JP2011514149A5 - - Google Patents

Download PDF

Info

Publication number
JP2011514149A5
JP2011514149A5 JP2010545219A JP2010545219A JP2011514149A5 JP 2011514149 A5 JP2011514149 A5 JP 2011514149A5 JP 2010545219 A JP2010545219 A JP 2010545219A JP 2010545219 A JP2010545219 A JP 2010545219A JP 2011514149 A5 JP2011514149 A5 JP 2011514149A5
Authority
JP
Japan
Prior art keywords
domain
polypeptide
loop
polypeptide according
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010545219A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011514149A (ja
JP5889533B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2009/032692 external-priority patent/WO2009099961A2/en
Publication of JP2011514149A publication Critical patent/JP2011514149A/ja
Publication of JP2011514149A5 publication Critical patent/JP2011514149A5/ja
Application granted granted Critical
Publication of JP5889533B2 publication Critical patent/JP5889533B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2010545219A 2008-01-31 2009-01-30 改変された抗体定常ドメイン分子 Active JP5889533B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6324508P 2008-01-31 2008-01-31
US61/063,245 2008-01-31
PCT/US2009/032692 WO2009099961A2 (en) 2008-01-31 2009-01-30 Engineered antibody constant domain molecules

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014112059A Division JP2014155503A (ja) 2008-01-31 2014-05-30 改変された抗体定常ドメイン分子

Publications (3)

Publication Number Publication Date
JP2011514149A JP2011514149A (ja) 2011-05-06
JP2011514149A5 true JP2011514149A5 (enExample) 2012-01-26
JP5889533B2 JP5889533B2 (ja) 2016-03-22

Family

ID=40613065

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2010545219A Active JP5889533B2 (ja) 2008-01-31 2009-01-30 改変された抗体定常ドメイン分子
JP2014112059A Pending JP2014155503A (ja) 2008-01-31 2014-05-30 改変された抗体定常ドメイン分子

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2014112059A Pending JP2014155503A (ja) 2008-01-31 2014-05-30 改変された抗体定常ドメイン分子

Country Status (7)

