JP2011514149A5 - - Google Patents
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- JP2011514149A5 JP2011514149A5 JP2010545219A JP2010545219A JP2011514149A5 JP 2011514149 A5 JP2011514149 A5 JP 2011514149A5 JP 2010545219 A JP2010545219 A JP 2010545219A JP 2010545219 A JP2010545219 A JP 2010545219A JP 2011514149 A5 JP2011514149 A5 JP 2011514149A5
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- JP
- Japan
- Prior art keywords
- domain
- polypeptide
- loop
- polypeptide according
- amino acid
- Prior art date
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6324508P | 2008-01-31 | 2008-01-31 | |
| US61/063,245 | 2008-01-31 | ||
| PCT/US2009/032692 WO2009099961A2 (en) | 2008-01-31 | 2009-01-30 | Engineered antibody constant domain molecules |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014112059A Division JP2014155503A (ja) | 2008-01-31 | 2014-05-30 | 改変された抗体定常ドメイン分子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011514149A JP2011514149A (ja) | 2011-05-06 |
| JP2011514149A5 true JP2011514149A5 (enExample) | 2012-01-26 |
| JP5889533B2 JP5889533B2 (ja) | 2016-03-22 |
Family
ID=40613065
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010545219A Active JP5889533B2 (ja) | 2008-01-31 | 2009-01-30 | 改変された抗体定常ドメイン分子 |
| JP2014112059A Pending JP2014155503A (ja) | 2008-01-31 | 2014-05-30 | 改変された抗体定常ドメイン分子 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014112059A Pending JP2014155503A (ja) | 2008-01-31 | 2014-05-30 | 改変された抗体定常ドメイン分子 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US8580927B2 (enExample) |
| EP (2) | EP2594584B1 (enExample) |
| JP (2) | JP5889533B2 (enExample) |
| CN (2) | CN101977932B (enExample) |
| AU (1) | AU2009212747B2 (enExample) |
| CA (2) | CA3052615A1 (enExample) |
| WO (1) | WO2009099961A2 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090298195A1 (en) | 2005-01-05 | 2009-12-03 | F-Star Biotechnologische Forschungs-Und Entwicklun Gseges M.B.H. | Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions |
| AT503889B1 (de) | 2006-07-05 | 2011-12-15 | Star Biotechnologische Forschungs Und Entwicklungsges M B H F | Multivalente immunglobuline |
| PL3241842T3 (pl) | 2007-06-26 | 2024-06-10 | F-Star Therapeutics Limited | Prezentacja środków wiążących |
| WO2009089295A2 (en) * | 2008-01-07 | 2009-07-16 | Government Of The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services | Anti-hiv domain antibodies and method of making and using same |
| JP5889533B2 (ja) | 2008-01-31 | 2016-03-22 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 改変された抗体定常ドメイン分子 |
| EP2113255A1 (en) | 2008-05-02 | 2009-11-04 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Cytotoxic immunoglobulin |
| WO2010000758A1 (de) * | 2008-06-30 | 2010-01-07 | Boehringer Ingelheim International Gmbh | Verfahren zur optimierung von proteinen, die das immunoglobulinfaltungsmuster aufweisen |
| EP2451838A1 (en) * | 2009-07-09 | 2012-05-16 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Stabilized immunoglobulin constant domains |
| AU2010318542B2 (en) * | 2009-10-29 | 2015-08-27 | Janssen Biotech Inc. | Antibody glycosylation variants |
| EP2533811A4 (en) * | 2010-02-12 | 2013-12-25 | Res Corp Technologies Inc | MULTIMETER PROTEINS WITH IMMUNE LOBULIN CONSTANTS DOMAINS |
| CA2815342A1 (en) * | 2010-10-20 | 2012-04-26 | Medimmune, Llc | Methods for processing inclusion bodies |
| US9156917B2 (en) | 2011-02-11 | 2015-10-13 | Research Corporation Technologies, Inc. | CH2 domain template molecules derived from rational grafting of donor loops onto CH2 scaffolds |
| JP5997151B2 (ja) | 2011-06-30 | 2016-09-28 | 中外製薬株式会社 | ヘテロ二量化ポリペプチド |
| US9688731B2 (en) * | 2011-12-22 | 2017-06-27 | Wisconsin Alumni Research Foundation | Isolation and application of BAD-1 for diagnosing infections with Blastomyces dermatitidis |
| AU2013216943B2 (en) * | 2012-02-10 | 2018-04-19 | Research Corporation Technologies, Inc. | Fusion proteins comprising immunoglobulin constant domain-derived scaffolds |
