JP2011515458A5 - - Google Patents
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- Publication number
- JP2011515458A5 JP2011515458A5 JP2011501337A JP2011501337A JP2011515458A5 JP 2011515458 A5 JP2011515458 A5 JP 2011515458A5 JP 2011501337 A JP2011501337 A JP 2011501337A JP 2011501337 A JP2011501337 A JP 2011501337A JP 2011515458 A5 JP2011515458 A5 JP 2011515458A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- oral pharmaceutical
- protease inhibitor
- composition according
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6477908P | 2008-03-26 | 2008-03-26 | |
| US61/064,779 | 2008-03-26 | ||
| PCT/IL2009/000223 WO2009118722A2 (en) | 2008-03-26 | 2009-02-26 | Methods and compositions for oral administration of proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011515458A JP2011515458A (ja) | 2011-05-19 |
| JP2011515458A5 true JP2011515458A5 (cg-RX-API-DMAC7.html) | 2012-04-05 |
| JP5395160B2 JP5395160B2 (ja) | 2014-01-22 |
Family
ID=41114402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011501337A Active JP5395160B2 (ja) | 2008-03-26 | 2009-02-26 | タンパク質の経口投与方法及び組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US10058593B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3777831B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5395160B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN102037121B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2009230718B2 (cg-RX-API-DMAC7.html) |
| CA (3) | CA2719272C (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ588603A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2504373C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009118722A2 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201007522B (cg-RX-API-DMAC7.html) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2722054B1 (en) * | 2005-09-06 | 2018-03-21 | Oramed Pharmaceuticals Inc. | Methods and compositions for oral administration of proteins |
| RU2504373C2 (ru) | 2008-03-26 | 2014-01-20 | ОРАМЕД Лтд. | Способы и композиции для перорального введения протеинов |
| CA2723434C (en) * | 2008-05-05 | 2018-01-23 | Oramed Ltd. | Methods and compositions for oral administration of exenatide |
| MX346316B (es) * | 2010-02-25 | 2017-03-15 | Evonik Roehm Gmbh | Formulacion farmaceutica o nutraceutica. |
| BR112013000452A2 (pt) | 2010-07-09 | 2020-02-11 | Affibody Ab | Polipeptídeo de ligação de albumina, proteína de fusão ou conjugado, polinucleotídeo, método para produzir um polipeptídeo, composição, método para a preparação de uma composição, e, método para aumentar a solubilidade de um composto |
| WO2013102899A1 (en) | 2012-01-03 | 2013-07-11 | Oramed Ltd. | Methods and compositions for treating diabetes |
| ES2912138T3 (es) * | 2012-02-01 | 2022-05-24 | Oramed Ltd | Composiciones que contienen inhibidores de proteasa, composiciones que comprenden las mismas y métodos para producir y usar las misma |
| JP2015512902A (ja) * | 2012-03-28 | 2015-04-30 | アフィボディ・アーベー | 経口投与 |
| US10155792B2 (en) | 2012-09-25 | 2018-12-18 | Affibody Ab | Albumin binding polypeptide |
| CN104902921A (zh) | 2013-01-03 | 2015-09-09 | 奥拉姆德有限公司 | 用于治疗nafld、肝性脂肪变性及其后遗症的方法和组合物 |
| EP3003267A1 (en) * | 2013-05-30 | 2016-04-13 | Novo Nordisk A/S | Novel oral pharmaceutical composition for treatment of diabetes |
