JP2011517407A5 - - Google Patents
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- JP2011517407A5 JP2011517407A5 JP2011501318A JP2011501318A JP2011517407A5 JP 2011517407 A5 JP2011517407 A5 JP 2011517407A5 JP 2011501318 A JP2011501318 A JP 2011501318A JP 2011501318 A JP2011501318 A JP 2011501318A JP 2011517407 A5 JP2011517407 A5 JP 2011517407A5
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- JP
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- Prior art keywords
- administration
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- inhibition
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- 108010061608 Dermatophagoides pteronyssinus antigen p 2 Proteins 0.000 description 5
- 230000005764 inhibitory process Effects 0.000 description 5
- 108010061629 Dermatophagoides pteronyssinus antigen p 1 Proteins 0.000 description 4
- 239000012634 fragment Substances 0.000 description 2
- 210000004698 lymphocyte Anatomy 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 230000000172 allergic effect Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200800827 | 2008-03-25 | ||
| ES200800827 | 2008-03-25 | ||
| PCT/IB2009/005114 WO2009118642A2 (en) | 2008-03-25 | 2009-03-24 | Hypoallergenic hybrid proteins of major group 1 and 2 mite allergens for use in the treatment of allergies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015075517A Division JP6068544B2 (ja) | 2008-03-25 | 2015-04-02 | アレルギーの治療に用いるための、主要グループ１ダニアレルゲンおよび主要グループ２ダニアレルゲンの低アレルゲン性ハイブリッドタンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011517407A JP2011517407A (ja) | 2011-06-09 |
| JP2011517407A5 true JP2011517407A5 (cg-RX-API-DMAC10.html) | 2012-05-17 |
| JP5793073B2 JP5793073B2 (ja) | 2015-10-14 |
Family
ID=41110539
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011501318A Expired - Fee Related JP5793073B2 (ja) | 2008-03-25 | 2009-03-24 | アレルギーの治療に用いるための、主要グループ１ダニアレルゲンおよび主要グループ２ダニアレルゲンの低アレルゲン性ハイブリッドタンパク質 |
| JP2015075517A Expired - Fee Related JP6068544B2 (ja) | 2008-03-25 | 2015-04-02 | アレルギーの治療に用いるための、主要グループ１ダニアレルゲンおよび主要グループ２ダニアレルゲンの低アレルゲン性ハイブリッドタンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015075517A Expired - Fee Related JP6068544B2 (ja) | 2008-03-25 | 2015-04-02 | アレルギーの治療に用いるための、主要グループ１ダニアレルゲンおよび主要グループ２ダニアレルゲンの低アレルゲン性ハイブリッドタンパク質 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8951530B2 (cg-RX-API-DMAC10.html) |
| EP (3) | EP2436691B1 (cg-RX-API-DMAC10.html) |
| JP (2) | JP5793073B2 (cg-RX-API-DMAC10.html) |
| CN (2) | CN101977929B (cg-RX-API-DMAC10.html) |
| BR (1) | BRPI0908848A2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2718994C (cg-RX-API-DMAC10.html) |
| ES (2) | ES2638271T3 (cg-RX-API-DMAC10.html) |
| MX (1) | MX2010010353A (cg-RX-API-DMAC10.html) |
| WO (1) | WO2009118642A2 (cg-RX-API-DMAC10.html) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105903012B (zh) * | 2010-06-03 | 2022-02-01 | 爱尔开-阿贝优公司 | 包含螨过敏原提取物的药品及其制备方法 |
| EP2460824A1 (en) | 2010-12-01 | 2012-06-06 | Biomay Ag | Hypoallergenic polypeptides for the treatment of house dust mite allergy |
| CN102676568A (zh) * | 2012-05-08 | 2012-09-19 | 崔玉宝 | 一种生产重组粉尘螨变应原Der f1和Der f2融合蛋白的方法 |
| US9163069B2 (en) | 2012-09-20 | 2015-10-20 | Universidad De Cartagena | Fusion proteins representing different allergens and a vaccine against allergy to mites |
| JP6813359B2 (ja) * | 2014-12-02 | 2021-01-13 | 大鵬薬品工業株式会社 | 新規コナヒョウヒダニタンパク質 |
| NL2014882B1 (en) * | 2015-05-29 | 2017-01-31 | Citeq B V | Allergy-specific immunotherapy compositions for use in the treatment of house-dust mite allergy. |
| WO2017055235A1 (en) * | 2015-09-30 | 2017-04-06 | Boehringer Ingelheim Vetmedica Gmbh | Improved modular antigen transportation molecules and uses therof in animals |
| KR101858840B1 (ko) | 2016-01-15 | 2018-05-16 | 단국대학교 천안캠퍼스 산학협력단 | 집먼지진드기 유래 알레르겐에 의한 과민반응 면역조절제 |
