JP2011514149A5 - - Google Patents
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- JP2011514149A5 JP2011514149A5 JP2010545219A JP2010545219A JP2011514149A5 JP 2011514149 A5 JP2011514149 A5 JP 2011514149A5 JP 2010545219 A JP2010545219 A JP 2010545219A JP 2010545219 A JP2010545219 A JP 2010545219A JP 2011514149 A5 JP2011514149 A5 JP 2011514149A5
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- Prior art keywords
- domain
- polypeptide
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6324508P | 2008-01-31 | 2008-01-31 | |
| US61/063,245 | 2008-01-31 | ||
| PCT/US2009/032692 WO2009099961A2 (en) | 2008-01-31 | 2009-01-30 | Engineered antibody constant domain molecules |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014112059A Division JP2014155503A (ja) | 2008-01-31 | 2014-05-30 | 改変された抗体定常ドメイン分子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011514149A JP2011514149A (ja) | 2011-05-06 |
| JP2011514149A5 true JP2011514149A5 (enExample) | 2012-01-26 |
| JP5889533B2 JP5889533B2 (ja) | 2016-03-22 |
Family
ID=40613065
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010545219A Active JP5889533B2 (ja) | 2008-01-31 | 2009-01-30 | 改変された抗体定常ドメイン分子 |
| JP2014112059A Pending JP2014155503A (ja) | 2008-01-31 | 2014-05-30 | 改変された抗体定常ドメイン分子 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014112059A Pending JP2014155503A (ja) | 2008-01-31 | 2014-05-30 | 改変された抗体定常ドメイン分子 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US8580927B2 (enExample) |
| EP (2) | EP2250196B1 (enExample) |
| JP (2) | JP5889533B2 (enExample) |
| CN (2) | CN104250301A (enExample) |
| AU (1) | AU2009212747B2 (enExample) |
| CA (2) | CA3052615A1 (enExample) |
| WO (1) | WO2009099961A2 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130105885A (ko) | 2005-01-05 | 2013-09-26 | 에프-스타 비오테크놀로기쉐 포르슝스 운드 엔트비클룽스게스.엠.베.하. | 상보성 결정부위와 다른 분자의 부위에서 처리된 결합성을 갖는 합성 면역글로불린 영역 |
| AT503889B1 (de) | 2006-07-05 | 2011-12-15 | Star Biotechnologische Forschungs Und Entwicklungsges M B H F | Multivalente immunglobuline |
| ES2627223T3 (es) | 2007-06-26 | 2017-07-27 | F-Star Biotechnologische Forschungs- Und Entwicklungsges.M.B.H | Presentación de agentes de unión |
| EP2238165B1 (en) * | 2008-01-07 | 2017-07-05 | Government of the United States of America, as represented by the Secretary, Department of Health and Human Services | Anti-hiv domain antibodies and method of making and using same |
| AU2009212747B2 (en) | 2008-01-31 | 2013-11-07 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Engineered antibody constant domain molecules |
| EP2113255A1 (en) | 2008-05-02 | 2009-11-04 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Cytotoxic immunoglobulin |
| CA2729591A1 (en) * | 2008-06-30 | 2010-01-07 | Boehringer Ingelheim International Gmbh | Method for optimizing proteins having the folding pattern of immunoglobulin |
| US20120094874A1 (en) * | 2009-07-09 | 2012-04-19 | F-Star Biotechnologische Forschungs-Und Entwicklungsges. M.B.H | Stabilized immunoglobulin constant domains |
| BR112012010252A2 (pt) * | 2009-10-29 | 2016-12-06 | Janssen Biotech Inc | variantes de glicosilação de anticorpo |
| US20130189247A1 (en) * | 2010-02-12 | 2013-07-25 | Research Corporation Technologies, Inc. | Multimeric Proteins Comprising Immunoglobulin Constant Domains |
| EP2630153A4 (en) * | 2010-10-20 | 2015-06-03 | Medimmune Llc | PROCESS FOR PROCESSING INCLUSIVE BODIES |
| AU2012214274B2 (en) * | 2011-02-11 | 2017-02-02 | Research Corporation Technologies, Inc. | CH2 domain template molecules derived from rational grafting of donor loops onto CH2 scaffolds |
| US9890218B2 (en) | 2011-06-30 | 2018-02-13 | Chugai Seiyaku Kabushiki Kaisha | Heterodimerized polypeptide |
| US9688731B2 (en) * | 2011-12-22 | 2017-06-27 | Wisconsin Alumni Research Foundation | Isolation and application of BAD-1 for diagnosing infections with Blastomyces dermatitidis |