| WO2015091957A1 (en) | 2013-12-20 | 2015-06-25 | Affibody Ab | Engineered albumin binding polypeptide |
| CN104922682A (zh) * | 2014-03-20 | 2015-09-23 | 中国科学院大连化学物理研究所 | 一种胰蛋白酶抑制剂及其应用 |
| WO2015176031A2 (en) | 2014-05-15 | 2015-11-19 | Incube Labs, Llc | Pharmaceutical compositions and methods for fabrication of solid masses comprising polypeptides and/or proteins |
| US10689460B2 (en) | 2014-05-15 | 2020-06-23 | Incube Labs, Llc | PCSK9 antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| JP7211704B2 (ja) | 2015-01-29 | 2023-01-24 | ノヴォ ノルディスク アー/エス | Glp-1アゴニスト及び腸溶コーティングを含む錠剤 |
| CN113230386B (zh) * | 2021-03-07 | 2022-04-12 | 合肥天汇孵化科技有限公司 | 胸腺法新组合物及其用途 |
| US20240366731A1 (en) * | 2021-08-12 | 2024-11-07 | Celagenex Research (India) Pvt. Ltd. | Oral algal oil based gastro-intestinal tract permeable peptide composition |
| EP4400094A4 (en) * | 2021-09-07 | 2025-08-27 | D&D Pharmatech Inc | PHARMACEUTICAL COMPOSITION COMPRISING A PHYSIOLOGICALLY ACTIVE SUBSTANCE AND AN EXCIPIENT |
| WO2025147459A1 (en) * | 2024-01-04 | 2025-07-10 | Nano Precision Medical, Inc. | Stabilization of peptides and proteins in implantable devices and formulations |
| US12466883B1 (en) | 2024-05-13 | 2025-11-11 | Lumen Bioscience, Inc. | Leptin compositions and methods of making and using the same to support weight loss and/or maintenance |
Family Cites Families (59)
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|---|---|---|---|---|
| IL68769A (en) | 1983-05-23 | 1986-02-28 | Hadassah Med Org | Pharmaceutical compositions containing insulin for oral administration |
| JPS6350793A (ja) | 1986-08-20 | 1988-03-03 | 株式会社東芝 | 高速増殖炉の崩壊熱除去システム |
| US5034415A (en) | 1987-08-07 | 1991-07-23 | Century Laboratories, Inc. | Treatment of diabetes mellitus |
| EP0351651B1 (en) | 1988-07-21 | 1993-09-15 | F. Hoffmann-La Roche Ag | Insulin preparation |
| JPH02250823A (ja) | 1989-03-24 | 1990-10-08 | Tsumura & Co | マイクロカプセル剤およびその製造方法 |
| GB9007052D0 (en) | 1990-03-29 | 1990-05-30 | Skua Investments Ltd | Pharmaceutical formulations |
| US5206219A (en) * | 1991-11-25 | 1993-04-27 | Applied Analytical Industries, Inc. | Oral compositions of proteinaceous medicaments |
| US6692766B1 (en) * | 1994-06-15 | 2004-02-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Controlled release oral drug delivery system |
| US5824638A (en) * | 1995-05-22 | 1998-10-20 | Shire Laboratories, Inc. | Oral insulin delivery |
| IL114673A (en) | 1995-07-19 | 2000-12-06 | Hadasit Med Res Service | Pharmaceutical compositions containing protein for oral administration |
| JPH09208485A (ja) | 1996-01-31 | 1997-08-12 | Teijin Ltd | ペプチド・蛋白質性薬物の水難溶性組成物 |
| DE69740096D1 (de) * | 1996-08-08 | 2011-02-17 | Amylin Pharmaceuticals Inc | Pharmazeutische Zusammensetzung mit einem Exendin-4-Peptid |
| JPH10330287A (ja) | 1997-03-31 | 1998-12-15 | Nippon Suisan Kaisha Ltd | 多価不飽和脂肪酸からなる消化管吸収促進剤およびそれを含有する薬剤 |
| JP2000050793A (ja) | 1998-08-07 | 2000-02-22 | Meiji Milk Prod Co Ltd | 人工乳組成物 |
| JP2000128805A (ja) | 1998-10-27 | 2000-05-09 | Nippon Suisan Kaisha Ltd | 多価不飽和脂肪酸および高分子ゲルからなる経粘膜吸収促進剤及びそれを含有する薬剤 |
| US6761903B2 (en) * | 1999-06-30 | 2004-07-13 | Lipocine, Inc. | Clear oil-containing pharmaceutical compositions containing a therapeutic agent |
