JP2011511774A - 皮膚、粘膜、頭皮または爪の処置、保護または洗浄において有用なペプチド誘導体 - Google Patents
皮膚、粘膜、頭皮または爪の処置、保護または洗浄において有用なペプチド誘導体 Download PDFInfo
- Publication number
- JP2011511774A JP2011511774A JP2010544705A JP2010544705A JP2011511774A JP 2011511774 A JP2011511774 A JP 2011511774A JP 2010544705 A JP2010544705 A JP 2010544705A JP 2010544705 A JP2010544705 A JP 2010544705A JP 2011511774 A JP2011511774 A JP 2011511774A
- Authority
- JP
- Japan
- Prior art keywords
- phg
- substituted
- unsubstituted
- arg
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 118
- 210000003491 skin Anatomy 0.000 title claims abstract description 71
- 238000011282 treatment Methods 0.000 title claims abstract description 68
- 210000004761 scalp Anatomy 0.000 title claims abstract description 45
- 210000004400 mucous membrane Anatomy 0.000 title claims abstract description 34
- 230000004224 protection Effects 0.000 title claims abstract description 22
- 238000005406 washing Methods 0.000 title claims abstract description 16
- 210000000282 nail Anatomy 0.000 title 1
- 239000000203 mixture Substances 0.000 claims abstract description 99
- 239000002537 cosmetic Substances 0.000 claims abstract description 84
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 58
- 150000003839 salts Chemical class 0.000 claims abstract description 56
- 238000000034 method Methods 0.000 claims abstract description 46
- 230000000813 microbial effect Effects 0.000 claims abstract description 20
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 19
- 230000012010 growth Effects 0.000 claims abstract description 19
- 208000024891 symptom Diseases 0.000 claims abstract description 14
- 230000007170 pathology Effects 0.000 claims abstract description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 189
- -1 tert-butanoyl Chemical group 0.000 claims description 55
- 238000003786 synthesis reaction Methods 0.000 claims description 34
- 230000015572 biosynthetic process Effects 0.000 claims description 32
- 239000012071 phase Substances 0.000 claims description 30
- 239000000284 extract Substances 0.000 claims description 25
- 208000015181 infectious disease Diseases 0.000 claims description 24
- 238000004519 manufacturing process Methods 0.000 claims description 24
- 125000003118 aryl group Chemical group 0.000 claims description 20
- 125000004432 carbon atom Chemical group C* 0.000 claims description 19
- 102000000541 Defensins Human genes 0.000 claims description 18
- 108010002069 Defensins Proteins 0.000 claims description 18
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 18
- 210000004209 hair Anatomy 0.000 claims description 18
- 208000035475 disorder Diseases 0.000 claims description 17
- 125000000623 heterocyclic group Chemical group 0.000 claims description 17
- 239000003795 chemical substances by application Substances 0.000 claims description 16
- 125000000217 alkyl group Chemical group 0.000 claims description 15
- 210000004027 cell Anatomy 0.000 claims description 14
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 14
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 13
- 229920000642 polymer Polymers 0.000 claims description 13
- 239000000126 substance Substances 0.000 claims description 13
- 230000000694 effects Effects 0.000 claims description 12
- 239000006210 lotion Substances 0.000 claims description 12
- 239000000243 solution Substances 0.000 claims description 12
- 241000222122 Candida albicans Species 0.000 claims description 11
- 230000000844 anti-bacterial effect Effects 0.000 claims description 11
- 125000003438 dodecyl group Chemical class [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 11
- 230000035876 healing Effects 0.000 claims description 11
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims description 11
- 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 claims description 10
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 claims description 10
- 125000001931 aliphatic group Chemical group 0.000 claims description 10
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 10
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 10
- 125000000913 palmityl group Chemical class [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 10
- 239000007787 solid Substances 0.000 claims description 10
- 206010006326 Breath odour Diseases 0.000 claims description 9
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 9
- 229910052739 hydrogen Inorganic materials 0.000 claims description 9
- 210000002510 keratinocyte Anatomy 0.000 claims description 9
- 125000000400 lauroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 9
- 125000001419 myristoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 9
- 206010007134 Candida infections Diseases 0.000 claims description 8
- 239000000853 adhesive Substances 0.000 claims description 8
- 230000001070 adhesive effect Effects 0.000 claims description 8
- 201000003984 candidiasis Diseases 0.000 claims description 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 8
- 239000000839 emulsion Substances 0.000 claims description 8
- 239000004744 fabric Substances 0.000 claims description 8
- 230000006698 induction Effects 0.000 claims description 8
- 239000004745 nonwoven fabric Substances 0.000 claims description 8
- 239000003921 oil Substances 0.000 claims description 8
- 235000019198 oils Nutrition 0.000 claims description 8
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 8
- 239000007790 solid phase Substances 0.000 claims description 8
- 230000004936 stimulating effect Effects 0.000 claims description 8
- 101000912247 Homo sapiens Beta-defensin 103 Proteins 0.000 claims description 7
- 125000002015 acyclic group Chemical group 0.000 claims description 7
- 125000003342 alkenyl group Chemical group 0.000 claims description 7
- 125000000304 alkynyl group Chemical group 0.000 claims description 7
- 125000003277 amino group Chemical group 0.000 claims description 7
- 229910052799 carbon Inorganic materials 0.000 claims description 7
- 230000007123 defense Effects 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 7
- 239000000499 gel Substances 0.000 claims description 7
- 102000055779 human DEFB103A Human genes 0.000 claims description 7
- 239000007924 injection Substances 0.000 claims description 7
- 238000002347 injection Methods 0.000 claims description 7
- 239000002502 liposome Substances 0.000 claims description 7
- 210000004877 mucosa Anatomy 0.000 claims description 7
- 201000001245 periodontitis Diseases 0.000 claims description 7
- 239000000419 plant extract Substances 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 7
- 230000000638 stimulation Effects 0.000 claims description 7
- 238000013268 sustained release Methods 0.000 claims description 7
- 239000012730 sustained-release form Substances 0.000 claims description 7
- 239000000341 volatile oil Substances 0.000 claims description 7
- 201000004624 Dermatitis Diseases 0.000 claims description 6
- 206010012438 Dermatitis atopic Diseases 0.000 claims description 6
- 239000002671 adjuvant Substances 0.000 claims description 6
- 229940121375 antifungal agent Drugs 0.000 claims description 6
- 201000008937 atopic dermatitis Diseases 0.000 claims description 6
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 6
- 239000002552 dosage form Substances 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 6
- 238000002560 therapeutic procedure Methods 0.000 claims description 6
- 230000000699 topical effect Effects 0.000 claims description 6
- 208000002874 Acne Vulgaris Diseases 0.000 claims description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 5
- 208000001840 Dandruff Diseases 0.000 claims description 5
- 206010000496 acne Diseases 0.000 claims description 5
- 208000010668 atopic eczema Diseases 0.000 claims description 5
- 230000003385 bacteriostatic effect Effects 0.000 claims description 5
- 238000000855 fermentation Methods 0.000 claims description 5
- 230000004151 fermentation Effects 0.000 claims description 5
- 230000000855 fungicidal effect Effects 0.000 claims description 5
- 208000007565 gingivitis Diseases 0.000 claims description 5
- 230000013632 homeostatic process Effects 0.000 claims description 5
- 235000013336 milk Nutrition 0.000 claims description 5
- 210000004080 milk Anatomy 0.000 claims description 5
- 230000037307 sensitive skin Effects 0.000 claims description 5
- 125000006714 (C3-C10) heterocyclyl group Chemical group 0.000 claims description 4
- 208000004926 Bacterial Vaginosis Diseases 0.000 claims description 4
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 claims description 4
- 101000884714 Homo sapiens Beta-defensin 4A Proteins 0.000 claims description 4
- 239000004909 Moisturizer Substances 0.000 claims description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 208000037009 Vaginitis bacterial Diseases 0.000 claims description 4
- 239000003242 anti bacterial agent Substances 0.000 claims description 4
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 4
- 125000004429 atom Chemical group 0.000 claims description 4
- 239000006071 cream Substances 0.000 claims description 4
- 239000000417 fungicide Substances 0.000 claims description 4
- 239000008267 milk Substances 0.000 claims description 4
- 230000001333 moisturizer Effects 0.000 claims description 4
- 239000002674 ointment Substances 0.000 claims description 4
- 239000000344 soap Substances 0.000 claims description 4
- 125000003974 3-carbamimidamidopropyl group Chemical group C(N)(=N)NCCC* 0.000 claims description 3
- 241001303601 Rosacea Species 0.000 claims description 3
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 claims description 3
- 230000000202 analgesic effect Effects 0.000 claims description 3
- 230000001166 anti-perspirative effect Effects 0.000 claims description 3
- 239000003429 antifungal agent Substances 0.000 claims description 3
- 239000003213 antiperspirant Substances 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 3
- 230000015556 catabolic process Effects 0.000 claims description 3
- 235000015218 chewing gum Nutrition 0.000 claims description 3
- 239000002781 deodorant agent Substances 0.000 claims description 3
- 102000049262 human DEFB4A Human genes 0.000 claims description 3
- 239000000017 hydrogel Substances 0.000 claims description 3
- 239000003410 keratolytic agent Substances 0.000 claims description 3
- 150000002632 lipids Chemical class 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 244000005706 microflora Species 0.000 claims description 3
- 239000004005 microsphere Substances 0.000 claims description 3
- 210000002200 mouth mucosa Anatomy 0.000 claims description 3
- 230000035935 pregnancy Effects 0.000 claims description 3
- 239000003755 preservative agent Substances 0.000 claims description 3
- 201000004700 rosacea Diseases 0.000 claims description 3
- 208000008742 seborrheic dermatitis Diseases 0.000 claims description 3
- 239000002453 shampoo Substances 0.000 claims description 3
- 210000000434 stratum corneum Anatomy 0.000 claims description 3
- 239000004094 surface-active agent Substances 0.000 claims description 3