| EP2812432B1 (en) * | 2012-02-10 | 2020-10-14 | Research Corporation Technologies, Inc. | Fusion proteins comprising immunoglobulin constant domain-derived scaffolds |
| EP2825557B1 (en) | 2012-03-16 | 2017-06-28 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Soluble engineered monomeric fc |
| MX2014014894A (es) * | 2012-06-04 | 2015-02-20 | Irm Llc | Metodos de marcado especifico del sitio y moleculas producidas mediante los mismos. |
| JP6628966B2 (ja) * | 2012-06-14 | 2020-01-15 | 中外製薬株式会社 | 改変されたFc領域を含む抗原結合分子 |
| EP3597747B1 (en) | 2012-08-24 | 2023-03-15 | Chugai Seiyaku Kabushiki Kaisha | Mouse fcgammarii-specific fc antibody |
| JP6144487B2 (ja) | 2012-12-26 | 2017-06-07 | 三菱航空機株式会社 | フラップの展開装置、及び、航空機 |
| CN105940107B (zh) | 2013-11-11 | 2021-06-15 | 中外制药株式会社 | 含有改变了抗体可变区的抗原结合分子 |
| CA2963556C (en) * | 2014-10-24 | 2023-03-14 | Research Corporation Technologies, Inc. | Small antibody-like polypeptides that bind to epha2 receptor |
| TWI740809B (zh) | 2014-11-11 | 2021-10-01 | 日商中外製藥股份有限公司 | 包含經改變之抗體可變區之抗原結合分子的資料庫 |
| JP6872797B2 (ja) * | 2015-12-29 | 2021-05-19 | 国立大学法人東京工業大学 | 標的結合ペプチドの安定化方法 |
| JP7366742B2 (ja) * | 2016-08-26 | 2023-10-23 | サノフイ | 選択的な軽鎖対形成を容易にする多重特異性抗体 |
| EP3882265B1 (en) | 2017-01-09 | 2022-11-02 | Lentigen Technology, Inc. | Compositions and methods for treating cancer with anti-mesothelin immunotherapy |
| ES2932759T3 (es) | 2017-02-17 | 2023-01-25 | Denali Therapeutics Inc | Polipéptidos de unión al receptor de transferrina diseñados |
| CA3057619A1 (en) * | 2017-03-22 | 2018-09-27 | Research Corporation Technologies, Inc. | Engineered stable ch2 polypeptides |
| SG11201909265QA (en) | 2017-04-19 | 2019-11-28 | Inst Res Biomedicine | Plasmodium sporozoite npdp peptides as vaccine and target novel malaria vaccines and antibodies binding to |
| EP3720963A4 (en) | 2017-12-05 | 2021-12-08 | Chugai Seiyaku Kabushiki Kaisha | ANTIGEN-BINDING MOLECULE WITH CHANGED BINDING OF THE VARIABLE ANTIBODY REGIONS CD3 AND CD137 |
| AU2018387741B2 (en) * | 2017-12-19 | 2025-09-25 | Invox Pharma Limited | FC binding fragments comprising a PD-L1 antigen-binding site |
| CN108191974B (zh) * | 2017-12-31 | 2021-04-09 | 武汉班科生物技术股份有限公司 | 抗聚集人源IgG抗体CH2结构域突变体及应用 |
| WO2021062012A1 (en) | 2019-09-25 | 2021-04-01 | Emory University | Use of klk10 and engineered derivatizations thereof |
| TWI799824B (zh) | 2020-03-31 | 2023-04-21 | 日商中外製藥股份有限公司 | Dll3靶向之多特異性抗原結合分子及其用途 |
| WO2022067020A1 (en) * | 2020-09-24 | 2022-03-31 | The Broad Institute, Inc. | Cell-free antibody engineering platform and neutralizing antibodies for sars-cov-2 |
| WO2023087017A1 (en) * | 2021-11-15 | 2023-05-19 | Alector Llc | Proteins comprising blood brain barrier (bbb)-binding domains within constant domains |
| CN116063468A (zh) * | 2022-08-30 | 2023-05-05 | 武汉班科生物技术有限公司 | 中和呼吸道合胞病毒的c-型单域抗体及应用 |
Family Cites Families (34)
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| US3060165A (en) | 1962-10-23 | Preparation of toxic ricin | ||
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4957735A (en) | 1984-06-12 | 1990-09-18 | The University Of Tennessee Research Corporation | Target-sensitive immunoliposomes- preparation and characterization |
| US5079163A (en) | 1985-03-29 | 1992-01-07 | Cetus Corporation | Recombinant ricin toxin fragments |
| US4689401A (en) | 1986-03-06 | 1987-08-25 | Cetus Corporation | Method of recovering microbially produced recombinant ricin toxin a chain |
| US5792458A (en) | 1987-10-05 | 1998-08-11 | The United States Of America As Represented By The Department Of Health And Human Services | Mutant diphtheria toxin conjugates |
| US5208021A (en) | 1987-10-05 | 1993-05-04 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of preparing diphtheria immunotoxins |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5061620A (en) | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
| US5965709A (en) * | 1991-08-14 | 1999-10-12 | Genentech, Inc. | IgE antagonists |