| GB201602850D0 (en) * | 2016-02-18 | 2016-04-06 | Bial Ind Farmaceutica S A | Fusion proteins |
| CN108265056B (zh) * | 2016-12-31 | 2019-08-30 | 江苏众红生物工程创药研究院有限公司 | 一种重组户尘螨1类变应原蛋白及其制备方法和应用 |
| CN109852652B (zh) * | 2017-11-30 | 2023-05-02 | 江苏众红生物工程创药研究院有限公司 | 重组尘螨Ⅰ型变应原Der p1和Der f1蛋白的制备与应用 |
| EP3569612A1 (en) | 2018-05-18 | 2019-11-20 | Biomay Ag | Treatment and prevention of house dust mite allergies |
| CN113831400A (zh) * | 2021-07-29 | 2021-12-24 | 沈阳医学院 | 一种尘螨致敏蛋白Der p 1的分离纯化方法 |
| CN116063442A (zh) * | 2022-09-28 | 2023-05-05 | 深圳市龙岗区耳鼻咽喉医院 | Der p2的3个B细胞表位肽及其应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2993967B2 (ja) * | 1987-06-17 | 1999-12-27 | インスティテュート・フォー・チャイルド・ヘルス・リサーチ | ダニアレルゲンのクローニング |
| US5433948A (en) * | 1990-02-13 | 1995-07-18 | Thomas; Wayne R. | Cloning and sequencing of allergens of dermatophagoides (house dust mite) |
| US7288256B1 (en) * | 1991-10-16 | 2007-10-30 | Merck Patent Gmbh | T cell epitopes of the major allergens from dermatophagoides (house dust mite) |
| GB9724531D0 (en) | 1997-11-19 | 1998-01-21 | Smithkline Biolog | Novel compounds |
| EP1221317A1 (en) | 2000-12-28 | 2002-07-10 | SHAN-Beteiligungsgesellschaft m.b.H. | Vaccines containing hybrid polypeptides consisting of at least two different allergenic proteins |
| FR2841906B1 (fr) | 2002-07-05 | 2006-08-18 | Stallergenes Sa | Molecule d'acide nucleique codant une preproproteine d'allergene d'un acarien du genre dermatophagoides ou euroglyphus et son utilisation pour la production dudit allergene dans les plantes |
| ES2247433T3 (es) * | 2003-01-21 | 2006-03-01 | Biomay Produktions- Und Handels- Aktiengesellschaft | Procedimiento para la preparacion de proteinas de mosaico hipoalergenicas. |
| CN1780852A (zh) * | 2003-04-25 | 2006-05-31 | 诺和酶股份有限公司 | 组1螨多肽变体 |
| ITRM20040103A1 (it) | 2004-02-27 | 2004-05-27 | Consiglio Nazionale Ricerche | Proteine di fusione comprendenti allergeni della famiglia delle ns-ltps, loro usi e composizioni farmaceutiche che le comprendono. |
| AT501101B1 (de) * | 2004-12-02 | 2008-01-15 | Biomay Ag | Protein-allergen-derivat |
| US20070065468A1 (en) * | 2005-08-29 | 2007-03-22 | National University Of Singapore | Chimeric allergens for immunotherapy |
| CN100374152C (zh) * | 2005-12-23 | 2008-03-12 | 中国农业大学 | 一种过敏性反应抑制剂 |
| GB0607377D0 (en) | 2006-04-12 | 2006-05-24 | Glaxosmithkline Biolog Sa | Novel Methods |
| EP1908776A1 (en) * | 2006-10-06 | 2008-04-09 | Stallergenes Sa | Mite fusion proteins |
| EP1908777B1 (en) * | 2006-10-06 | 2016-02-03 | Stallergenes | Mite fusion proteins |
-
2009
- 2009-03-24 ES ES11179771.8T patent/ES2638271T3/es active Active
- 2009-03-24 MX MX2010010353A patent/MX2010010353A/es active IP Right Grant
- 2009-03-24 CN CN200980110215.6A patent/CN101977929B/zh not_active Expired - Fee Related
- 2009-03-24 CA CA2718994A patent/CA2718994C/en not_active Expired - Fee Related
- 2009-03-24 EP EP11179765.0A patent/EP2436691B1/en not_active Not-in-force
- 2009-03-24 ES ES11179765.0T patent/ES2638308T3/es active Active
- 2009-03-24 WO PCT/IB2009/005114 patent/WO2009118642A2/en not_active Ceased
- 2009-03-24 EP EP09724998A patent/EP2268662A2/en not_active Ceased
- 2009-03-24 US US12/934,418 patent/US8951530B2/en not_active Expired - Fee Related
- 2009-03-24 BR BRPI0908848A patent/BRPI0908848A2/pt not_active IP Right Cessation
- 2009-03-24 JP JP2011501318A patent/JP5793073B2/ja not_active Expired - Fee Related
- 2009-03-24 CN CN201610835971.7A patent/CN107118265A/zh active Pending
- 2009-03-24 EP EP11179771.8A patent/EP2436692B1/en not_active Not-in-force
-
2015
- 2015-02-09 US US14/617,136 patent/US20150152148A1/en not_active Abandoned
- 2015-04-02 JP JP2015075517A patent/JP6068544B2/ja not_active Expired - Fee Related