- 238000011477 surgical intervention Methods 0.000 claims description 3
- 235000007173 Abies balsamea Nutrition 0.000 claims description 2
- 241000195940 Bryophyta Species 0.000 claims description 2
- 108090000695 Cytokines Proteins 0.000 claims description 2
- 102000004127 Cytokines Human genes 0.000 claims description 2
- 108010010803 Gelatin Proteins 0.000 claims description 2
- 244000018716 Impatiens biflora Species 0.000 claims description 2
- 239000005913 Maltodextrin Substances 0.000 claims description 2
- 229920002774 Maltodextrin Polymers 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 239000000443 aerosol Substances 0.000 claims description 2
- 239000003963 antioxidant agent Substances 0.000 claims description 2
- 239000003899 bactericide agent Substances 0.000 claims description 2
- 239000000440 bentonite Substances 0.000 claims description 2
- 229910000278 bentonite Inorganic materials 0.000 claims description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 2
- 229940112822 chewing gum Drugs 0.000 claims description 2
- 239000003086 colorant Substances 0.000 claims description 2
- 125000003074 decanoyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(*)=O 0.000 claims description 2
- 239000006185 dispersion Substances 0.000 claims description 2
- 239000008298 dragée Substances 0.000 claims description 2
- 238000004520 electroporation Methods 0.000 claims description 2
- 239000006260 foam Substances 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 239000007903 gelatin capsule Substances 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 239000003102 growth factor Substances 0.000 claims description 2
- 125000003104 hexanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 235000015110 jellies Nutrition 0.000 claims description 2
- 125000002669 linoleoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 230000004130 lipolysis Effects 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 229940035034 maltodextrin Drugs 0.000 claims description 2
- 230000001404 mediated effect Effects 0.000 claims description 2
- 239000000693 micelle Substances 0.000 claims description 2
- 239000004530 micro-emulsion Substances 0.000 claims description 2
- 238000000520 microinjection Methods 0.000 claims description 2
- 239000011859 microparticle Substances 0.000 claims description 2
- 235000011929 mousse Nutrition 0.000 claims description 2
- 239000007908 nanoemulsion Substances 0.000 claims description 2
- 239000002105 nanoparticle Substances 0.000 claims description 2
- 239000002077 nanosphere Substances 0.000 claims description 2
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 claims description 2
- 125000002811 oleoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 229920000620 organic polymer Polymers 0.000 claims description 2
- 230000001012 protector Effects 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- 239000000377 silicon dioxide Substances 0.000 claims description 2
- 239000002047 solid lipid nanoparticle Substances 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 125000003696 stearoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- 239000006188 syrup Substances 0.000 claims description 2
- 235000020357 syrup Nutrition 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 239000000454 talc Substances 0.000 claims description 2
- 229910052623 talc Inorganic materials 0.000 claims description 2
- 238000002604 ultrasonography Methods 0.000 claims description 2
- 239000000021 stimulant Substances 0.000 claims 7
- 239000013543 active substance Substances 0.000 claims 6
- 239000003112 inhibitor Substances 0.000 claims 6
- 102000016942 Elastin Human genes 0.000 claims 2
- 108010014258 Elastin Proteins 0.000 claims 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims 2
- 239000000022 bacteriostatic agent Substances 0.000 claims 2
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 claims 2
- 238000006731 degradation reaction Methods 0.000 claims 2
- 229920002549 elastin Polymers 0.000 claims 2
- 239000000049 pigment Substances 0.000 claims 2
- 230000035755 proliferation Effects 0.000 claims 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
- 125000000143 2-carboxyethyl group Chemical group [H]OC(=O)C([H])([H])C([H])([H])* 0.000 claims 1
- 239000004857 Balsam Substances 0.000 claims 1
- 208000035484 Cellulite Diseases 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 238000012270 DNA recombination Methods 0.000 claims 1
- 102000004237 Decorin Human genes 0.000 claims 1
- 108090000738 Decorin Proteins 0.000 claims 1
- 229940123457 Free radical scavenger Drugs 0.000 claims 1
- 229920002683 Glycosaminoglycan Polymers 0.000 claims 1
- 108010006519 Molecular Chaperones Proteins 0.000 claims 1
- 102000008299 Nitric Oxide Synthase Human genes 0.000 claims 1
- 108010021487 Nitric Oxide Synthase Proteins 0.000 claims 1
- 206010033733 Papule Diseases 0.000 claims 1
- 206010049752 Peau d'orange Diseases 0.000 claims 1
- 208000003251 Pruritus Diseases 0.000 claims 1
- 239000000809 air pollutant Substances 0.000 claims 1
- 229940061720 alpha hydroxy acid Drugs 0.000 claims 1
- 150000001280 alpha hydroxy acids Chemical class 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 239000000730 antalgic agent Substances 0.000 claims 1
- 230000003712 anti-aging effect Effects 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002249 anxiolytic agent Substances 0.000 claims 1
- 150000001277 beta hydroxy acids Chemical class 0.000 claims 1
- 230000019522 cellular metabolic process Effects 0.000 claims 1
- 230000036232 cellulite Effects 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 claims 1
- 230000004087 circulation Effects 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 230000011382 collagen catabolic process Effects 0.000 claims 1
- 239000007854 depigmenting agent Substances 0.000 claims 1
- 210000004207 dermis Anatomy 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 239000003995 emulsifying agent Substances 0.000 claims 1
- 210000000887 face Anatomy 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 239000003205 fragrance Substances 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 230000006872 improvement Effects 0.000 claims 1
- 239000008274 jelly Substances 0.000 claims 1
- 230000008099 melanin synthesis Effects 0.000 claims 1
- 230000004089 microcirculation Effects 0.000 claims 1
- 239000002088 nanocapsule Substances 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 230000003711 photoprotective effect Effects 0.000 claims 1
- 230000019612 pigmentation Effects 0.000 claims 1
- 239000003380 propellant Substances 0.000 claims 1
- 239000003223 protective agent Substances 0.000 claims 1
- 239000002516 radical scavenger Substances 0.000 claims 1
- 238000007665 sagging Methods 0.000 claims 1
- 210000002374 sebum Anatomy 0.000 claims 1
- 229940125723 sedative agent Drugs 0.000 claims 1
- 239000000932 sedative agent Substances 0.000 claims 1
- 230000000475 sunscreen effect Effects 0.000 claims 1
- 239000000516 sunscreening agent Substances 0.000 claims 1
- 239000002562 thickening agent Substances 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 230000002087 whitening effect Effects 0.000 claims 1
- 230000037303 wrinkles Effects 0.000 claims 1
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 38
- 150000001875 compounds Chemical class 0.000 description 27
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 26
- 150000001413 amino acids Chemical class 0.000 description 25
- 125000006239 protecting group Chemical group 0.000 description 25
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 22
- 229940024606 amino acid Drugs 0.000 description 22
- 239000011347 resin Substances 0.000 description 22
- 229920005989 resin Polymers 0.000 description 22
- 235000001014 amino acid Nutrition 0.000 description 21
- 101150019065 HBD gene Proteins 0.000 description 20
- 230000014509 gene expression Effects 0.000 description 20
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 19
- 241000282414 Homo sapiens Species 0.000 description 19
- 230000008569 process Effects 0.000 description 19
- 239000012634 fragment Substances 0.000 description 15
- 241000894006 Bacteria Species 0.000 description 13
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- 244000005700 microbiome Species 0.000 description 12
- 108090000623 proteins and genes Proteins 0.000 description 12
- 102000012265 beta-defensin Human genes 0.000 description 11
- 108050002883 beta-defensin Proteins 0.000 description 11
- 239000002904 solvent Substances 0.000 description 11
- 239000004615 ingredient Substances 0.000 description 10
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 10
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- 230000001939 inductive effect Effects 0.000 description 9
- 244000005714 skin microbiome Species 0.000 description 9
- MJZMSEWWBGCBFM-UHFFFAOYSA-N 2-(2-acetamidopropanoylamino)propanoic acid Chemical compound OC(=O)C(C)NC(=O)C(C)NC(C)=O MJZMSEWWBGCBFM-UHFFFAOYSA-N 0.000 description 8
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 8
- 206010052428 Wound Diseases 0.000 description 8
- 239000011203 carbon fibre reinforced carbon Substances 0.000 description 8
- 238000009472 formulation Methods 0.000 description 8
- 238000007911 parenteral administration Methods 0.000 description 8
- 230000002265 prevention Effects 0.000 description 8
- 102000004196 processed proteins & peptides Human genes 0.000 description 8
- DTQVDTLACAAQTR-UHFFFAOYSA-N trifluoroacetic acid Substances OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 8
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 7
- 208000027418 Wounds and injury Diseases 0.000 description 7
- 244000000010 microbial pathogen Species 0.000 description 7
- 239000003910 polypeptide antibiotic agent Substances 0.000 description 7
- 238000010532 solid phase synthesis reaction Methods 0.000 description 7
- BDNKZNFMNDZQMI-UHFFFAOYSA-N 1,3-diisopropylcarbodiimide Chemical compound CC(C)N=C=NC(C)C BDNKZNFMNDZQMI-UHFFFAOYSA-N 0.000 description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 6
- 108060001084 Luciferase Proteins 0.000 description 6
- 244000042664 Matricaria chamomilla Species 0.000 description 6
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 6
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 238000007792 addition Methods 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 238000005859 coupling reaction Methods 0.000 description 6
- 150000002148 esters Chemical class 0.000 description 6
- BRZYSWJRSDMWLG-CAXSIQPQSA-N geneticin Natural products O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](C(C)O)O2)N)[C@@H](N)C[C@H]1N BRZYSWJRSDMWLG-CAXSIQPQSA-N 0.000 description 6
- 230000002458 infectious effect Effects 0.000 description 6
- 229920001296 polysiloxane Polymers 0.000 description 6
- 235000018102 proteins Nutrition 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- UHPQFNXOFFPHJW-UHFFFAOYSA-N (4-methylphenyl)-phenylmethanamine Chemical compound C1=CC(C)=CC=C1C(N)C1=CC=CC=C1 UHPQFNXOFFPHJW-UHFFFAOYSA-N 0.000 description 5