Country Link
US (3) US8580927B2 (enExample)
EP (2) EP2594584B1 (enExample)
JP (2) JP5889533B2 (enExample)
CN (2) CN101977932B (enExample)
AU (1) AU2009212747B2 (enExample)
CA (2) CA3052615A1 (enExample)
WO (1) WO2009099961A2 (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090298195A1 (en) 2005-01-05 2009-12-03 F-Star Biotechnologische Forschungs-Und Entwicklun Gseges M.B.H. Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions
AT503889B1 (de) 2006-07-05 2011-12-15 Star Biotechnologische Forschungs Und Entwicklungsges M B H F Multivalente immunglobuline
PL3241842T3 (pl) 2007-06-26 2024-06-10 F-Star Therapeutics Limited Prezentacja środków wiążących
WO2009089295A2 (en) * 2008-01-07 2009-07-16 Government Of The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Anti-hiv domain antibodies and method of making and using same
JP5889533B2 (ja) 2008-01-31 2016-03-22 ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ 改変された抗体定常ドメイン分子
EP2113255A1 (en) 2008-05-02 2009-11-04 f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. Cytotoxic immunoglobulin
WO2010000758A1 (de) * 2008-06-30 2010-01-07 Boehringer Ingelheim International Gmbh Verfahren zur optimierung von proteinen, die das immunoglobulinfaltungsmuster aufweisen
EP2451838A1 (en) * 2009-07-09 2012-05-16 f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. Stabilized immunoglobulin constant domains
AU2010318542B2 (en) * 2009-10-29 2015-08-27 Janssen Biotech Inc. Antibody glycosylation variants
EP2533811A4 (en) * 2010-02-12 2013-12-25 Res Corp Technologies Inc MULTIMETER PROTEINS WITH IMMUNE LOBULIN CONSTANTS DOMAINS
CA2815342A1 (en) * 2010-10-20 2012-04-26 Medimmune, Llc Methods for processing inclusion bodies
US9156917B2 (en) 2011-02-11 2015-10-13 Research Corporation Technologies, Inc. CH2 domain template molecules derived from rational grafting of donor loops onto CH2 scaffolds
JP5997151B2 (ja) 2011-06-30 2016-09-28 中外製薬株式会社 ヘテロ二量化ポリペプチド
US9688731B2 (en) * 2011-12-22 2017-06-27 Wisconsin Alumni Research Foundation Isolation and application of BAD-1 for diagnosing infections with Blastomyces dermatitidis
AU2013216943B2 (en) * 2012-02-10 2018-04-19 Research Corporation Technologies, Inc. Fusion proteins comprising immunoglobulin constant domain-derived scaffolds
US9676857B2 (en) 2012-03-16 2017-06-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Soluble engineered monomeric Fc
SG11201407017WA (en) * 2012-06-04 2014-12-30 Irm Llc Site-specific labeling methods and molecules produced thereby
EP4310191A3 (en) 2012-06-14 2024-05-15 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule containing modified fc region
WO2014030750A1 (ja) 2012-08-24 2014-02-27 中外製薬株式会社 マウスFcγRII特異的Fc抗体
JP6144487B2 (ja) 2012-12-26 2017-06-07 三菱航空機株式会社 フラップの展開装置、及び、航空機
TWI652279B (zh) 2013-11-11 2019-03-01 中外製藥股份有限公司 含改變的抗體可變區之抗原結合分子
AU2015335725B2 (en) * 2014-10-24 2021-06-03 Research Corporation Technologies, Inc. Small antibody-like polypeptides that bind to EphA2 receptor
EP4632120A3 (en) 2014-11-11 2026-01-07 Chugai Seiyaku Kabushiki Kaisha Library of antigen-binding molecules including modified antibody variable region
JP6872797B2 (ja) * 2015-12-29 2021-05-19 国立大学法人東京工業大学 標的結合ペプチドの安定化方法
ES2975750T3 (es) * 2016-08-26 2024-07-12 Sanofi Sa Anticuerpos multiespecíficos que facilitan el emparejamiento selectivo de las cadenas ligeras
CA3096798C (en) * 2017-01-09 2026-02-24 The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Compositions and methods for treating cancer with anti-mesothelin immunotherapy
NZ756763A (en) 2017-02-17 2023-04-28 Denali Therapeutics Inc Engineered transferrin receptor binding polypeptides
CA3057619A1 (en) 2017-03-22 2018-09-27 Research Corporation Technologies, Inc. Engineered stable ch2 polypeptides
CN110945022B (zh) 2017-04-19 2024-04-05 生物医学研究所 作为疫苗及新疟疾疫苗和抗体结合靶标的疟原虫子孢子npdp肽
EP3720963A4 (en) 2017-12-05 2021-12-08 Chugai Seiyaku Kabushiki Kaisha ANTIGEN-BINDING MOLECULE WITH CHANGED BINDING OF THE VARIABLE ANTIBODY REGIONS CD3 AND CD137
JP7489316B2 (ja) * 2017-12-19 2024-05-23 エフ-スター セラピューティクス リミテッド Pd-li抗原結合部位を有するfc結合断片
CN108191974B (zh) * 2017-12-31 2021-04-09 武汉班科生物技术股份有限公司 抗聚集人源IgG抗体CH2结构域突变体及应用
WO2021062012A1 (en) 2019-09-25 2021-04-01 Emory University Use of klk10 and engineered derivatizations thereof
CA3173587A1 (en) 2020-03-31 2021-10-07 Chugai Seiyaku Kabushiki-Kaisha Dll3-targeting multispecific antigen-binding molecules and uses thereof
CN116390945A (zh) * 2020-09-24 2023-07-04 博德研究所 无细胞抗体工程化平台和针对SARS-CoV-2的中和抗体
AU2022206475A1 (en) * 2021-01-11 2023-08-17 Adimab, Llc Variant ch3 domains engineered for preferential ch3 heterodimerization, multi-specific antibodies comprising the same, and methods of making thereof
WO2023087017A1 (en) * 2021-11-15 2023-05-19 Alector Llc Proteins comprising blood brain barrier (bbb)-binding domains within constant domains
CN116063468A (zh) * 2022-08-30 2023-05-05 武汉班科生物技术有限公司 中和呼吸道合胞病毒的c-型单域抗体及应用

