JP2011515430A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011515430A5 JP2011515430A5 JP2011501141A JP2011501141A JP2011515430A5 JP 2011515430 A5 JP2011515430 A5 JP 2011515430A5 JP 2011501141 A JP2011501141 A JP 2011501141A JP 2011501141 A JP2011501141 A JP 2011501141A JP 2011515430 A5 JP2011515430 A5 JP 2011515430A5
- Authority
- JP
- Japan
- Prior art keywords
- treatment
- drug
- anxiety
- stress
- anesthetics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000011117 substance-related disease Diseases 0.000 claims description 8
- 208000007848 Alcoholism Diseases 0.000 claims description 4
- 208000024827 Alzheimer disease Diseases 0.000 claims description 4
- 206010013654 Drug abuse Diseases 0.000 claims description 4
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims description 4
- 206010013663 drug dependence Diseases 0.000 claims description 4
- 230000001105 regulatory effect Effects 0.000 claims description 4
- 208000019901 Anxiety disease Diseases 0.000 claims description 3
- 230000036506 anxiety Effects 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 3
- 239000003193 general anesthetic agent Substances 0.000 claims description 3
- 208000032841 Bulimia Diseases 0.000 claims description 2
- 206010006550 Bulimia nervosa Diseases 0.000 claims description 2
- 206010006895 Cachexia Diseases 0.000 claims description 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 2
- 208000028698 Cognitive impairment Diseases 0.000 claims description 2
- 206010011878 Deafness Diseases 0.000 claims description 2
- 206010012735 Diarrhoea Diseases 0.000 claims description 2
- 208000030814 Eating disease Diseases 0.000 claims description 2
- 208000019454 Feeding and Eating disease Diseases 0.000 claims description 2
- 206010020772 Hypertension Diseases 0.000 claims description 2
- 208000001953 Hypotension Diseases 0.000 claims description 2
- 208000019695 Migraine disease Diseases 0.000 claims description 2
- 208000026251 Opioid-Related disease Diseases 0.000 claims description 2
- 208000003251 Pruritus Diseases 0.000 claims description 2
- 206010039966 Senile dementia Diseases 0.000 claims description 2
- 201000001880 Sexual dysfunction Diseases 0.000 claims description 2
- 208000009205 Tinnitus Diseases 0.000 claims description 2
- 206010046543 Urinary incontinence Diseases 0.000 claims description 2
- 206010001584 alcohol abuse Diseases 0.000 claims description 2
- 201000007930 alcohol dependence Diseases 0.000 claims description 2
- 208000025746 alcohol use disease Diseases 0.000 claims description 2
- 208000022531 anorexia Diseases 0.000 claims description 2
- 230000002921 anti-spasmodic effect Effects 0.000 claims description 2
- 208000010877 cognitive disease Diseases 0.000 claims description 2
- 206010061428 decreased appetite Diseases 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 208000035475 disorder Diseases 0.000 claims description 2
- 235000014632 disordered eating Nutrition 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 206010015037 epilepsy Diseases 0.000 claims description 2
- 230000010370 hearing loss Effects 0.000 claims description 2
- 231100000888 hearing loss Toxicity 0.000 claims description 2
- 208000016354 hearing loss disease Diseases 0.000 claims description 2
- 230000036543 hypotension Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 206010027175 memory impairment Diseases 0.000 claims description 2
- 206010027599 migraine Diseases 0.000 claims description 2