- ASOKPJOREAFHNY-UHFFFAOYSA-N 1-Hydroxybenzotriazole Chemical compound C1=CC=C2N(O)N=NC2=C1 ASOKPJOREAFHNY-UHFFFAOYSA-N 0.000 description 5
- 208000030507 AIDS Diseases 0.000 description 5
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 5
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 5
- 208000008454 Hyperhidrosis Diseases 0.000 description 5
- 108010076876 Keratins Proteins 0.000 description 5
- 102000011782 Keratins Human genes 0.000 description 5
- 241000555688 Malassezia furfur Species 0.000 description 5
- 241000124008 Mammalia Species 0.000 description 5
- 208000002474 Tinea Diseases 0.000 description 5
- 206010043866 Tinea capitis Diseases 0.000 description 5
- 201000007096 Vulvovaginal Candidiasis Diseases 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- 238000013019 agitation Methods 0.000 description 5
- 230000000843 anti-fungal effect Effects 0.000 description 5
- 238000003556 assay Methods 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 230000008878 coupling Effects 0.000 description 5
- 238000010168 coupling process Methods 0.000 description 5
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 5
- 238000010511 deprotection reaction Methods 0.000 description 5
- 239000002158 endotoxin Substances 0.000 description 5
- 125000000524 functional group Chemical group 0.000 description 5
- 238000007429 general method Methods 0.000 description 5
- 238000004128 high performance liquid chromatography Methods 0.000 description 5
- 235000014655 lactic acid Nutrition 0.000 description 5
- 239000004310 lactic acid Substances 0.000 description 5
- 229920006008 lipopolysaccharide Polymers 0.000 description 5
- 108020004999 messenger RNA Proteins 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 238000010647 peptide synthesis reaction Methods 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 229920006395 saturated elastomer Polymers 0.000 description 5
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 5
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 4
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 description 4
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 4
- 239000004475 Arginine Substances 0.000 description 4
- 241000193880 Demodex folliculorum Species 0.000 description 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 4
- 241000282412 Homo Species 0.000 description 4
- 235000017309 Hypericum perforatum Nutrition 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- 239000005089 Luciferase Substances 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 241000736262 Microbiota Species 0.000 description 4
- 102000007079 Peptide Fragments Human genes 0.000 description 4
- 108010033276 Peptide Fragments Proteins 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 4
- 241000295644 Staphylococcaceae Species 0.000 description 4
- 241000191967 Staphylococcus aureus Species 0.000 description 4
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 4
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 4
- 229960003121 arginine Drugs 0.000 description 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 4
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 description 4
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 4
- 210000004899 c-terminal region Anatomy 0.000 description 4
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 4
- 238000002330 electrospray ionisation mass spectrometry Methods 0.000 description 4
- 235000013922 glutamic acid Nutrition 0.000 description 4
- 239000004220 glutamic acid Substances 0.000 description 4
- 235000011187 glycerol Nutrition 0.000 description 4
- NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 description 4
- 239000000411 inducer Substances 0.000 description 4
- 229960000310 isoleucine Drugs 0.000 description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 4
- 210000000214 mouth Anatomy 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 238000012552 review Methods 0.000 description 4
- 208000017520 skin disease Diseases 0.000 description 4
- JFLSOKIMYBSASW-UHFFFAOYSA-N 1-chloro-2-[chloro(diphenyl)methyl]benzene Chemical compound ClC1=CC=CC=C1C(Cl)(C=1C=CC=CC=1)C1=CC=CC=C1 JFLSOKIMYBSASW-UHFFFAOYSA-N 0.000 description 3
- XYWPNWJLJURBME-UHFFFAOYSA-N 2-[2-[4-(aminomethyl)-2,4-dimethoxycyclohexa-1,5-dien-1-yl]phenoxy]acetic acid Chemical compound C1=CC(CN)(OC)CC(OC)=C1C1=CC=CC=C1OCC(O)=O XYWPNWJLJURBME-UHFFFAOYSA-N 0.000 description 3
- ATYUCXIJDKHOPX-UHFFFAOYSA-N 5-[4-[(9h-fluoren-9-ylmethoxycarbonylamino)methyl]-3,5-dimethoxyphenoxy]pentanoic acid Chemical compound COC1=CC(OCCCCC(O)=O)=CC(OC)=C1CNC(=O)OCC1C2=CC=CC=C2C2=CC=CC=C21 ATYUCXIJDKHOPX-UHFFFAOYSA-N 0.000 description 3
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 description 3
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- 241000228212 Aspergillus Species 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- 240000001432 Calendula officinalis Species 0.000 description 3
- 235000005881 Calendula officinalis Nutrition 0.000 description 3
- 241000186427 Cutibacterium acnes Species 0.000 description 3
- 108020004414 DNA Proteins 0.000 description 3
- 206010012504 Dermatophytosis Diseases 0.000 description 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 3
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 3
- 208000001860 Eye Infections Diseases 0.000 description 3
- 241000233866 Fungi Species 0.000 description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 3
- 208000032139 Halitosis Diseases 0.000 description 3
- 241000546188 Hypericum Species 0.000 description 3
- 235000007232 Matricaria chamomilla Nutrition 0.000 description 3
- 235000004429 Matricaria chamomilla var recutita Nutrition 0.000 description 3
- 102400000740 Melanocyte-stimulating hormone alpha Human genes 0.000 description 3
- 101710200814 Melanotropin alpha Proteins 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 3
- 208000010195 Onychomycosis Diseases 0.000 description 3
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 3
- 239000012980 RPMI-1640 medium Substances 0.000 description 3
- 206010042674 Swelling Diseases 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 150000001408 amides Chemical class 0.000 description 3
- 230000000845 anti-microbial effect Effects 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 3
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 3
- 230000003115 biocidal effect Effects 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 229940095731 candida albicans Drugs 0.000 description 3
- 238000012512 characterization method Methods 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 3
- 230000008482 dysregulation Effects 0.000 description 3
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 3
- 239000012091 fetal bovine serum Substances 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 210000002683 foot Anatomy 0.000 description 3
- 210000004392 genitalia Anatomy 0.000 description 3
- 229930182478 glucoside Natural products 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 238000002955 isolation Methods 0.000 description 3
- 238000004020 luminiscence type Methods 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 244000045947 parasite Species 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 3
- 125000003367 polycyclic group Chemical group 0.000 description 3
- 239000002243 precursor Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 229940055019 propionibacterium acne Drugs 0.000 description 3
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 238000011002 quantification Methods 0.000 description 3
- 238000003757 reverse transcription PCR Methods 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 125000001424 substituent group Chemical group 0.000 description 3
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 3
- 229910052717 sulfur Inorganic materials 0.000 description 3
- 230000035900 sweating Effects 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 201000004647 tinea pedis Diseases 0.000 description 3
- 201000005882 tinea unguium Diseases 0.000 description 3
- 210000002105 tongue Anatomy 0.000 description 3
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 description 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 3
- WHNFPRLDDSXQCL-UAZQEYIDSA-N α-msh Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(N)=O)NC(=O)[C@H](CO)NC(C)=O)C1=CC=C(O)C=C1 WHNFPRLDDSXQCL-UAZQEYIDSA-N 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- GKPMARPRXONRJX-BWJWTDLKSA-N (3s)-4-[[(2s,3s)-1-[[(2s)-1-amino-5-(carbamoylamino)-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-[[(2s)-2,6-diaminohexanoyl]amino]-4-oxobutanoic acid Chemical group NC(=O)NCCC[C@@H](C(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)CCCCN GKPMARPRXONRJX-BWJWTDLKSA-N 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 2
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 2
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 description 2
- FPIRBHDGWMWJEP-UHFFFAOYSA-N 1-hydroxy-7-azabenzotriazole Chemical compound C1=CN=C2N(O)N=NC2=C1 FPIRBHDGWMWJEP-UHFFFAOYSA-N 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 2
- LJCZNYWLQZZIOS-UHFFFAOYSA-N 2,2,2-trichlorethoxycarbonyl chloride Chemical compound ClC(=O)OCC(Cl)(Cl)Cl LJCZNYWLQZZIOS-UHFFFAOYSA-N 0.000 description 2
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
- HISMSXHVLNAPEQ-UHFFFAOYSA-N 5-[4-(aminomethyl)-3,5-dimethoxyphenoxy]pentanoic acid Chemical compound COC1=CC(OCCCCC(O)=O)=CC(OC)=C1CN HISMSXHVLNAPEQ-UHFFFAOYSA-N 0.000 description 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
- 241000186046 Actinomyces Species 0.000 description 2
- 240000002234 Allium sativum Species 0.000 description 2
- 235000002961 Aloe barbadensis Nutrition 0.000 description 2
- 244000144927 Aloe barbadensis Species 0.000 description 2
- 235000009328 Amaranthus caudatus Nutrition 0.000 description 2
- 240000001592 Amaranthus caudatus Species 0.000 description 2
- 244000144730 Amygdalus persica Species 0.000 description 2
- 102000044503 Antimicrobial Peptides Human genes 0.000 description 2
- 108700042778 Antimicrobial Peptides Proteins 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 208000015898 Bacterial Skin disease Diseases 0.000 description 2
- MNIPYSSQXLZQLJ-UHFFFAOYSA-N Biofenac Chemical compound OC(=O)COC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl MNIPYSSQXLZQLJ-UHFFFAOYSA-N 0.000 description 2
- 206010005913 Body tinea Diseases 0.000 description 2
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 244000192528 Chrysanthemum parthenium Species 0.000 description 2
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 2
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 2
- 241000193163 Clostridioides difficile Species 0.000 description 2
- 241000193403 Clostridium Species 0.000 description 2
- 241000223233 Cutaneotrichosporon cutaneum Species 0.000 description 2
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 2
- 206010012444 Dermatitis diaper Diseases 0.000 description 2
- 208000003105 Diaper Rash Diseases 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 108010016626 Dipeptides Proteins 0.000 description 2