| CZ305123B6 (cs) | 1999-10-04 | 2015-05-13 | Novartis Vaccines And Diagnostics, Inc. | Způsob výroby kapalného farmaceutického prostředku |
| JP2001240558A (ja) | 2000-02-29 | 2001-09-04 | Nippon Suisan Kaisha Ltd | 多価不飽和脂肪酸を経粘膜吸収促進剤として含有する固形製剤。 |
| US6673574B2 (en) * | 2000-11-30 | 2004-01-06 | Unigene Laboratories Inc. | Oral delivery of peptides using enzyme-cleavable membrane translocators |
| KR20010069322A (ko) | 2001-03-08 | 2001-07-25 | 서종수 | 휴대형정보단말기 또는 화상이동통신장치를 이용한전자경매방법 |
| KR20010069433A (ko) | 2001-03-22 | 2001-07-25 | 김윤완 | 노루궁뎅이버섯을 이용한 건강 보조 식품 |
| CN1160122C (zh) | 2001-04-20 | 2004-08-04 | 清华大学 | 一种制备口服胰岛素油相制剂的方法 |
| CN1741805A (zh) | 2001-07-18 | 2006-03-01 | 索莱有限责任公司 | 高蛋白质鲍曼-比尔克抑制剂浓缩物及其生产方法 |
| US20030198666A1 (en) | 2002-01-07 | 2003-10-23 | Richat Abbas | Oral insulin therapy |
| US7767828B2 (en) * | 2003-11-12 | 2010-08-03 | Phenomix Corporation | Methyl and ethyl substituted pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
| US20060286129A1 (en) * | 2003-12-19 | 2006-12-21 | Emisphere Technologies, Inc. | Oral GLP-1 formulations |
| US20050143303A1 (en) * | 2003-12-26 | 2005-06-30 | Nastech Pharmaceutical Company Inc. | Intranasal administration of glucose-regulating peptides |
| US8076288B2 (en) * | 2004-02-11 | 2011-12-13 | Amylin Pharmaceuticals, Inc. | Hybrid polypeptides having glucose lowering activity |
| CA2563533C (en) * | 2004-04-15 | 2013-10-01 | Shmuel A. Ben-Sasson | Compositions capable of facilitating penetration across a biological barrier |
| CN101027318B (zh) * | 2004-07-19 | 2016-05-25 | 比奥孔有限公司 | 胰岛素-低聚物共轭物,制剂及其用途 |
| US20060046962A1 (en) * | 2004-08-25 | 2006-03-02 | Aegis Therapeutics Llc | Absorption enhancers for drug administration |
| EP1789075A4 (en) * | 2004-08-25 | 2009-07-01 | Uab Research Foundation | ABSORPTION ENHANCER FOR DRUG ADMINISTRATION |
| EP2722054B1 (en) | 2005-09-06 | 2018-03-21 | Oramed Pharmaceuticals Inc. | Methods and compositions for oral administration of proteins |
| US20070086972A1 (en) | 2005-09-12 | 2007-04-19 | Jacob Birnbaum | Hair growth compositions and methods for treating hair loss or related conditions |
| US20070077283A1 (en) * | 2005-09-30 | 2007-04-05 | Nastech Pharmaceutical Company Inc. | Method of enhancing transmucosal delivery of therapeutic compounds |
| CN101095942B (zh) | 2006-06-30 | 2011-11-16 | 北京民海生物科技有限公司 | 一种包含稳定剂的Exendin-4注射剂药物配方 |
| WO2008142482A2 (en) | 2006-11-01 | 2008-11-27 | Pronova Biopharma Norge As | Omega-3 lipid compounds |
| PL2144618T5 (pl) | 2007-03-28 | 2025-07-21 | Aker Biomarine Human Ingredients As | Bio-skuteczne kompozycje oleju z kryla |
| RU2504373C2 (ru) | 2008-03-26 | 2014-01-20 | ОРАМЕД Лтд. | Способы и композиции для перорального введения протеинов |
| CA2723434C (en) | 2008-05-05 | 2018-01-23 | Oramed Ltd. | Methods and compositions for oral administration of exenatide |
| PE20100156A1 (es) | 2008-06-03 | 2010-02-23 | Boehringer Ingelheim Int | Tratamiento de nafld |
| JPWO2009151125A1 (ja) | 2008-06-13 | 2011-11-17 | 持田製薬株式会社 | 肝障害の診断及び治療 |
| WO2009154230A1 (ja) | 2008-06-17 | 2009-12-23 | 持田製薬株式会社 | 非アルコール性脂肪肝炎の予防/改善・治療薬 |
| ES2558842T3 (es) | 2008-06-17 | 2016-02-09 | Indiana University Research And Technology Corporation | Agonistas mixtos a base de GIP para el tratamiento de trastornos metabólicos y obesidad |