| US9676857B2 (en) | 2012-03-16 | 2017-06-13 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Soluble engineered monomeric Fc |
| SG11201407017WA (en) * | 2012-06-04 | 2014-12-30 | Irm Llc | Site-specific labeling methods and molecules produced thereby |
| EP4310191A3 (en) | 2012-06-14 | 2024-05-15 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule containing modified fc region |
| WO2014030750A1 (ja) | 2012-08-24 | 2014-02-27 | 中外製薬株式会社 | マウスFcγRII特異的Fc抗体 |
| JP6144487B2 (ja) | 2012-12-26 | 2017-06-07 | 三菱航空機株式会社 | フラップの展開装置、及び、航空機 |
| TWI652279B (zh) | 2013-11-11 | 2019-03-01 | 中外製藥股份有限公司 | 含改變的抗體可變區之抗原結合分子 |
| AU2015335725B2 (en) * | 2014-10-24 | 2021-06-03 | Research Corporation Technologies, Inc. | Small antibody-like polypeptides that bind to EphA2 receptor |
| EP4632120A3 (en) | 2014-11-11 | 2026-01-07 | Chugai Seiyaku Kabushiki Kaisha | Library of antigen-binding molecules including modified antibody variable region |
| JP6872797B2 (ja) * | 2015-12-29 | 2021-05-19 | 国立大学法人東京工業大学 | 標的結合ペプチドの安定化方法 |
| ES2975750T3 (es) * | 2016-08-26 | 2024-07-12 | Sanofi Sa | Anticuerpos multiespecíficos que facilitan el emparejamiento selectivo de las cadenas ligeras |
| CA3096798C (en) * | 2017-01-09 | 2026-02-24 | The U.S.A., As Represented By The Secretary, Department Of Health And Human Services | Compositions and methods for treating cancer with anti-mesothelin immunotherapy |
| NZ756763A (en) | 2017-02-17 | 2023-04-28 | Denali Therapeutics Inc | Engineered transferrin receptor binding polypeptides |
| CA3057619A1 (en) | 2017-03-22 | 2018-09-27 | Research Corporation Technologies, Inc. | Engineered stable ch2 polypeptides |
| CN110945022B (zh) | 2017-04-19 | 2024-04-05 | 生物医学研究所 | 作为疫苗及新疟疾疫苗和抗体结合靶标的疟原虫子孢子npdp肽 |
| EP3720963A4 (en) | 2017-12-05 | 2021-12-08 | Chugai Seiyaku Kabushiki Kaisha | ANTIGEN-BINDING MOLECULE WITH CHANGED BINDING OF THE VARIABLE ANTIBODY REGIONS CD3 AND CD137 |
| JP7489316B2 (ja) * | 2017-12-19 | 2024-05-23 | エフ-スター セラピューティクス リミテッド | Pd-li抗原結合部位を有するfc結合断片 |
| CN108191974B (zh) * | 2017-12-31 | 2021-04-09 | 武汉班科生物技术股份有限公司 | 抗聚集人源IgG抗体CH2结构域突变体及应用 |
| WO2021062012A1 (en) | 2019-09-25 | 2021-04-01 | Emory University | Use of klk10 and engineered derivatizations thereof |
| CA3173587A1 (en) | 2020-03-31 | 2021-10-07 | Chugai Seiyaku Kabushiki-Kaisha | Dll3-targeting multispecific antigen-binding molecules and uses thereof |
| CN116390945A (zh) * | 2020-09-24 | 2023-07-04 | 博德研究所 | 无细胞抗体工程化平台和针对SARS-CoV-2的中和抗体 |
| AU2022206475A1 (en) * | 2021-01-11 | 2023-08-17 | Adimab, Llc | Variant ch3 domains engineered for preferential ch3 heterodimerization, multi-specific antibodies comprising the same, and methods of making thereof |
| WO2023087017A1 (en) * | 2021-11-15 | 2023-05-19 | Alector Llc | Proteins comprising blood brain barrier (bbb)-binding domains within constant domains |
| CN116063468A (zh) * | 2022-08-30 | 2023-05-05 | 武汉班科生物技术有限公司 | 中和呼吸道合胞病毒的c-型单域抗体及应用 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US3060165A (en) | 1962-10-23 | Preparation of toxic ricin | ||
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4957735A (en) | 1984-06-12 | 1990-09-18 | The University Of Tennessee Research Corporation | Target-sensitive immunoliposomes- preparation and characterization |
| US5079163A (en) | 1985-03-29 | 1992-01-07 | Cetus Corporation | Recombinant ricin toxin fragments |
| US4689401A (en) | 1986-03-06 | 1987-08-25 | Cetus Corporation | Method of recovering microbially produced recombinant ricin toxin a chain |
| US5208021A (en) | 1987-10-05 | 1993-05-04 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of preparing diphtheria immunotoxins |
| US5792458A (en) | 1987-10-05 | 1998-08-11 | The United States Of America As Represented By The Department Of Health And Human Services | Mutant diphtheria toxin conjugates |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5061620A (en) | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
| US5965709A (en) * | 1991-08-14 | 1999-10-12 | Genentech, Inc. | IgE antagonists |