- 244000133098 Echinacea angustifolia Species 0.000 description 2
- 241001480035 Epidermophyton Species 0.000 description 2
- 201000000297 Erysipelas Diseases 0.000 description 2
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 2
- 241000192125 Firmicutes Species 0.000 description 2
- 206010016936 Folliculitis Diseases 0.000 description 2
- 206010017533 Fungal infection Diseases 0.000 description 2
- 241000605909 Fusobacterium Species 0.000 description 2
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 description 2
- 241000207201 Gardnerella vaginalis Species 0.000 description 2
- 206010018143 Genital candidiasis Diseases 0.000 description 2
- 235000010469 Glycine max Nutrition 0.000 description 2
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 206010021531 Impetigo Diseases 0.000 description 2
- 241000588748 Klebsiella Species 0.000 description 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 2
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 description 2
- 229930182844 L-isoleucine Natural products 0.000 description 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 2
- 108010023244 Lactoperoxidase Proteins 0.000 description 2
- 102000045576 Lactoperoxidases Human genes 0.000 description 2
- ARIWANIATODDMH-UHFFFAOYSA-N Lauric acid monoglyceride Natural products CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 description 2
- SBDNJUWAMKYJOX-UHFFFAOYSA-N Meclofenamic Acid Chemical compound CC1=CC=C(Cl)C(NC=2C(=CC=CC=2)C(O)=O)=C1Cl SBDNJUWAMKYJOX-UHFFFAOYSA-N 0.000 description 2
- 241000366182 Melaleuca alternifolia Species 0.000 description 2
- 108010007013 Melanocyte-Stimulating Hormones Proteins 0.000 description 2
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 description 2
- 206010065764 Mucosal infection Diseases 0.000 description 2
- 241000237955 Nassarius Species 0.000 description 2
- 206010073310 Occupational exposures Diseases 0.000 description 2
- 240000000783 Origanum majorana Species 0.000 description 2
- 241000191992 Peptostreptococcus Species 0.000 description 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- 108010009736 Protein Hydrolysates Proteins 0.000 description 2
- 235000006040 Prunus persica var persica Nutrition 0.000 description 2
- 201000004681 Psoriasis Diseases 0.000 description 2
- 241001278097 Salix alba Species 0.000 description 2
- 206010039792 Seborrhoea Diseases 0.000 description 2
- 241000194017 Streptococcus Species 0.000 description 2
- 241000194019 Streptococcus mutans Species 0.000 description 2
- 241000193996 Streptococcus pyogenes Species 0.000 description 2
- 241000194023 Streptococcus sanguinis Species 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 2
- 241001459572 Trichophyton interdigitale Species 0.000 description 2
- 241001045770 Trichophyton mentagrophytes Species 0.000 description 2
- 241000223229 Trichophyton rubrum Species 0.000 description 2
- 241000893966 Trichophyton verrucosum Species 0.000 description 2
- 241001621834 Trichophyton yaoundei Species 0.000 description 2
- 208000007501 Trichosporonosis Diseases 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 2
- 206010047642 Vitiligo Diseases 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 229960004420 aceclofenac Drugs 0.000 description 2
- 235000011054 acetic acid Nutrition 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000001361 adipic acid Substances 0.000 description 2
- 235000011037 adipic acid Nutrition 0.000 description 2
- 229960003767 alanine Drugs 0.000 description 2
- 150000003973 alkyl amines Chemical class 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
- 235000011399 aloe vera Nutrition 0.000 description 2
- 102000018568 alpha-Defensin Human genes 0.000 description 2
- 108050007802 alpha-defensin Proteins 0.000 description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 2
- 239000004178 amaranth Substances 0.000 description 2
- 235000012735 amaranth Nutrition 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 description 2
- SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 description 2
- LLEMOWNGBBNAJR-UHFFFAOYSA-N biphenyl-2-ol Chemical compound OC1=CC=CC=C1C1=CC=CC=C1 LLEMOWNGBBNAJR-UHFFFAOYSA-N 0.000 description 2
- VHRGRCVQAFMJIZ-UHFFFAOYSA-N cadaverine Chemical compound NCCCCCN VHRGRCVQAFMJIZ-UHFFFAOYSA-N 0.000 description 2
- GHBFNMLVSPCDGN-UHFFFAOYSA-N caprylic acid monoglyceride Natural products CCCCCCCC(=O)OCC(O)CO GHBFNMLVSPCDGN-UHFFFAOYSA-N 0.000 description 2
- 235000011472 cat’s claw Nutrition 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 235000013985 cinnamic acid Nutrition 0.000 description 2
- 229930016911 cinnamic acid Natural products 0.000 description 2
- 235000015165 citric acid Nutrition 0.000 description 2
- 238000003776 cleavage reaction Methods 0.000 description 2
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 201000007717 corneal ulcer Diseases 0.000 description 2
- 239000008406 cosmetic ingredient Substances 0.000 description 2
- 125000004122 cyclic group Chemical group 0.000 description 2
- 235000013365 dairy product Nutrition 0.000 description 2
- NNBZCPXTIHJBJL-UHFFFAOYSA-N decalin Chemical compound C1CCCC2CCCCC21 NNBZCPXTIHJBJL-UHFFFAOYSA-N 0.000 description 2
- 208000002925 dental caries Diseases 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 235000021434 dietary agent Nutrition 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- WSDISUOETYTPRL-UHFFFAOYSA-N dmdm hydantoin Chemical compound CC1(C)N(CO)C(=O)N(CO)C1=O WSDISUOETYTPRL-UHFFFAOYSA-N 0.000 description 2
- 235000014134 echinacea Nutrition 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 235000019197 fats Nutrition 0.000 description 2
- 235000008384 feverfew Nutrition 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 239000001530 fumaric acid Substances 0.000 description 2
- 208000024386 fungal infectious disease Diseases 0.000 description 2
- 235000004611 garlic Nutrition 0.000 description 2
- 229930195712 glutamate Natural products 0.000 description 2
- 229940049906 glutamate Drugs 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- 210000003780 hair follicle Anatomy 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 238000000265 homogenisation Methods 0.000 description 2
- 230000003054 hormonal effect Effects 0.000 description 2
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- ZCTXEAQXZGPWFG-UHFFFAOYSA-N imidurea Chemical compound O=C1NC(=O)N(CO)C1NC(=O)NCNC(=O)NC1C(=O)NC(=O)N1CO ZCTXEAQXZGPWFG-UHFFFAOYSA-N 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000015788 innate immune response Effects 0.000 description 2
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 2
- ZNJFBWYDHIGLCU-HWKXXFMVSA-N jasmonic acid Chemical compound CC\C=C/C[C@@H]1[C@@H](CC(O)=O)CCC1=O ZNJFBWYDHIGLCU-HWKXXFMVSA-N 0.000 description 2
- 229940057428 lactoperoxidase Drugs 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 239000001630 malic acid Substances 0.000 description 2
- 235000011090 malic acid Nutrition 0.000 description 2
- 229960003803 meclofenamic acid Drugs 0.000 description 2
- 210000004379 membrane Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 229960004452 methionine Drugs 0.000 description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 2
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 2
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 125000002950 monocyclic group Chemical group 0.000 description 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 description 2
- BDJRBEYXGGNYIS-UHFFFAOYSA-N nonanedioic acid Chemical compound OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 231100000675 occupational exposure Toxicity 0.000 description 2
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 description 2
- 230000037312 oily skin Effects 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 125000001151 peptidyl group Chemical group 0.000 description 2
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 2
- 210000002826 placenta Anatomy 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 235000019260 propionic acid Nutrition 0.000 description 2
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 2
- 229960003415 propylparaben Drugs 0.000 description 2
- KIDHWZJUCRJVML-UHFFFAOYSA-N putrescine Chemical compound NCCCCN KIDHWZJUCRJVML-UHFFFAOYSA-N 0.000 description 2
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 2
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 2
- 125000006413 ring segment Chemical group 0.000 description 2
- 229920002477 rna polymer Polymers 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- WVYADZUPLLSGPU-UHFFFAOYSA-N salsalate Chemical compound OC(=O)C1=CC=CC=C1OC(=O)C1=CC=CC=C1O WVYADZUPLLSGPU-UHFFFAOYSA-N 0.000 description 2
- 230000007017 scission Effects 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000007929 subcutaneous injection Substances 0.000 description 2
- 238000010254 subcutaneous injection Methods 0.000 description 2
- 239000011593 sulfur Substances 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 210000004243 sweat Anatomy 0.000 description 2
- 208000013460 sweaty Diseases 0.000 description 2
- 235000002906 tartaric acid Nutrition 0.000 description 2
- 239000011975 tartaric acid Substances 0.000 description 2
- BWMISRWJRUSYEX-SZKNIZGXSA-N terbinafine hydrochloride Chemical compound Cl.C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 BWMISRWJRUSYEX-SZKNIZGXSA-N 0.000 description 2
- 239000004753 textile Substances 0.000 description 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 210000003437 trachea Anatomy 0.000 description 2
- 230000001052 transient effect Effects 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 2
- 239000004474 valine Substances 0.000 description 2
- 239000011719 vitamin A Substances 0.000 description 2
- 235000019155 vitamin A Nutrition 0.000 description 2
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 2
- 235000005282 vitamin D3 Nutrition 0.000 description 2
- 239000011647 vitamin D3 Substances 0.000 description 2
- 229940045997 vitamin a Drugs 0.000 description 2
- 229940021056 vitamin d3 Drugs 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 description 1
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 description 1
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 description 1
- PCJHOCNJLMFYCV-OAQYLSRUSA-N (2r)-2-(9h-fluoren-9-ylmethoxycarbonylamino)-2-phenylacetic acid Chemical compound C1([C@@H](NC(=O)OCC2C3=CC=CC=C3C3=CC=CC=C32)C(=O)O)=CC=CC=C1 PCJHOCNJLMFYCV-OAQYLSRUSA-N 0.000 description 1
- BUBGAUHBELNDEW-GOSISDBHSA-N (2r)-2-(9h-fluoren-9-ylmethoxycarbonylamino)-4-methylsulfanylbutanoic acid Chemical compound C1=CC=C2C(COC(=O)N[C@H](CCSC)C(O)=O)C3=CC=CC=C3C2=C1 BUBGAUHBELNDEW-GOSISDBHSA-N 0.000 description 1
- OTKXCALUHMPIGM-HXUWFJFHSA-N (2r)-2-(9h-fluoren-9-ylmethoxycarbonylamino)-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoic acid Chemical compound C1=CC=C2C(COC(=O)N[C@H](CCC(=O)OC(C)(C)C)C(O)=O)C3=CC=CC=C3C2=C1 OTKXCALUHMPIGM-HXUWFJFHSA-N 0.000 description 1