| ATE463573T1 (de) | 1991-12-02 | 2010-04-15 | Medimmune Ltd | Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken |
| EP1498427B1 (en) | 1992-08-21 | 2009-12-16 | Vrije Universiteit Brussel | Immunoglobulins devoid of light chains |
| DK0698097T3 (da) | 1993-04-29 | 2001-10-08 | Unilever Nv | Produktion af antistoffer eller (funktionaliserede) fragmenter deraf afledt af Camelidae-immunoglobuliner med tung kæde |
| EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
| US6828422B1 (en) | 1995-08-18 | 2004-12-07 | Morphosys Ag | Protein/(poly)peptide libraries |
| US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| US6083715A (en) | 1997-06-09 | 2000-07-04 | Board Of Regents, The University Of Texas System | Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells |
| US7829084B2 (en) * | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
| CA2447851C (en) | 2001-06-28 | 2012-08-28 | Domantis Limited | Dual-specific ligand and its use |
| WO2004029207A2 (en) | 2002-09-27 | 2004-04-08 | Xencor Inc. | Optimized fc variants and methods for their generation |
| ITRM20020588A1 (it) | 2002-11-21 | 2004-05-22 | Lay Line Genomics Spa | Metodo per isolare anticorpi intracellulari neutralizzanti di interazioni proteiche. |
| SI1639011T1 (sl) | 2003-06-30 | 2009-04-30 | Domantis Ltd | Pegilirana protitelesa z enojno domeno (dAb) |
| CN101103045B (zh) | 2004-09-24 | 2015-11-25 | 安姆根有限公司 | 修饰的Fc分子 |
| US7632497B2 (en) | 2004-11-10 | 2009-12-15 | Macrogenics, Inc. | Engineering Fc Antibody regions to confer effector function |
| KR20130105885A (ko) * | 2005-01-05 | 2013-09-26 | 에프-스타 비오테크놀로기쉐 포르슝스 운드 엔트비클룽스게스.엠.베.하. | 상보성 결정부위와 다른 분자의 부위에서 처리된 결합성을 갖는 합성 면역글로불린 영역 |
| EP1877441A2 (en) * | 2005-04-26 | 2008-01-16 | Bioren, Inc. | Method of producing human igg antibodies with enhanced effector functions |
| AU2006299429B2 (en) | 2005-10-03 | 2012-02-23 | Xencor, Inc. | Fc variants with optimized Fc receptor binding properties |
| CA2634784A1 (en) * | 2005-12-22 | 2007-07-05 | Centocor, Inc. | Human glp-1 mimetibodies and compositions for treating obesity and related disorders, methods and uses |
| AT503889B1 (de) * | 2006-07-05 | 2011-12-15 | Star Biotechnologische Forschungs Und Entwicklungsges M B H F | Multivalente immunglobuline |
| WO2008100470A2 (en) | 2007-02-15 | 2008-08-21 | Transtech Pharma, Inc. | Rage - immunoglobulin fusion proteins |
| JP5591691B2 (ja) * | 2007-05-22 | 2014-09-17 | アムジエン・インコーポレーテツド | 生物活性を有する融合タンパク質を作製するための組成物及び方法 |
| AU2009212747B2 (en) * | 2008-01-31 | 2013-11-07 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Engineered antibody constant domain molecules |
| US20130189247A1 (en) * | 2010-02-12 | 2013-07-25 | Research Corporation Technologies, Inc. | Multimeric Proteins Comprising Immunoglobulin Constant Domains |
| AU2012214274B2 (en) * | 2011-02-11 | 2017-02-02 | Research Corporation Technologies, Inc. | CH2 domain template molecules derived from rational grafting of donor loops onto CH2 scaffolds |
-
2009
- 2009-01-30 AU AU2009212747A patent/AU2009212747B2/en active Active
- 2009-01-30 EP EP09709399A patent/EP2250196B1/en active Active
- 2009-01-30 CN CN201410422052.8A patent/CN104250301A/zh active Pending
- 2009-01-30 WO PCT/US2009/032692 patent/WO2009099961A2/en not_active Ceased
- 2009-01-30 US US12/864,758 patent/US8580927B2/en active Active
- 2009-01-30 CA CA3052615A patent/CA3052615A1/en not_active Abandoned
- 2009-01-30 CA CA2713281A patent/CA2713281C/en active Active
- 2009-01-30 JP JP2010545219A patent/JP5889533B2/ja active Active
- 2009-01-30 EP EP12198382.9A patent/EP2594584B1/en active Active
- 2009-01-30 CN CN200980110221.1A patent/CN101977932B/zh active Active
-
2013
- 2013-10-01 US US14/043,366 patent/US9527903B2/en active Active
-
2014
- 2014-05-30 JP JP2014112059A patent/JP2014155503A/ja active Pending
-
2016
- 2016-12-02 US US15/367,488 patent/US10358481B2/en active Active
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