- 230000037023 motor activity Effects 0.000 claims description 2
- 239000003158 myorelaxant agent Substances 0.000 claims description 2
- 230000004770 neurodegeneration Effects 0.000 claims description 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 2
- 230000003957 neurotransmitter release Effects 0.000 claims description 2
- 230000001777 nootropic effect Effects 0.000 claims description 2
- 201000005040 opiate dependence Diseases 0.000 claims description 2
- 239000000014 opioid analgesic Substances 0.000 claims description 2
- 229940005483 opioid analgesics Drugs 0.000 claims description 2
- 229940052318 opioid anesthetics Drugs 0.000 claims description 2
- 210000000056 organ Anatomy 0.000 claims description 2
- 231100000872 sexual dysfunction Toxicity 0.000 claims description 2
- 208000011580 syndromic disease Diseases 0.000 claims description 2
- 231100000886 tinnitus Toxicity 0.000 claims description 2
- 208000004880 Polyuria Diseases 0.000 claims 1
- 229940035674 anesthetics Drugs 0.000 claims 1
- 229940124575 antispasmodic agent Drugs 0.000 claims 1
- 230000035619 diuresis Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229940035363 muscle relaxants Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 230000000049 anti-anxiety effect Effects 0.000 description 1
- 230000001598 anti-natriuretic effect Effects 0.000 description 1
- 239000002249 anxiolytic agent Substances 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 230000008991 intestinal motility Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08005804 | 2008-03-27 | ||
| EP08005804.3 | 2008-03-27 | ||
| PCT/EP2009/002180 WO2009118169A1 (de) | 2008-03-27 | 2009-03-25 | Spiro(5.5)undecan derivate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011515430A JP2011515430A (ja) | 2011-05-19 |
| JP2011515430A5 true JP2011515430A5 (cg-RX-API-DMAC10.html) | 2014-04-17 |
| JP5542119B2 JP5542119B2 (ja) | 2014-07-09 |
Family
ID=39535606
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011501141A Expired - Fee Related JP5542119B2 (ja) | 2008-03-27 | 2009-03-25 | スピロ（５．５）ウンデカン誘導体 |
Country Status (18)
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5542119B2 (ja) | 2008-03-27 | 2014-07-09 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | スピロ（５．５）ウンデカン誘導体 |
| EP2260022B1 (de) | 2008-03-27 | 2017-01-04 | Grünenthal GmbH | Substituierte cyclohexyldiamine |
| AU2009228637B2 (en) * | 2008-03-27 | 2013-12-19 | Grunenthal Gmbh | (Hetero-)aryl cyclohexane derivatives |
| HRP20140650T1 (hr) | 2008-03-27 | 2014-09-26 | Grünenthal GmbH | Hidroksimetilcikloheksilamini |
| KR20120075500A (ko) | 2008-03-27 | 2012-07-06 | 그뤼넨탈 게엠베하 | 치환된 4-아미노사이클로헥산 유도체 |
| CL2009000731A1 (es) | 2008-03-27 | 2009-05-15 | Gruenenthal Gmbh | Compuestos derivados de ciclohexano espirociclicos sustituidos, composicion farmaceutica que contiene a dicho compuesto y su uso como moduladores del receptor de opioides µ y el receptor orl-1 para tratar el dolor, ansiedad, depresion, epilepsia, alzheimer, abuso de alcohol, hipertension, anorexia, obesidad y diarrea. |
| PL2649044T3 (pl) * | 2010-12-08 | 2018-02-28 | Grünenthal GmbH | Sposób syntezy podstawionych pochodnych aminocykloheksanonu |
| TW201607923A (zh) | 2014-07-15 | 2016-03-01 | 歌林達有限公司 | 被取代之氮螺環（４．５）癸烷衍生物 |
| ES2686326T3 (es) * | 2014-07-15 | 2018-10-17 | Grünenthal GmbH | Derivados de azaspiro(4,5)decano sustituidos |