- QWXZOFZKSQXPDC-LLVKDONJSA-N (2r)-2-(9h-fluoren-9-ylmethoxycarbonylamino)propanoic acid Chemical compound C1=CC=C2C(COC(=O)N[C@H](C)C(O)=O)C3=CC=CC=C3C2=C1 QWXZOFZKSQXPDC-LLVKDONJSA-N 0.000 description 1
- HNICLNKVURBTKV-MUUNZHRXSA-N (2r)-5-[[amino-[(2,2,4,6,7-pentamethyl-3h-1-benzofuran-5-yl)sulfonylamino]methylidene]amino]-2-(9h-fluoren-9-ylmethoxycarbonylamino)pentanoic acid Chemical compound C12=CC=CC=C2C2=CC=CC=C2C1COC(=O)N[C@@H](C(O)=O)CCCN=C(N)NS(=O)(=O)C1=C(C)C(C)=C2OC(C)(C)CC2=C1C HNICLNKVURBTKV-MUUNZHRXSA-N 0.000 description 1
- QXVFEIPAZSXRGM-BFUOFWGJSA-N (2r,3r)-2-(9h-fluoren-9-ylmethoxycarbonylamino)-3-methylpentanoic acid Chemical compound C1=CC=C2C(COC(=O)N[C@H]([C@H](C)CC)C(O)=O)C3=CC=CC=C3C2=C1 QXVFEIPAZSXRGM-BFUOFWGJSA-N 0.000 description 1
- RDJGLLICXDHJDY-NSHDSACASA-N (2s)-2-(3-phenoxyphenyl)propanoic acid Chemical compound OC(=O)[C@@H](C)C1=CC=CC(OC=2C=CC=CC=2)=C1 RDJGLLICXDHJDY-NSHDSACASA-N 0.000 description 1
- BUBGAUHBELNDEW-SFHVURJKSA-N (2s)-2-(9h-fluoren-9-ylmethoxycarbonylamino)-4-methylsulfanylbutanoic acid Chemical compound C1=CC=C2C(COC(=O)N[C@@H](CCSC)C(O)=O)C3=CC=CC=C3C2=C1 BUBGAUHBELNDEW-SFHVURJKSA-N 0.000 description 1
- OTKXCALUHMPIGM-FQEVSTJZSA-N (2s)-2-(9h-fluoren-9-ylmethoxycarbonylamino)-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoic acid Chemical compound C1=CC=C2C(COC(=O)N[C@@H](CCC(=O)OC(C)(C)C)C(O)=O)C3=CC=CC=C3C2=C1 OTKXCALUHMPIGM-FQEVSTJZSA-N 0.000 description 1
- VCFCFPNRQDANPN-IBGZPJMESA-N (2s)-2-(9h-fluoren-9-ylmethoxycarbonylamino)hexanoic acid Chemical compound C1=CC=C2C(COC(=O)N[C@@H](CCCC)C(O)=O)C3=CC=CC=C3C2=C1 VCFCFPNRQDANPN-IBGZPJMESA-N 0.000 description 1
- QWXZOFZKSQXPDC-NSHDSACASA-N (2s)-2-(9h-fluoren-9-ylmethoxycarbonylamino)propanoic acid Chemical compound C1=CC=C2C(COC(=O)N[C@@H](C)C(O)=O)C3=CC=CC=C3C2=C1 QWXZOFZKSQXPDC-NSHDSACASA-N 0.000 description 1
- MDKGKXOCJGEUJW-VIFPVBQESA-N (2s)-2-[4-(thiophene-2-carbonyl)phenyl]propanoic acid Chemical compound C1=CC([C@@H](C(O)=O)C)=CC=C1C(=O)C1=CC=CS1 MDKGKXOCJGEUJW-VIFPVBQESA-N 0.000 description 1
- HNICLNKVURBTKV-NDEPHWFRSA-N (2s)-5-[[amino-[(2,2,4,6,7-pentamethyl-3h-1-benzofuran-5-yl)sulfonylamino]methylidene]amino]-2-(9h-fluoren-9-ylmethoxycarbonylamino)pentanoic acid Chemical compound C12=CC=CC=C2C2=CC=CC=C2C1COC(=O)N[C@H](C(O)=O)CCCN=C(N)NS(=O)(=O)C1=C(C)C(C)=C2OC(C)(C)CC2=C1C HNICLNKVURBTKV-NDEPHWFRSA-N 0.000 description 1
- QXVFEIPAZSXRGM-DJJJIMSYSA-N (2s,3s)-2-(9h-fluoren-9-ylmethoxycarbonylamino)-3-methylpentanoic acid Chemical compound C1=CC=C2C(COC(=O)N[C@@H]([C@@H](C)CC)C(O)=O)C3=CC=CC=C3C2=C1 QXVFEIPAZSXRGM-DJJJIMSYSA-N 0.000 description 1
- 125000006686 (C1-C24) alkyl group Chemical group 0.000 description 1
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 description 1
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 description 1
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 description 1
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 description 1
- WUOACPNHFRMFPN-SECBINFHSA-N (S)-(-)-alpha-terpineol Chemical compound CC1=CC[C@@H](C(C)(C)O)CC1 WUOACPNHFRMFPN-SECBINFHSA-N 0.000 description 1
- MXOAEAUPQDYUQM-QMMMGPOBSA-N (S)-chlorphenesin Chemical compound OC[C@H](O)COC1=CC=C(Cl)C=C1 MXOAEAUPQDYUQM-QMMMGPOBSA-N 0.000 description 1
- 229940015975 1,2-hexanediol Drugs 0.000 description 1
- 229940031723 1,2-octanediol Drugs 0.000 description 1
- DTOUUUZOYKYHEP-UHFFFAOYSA-N 1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine Chemical compound CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1 DTOUUUZOYKYHEP-UHFFFAOYSA-N 0.000 description 1
- 229940043375 1,5-pentanediol Drugs 0.000 description 1
- KQBIYVMDUVJOIB-UHFFFAOYSA-N 1-(4-chlorophenyl)-1-[4-chloro-3-(trifluoromethyl)phenyl]urea Chemical compound C=1C=C(Cl)C(C(F)(F)F)=CC=1N(C(=O)N)C1=CC=C(Cl)C=C1 KQBIYVMDUVJOIB-UHFFFAOYSA-N 0.000 description 1
- FJLUATLTXUNBOT-UHFFFAOYSA-N 1-Hexadecylamine Chemical compound CCCCCCCCCCCCCCCCN FJLUATLTXUNBOT-UHFFFAOYSA-N 0.000 description 1
- 125000004972 1-butynyl group Chemical group [H]C([H])([H])C([H])([H])C#C* 0.000 description 1
- BSXPDVKSFWQFRT-UHFFFAOYSA-N 1-hydroxytriazolo[4,5-b]pyridine Chemical compound C1=CC=C2N(O)N=NC2=N1 BSXPDVKSFWQFRT-UHFFFAOYSA-N 0.000 description 1
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 description 1
- IBLKWZIFZMJLFL-UHFFFAOYSA-N 1-phenoxypropan-2-ol Chemical compound CC(O)COC1=CC=CC=C1 IBLKWZIFZMJLFL-UHFFFAOYSA-N 0.000 description 1
- 125000000530 1-propynyl group Chemical group [H]C([H])([H])C#C* 0.000 description 1
- FRPZMMHWLSIFAZ-UHFFFAOYSA-N 10-undecenoic acid Chemical compound OC(=O)CCCCCCCCC=C FRPZMMHWLSIFAZ-UHFFFAOYSA-N 0.000 description 1
- 108020004463 18S ribosomal RNA Proteins 0.000 description 1
- YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Natural products C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 description 1
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 description 1
- NCKMMSIFQUPKCK-UHFFFAOYSA-N 2-benzyl-4-chlorophenol Chemical compound OC1=CC=C(Cl)C=C1CC1=CC=CC=C1 NCKMMSIFQUPKCK-UHFFFAOYSA-N 0.000 description 1
- TYBHZVUFOINFDV-UHFFFAOYSA-N 2-bromo-6-[(3-bromo-5-chloro-2-hydroxyphenyl)methyl]-4-chlorophenol Chemical compound OC1=C(Br)C=C(Cl)C=C1CC1=CC(Cl)=CC(Br)=C1O TYBHZVUFOINFDV-UHFFFAOYSA-N 0.000 description 1
- 125000000069 2-butynyl group Chemical group [H]C([H])([H])C#CC([H])([H])* 0.000 description 1
- 125000004493 2-methylbut-1-yl group Chemical group CC(C*)CC 0.000 description 1
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 description 1
- 125000000474 3-butynyl group Chemical group [H]C#CC([H])([H])C([H])([H])* 0.000 description 1
- SHUUQMNVBZFPBR-UHFFFAOYSA-N 3-chloro-2,2-dimethyl-1,3-oxazolidine Chemical compound ClN1C(OCC1)(C)C SHUUQMNVBZFPBR-UHFFFAOYSA-N 0.000 description 1
- DQYSALLXMHVJAV-UHFFFAOYSA-M 3-heptyl-2-[(3-heptyl-4-methyl-1,3-thiazol-3-ium-2-yl)methylidene]-4-methyl-1,3-thiazole;iodide Chemical compound [I-].CCCCCCCN1C(C)=CS\C1=C\C1=[N+](CCCCCCC)C(C)=CS1 DQYSALLXMHVJAV-UHFFFAOYSA-M 0.000 description 1
- 229940099451 3-iodo-2-propynylbutylcarbamate Drugs 0.000 description 1
- WYVVKGNFXHOCQV-UHFFFAOYSA-N 3-iodoprop-2-yn-1-yl butylcarbamate Chemical compound CCCCNC(=O)OCC#CI WYVVKGNFXHOCQV-UHFFFAOYSA-N 0.000 description 1
- TZZGHGKTHXIOMN-UHFFFAOYSA-N 3-trimethoxysilyl-n-(3-trimethoxysilylpropyl)propan-1-amine Chemical compound CO[Si](OC)(OC)CCCNCCC[Si](OC)(OC)OC TZZGHGKTHXIOMN-UHFFFAOYSA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 1
- CFKMVGJGLGKFKI-UHFFFAOYSA-N 4-chloro-m-cresol Chemical compound CC1=CC(O)=CC=C1Cl CFKMVGJGLGKFKI-UHFFFAOYSA-N 0.000 description 1
- 229940046305 5-bromo-5-nitro-1,3-dioxane Drugs 0.000 description 1
- BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 description 1
- DFTNLVRGBAMNHG-UHFFFAOYSA-N 6,6-dibromo-4,4-dichloro-2-[(2-hydroxyphenyl)methyl]cyclohex-2-en-1-ol Chemical compound ClC1(Cl)CC(Br)(Br)C(O)C(CC=2C(=CC=CC=2)O)=C1 DFTNLVRGBAMNHG-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- ZRCMGIXRGFOXNT-UHFFFAOYSA-N 7a-ethyl-1,3,5,7-tetrahydro-[1,3]oxazolo[3,4-c][1,3]oxazole Chemical compound C1OCN2COCC21CC ZRCMGIXRGFOXNT-UHFFFAOYSA-N 0.000 description 1
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 241000589291 Acinetobacter Species 0.000 description 1
- 244000099147 Ananas comosus Species 0.000 description 1
- 235000007119 Ananas comosus Nutrition 0.000 description 1
- WPQRDUGBKUNFJW-SLUROAMNSA-N Apigenin 7-(6''-p-coumarylglucoside) Natural products O=C(OC[C@@H]1[C@@H](O)[C@H](O)[C@H](O)[C@H](Oc2cc(O)c3C(=O)C=C(c4ccc(O)cc4)Oc3c2)O1)/C=C/c1ccc(O)cc1 WPQRDUGBKUNFJW-SLUROAMNSA-N 0.000 description 1
- 241000208983 Arnica Species 0.000 description 1
- 241000086254 Arnica montana Species 0.000 description 1
- 235000004355 Artemisia lactiflora Nutrition 0.000 description 1
- 235000003261 Artemisia vulgaris Nutrition 0.000 description 1
- 240000006891 Artemisia vulgaris Species 0.000 description 1
- 241001555820 Asarum maximum Species 0.000 description 1
- 235000000832 Ayote Nutrition 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- 239000004342 Benzoyl peroxide Substances 0.000 description 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
- MOZDKDIOPSPTBH-UHFFFAOYSA-N Benzyl parahydroxybenzoate Chemical compound C1=CC(O)=CC=C1C(=O)OCC1=CC=CC=C1 MOZDKDIOPSPTBH-UHFFFAOYSA-N 0.000 description 1
- 241000186000 Bifidobacterium Species 0.000 description 1
- 241001474374 Blennius Species 0.000 description 1
- 208000035985 Body Odor Diseases 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 101800001415 Bri23 peptide Proteins 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- LVDKZNITIUWNER-UHFFFAOYSA-N Bronopol Chemical compound OCC(Br)(CO)[N+]([O-])=O LVDKZNITIUWNER-UHFFFAOYSA-N 0.000 description 1
- 102400000107 C-terminal peptide Human genes 0.000 description 1
- 101800000655 C-terminal peptide Proteins 0.000 description 1
- 102000000905 Cadherin Human genes 0.000 description 1
- 108050007957 Cadherin Proteins 0.000 description 1
- 235000014138 Caesalpinia decapetala Nutrition 0.000 description 1
- 244000197813 Camelina sativa Species 0.000 description 1
- 241000393548 Candidae Species 0.000 description 1
- LKUNXBRZDFMZOK-GFCCVEGCSA-N Capric acid monoglyceride Natural products CCCCCCCCCC(=O)OC[C@H](O)CO LKUNXBRZDFMZOK-GFCCVEGCSA-N 0.000 description 1
- 235000002566 Capsicum Nutrition 0.000 description 1
- 240000008574 Capsicum frutescens Species 0.000 description 1
- 235000009024 Ceanothus sanguineus Nutrition 0.000 description 1
- 235000004032 Centella asiatica Nutrition 0.000 description 1
- 244000146462 Centella asiatica Species 0.000 description 1
- 241000734239 Centipeda cunninghamii Species 0.000 description 1
- 240000006162 Chenopodium quinoa Species 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- UDKCHVLMFQVBAA-UHFFFAOYSA-M Choline salicylate Chemical compound C[N+](C)(C)CCO.OC1=CC=CC=C1C([O-])=O UDKCHVLMFQVBAA-UHFFFAOYSA-M 0.000 description 1
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 1
- 241000132536 Cirsium Species 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 102000007644 Colony-Stimulating Factors Human genes 0.000 description 1
- 108010071942 Colony-Stimulating Factors Proteins 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 108010039419 Connective Tissue Growth Factor Proteins 0.000 description 1
- 102000015225 Connective Tissue Growth Factor Human genes 0.000 description 1
- OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical class [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 description 1
- 241000186216 Corynebacterium Species 0.000 description 1
- 241001508000 Corynebacterium bovis Species 0.000 description 1
- 241000186245 Corynebacterium xerosis Species 0.000 description 1
- 240000003527 Crinum asiaticum Species 0.000 description 1
- 240000004244 Cucurbita moschata Species 0.000 description 1
- 235000009854 Cucurbita moschata Nutrition 0.000 description 1
- 235000009804 Cucurbita pepo subsp pepo Nutrition 0.000 description 1
- 241001464974 Cutibacterium avidum Species 0.000 description 1
- 241001464975 Cutibacterium granulosum Species 0.000 description 1
- WHUUTDBJXJRKMK-GSVOUGTGSA-N D-glutamic acid Chemical compound OC(=O)[C@H](N)CCC(O)=O WHUUTDBJXJRKMK-GSVOUGTGSA-N 0.000 description 1