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3060165A (en) 1962-10-23 Preparation of toxic ricin
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4957735A (en) 1984-06-12 1990-09-18 The University Of Tennessee Research Corporation Target-sensitive immunoliposomes- preparation and characterization
US5079163A (en) 1985-03-29 1992-01-07 Cetus Corporation Recombinant ricin toxin fragments
US4689401A (en) 1986-03-06 1987-08-25 Cetus Corporation Method of recovering microbially produced recombinant ricin toxin a chain
US5208021A (en) 1987-10-05 1993-05-04 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method of preparing diphtheria immunotoxins
US5792458A (en) 1987-10-05 1998-08-11 The United States Of America As Represented By The Department Of Health And Human Services Mutant diphtheria toxin conjugates
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5061620A (en) 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
US5965709A (en) * 1991-08-14 1999-10-12 Genentech, Inc. IgE antagonists
PT1696031E (pt) 1991-12-02 2010-06-25 Medical Res Council Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos
PT1621554E (pt) 1992-08-21 2009-07-13 Univ Bruxelles Imunoglobtainas desprovidas de cadeias leves
US6838254B1 (en) 1993-04-29 2005-01-04 Conopco, Inc. Production of antibodies or (functionalized) fragments thereof derived from heavy chain immunoglobulins of camelidae
EP0739981A1 (en) 1995-04-25 1996-10-30 Vrije Universiteit Brussel Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes
US6696248B1 (en) 1995-08-18 2004-02-24 Morphosys Ag Protein/(poly)peptide libraries
US6277375B1 (en) 1997-03-03 2001-08-21 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
US6083715A (en) 1997-06-09 2000-07-04 Board Of Regents, The University Of Texas System Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells
US7829084B2 (en) 2001-01-17 2010-11-09 Trubion Pharmaceuticals, Inc. Binding constructs and methods for use thereof
AU2002319402B2 (en) 2001-06-28 2008-09-11 Domantis Limited Dual-specific ligand and its use
WO2004029207A2 (en) 2002-09-27 2004-04-08 Xencor Inc. Optimized fc variants and methods for their generation
ITRM20020588A1 (it) 2002-11-21 2004-05-22 Lay Line Genomics Spa Metodo per isolare anticorpi intracellulari neutralizzanti di interazioni proteiche.
SI1639011T1 (sl) 2003-06-30 2009-04-30 Domantis Ltd Pegilirana protitelesa z enojno domeno (dAb)
US20070148170A1 (en) * 2005-10-03 2007-06-28 Desjarlais John R Fc Variants With Optimized Fc Receptor Binding Properties
US7442778B2 (en) * 2004-09-24 2008-10-28 Amgen Inc. Modified Fc molecules
WO2007024249A2 (en) 2004-11-10 2007-03-01 Macrogenics, Inc. Engineering fc antibody regions to confer effector function
US20090298195A1 (en) * 2005-01-05 2009-12-03 F-Star Biotechnologische Forschungs-Und Entwicklun Gseges M.B.H. Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions
CA2605697A1 (en) * 2005-04-26 2006-11-02 Bioren, Inc. Method of producing human igg antibodies with enhanced effector functions
CA2634784A1 (en) * 2005-12-22 2007-07-05 Centocor, Inc. Human glp-1 mimetibodies and compositions for treating obesity and related disorders, methods and uses
AT503889B1 (de) * 2006-07-05 2011-12-15 Star Biotechnologische Forschungs Und Entwicklungsges M B H F Multivalente immunglobuline
US20080199467A1 (en) * 2007-02-15 2008-08-21 Mjalli Adnan M M Immunoglobulin fusion proteins and methods of making
EP2738257A1 (en) * 2007-05-22 2014-06-04 Amgen Inc. Compositions and methods for producing bioactive fusion proteins
JP5889533B2 (ja) * 2008-01-31 2016-03-22 ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ 改変された抗体定常ドメイン分子
EP2533811A4 (en) * 2010-02-12 2013-12-25 Res Corp Technologies Inc MULTIMETER PROTEINS WITH IMMUNE LOBULIN CONSTANTS DOMAINS
US9156917B2 (en) * 2011-02-11 2015-10-13 Research Corporation Technologies, Inc. CH2 domain template molecules derived from rational grafting of donor loops onto CH2 scaffolds

Similar Documents

Publication Publication Date Title
JP7568756B2 (ja) プラスミノーゲン活性化因子阻害剤-1(pai-1)に対する抗体及びその使用
JP2021020905A5 (enExample)
JP2022177097A (ja) ヘテロ二量体多重特異性抗体フォーマット
TWI713942B (zh) 與集落刺激因子1受體(csf1r)結合之抗體類
JP7496091B2 (ja) 合理的に設計された新規なタンパク質組成物
JP2011526480A5 (enExample)
JP2020186248A5 (enExample)
JP7486810B2 (ja) IgG1 Fcモノマー、及びその使用
Golay et al. Design and validation of a novel generic platform for the production of tetravalent IgG1-like bispecific antibodies
JP2021522162A5 (enExample)
JP2017531427A5 (enExample)
JP2013529070A5 (enExample)
CN112513097B (zh) 四价对称双特异性抗体
JP2015519375A5 (enExample)
JP2020505919A5 (enExample)
JP2014521313A5 (enExample)
JP2012532838A (ja) 安定化された免疫グロブリン定常ドメイン
CN111526887A (zh) 用于使血清中的蛋白质半衰期增加的组合物和方法
JP2015520172A5 (enExample)
JP2019505565A5 (enExample)
CN111819200A (zh) 抗c-met抗体
JP2022540918A5 (enExample)
JP2024500335A5 (enExample)
EP4069298A1 (en) Composition of triaxial antibodies and method of making and using thereof
JP2008507253A5 (enExample)