Family Cites Families (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US759311A (en) * | 1903-11-19 | 1904-05-10 | Press Publishing Company | News-stand. |
| GB1055203A (en) | 1964-09-16 | 1967-01-18 | Ici Ltd | -ß-carboline derivatives, a process for their manufacture, and compositions containing them |
| US4065573A (en) | 1976-06-03 | 1977-12-27 | The Upjohn Company | 4-Amino-4-phenylcyclohexanone ketal compositions and process of use |
| US4115589A (en) | 1977-05-17 | 1978-09-19 | The Upjohn Company | Compounds, compositions and method of use |
| US4366172A (en) | 1977-09-29 | 1982-12-28 | The Upjohn Company | 4-Amino-cyclohexanols, their pharmaceutical compositions and methods of use |
| US4291039A (en) | 1980-08-08 | 1981-09-22 | Miles Laboratories, Inc. | Tetrahydro β-carbolines having anti-hypertensive activity |
| DE3309596A1 (de) | 1982-08-05 | 1984-04-05 | Basf Ag, 6700 Ludwigshafen | 2-substituierte 1-(3'-aminoalkyl)-1,2,3,4-tetrahydro-ss-carboline, ihre herstellung und verwendung als arzneimittel |
| US4616028A (en) * | 1985-04-22 | 1986-10-07 | American Home Products Corporation | Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives, compositions and use |
| US5328905A (en) | 1987-07-20 | 1994-07-12 | Duphar International Research B.V. | 8,9-anellated-1,2,3,4-tetrahydro-β-carboline derivatives |
| EP0620222A3 (en) | 1993-04-14 | 1995-04-12 | Lilly Co Eli | Tetrahydro-beta-carbolines. |
| US5631265A (en) | 1994-03-11 | 1997-05-20 | Eli Lilly And Company | 8-substituted tetrahydro-beta-carbolines |
| US5861409A (en) | 1995-05-19 | 1999-01-19 | Eli Lilly And Company | Tetrahydro-beta-carbolines |
| GB0012240D0 (en) | 2000-05-19 | 2000-07-12 | Merck Sharp & Dohme | Therapeutic agents |
| DE10123163A1 (de) | 2001-05-09 | 2003-01-16 | Gruenenthal Gmbh | Substituierte Cyclohexan-1,4-diaminderivate |
| DE10135636A1 (de) | 2001-07-17 | 2003-02-06 | Gruenenthal Gmbh | Substituierte 4-Aminocyclohexanole |
| EP1407092A1 (en) | 2001-07-18 | 2004-04-14 | Dipiemme Dies and Plastic Machinery S.r.l. | A corrugated/undulated sheet having protuberances in the grooves defined by the corrugations; process and apparatus |
| DE10213051B4 (de) | 2002-03-23 | 2013-03-07 | Grünenthal GmbH | Substituierte 4-Aminocyclohexanole |
| TWI329111B (en) | 2002-05-24 | 2010-08-21 | X Ceptor Therapeutics Inc | Azepinoindole and pyridoindole derivatives as pharmaceutical agents |
| US7595311B2 (en) | 2002-05-24 | 2009-09-29 | Exelixis, Inc. | Azepinoindole derivatives as pharmaceutical agents |
| DE10252667A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE10252666A1 (de) | 2002-11-11 | 2004-08-05 | Grünenthal GmbH | N-Piperidyl-cyclohexan-Derivate |
| DE10252650A1 (de) | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Cyclohexyl-Harnstoff-Derivate |
| DE10252665A1 (de) | 2002-11-11 | 2004-06-03 | Grünenthal GmbH | 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate |
| DE50306277D1 (de) | 2002-11-12 | 2007-02-22 | Gruenenthal Gmbh | 4-alkyl-/4-alkenyl-/4-alkinylmethyl/-1-arylcyclohexylamin-derivate |
| ATE457299T1 (de) | 2002-11-12 | 2010-02-15 | Gruenenthal Gmbh | 4-hydroxymethyl-1-aryl-cyclohexylamin-derivativ |
| EP1633751A1 (en) | 2003-06-16 | 2006-03-15 | Chroma Therapeutics Limited | Carboline and betacarboline derivatives for use as hdac enzyme inhibitors |
| DE10360793A1 (de) | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE10360792A1 (de) | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE102004023506A1 (de) | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Kettenverlängerte substituierte Cyclohexyl-1,4-diamin-Derivate |