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 244000000626 Daucus carota Species 0.000 description 1
- 235000002767 Daucus carota Nutrition 0.000 description 1
- 239000004287 Dehydroacetic acid Substances 0.000 description 1
- 208000007163 Dermatomycoses Diseases 0.000 description 1
- 206010056340 Diabetic ulcer Diseases 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
- OJIYIVCMRYCWSE-UHFFFAOYSA-M Domiphen bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CCOC1=CC=CC=C1 OJIYIVCMRYCWSE-UHFFFAOYSA-M 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 238000012286 ELISA Assay Methods 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241001480036 Epidermophyton floccosum Species 0.000 description 1
- 241000195950 Equisetum arvense Species 0.000 description 1
- 239000005768 Equisetum arvense L. Substances 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
- 102000018233 Fibroblast Growth Factor Human genes 0.000 description 1
- 108050007372 Fibroblast Growth Factor Proteins 0.000 description 1
- 102000003972 Fibroblast growth factor 7 Human genes 0.000 description 1
- 108090000385 Fibroblast growth factor 7 Proteins 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- 108010058643 Fungal Proteins Proteins 0.000 description 1
- 241000605994 Fusobacterium periodonticum Species 0.000 description 1
- 240000001972 Gardenia jasminoides Species 0.000 description 1
- 241000726221 Gemma Species 0.000 description 1
- 241001071795 Gentiana Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000004366 Glucose oxidase Substances 0.000 description 1
- 108010015776 Glucose oxidase Proteins 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 241000208681 Hamamelis virginiana Species 0.000 description 1
- 241000254191 Harpagophytum procumbens Species 0.000 description 1
- 244000020551 Helianthus annuus Species 0.000 description 1
- 235000003222 Helianthus annuus Nutrition 0.000 description 1
- GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 235000005206 Hibiscus Nutrition 0.000 description 1
- 235000007185 Hibiscus lunariifolius Nutrition 0.000 description 1
- 244000284380 Hibiscus rosa sinensis Species 0.000 description 1
- 101001054921 Homo sapiens Lymphatic vessel endothelial hyaluronic acid receptor 1 Proteins 0.000 description 1
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 description 1
- 241000725303 Human immunodeficiency virus Species 0.000 description 1
- 244000141009 Hypericum perforatum Species 0.000 description 1
- 206010055171 Hypertensive nephropathy Diseases 0.000 description 1
- 235000010650 Hyssopus officinalis Nutrition 0.000 description 1
- 240000001812 Hyssopus officinalis Species 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- 206010061598 Immunodeficiency Diseases 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 206010062016 Immunosuppression Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 102000015696 Interleukins Human genes 0.000 description 1
- 108010063738 Interleukins Proteins 0.000 description 1
- 229920001202 Inulin Polymers 0.000 description 1
- XPJVKCRENWUEJH-UHFFFAOYSA-N Isobutylparaben Chemical compound CC(C)COC(=O)C1=CC=C(O)C=C1 XPJVKCRENWUEJH-UHFFFAOYSA-N 0.000 description 1
- 240000007049 Juglans regia Species 0.000 description 1
- 235000009496 Juglans regia Nutrition 0.000 description 1
- QNAYBMKLOCPYGJ-UWTATZPHSA-N L-Alanine Natural products C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 description 1
- FFEARJCKVFRZRR-UHFFFAOYSA-N L-Methionine Natural products CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- 229930195722 L-methionine Natural products 0.000 description 1
- 208000034693 Laceration Diseases 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 102000010445 Lactoferrin Human genes 0.000 description 1
- 108010063045 Lactoferrin Proteins 0.000 description 1
- 240000003553 Leptospermum scoparium Species 0.000 description 1
- 206010024380 Leukoderma Diseases 0.000 description 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- 235000015459 Lycium barbarum Nutrition 0.000 description 1
- 102100026849 Lymphatic vessel endothelial hyaluronic acid receptor 1 Human genes 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- BNMGUJRJUUDLHW-HLUHVYOBSA-N Madecassoside Natural products C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5[C@H](O)C[C@@]34C)[C@@H]2[C@H]1C)C(=O)O[C@@H]6O[C@H](CO[C@@H]7O[C@H](CO)[C@@H](O[C@@H]8O[C@H](C)[C@H](O)[C@@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@@H](O)[C@H](O)[C@H]6O BNMGUJRJUUDLHW-HLUHVYOBSA-N 0.000 description 1
- BNMGUJRJUUDLHW-HCZMHFOYSA-N Madecassoside Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O)OC[C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)[C@]12CC[C@H]([C@@H]([C@H]1C=1[C@@]([C@@]3(C[C@@H](O)[C@H]4[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]4(C)[C@H]3CC=1)C)(C)CC2)C)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O BNMGUJRJUUDLHW-HCZMHFOYSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- MQHWFIOJQSCFNM-UHFFFAOYSA-L Magnesium salicylate Chemical compound [Mg+2].OC1=CC=CC=C1C([O-])=O.OC1=CC=CC=C1C([O-])=O MQHWFIOJQSCFNM-UHFFFAOYSA-L 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-L Malonate Chemical compound [O-]C(=O)CC([O-])=O OFOBLEOULBTSOW-UHFFFAOYSA-L 0.000 description 1
- 240000000982 Malva neglecta Species 0.000 description 1
- 235000000060 Malva neglecta Nutrition 0.000 description 1
- 235000006770 Malva sylvestris Nutrition 0.000 description 1
- 240000002129 Malva sylvestris Species 0.000 description 1
- 102000002274 Matrix Metalloproteinases Human genes 0.000 description 1
- 108010000684 Matrix Metalloproteinases Proteins 0.000 description 1
- 239000000637 Melanocyte-Stimulating Hormone Substances 0.000 description 1
- ZRVUJXDFFKFLMG-UHFFFAOYSA-N Meloxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=NC=C(C)S1 ZRVUJXDFFKFLMG-UHFFFAOYSA-N 0.000 description 1
- 235000006679 Mentha X verticillata Nutrition 0.000 description 1
- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
- XADCESSVHJOZHK-UHFFFAOYSA-N Meperidine Chemical compound C=1C=CC=CC=1C1(C(=O)OCC)CCN(C)CC1 XADCESSVHJOZHK-UHFFFAOYSA-N 0.000 description 1
- 241001460074 Microsporum distortum Species 0.000 description 1
- 102000014171 Milk Proteins Human genes 0.000 description 1
- 108010011756 Milk Proteins Proteins 0.000 description 1
- 241000978725 Mimosa tenuiflora Species 0.000 description 1
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 241000186359 Mycobacterium Species 0.000 description 1
- 241000187488 Mycobacterium sp. Species 0.000 description 1
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 1
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 1
- BLXXJMDCKKHMKV-UHFFFAOYSA-N Nabumetone Chemical compound C1=C(CCC(C)=O)C=CC2=CC(OC)=CC=C21 BLXXJMDCKKHMKV-UHFFFAOYSA-N 0.000 description 1
- 206010061304 Nail infection Diseases 0.000 description 1
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 description 1
- 241000588653 Neisseria Species 0.000 description 1
- 229930193140 Neomycin Natural products 0.000 description 1
- NVNLLIYOARQCIX-MSHCCFNRSA-N Nisin Chemical compound N1C(=O)[C@@H](CC(C)C)NC(=O)C(=C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@@H](NC(=O)C(=C/C)/NC(=O)[C@H](N)[C@H](C)CC)CSC[C@@H]1C(=O)N[C@@H]1C(=O)N2CCC[C@@H]2C(=O)NCC(=O)N[C@@H](C(=O)N[C@H](CCCCN)C(=O)N[C@@H]2C(NCC(=O)N[C@H](C)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCSC)C(=O)NCC(=O)N[C@H](CS[C@@H]2C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CCSC)C(=O)N[C@H](CCCCN)C(=O)N[C@@H]2C(N[C@H](C)C(=O)N[C@@H]3C(=O)N[C@@H](C(N[C@H](CC=4NC=NC=4)C(=O)N[C@H](CS[C@@H]3C)C(=O)N[C@H](CO)C(=O)N[C@H]([C@H](C)CC)C(=O)N[C@H](CC=3NC=NC=3)C(=O)N[C@H](C(C)C)C(=O)NC(=C)C(=O)N[C@H](CCCCN)C(O)=O)=O)CS[C@@H]2C)=O)=O)CS[C@@H]1C NVNLLIYOARQCIX-MSHCCFNRSA-N 0.000 description 1
- 108010053775 Nisin Proteins 0.000 description 1
- 102000001490 Opioid Peptides Human genes 0.000 description 1
- 108010093625 Opioid Peptides Proteins 0.000 description 1
- 235000011203 Origanum Nutrition 0.000 description 1
- 235000006297 Origanum majorana Nutrition 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 description 1
- 208000025174 PANDAS Diseases 0.000 description 1
- 238000009004 PCR Kit Methods 0.000 description 1
- 208000021155 Paediatric autoimmune neuropsychiatric disorders associated with streptococcal infection Diseases 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 240000004718 Panda Species 0.000 description 1
- 235000016496 Panda oleosa Nutrition 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 description 1
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 description 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 108010039918 Polylysine Proteins 0.000 description 1
- 241000605862 Porphyromonas gingivalis Species 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 241001135221 Prevotella intermedia Species 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102000002727 Protein Tyrosine Phosphatase Human genes 0.000 description 1
- 241000519590 Pseudoalteromonas Species 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- 241001672981 Purpura Species 0.000 description 1
- 206010037549 Purpura Diseases 0.000 description 1
- 239000005700 Putrescine Substances 0.000 description 1
- 241000405414 Rehmannia Species 0.000 description 1
- 108010039491 Ricin Proteins 0.000 description 1
- 235000000657 Rosa moschata Nutrition 0.000 description 1
- 244000018676 Rosa sp Species 0.000 description 1
- 239000006146 Roswell Park Memorial Institute medium Substances 0.000 description 1
- 241001453443 Rothia <bacteria> Species 0.000 description 1
- 244000151637 Sambucus canadensis Species 0.000 description 1
- 235000018735 Sambucus canadensis Nutrition 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 102000003800 Selectins Human genes 0.000 description 1
- 108090000184 Selectins Proteins 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 229910021607 Silver chloride Inorganic materials 0.000 description 1
- 235000010841 Silybum marianum Nutrition 0.000 description 1
- 244000272459 Silybum marianum Species 0.000 description 1
- 206010040904 Skin odour abnormal Diseases 0.000 description 1
- 235000008981 Smilax officinalis Nutrition 0.000 description 1
- 240000002493 Smilax officinalis Species 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- 102000013275 Somatomedins Human genes 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- 238000003120 Steady-Glo Luciferase Assay System Methods 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- 241001442052 Symphytum Species 0.000 description 1
- 241001135235 Tannerella forsythia Species 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 239000005844 Thymol Substances 0.000 description 1
- 241000130764 Tinea Species 0.000 description 1
- 102000040945 Transcription factor Human genes 0.000 description 1
- 108091023040 Transcription factor Proteins 0.000 description 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 description 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 description 1