| US20090312302A1 (en) | 2008-06-17 | 2009-12-17 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating nonalcoholic fatty liver disease-associated disorders |
| CN102123697B (zh) | 2008-08-18 | 2015-06-10 | 安特拉贝欧有限公司 | 用于口服给予蛋白质的方法和组合物 |
| UY32177A (es) | 2008-10-16 | 2010-05-31 | Boehringer Ingelheim Int | Tratamiento de diabetes en pacientes con control glucémico insuficiente a pesar de la terapia con fármaco, oral o no, antidiabético |
| KR101783817B1 (ko) | 2009-05-08 | 2017-10-23 | 프로노바 바이오파마 너지 에이에스 | 심혈관 질병, 대사 질병, 및 염증성 질환 분야관련 질병의 치료를 위한 다중 불포화 지방산 |
| US20120202849A1 (en) | 2009-10-12 | 2012-08-09 | Anil Pareek | Pharmaceutical compositions for the treatment/prophylaxis of non-alcoholic fatty liver disease |
| CN103988973A (zh) | 2009-12-30 | 2014-08-20 | 索莱有限责任公司 | 大豆乳清蛋白组合物及其回收方法 |
| US20130273154A1 (en) | 2011-03-02 | 2013-10-17 | Joseph M. Fayad | Oral formulations Mimetic of Roux-en-Y gastric bypass actions on the ileal brake; Compositions, Methods of Treatment, Diagnostics and Systems for treatment of metabolic syndrome manifestations including insulin resistance, fatty liver disease, hpperlipidemia, and type 2 diabetes |
| PH12012502524A1 (en) | 2010-06-24 | 2014-02-10 | Boehringer Ingelheim Int | Diabetes therapy |
| CA2804506C (en) | 2010-07-06 | 2018-08-21 | Janssen Pharmaceutica Nv | Formulation for co-therapy treatment of diabetes |
| US20120264824A1 (en) | 2011-04-15 | 2012-10-18 | Mochida Pharmaceutical Co., Ltd. | Compositions and methods for treating non-alcoholic steatohepatitis |
| US20140220134A1 (en) | 2011-06-24 | 2014-08-07 | Astrazeneca Pharamceuticals LP | Method for treating diabetes with extended release formulation of glp-1 receptor agonists |
| WO2013102899A1 (en) | 2012-01-03 | 2013-07-11 | Oramed Ltd. | Methods and compositions for treating diabetes |
| ES2912138T3 (es) | 2012-02-01 | 2022-05-24 | Oramed Ltd | Composiciones que contienen inhibidores de proteasa, composiciones que comprenden las mismas y métodos para producir y usar las misma |
| CN104902921A (zh) | 2013-01-03 | 2015-09-09 | 奥拉姆德有限公司 | 用于治疗nafld、肝性脂肪变性及其后遗症的方法和组合物 |
| IL241462A0 (en) * | 2015-09-10 | 2015-11-30 | Yeda Res & Dev | Heterologous engineering of betalain pigments in plants |
-
2009
- 2009-02-26 RU RU2010141292/10A patent/RU2504373C2/ru active
- 2009-02-26 CA CA2719272A patent/CA2719272C/en active Active
- 2009-02-26 EP EP20181613.9A patent/EP3777831B1/en active Active
- 2009-02-26 AU AU2009230718A patent/AU2009230718B2/en active Active
- 2009-02-26 US US12/934,754 patent/US10058593B2/en active Active
- 2009-02-26 NZ NZ588603A patent/NZ588603A/en unknown
- 2009-02-26 EP EP09725603.6A patent/EP2279244B1/en active Active
- 2009-02-26 CN CN2009801186734A patent/CN102037121B/zh active Active
- 2009-02-26 JP JP2011501337A patent/JP5395160B2/ja active Active
- 2009-02-26 CA CA3083198A patent/CA3083198A1/en active Pending
- 2009-02-26 CA CA3083698A patent/CA3083698A1/en not_active Abandoned
- 2009-02-26 WO PCT/IL2009/000223 patent/WO2009118722A2/en not_active Ceased
-
2010
- 2010-10-21 ZA ZA2010/07522A patent/ZA201007522B/en unknown
-
2018
- 2018-07-27 US US16/047,418 patent/US10881714B2/en active Active
-
2020
- 2020-12-23 US US17/132,117 patent/US11660327B2/en active Active
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