| DE102004023501A1 (de) | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Oxosubstituierte Cyclohexyl-1,4-diamin-Derivate |
| DE102004023507A1 (de) | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Substituierte Cyclohexylessigsäure-Derivate |
| DE102004023632A1 (de) | 2004-05-10 | 2005-12-08 | Grünenthal GmbH | Substituierte Cyclohexylcarbonsäure-Derivate |
| DE102004023522A1 (de) | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Substituierte Cyclohexyl-1,4-diamin-Derivate |
| DE102004023508A1 (de) | 2004-05-10 | 2005-12-08 | Grünenthal GmbH | Säurederivate substituierter Cyclohexyl-1,4-diamine |
| DE102004023635A1 (de) | 2004-05-10 | 2006-04-13 | Grünenthal GmbH | Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate |
| DE102004039382A1 (de) | 2004-08-13 | 2006-02-23 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| EP1817025A2 (en) | 2004-11-23 | 2007-08-15 | PTC Therapeutics, Inc. | Tetrahydrocarbazoles as active agents for inhibiting vegf production by translational control |
| DE102005016460A1 (de) | 2005-04-11 | 2006-10-19 | Grünenthal GmbH | Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit |
| EP1747779A1 (en) | 2005-07-28 | 2007-01-31 | Laboratorios Del Dr. Esteve, S.A. | Tetrahydro-b-carbolin-sulfonamide derivatives as 5-HT6 ligands |
| WO2007062175A2 (en) * | 2005-11-21 | 2007-05-31 | Amgen Inc. | Spiro-substituted tricyclic heterocycles cxcr3 antagonists |
| DE102005061430A1 (de) | 2005-12-22 | 2007-07-05 | Grünenthal GmbH | Substituierte Imidazolin-Derivate |
| DE102005061427A1 (de) | 2005-12-22 | 2007-06-28 | Grünenthal GmbH | Substituierte Oxadiazol-Derivate |
| DE102005061429A1 (de) | 2005-12-22 | 2007-06-28 | Grünenthal GmbH | Substituierte Oxazol-Derivate |
| DE102005061428A1 (de) | 2005-12-22 | 2007-08-16 | Grünenthal GmbH | Substituierte Cyclohexylmethyl-Derivate |
| DE102006019597A1 (de) * | 2006-04-27 | 2007-10-31 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| KR20090012230A (ko) | 2006-04-28 | 2009-02-02 | 마이크로닉 레이저 시스템즈 에이비 | 표면의 영상 및 연구 기록을 위한 방법 및 장치 |
| DE102006033114A1 (de) | 2006-07-18 | 2008-01-24 | Grünenthal GmbH | Spirocyclische Azaindol-Derivate |
| DE102006033109A1 (de) | 2006-07-18 | 2008-01-31 | Grünenthal GmbH | Substituierte Heteroaryl-Derivate |
| DE102006046745A1 (de) | 2006-09-29 | 2008-04-03 | Grünenthal GmbH | Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz |
| DE102007009235A1 (de) | 2007-02-22 | 2008-09-18 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE102007009319A1 (de) | 2007-02-22 | 2008-08-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| FR2921217B1 (fr) | 2007-09-14 | 2016-11-25 | Eads Secure Networks | Systeme de radiocommunications large bande, station recptrice complementaire, et procede d'optimisation d'une liaison de donnees dans un systeme de radiocommunications. |
| JP5542119B2 (ja) | 2008-03-27 | 2014-07-09 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | スピロ（５．５）ウンデカン誘導体 |
| AU2009228637B2 (en) | 2008-03-27 | 2013-12-19 | Grunenthal Gmbh | (Hetero-)aryl cyclohexane derivatives |
| HRP20140650T1 (hr) | 2008-03-27 | 2014-09-26 | Grünenthal GmbH | Hidroksimetilcikloheksilamini |
| CL2009000731A1 (es) | 2008-03-27 | 2009-05-15 | Gruenenthal Gmbh | Compuestos derivados de ciclohexano espirociclicos sustituidos, composicion farmaceutica que contiene a dicho compuesto y su uso como moduladores del receptor de opioides µ y el receptor orl-1 para tratar el dolor, ansiedad, depresion, epilepsia, alzheimer, abuso de alcohol, hipertension, anorexia, obesidad y diarrea. |