- 241000589892 Treponema denticola Species 0.000 description 1
- 241000223238 Trichophyton Species 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- 229940123445 Tricyclic antidepressant Drugs 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
- 206010064996 Ulcerative keratitis Diseases 0.000 description 1
- 241000683228 Uncaria guianensis Species 0.000 description 1
- 150000001224 Uranium Chemical class 0.000 description 1
- 208000000558 Varicose Ulcer Diseases 0.000 description 1
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 241000269370 Xenopus <genus> Species 0.000 description 1
- 241000209149 Zea Species 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- JUIUXBHZFNHITF-IEOSBIPESA-N [(2r)-2,5,7,8-tetramethyl-2-[(4r,8r)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] dihydrogen phosphate Chemical compound OP(=O)(O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C JUIUXBHZFNHITF-IEOSBIPESA-N 0.000 description 1
- WPQRDUGBKUNFJW-ZZSHFKPLSA-N [(2r,3s,4s,5r,6s)-3,4,5-trihydroxy-6-[5-hydroxy-2-(4-hydroxyphenyl)-4-oxochromen-7-yl]oxyoxan-2-yl]methyl (e)-3-(4-hydroxyphenyl)prop-2-enoate Chemical compound C([C@@H]1[C@H]([C@@H]([C@@H](O)[C@H](OC=2C=C3C(C(C=C(O3)C=3C=CC(O)=CC=3)=O)=C(O)C=2)O1)O)O)OC(=O)\C=C\C1=CC=C(O)C=C1 WPQRDUGBKUNFJW-ZZSHFKPLSA-N 0.000 description 1
- BNGRKDJZQIGWQF-UHFFFAOYSA-N [4-benzamido-5-(naphthalen-2-ylamino)-5-oxopentyl]-(diaminomethylidene)azanium;chloride Chemical compound Cl.C=1C=C2C=CC=CC2=CC=1NC(=O)C(CCCNC(=N)N)NC(=O)C1=CC=CC=C1 BNGRKDJZQIGWQF-UHFFFAOYSA-N 0.000 description 1
- ORBWTRACSRKLIS-UHFFFAOYSA-N [Se]=S.S1N=CC(C1)=O Chemical compound [Se]=S.S1N=CC(C1)=O ORBWTRACSRKLIS-UHFFFAOYSA-N 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 150000001266 acyl halides Chemical class 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 235000014104 aloe vera supplement Nutrition 0.000 description 1
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 description 1
- OVKDFILSBMEKLT-UHFFFAOYSA-N alpha-Terpineol Natural products CC(=C)C1(O)CCC(C)=CC1 OVKDFILSBMEKLT-UHFFFAOYSA-N 0.000 description 1
- TUFYVOCKVJOUIR-UHFFFAOYSA-N alpha-Thujaplicin Natural products CC(C)C=1C=CC=CC(=O)C=1O TUFYVOCKVJOUIR-UHFFFAOYSA-N 0.000 description 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 description 1
- 229940088601 alpha-terpineol Drugs 0.000 description 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 125000000909 amidinium group Chemical group 0.000 description 1
- 229960002684 aminocaproic acid Drugs 0.000 description 1
- KRMDCWKBEZIMAB-UHFFFAOYSA-N amitriptyline Chemical compound C1CC2=CC=CC=C2C(=CCCN(C)C)C2=CC=CC=C21 KRMDCWKBEZIMAB-UHFFFAOYSA-N 0.000 description 1
- 229960000836 amitriptyline Drugs 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 125000005427 anthranyl group Chemical group 0.000 description 1
- 229940124350 antibacterial drug Drugs 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 235000019568 aromas Nutrition 0.000 description 1
- 125000004104 aryloxy group Chemical group 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- QCYLIQBVLZBPNK-UHFFFAOYSA-N asiaticoside A Natural products O1C(C(=O)C(C)C)=CC(C)C(C2(C(OC(C)=O)CC34C5)C)C1CC2(C)C3CCC(C1(C)C)C45CCC1OC1OCC(O)C(O)C1O QCYLIQBVLZBPNK-UHFFFAOYSA-N 0.000 description 1
- 229940009098 aspartate Drugs 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 210000001099 axilla Anatomy 0.000 description 1
- 229960002255 azelaic acid Drugs 0.000 description 1
- 150000001540 azides Chemical class 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 101150004886 bai gene Proteins 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
- 229960001950 benzethonium chloride Drugs 0.000 description 1
- 229940050390 benzoate Drugs 0.000 description 1
- 229960005274 benzocaine Drugs 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 229960004365 benzoic acid Drugs 0.000 description 1
- QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical compound C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 description 1
- 239000012964 benzotriazole Substances 0.000 description 1
- 235000019400 benzoyl peroxide Nutrition 0.000 description 1
- 229960003328 benzoyl peroxide Drugs 0.000 description 1
- 229960002903 benzyl benzoate Drugs 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 229940034794 benzylparaben Drugs 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 125000002619 bicyclic group Chemical group 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 235000010290 biphenyl Nutrition 0.000 description 1
- 239000004305 biphenyl Substances 0.000 description 1
- 125000006267 biphenyl group Chemical group 0.000 description 1
- 229940036350 bisabolol Drugs 0.000 description 1
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 235000007123 blue elder Nutrition 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 150000001642 boronic acid derivatives Chemical class 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- XVBRCOKDZVQYAY-UHFFFAOYSA-N bronidox Chemical compound [O-][N+](=O)C1(Br)COCOC1 XVBRCOKDZVQYAY-UHFFFAOYSA-N 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 229940067596 butylparaben Drugs 0.000 description 1
- KHAVLLBUVKBTBG-UHFFFAOYSA-N caproleic acid Natural products OC(=O)CCCCCCCC=C KHAVLLBUVKBTBG-UHFFFAOYSA-N 0.000 description 1
- 239000001390 capsicum minimum Substances 0.000 description 1
- FFGPTBGBLSHEPO-UHFFFAOYSA-N carbamazepine Chemical compound C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 description 1
- 229960000623 carbamazepine Drugs 0.000 description 1
- 150000001718 carbodiimides Chemical class 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 229960003184 carprofen Drugs 0.000 description 1
- IVUMCTKHWDRRMH-UHFFFAOYSA-N carprofen Chemical compound C1=CC(Cl)=C[C]2C3=CC=C(C(C(O)=O)C)C=C3N=C21 IVUMCTKHWDRRMH-UHFFFAOYSA-N 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 229960000590 celecoxib Drugs 0.000 description 1
- RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- VDQQXEISLMTGAB-UHFFFAOYSA-N chloramine T Chemical compound [Na+].CC1=CC=C(S(=O)(=O)[N-]Cl)C=C1 VDQQXEISLMTGAB-UHFFFAOYSA-N 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 1
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 150000001805 chlorine compounds Chemical class 0.000 description 1
- VXIVSQZSERGHQP-UHFFFAOYSA-N chloroacetamide Chemical compound NC(=O)CCl VXIVSQZSERGHQP-UHFFFAOYSA-N 0.000 description 1
- 229960002023 chloroprocaine Drugs 0.000 description 1
- VDANGULDQQJODZ-UHFFFAOYSA-N chloroprocaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1Cl VDANGULDQQJODZ-UHFFFAOYSA-N 0.000 description 1
- MXOAEAUPQDYUQM-UHFFFAOYSA-N chlorphenesin Chemical compound OCC(O)COC1=CC=C(Cl)C=C1 MXOAEAUPQDYUQM-UHFFFAOYSA-N 0.000 description 1
- 229960003993 chlorphenesin Drugs 0.000 description 1
- 229960002688 choline salicylate Drugs 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 235000019504 cigarettes Nutrition 0.000 description 1
- 229960002173 citrulline Drugs 0.000 description 1
- 229960002227 clindamycin Drugs 0.000 description 1
- KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 description 1
- 229960002842 clobetasol Drugs 0.000 description 1
- CBGUOGMQLZIXBE-XGQKBEPLSA-N clobetasol propionate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CCl)(OC(=O)CC)[C@@]1(C)C[C@@H]2O CBGUOGMQLZIXBE-XGQKBEPLSA-N 0.000 description 1
- 229960004022 clotrimazole Drugs 0.000 description 1
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 description 1
- 238000010549 co-Evaporation Methods 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 229960004126 codeine Drugs 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000007799 cork Substances 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 239000003581 cosmetic carrier Substances 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 1
- 201000003146 cystitis Diseases 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 230000008260 defense mechanism Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 239000012024 dehydrating agents Substances 0.000 description 1
- 235000019258 dehydroacetic acid Nutrition 0.000 description 1
- PGRHXDWITVMQBC-UHFFFAOYSA-N dehydroacetic acid Natural products CC(=O)C1C(=O)OC(C)=CC1=O PGRHXDWITVMQBC-UHFFFAOYSA-N 0.000 description 1
- 229940061632 dehydroacetic acid Drugs 0.000 description 1
- JEQRBTDTEKWZBW-UHFFFAOYSA-N dehydroacetic acid Chemical compound CC(=O)C1=C(O)OC(C)=CC1=O JEQRBTDTEKWZBW-UHFFFAOYSA-N 0.000 description 1
- 238000001212 derivatisation Methods 0.000 description 1
- 201000003929 dermatomycosis Diseases 0.000 description 1
- 208000030011 dermatophytosis of scalp or beard Diseases 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229960003957 dexamethasone Drugs 0.000 description 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 229960002069 diamorphine Drugs 0.000 description 1
- 229960004698 dichlorobenzyl alcohol Drugs 0.000 description 1
- 229960001259 diclofenac Drugs 0.000 description 1
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
- 229960000616 diflunisal Drugs 0.000 description 1
- HUPFGZXOMWLGNK-UHFFFAOYSA-N diflunisal Chemical compound C1=C(O)C(C(=O)O)=CC(C=2C(=CC(F)=CC=2)F)=C1 HUPFGZXOMWLGNK-UHFFFAOYSA-N 0.000 description 1
- XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 description 1
- 206010013023 diphtheria Diseases 0.000 description 1
- 229940120889 dipyrone Drugs 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000009050 echinacin Substances 0.000 description 1
- 229960001484 edetic acid Drugs 0.000 description 1
- 235000018927 edible plant Nutrition 0.000 description 1
- 235000007124 elderberry Nutrition 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 229960003276 erythromycin Drugs 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 229960004756 ethanol Drugs 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 1
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 description 1
- 229960005293 etodolac Drugs 0.000 description 1
- XFBVBWWRPKNWHW-UHFFFAOYSA-N etodolac Chemical compound C1COC(CC)(CC(O)=O)C2=N[C]3C(CC)=CC=CC3=C21 XFBVBWWRPKNWHW-UHFFFAOYSA-N 0.000 description 1
- 235000008995 european elder Nutrition 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 208000011323 eye infectious disease Diseases 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 229960001395 fenbufen Drugs 0.000 description 1
- ZPAKPRAICRBAOD-UHFFFAOYSA-N fenbufen Chemical compound C1=CC(C(=O)CCC(=O)O)=CC=C1C1=CC=CC=C1 ZPAKPRAICRBAOD-UHFFFAOYSA-N 0.000 description 1
- 229960001419 fenoprofen Drugs 0.000 description 1
- 229940126864 fibroblast growth factor Drugs 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 229960002390 flurbiprofen Drugs 0.000 description 1
- SYTBZMRGLBWNTM-UHFFFAOYSA-N flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 239000010794 food waste Substances 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 229940013688 formic acid Drugs 0.000 description 1
- 235000014106 fortified food Nutrition 0.000 description 1
- 229940050411 fumarate Drugs 0.000 description 1
- 235000011087 fumaric acid Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 229960002870 gabapentin Drugs 0.000 description 1
