JP2011516499A - 嚢胞性線維症膜コンダクタンス制御因子を阻害するための二価ヒドラジド化合物コンジュゲート - Google Patents

嚢胞性線維症膜コンダクタンス制御因子を阻害するための二価ヒドラジド化合物コンジュゲート Download PDF

Info

Publication number
JP2011516499A
JP2011516499A JP2011503235A JP2011503235A JP2011516499A JP 2011516499 A JP2011516499 A JP 2011516499A JP 2011503235 A JP2011503235 A JP 2011503235A JP 2011503235 A JP2011503235 A JP 2011503235A JP 2011516499 A JP2011516499 A JP 2011516499A
Authority
JP
Japan
Prior art keywords
hydroxy
halo
mono
alkoxy
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011503235A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011516499A5 (cg-RX-API-DMAC10.html
Inventor
ヴァークマン，アラン，エス．
ソナウェイン，ナイチン，ディー．
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Publication of JP2011516499A publication Critical patent/JP2011516499A/ja
Publication of JP2011516499A5 publication Critical patent/JP2011516499A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C337/00—Derivatives of thiocarbonic acids containing functional groups covered by groups C07C333/00 or C07C335/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C337/06—Compounds containing any of the groups, e.g. thiosemicarbazides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/04—Amoebicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
JP2011503235A 2008-04-04 2009-04-03 嚢胞性線維症膜コンダクタンス制御因子を阻害するための二価ヒドラジド化合物コンジュゲート Pending JP2011516499A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4265108P 2008-04-04 2008-04-04
US61/042,651 2008-04-04
PCT/US2009/039566 WO2009146144A2 (en) 2008-04-04 2009-04-03 Divalent hydrazide compound conjugates for inhibiting cystic fibrosis transmembrane conductance regulator

Publications (2)

Publication Number Publication Date
JP2011516499A true JP2011516499A (ja) 2011-05-26
JP2011516499A5 JP2011516499A5 (cg-RX-API-DMAC10.html) 2012-05-31

Family

ID=41133847

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011503235A Pending JP2011516499A (ja) 2008-04-04 2009-04-03 嚢胞性線維症膜コンダクタンス制御因子を阻害するための二価ヒドラジド化合物コンジュゲート

Country Status (10)

Country Link
US (1) US20090253799A1 (cg-RX-API-DMAC10.html)
EP (1) EP2288592A2 (cg-RX-API-DMAC10.html)
JP (1) JP2011516499A (cg-RX-API-DMAC10.html)
KR (1) KR20110004413A (cg-RX-API-DMAC10.html)
AU (1) AU2009251519A1 (cg-RX-API-DMAC10.html)
BR (1) BRPI0910416A2 (cg-RX-API-DMAC10.html)
CA (1) CA2718676A1 (cg-RX-API-DMAC10.html)
MX (1) MX2010010783A (cg-RX-API-DMAC10.html)
TW (1) TW200946129A (cg-RX-API-DMAC10.html)
WO (1) WO2009146144A2 (cg-RX-API-DMAC10.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019088270A1 (ja) * 2017-11-02 2019-05-09 宇部興産株式会社 蛋白分解酵素の双頭型阻害剤

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0509282A (pt) * 2004-03-30 2007-09-18 Univ California compostos contendo hidrazida inibidores de cftr e seus usos
US8552067B2 (en) * 2006-12-22 2013-10-08 The Regents Of The University Of California Macromolecular conjugates of cystic fibrosis transmembrane conductance regulator protein inhibitors and uses therefor
EP2142498A2 (en) * 2007-04-02 2010-01-13 Institute for Oneworld Health Cftr inhibitor compounds and uses thereof
JP2011517674A (ja) * 2008-03-25 2011-06-16 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 嚢胞性線維症膜コンダクタンス制御因子の水溶性小分子阻害剤
US8236838B2 (en) * 2008-04-21 2012-08-07 Institute For Oneworld Health Compounds, compositions and methods comprising isoxazole derivatives
EP2278879B1 (en) 2008-04-21 2016-06-15 PATH Drug Solutions Compounds, compositions and methods comprising oxadiazole derivatives
WO2009131952A1 (en) * 2008-04-21 2009-10-29 Institute For Oneworld Health Compounds, compositions and methods comprising thiazole derivatives
US20090264481A1 (en) * 2008-04-21 2009-10-22 Institute For Oneworld Health Compounds, Compositions and Methods Comprising Oxadiazole Derivatives
WO2009131958A2 (en) * 2008-04-21 2009-10-29 Institute For Oneworld Health Compounds, compositions and methods comprising triazine derivatives
US20090270398A1 (en) * 2008-04-21 2009-10-29 Institute For Oneworld Health Compounds, Compositions and Methods Comprising Pyridazine Derivatives
WO2009131956A1 (en) * 2008-04-21 2009-10-29 Institute For Oneworld Health Compounds, compositions and methods comprising triazole derivatives
JP2012503005A (ja) * 2008-09-19 2012-02-02 インスティテュート フォア ワンワールド ヘルス イミダゾール誘導体およびトリアゾール誘導体を含む、化合物、組成物ならびに方法。
US8511216B2 (en) * 2009-03-30 2013-08-20 Kanzaki Kokyukoki Mfg. Co., Ltd. Hydraulic actuator unit
US8343976B2 (en) * 2009-04-20 2013-01-01 Institute For Oneworld Health Compounds, compositions and methods comprising pyrazole derivatives
EP2464354B1 (en) 2009-08-10 2015-04-01 The Regents of The University of California Pyrimido-pyrrolo-quinoxalinedione inhibitors of cystic fibrosis transmembrane conductance regulator protein and uses therefor
USRE48842E1 (en) 2011-05-27 2021-12-07 The Regents Of The University Of California Pyrimido-pyrrolo-oxazine-dione compound inhibitors of the cystic fibrosis transmembrane conductance regulator protein and uses therefor
KR20220046544A (ko) 2019-06-12 2022-04-14 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 답즙산 설사를 치료하는 방법

