18 | Hepacore Ltd. | Conjugates of carboxy polysaccharides with fibroblast growth factors and variants thereof |
| IN2014CN04251A (ja) | 2011-11-09 | 2015-07-17 | Ascend Biopharmaceuticals Ltd | |
| WO2015009787A1 (en) | 2013-07-19 | 2015-01-22 | The Johns Hopkins University | Biomaterials comprising hyaluronic acid binding peptides and extracellular matrix binding peptides for hyaluronic acid retention and tissue engineering applications |
| JP6959912B2 (ja) | 2015-09-23 | 2021-11-05 | ジェネンテック， インコーポレイテッド | 抗ｖｅｇｆ抗体の最適化変異体 |
| WO2017062407A1 (en) | 2015-10-07 | 2017-04-13 | Genentech, Inc. | Systems and methods for predicting vitreal half-life of therapeutic agent-polymer conjugates |
| CA3022905A1 (en) | 2015-12-09 | 2017-06-15 | The Regents Of The University Of California | Methods of treating an ocular disease or disorder |
| PE20191758A1 (es) | 2017-03-22 | 2019-12-12 | Genentech Inc | Composiciones de anticuerpo optimizadas para el tratamiento de trastornos oculares |
| AU2019232001A1 (en) | 2018-03-09 | 2020-10-22 | Valitor, Inc. | Multivalent peptide conjugates for sustained intra-articular treatment of joint inflammation |
| MX2022000037A (es) | 2019-07-01 | 2022-05-18 | Valitor Inc | Enlazadores hidrofilicos para conjugados de peptidos multivalentes. |
-
2009
- 2009-03-26 AU AU2009228217A patent/AU2009228217A1/en not_active Abandoned
- 2009-03-26 EP EP09724950.2A patent/EP2268673B1/en active Active
- 2009-03-26 JP JP2011502070A patent/JP2011517451A/ja not_active Withdrawn
- 2009-03-26 CA CA2719250A patent/CA2719250C/en active Active
- 2009-03-26 ES ES09724950.2T patent/ES2656350T3/es active Active
- 2009-03-26 KR KR1020107024088A patent/KR101694405B1/ko active IP Right Grant
- 2009-03-26 US US12/933,655 patent/US9428561B2/en active Active
- 2009-03-26 CN CN2009801201240A patent/CN102046661A/zh active Pending
- 2009-03-26 WO PCT/US2009/038446 patent/WO2009120893A2/en active Application Filing
-
2014
- 2014-12-12 JP JP2014251696A patent/JP6144249B2/ja active Active
-
2016
- 2016-07-19 US US15/214,398 patent/US9925237B2/en active Active
-
2017
- 2017-02-02 JP JP2017017249A patent/JP2017122092A/ja active Pending
-
2018
- 2018-02-20 US US15/900,011 patent/US10350267B2/en active Active
-
2019
- 2019-05-29 US US16/425,492 patent/US20200085910A1/en not_active Abandoned
-
2020
- 2020-09-01 US US17/009,472 patent/US11291707B2/en active Active
-
2022
- 2022-03-08 US US17/689,631 patent/US20220265763A1/en not_active Abandoned
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