| PT1696031E (pt) | 1991-12-02 | 2010-06-25 | Medical Res Council | Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos |
| PT1621554E (pt) | 1992-08-21 | 2009-07-13 | Univ Bruxelles | Imunoglobtainas desprovidas de cadeias leves |
| US6838254B1 (en) | 1993-04-29 | 2005-01-04 | Conopco, Inc. | Production of antibodies or (functionalized) fragments thereof derived from heavy chain immunoglobulins of camelidae |
| EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
| US6696248B1 (en) | 1995-08-18 | 2004-02-24 | Morphosys Ag | Protein/(poly)peptide libraries |
| US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| US6083715A (en) | 1997-06-09 | 2000-07-04 | Board Of Regents, The University Of Texas System | Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells |
| US7829084B2 (en) | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
| AU2002319402B2 (en) | 2001-06-28 | 2008-09-11 | Domantis Limited | Dual-specific ligand and its use |
| WO2004029207A2 (en) | 2002-09-27 | 2004-04-08 | Xencor Inc. | Optimized fc variants and methods for their generation |
| ITRM20020588A1 (it) | 2002-11-21 | 2004-05-22 | Lay Line Genomics Spa | Metodo per isolare anticorpi intracellulari neutralizzanti di interazioni proteiche. |
| SI1639011T1 (sl) | 2003-06-30 | 2009-04-30 | Domantis Ltd | Pegilirana protitelesa z enojno domeno (dAb) |
| US20070148170A1 (en) * | 2005-10-03 | 2007-06-28 | Desjarlais John R | Fc Variants With Optimized Fc Receptor Binding Properties |
| US7442778B2 (en) * | 2004-09-24 | 2008-10-28 | Amgen Inc. | Modified Fc molecules |
| WO2007024249A2 (en) | 2004-11-10 | 2007-03-01 | Macrogenics, Inc. | Engineering fc antibody regions to confer effector function |
| US20090298195A1 (en) * | 2005-01-05 | 2009-12-03 | F-Star Biotechnologische Forschungs-Und Entwicklun Gseges M.B.H. | Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions |
| CA2605697A1 (en) * | 2005-04-26 | 2006-11-02 | Bioren, Inc. | Method of producing human igg antibodies with enhanced effector functions |
| CA2634784A1 (en) * | 2005-12-22 | 2007-07-05 | Centocor, Inc. | Human glp-1 mimetibodies and compositions for treating obesity and related disorders, methods and uses |
| AT503889B1 (de) * | 2006-07-05 | 2011-12-15 | Star Biotechnologische Forschungs Und Entwicklungsges M B H F | Multivalente immunglobuline |
| US20080199467A1 (en) * | 2007-02-15 | 2008-08-21 | Mjalli Adnan M M | Immunoglobulin fusion proteins and methods of making |
| EP2738257A1 (en) * | 2007-05-22 | 2014-06-04 | Amgen Inc. | Compositions and methods for producing bioactive fusion proteins |
| JP5889533B2 (ja) * | 2008-01-31 | 2016-03-22 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 改変された抗体定常ドメイン分子 |
| EP2533811A4 (en) * | 2010-02-12 | 2013-12-25 | Res Corp Technologies Inc | MULTIMETER PROTEINS WITH IMMUNE LOBULIN CONSTANTS DOMAINS |
| US9156917B2 (en) * | 2011-02-11 | 2015-10-13 | Research Corporation Technologies, Inc. | CH2 domain template molecules derived from rational grafting of donor loops onto CH2 scaffolds |
-
2009
- 2009-01-30 JP JP2010545219A patent/JP5889533B2/ja active Active
- 2009-01-30 EP EP12198382.9A patent/EP2594584B1/en active Active
- 2009-01-30 CA CA3052615A patent/CA3052615A1/en not_active Abandoned
- 2009-01-30 US US12/864,758 patent/US8580927B2/en active Active
- 2009-01-30 CA CA2713281A patent/CA2713281C/en active Active
- 2009-01-30 CN CN200980110221.1A patent/CN101977932B/zh active Active
- 2009-01-30 AU AU2009212747A patent/AU2009212747B2/en active Active
- 2009-01-30 CN CN201410422052.8A patent/CN104250301A/zh active Pending
- 2009-01-30 WO PCT/US2009/032692 patent/WO2009099961A2/en not_active Ceased
- 2009-01-30 EP EP09709399A patent/EP2250196B1/en active Active
-
2013
- 2013-10-01 US US14/043,366 patent/US9527903B2/en active Active
-
2014
- 2014-05-30 JP JP2014112059A patent/JP2014155503A/ja active Pending
-
2016
- 2016-12-02 US US15/367,488 patent/US10358481B2/en active Active
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