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005094374A2 (en) * 2004-03-30 2005-10-13 The Regents Of The University Of California Hydrazide-containing cftr inhibitor compounds and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE103902T1 (de) * 1982-05-07 1994-04-15 Ciba Geigy Ag Verwendung von chinolinderivaten zum schuetzen von kulturpflanzen.
US6331555B1 (en) * 1995-06-01 2001-12-18 University Of California Treatment of platelet derived growth factor related disorders such as cancers
ES2161594B1 (es) * 1998-12-17 2003-04-01 Servier Lab Nuevos derivados de la hidrazida, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
US7235573B2 (en) * 2002-09-30 2007-06-26 The Regents Of The University Of California Methods of treating secretory diarrhea using cystic fibrosis transmembrane conductance regulator protein inhibitors
US20050023974A1 (en) 2003-08-01 2005-02-03 Universal Display Corporation Protected organic electronic devices and methods for making the same
US8552067B2 (en) * 2006-12-22 2013-10-08 The Regents Of The University Of California Macromolecular conjugates of cystic fibrosis transmembrane conductance regulator protein inhibitors and uses therefor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005094374A2 (en) * 2004-03-30 2005-10-13 The Regents Of The University Of California Hydrazide-containing cftr inhibitor compounds and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN6013048603; ＧＡＳＴＲＯＥＮＴＥＲＯＬＯＧＹ Ｖｏｌ．１３２, 2007, ｐ．１２３４-１２４４ *
JPN6013048604; ＰＭＳＥ　Ｐｒｅｐｒｉｎｔｓ Ｖｏｌ．９８, 2008, ｐ．８１０-８１１ *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019088270A1 (ja) * 2017-11-02 2019-05-09 宇部興産株式会社 蛋白分解酵素の双頭型阻害剤
JPWO2019088270A1 (ja) * 2017-11-02 2020-12-03 宇部興産株式会社 蛋白分解酵素の双頭型阻害剤
US11465965B2 (en) 2017-11-02 2022-10-11 Ube Industries, Ltd. Double-headed protease inhibitor

Also Published As

Publication number Publication date
TW200946129A (en) 2009-11-16
US20090253799A1 (en) 2009-10-08
EP2288592A2 (en) 2011-03-02
MX2010010783A (es) 2010-11-12
KR20110004413A (ko) 2011-01-13
AU2009251519A1 (en) 2009-12-03
CA2718676A1 (en) 2009-12-03
WO2009146144A3 (en) 2010-01-28
WO2009146144A2 (en) 2009-12-03
BRPI0910416A2 (pt) 2019-09-24

Similar Documents

Publication Publication Date Title
US20090253799A1 (en) Divalent hydrazide compound conjugates for inhibiting cystic fibrosis transmembrane conductance regulator
US8552067B2 (en) Macromolecular conjugates of cystic fibrosis transmembrane conductance regulator protein inhibitors and uses therefor
JP4344235B2 (ja) タキソール増強剤化合物
ES2505318T3 (es) Compuestos terapéuticos
US20100168112A1 (en) 2-Substituted and 4-substituted aryl nitrone compounds
JPH09507232A (ja) ２，４−ジスルホフェニルブチルニトロン、その塩および薬学的スピントラップ剤としてのそれらの使用
US11377473B2 (en) Albumin-binding prodrugs of auristatin E derivatives
BR112014027406B1 (pt) Composto, composição e uso de um composto
JP2011517674A (ja) 嚢胞性線維症膜コンダクタンス制御因子の水溶性小分子阻害剤
TW200533636A (en) Prodrugs of selective androgen receptor modulators and methods of use thereof
BR112013015174A2 (pt) compostos de tio-semicarbazona e aplicação no tratamento de cancer
JP7025358B2 (ja) 免疫グロブリン軽鎖アミロイドーシスを治療する方法
JP2008506723A (ja) 医薬用運搬体及び作用体並びに化学用相間移動剤としてのアンモニウム塩及びアンモニウム塩−鉱酸塩クラスレート化合物
CN118355013A (zh) 苯并咪唑衍生物化合物及其用途
JP5324921B2 (ja) 抗癌剤としてのデメチルペンクロメジン類似体とその使用
RU2795101C2 (ru) Альбумин-связывающие пролекарства на основе производных ауристатина е
CA3083983C (en) Albumin-binding prodrugs of auristatin e derivatives
CN111836803A (zh) 化合物及其在治疗癌症中的用途
HK40110772A (en) Albumin-binding prodrugs of auristatin e derivatives
WO2024185864A1 (ja) 抗ウイルス剤
CA2968483A1 (fr) Derives hydroxybisphosphoniques hydrosolubles de la doxorubicine
HK40040808B (en) Albumin-binding prodrugs of auristatin e derivatives
HK40040808A (en) Albumin-binding prodrugs of auristatin e derivatives

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20110223

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120329

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20120329

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20131001

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20131003

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20140325