| KR20120075500A (ko) | 2008-03-27 | 2012-07-06 | 그뤼넨탈 게엠베하 | 치환된 4-아미노사이클로헥산 유도체 |
| EP2260022B1 (de) | 2008-03-27 | 2017-01-04 | Grünenthal GmbH | Substituierte cyclohexyldiamine |
-
2009
- 2009-03-25 JP JP2011501141A patent/JP5542119B2/ja not_active Expired - Fee Related
- 2009-03-25 PL PL09725570T patent/PL2257526T3/pl unknown
- 2009-03-25 US US12/410,605 patent/US8288430B2/en not_active Expired - Fee Related
- 2009-03-25 RU RU2010143446/04A patent/RU2515895C2/ru not_active IP Right Cessation
- 2009-03-25 WO PCT/EP2009/002180 patent/WO2009118169A1/de not_active Ceased
- 2009-03-25 MX MX2010010337A patent/MX2010010337A/es active IP Right Grant
- 2009-03-25 ES ES09725570T patent/ES2375543T3/es active Active
- 2009-03-25 SI SI200930121T patent/SI2257526T1/sl unknown
- 2009-03-25 PT PT09725570T patent/PT2257526E/pt unknown
- 2009-03-25 CN CN200980110773.2A patent/CN102083790B/zh active Active
- 2009-03-25 AT AT09725570T patent/ATE537143T1/de active
- 2009-03-25 CA CA2719736A patent/CA2719736C/en not_active Expired - Fee Related
- 2009-03-25 AU AU2009228643A patent/AU2009228643B2/en not_active Ceased
- 2009-03-25 DK DK09725570.7T patent/DK2257526T3/da active
- 2009-03-25 EP EP09725570A patent/EP2257526B1/de not_active Not-in-force
- 2009-03-25 HR HR20120017T patent/HRP20120017T1/hr unknown
-
2010
- 2010-09-21 IL IL208279A patent/IL208279A/en not_active IP Right Cessation
-
2012
- 2012-02-13 CY CY20121100146T patent/CY1112322T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009543825A5 (cg-RX-API-DMAC10.html) | ||
| JP2011517670A5 (cg-RX-API-DMAC10.html) | ||
| JP2011512374A5 (cg-RX-API-DMAC10.html) | ||
| JP2011517669A5 (cg-RX-API-DMAC10.html) | ||
| US10919902B2 (en) | Hetero-halo inhibitors of histone deacetylase | |
| JP2012526061A5 (cg-RX-API-DMAC10.html) | ||
| JP6928629B2 (ja) | Ｃｎｓ疾患を治療するための縮合ジヒドロ−４ｈ−ピラゾロ［５，１−ｃ］［１，４］オキサジニル化合物およびアナログ | |
| AU2022413759A1 (en) | Benzoate salt of 5-methoxy-n,n-dimethyltryptamine | |
| US20050096327A1 (en) | Novel norepinephrine reuptake inhibitors for the treatment of central nervous system disorders | |
| JP2008524262A5 (cg-RX-API-DMAC10.html) | ||
| JP2011515429A5 (cg-RX-API-DMAC10.html) | ||
| RU2012126105A (ru) | Соли 4-[2-[[5-метил-1-(2-нафталинил)-1н-пиразол-3-ил]окси]этил]морфолина | |
| RU2010143437A (ru) | Производные замещенного спироциклического циклогексана | |
| JP2007514637A5 (cg-RX-API-DMAC10.html) | ||
| JP2011517668A5 (cg-RX-API-DMAC10.html) | ||
| TWI329109B (en) | Substituted 1-piperidin-4-yl-4-pyrrolidin-3-yl-piperazine derivatives and their use as neurokinin antagonists | |
| RU2010126622A (ru) | Конденсированные с арилом и гетероарилом имидазо[1, 5-а]пиразины в качестве ингибиторов фосфодиэстеразы 10 | |
| JP2000501728A (ja) | タキキニン受容体の拮抗薬としての３―ベンジルアミノピロリジン及び３―ベンジルアミノピペリジン | |
| JP2002523508A5 (cg-RX-API-DMAC10.html) | ||
| CN104918921B (zh) | 二唑酰胺 | |
| WO2016105448A1 (en) | Imidazoline receptor type 1 ligands for use as therapeutics | |
| UY32205A (es) | Compuestos de 7-azaspiro [3.5]nonano-7-carboxamida | |
| CN101880274A (zh) | 一种坦度螺酮及其类似物的制备方法 | |
| MX2010013975A (es) | Isoquinolinas e isoquinolinonas sustituidas en calidad de inhibidores de la rho-quinasa. | |
| TW201138776A (en) | 3,6-diazabicyclo[3.1.1]heptanes as neuronal nicotinic acetylcholine receptor ligands |