- 210000004475 gamma-delta t lymphocyte Anatomy 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 229940116332 glucose oxidase Drugs 0.000 description 1
- 235000019420 glucose oxidase Nutrition 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-L glutamate group Chemical group N[C@@H](CCC(=O)[O-])C(=O)[O-] WHUUTDBJXJRKMK-VKHMYHEASA-L 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
- 229960002449 glycine Drugs 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-N guanidine group Chemical group NC(=N)N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 1
- 229940093915 gynecological organic acid Drugs 0.000 description 1
- ZFSXZJXLKAJIGS-UHFFFAOYSA-N halocarban Chemical compound C1=C(Cl)C(C(F)(F)F)=CC(NC(=O)NC=2C=CC(Cl)=CC=2)=C1 ZFSXZJXLKAJIGS-UHFFFAOYSA-N 0.000 description 1
- 229950006625 halocarban Drugs 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000036072 healthy nails Effects 0.000 description 1
- 230000036074 healthy skin Effects 0.000 description 1
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 description 1
- 229960004867 hexetidine Drugs 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 230000009215 host defense mechanism Effects 0.000 description 1
- BNRNAKTVFSZAFA-UHFFFAOYSA-N hydrindane Chemical compound C1CCCC2CCCC21 BNRNAKTVFSZAFA-UHFFFAOYSA-N 0.000 description 1
- 125000001183 hydrocarbyl group Chemical group 0.000 description 1
- LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 description 1
- 229960000240 hydrocodone Drugs 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 229910000037 hydrogen sulfide Inorganic materials 0.000 description 1
- 239000000413 hydrolysate Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 230000003100 immobilizing effect Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 description 1
- 229960000905 indomethacin Drugs 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 102000006495 integrins Human genes 0.000 description 1
- 108010044426 integrins Proteins 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 238000007917 intracranial administration Methods 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 238000007913 intrathecal administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 1
- 229940029339 inulin Drugs 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 150000002519 isoleucine derivatives Chemical class 0.000 description 1
- 229960004592 isopropanol Drugs 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- NFIDBGJMFKNGGQ-UHFFFAOYSA-N isopropylmethylphenol Natural products CC(C)CC1=CC=CC=C1O NFIDBGJMFKNGGQ-UHFFFAOYSA-N 0.000 description 1
- ZNJFBWYDHIGLCU-UHFFFAOYSA-N jasmonic acid Natural products CCC=CCC1C(CC(O)=O)CCC1=O ZNJFBWYDHIGLCU-UHFFFAOYSA-N 0.000 description 1
- 206010023332 keratitis Diseases 0.000 description 1
- 229960004125 ketoconazole Drugs 0.000 description 1
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 description 1
- 229960000991 ketoprofen Drugs 0.000 description 1
- 229960004752 ketorolac Drugs 0.000 description 1
- OZWKMVRBQXNZKK-UHFFFAOYSA-N ketorolac Chemical compound OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 OZWKMVRBQXNZKK-UHFFFAOYSA-N 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 description 1
- 229940078795 lactoferrin Drugs 0.000 description 1
- 235000021242 lactoferrin Nutrition 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 229960004194 lidocaine Drugs 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 125000005647 linker group Chemical group 0.000 description 1
- 125000005645 linoleyl group Chemical group 0.000 description 1
- 239000008297 liquid dosage form Substances 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 229960002202 lornoxicam Drugs 0.000 description 1
- OXROWJKCGCOJDO-JLHYYAGUSA-N lornoxicam Chemical compound O=C1C=2SC(Cl)=CC=2S(=O)(=O)N(C)\C1=C(\O)NC1=CC=CC=N1 OXROWJKCGCOJDO-JLHYYAGUSA-N 0.000 description 1
- 229960002373 loxoprofen Drugs 0.000 description 1
- BAZQYVYVKYOAGO-UHFFFAOYSA-M loxoprofen sodium hydrate Chemical compound O.O.[Na+].C1=CC(C(C([O-])=O)C)=CC=C1CC1C(=O)CCC1 BAZQYVYVKYOAGO-UHFFFAOYSA-M 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 229940090813 madecassoside Drugs 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 229940072082 magnesium salicylate Drugs 0.000 description 1
- 238000003760 magnetic stirring Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 229960003464 mefenamic acid Drugs 0.000 description 1
- HYYBABOKPJLUIN-UHFFFAOYSA-N mefenamic acid Chemical compound CC1=CC=CC(NC=2C(=CC=CC=2)C(O)=O)=C1C HYYBABOKPJLUIN-UHFFFAOYSA-N 0.000 description 1
- 229960001929 meloxicam Drugs 0.000 description 1
- 150000002730 mercury Chemical class 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- LVWZTYCIRDMTEY-UHFFFAOYSA-N metamizole Chemical compound O=C1C(N(CS(O)(=O)=O)C)=C(C)N(C)N1C1=CC=CC=C1 LVWZTYCIRDMTEY-UHFFFAOYSA-N 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- UZKWTJUDCOPSNM-UHFFFAOYSA-N methoxybenzene Substances CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 229960001047 methyl salicylate Drugs 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 description 1
- 229960000282 metronidazole Drugs 0.000 description 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
- 235000021239 milk protein Nutrition 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- NALMPLUMOWIVJC-UHFFFAOYSA-N n,n,4-trimethylbenzeneamine oxide Chemical compound CC1=CC=C([N+](C)(C)[O-])C=C1 NALMPLUMOWIVJC-UHFFFAOYSA-N 0.000 description 1
- CMWYAOXYQATXSI-UHFFFAOYSA-N n,n-dimethylformamide;piperidine Chemical compound CN(C)C=O.C1CCNCC1 CMWYAOXYQATXSI-UHFFFAOYSA-N 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 229960004270 nabumetone Drugs 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 229960002009 naproxen Drugs 0.000 description 1
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 description 1
- 230000037125 natural defense Effects 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 229960004927 neomycin Drugs 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 229960000965 nimesulide Drugs 0.000 description 1
- HYWYRSMBCFDLJT-UHFFFAOYSA-N nimesulide Chemical compound CS(=O)(=O)NC1=CC=C([N+]([O-])=O)C=C1OC1=CC=CC=C1 HYWYRSMBCFDLJT-UHFFFAOYSA-N 0.000 description 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- 239000004309 nisin Substances 0.000 description 1
- 235000010297 nisin Nutrition 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 229920000847 nonoxynol Polymers 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 238000010534 nucleophilic substitution reaction Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229960000988 nystatin Drugs 0.000 description 1
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229940049964 oleate Drugs 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229940012843 omega-3 fatty acid Drugs 0.000 description 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 description 1
- 239000006014 omega-3 oil Substances 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 210000000287 oocyte Anatomy 0.000 description 1
- 239000003399 opiate peptide Substances 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 235000010292 orthophenyl phenol Nutrition 0.000 description 1
- 150000003891 oxalate salts Chemical class 0.000 description 1
- 229960002739 oxaprozin Drugs 0.000 description 1
- OFPXSFXSNFPTHF-UHFFFAOYSA-N oxaprozin Chemical compound O1C(CCC(=O)O)=NC(C=2C=CC=CC=2)=C1C1=CC=CC=C1 OFPXSFXSNFPTHF-UHFFFAOYSA-N 0.000 description 1
- 229960002085 oxycodone Drugs 0.000 description 1
- 229960000649 oxyphenbutazone Drugs 0.000 description 1
- HFHZKZSRXITVMK-UHFFFAOYSA-N oxyphenbutazone Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=C(O)C=C1 HFHZKZSRXITVMK-UHFFFAOYSA-N 0.000 description 1
- 229940070805 p-chloro-m-cresol Drugs 0.000 description 1
- 125000006503 p-nitrobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])* 0.000 description 1
- 210000002741 palatine tonsil Anatomy 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 229940101267 panthenol Drugs 0.000 description 1
- 235000020957 pantothenol Nutrition 0.000 description 1
- 239000011619 pantothenol Substances 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 229960005489 paracetamol Drugs 0.000 description 1
- 229960004662 parecoxib Drugs 0.000 description 1
- TZRHLKRLEZJVIJ-UHFFFAOYSA-N parecoxib Chemical compound C1=CC(S(=O)(=O)NC(=O)CC)=CC=C1C1=C(C)ON=C1C1=CC=CC=C1 TZRHLKRLEZJVIJ-UHFFFAOYSA-N 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
- 229960003330 pentetic acid Drugs 0.000 description 1
- 125000005981 pentynyl group Chemical group 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 206010034674 peritonitis Diseases 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229960000482 pethidine Drugs 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 125000005561 phenanthryl group Chemical group 0.000 description 1
- KHUXNRRPPZOJPT-UHFFFAOYSA-N phenoxy radical Chemical group O=C1C=C[CH]C=C1 KHUXNRRPPZOJPT-UHFFFAOYSA-N 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 229940106026 phenoxyisopropanol Drugs 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 1
- 229960002895 phenylbutazone Drugs 0.000 description 1
- VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 description 1
- PETXWIMJICIQTQ-UHFFFAOYSA-N phenylmethoxymethanol Chemical compound OCOCC1=CC=CC=C1 PETXWIMJICIQTQ-UHFFFAOYSA-N 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 150000004714 phosphonium salts Chemical class 0.000 description 1
- 230000029553 photosynthesis Effects 0.000 description 1
- 238000010672 photosynthesis Methods 0.000 description 1
- 230000000243 photosynthetic effect Effects 0.000 description 1
- 229960002702 piroxicam Drugs 0.000 description 1
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 description 1
- XIPFMBOWZXULIA-UHFFFAOYSA-N pivalamide Chemical compound CC(C)(C)C(N)=O XIPFMBOWZXULIA-UHFFFAOYSA-N 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 229960000502 poloxamer Drugs 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920000656 polylysine Polymers 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229950008882 polysorbate Drugs 0.000 description 1
- 230000030786 positive chemotaxis Effects 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 229960004618 prednisone Drugs 0.000 description 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
- AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 description 1
- 229960001233 pregabalin Drugs 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- AAEVYOVXGOFMJO-UHFFFAOYSA-N prometryn Chemical compound CSC1=NC(NC(C)C)=NC(NC(C)C)=N1 AAEVYOVXGOFMJO-UHFFFAOYSA-N 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 229940055009 propionibacterium avidum Drugs 0.000 description 1
- 229940095574 propionic acid Drugs 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 239000003531 protein hydrolysate Substances 0.000 description 1
- 230000007065 protein hydrolysis Effects 0.000 description 1
- 108020000494 protein-tyrosine phosphatase Proteins 0.000 description 1
- 235000015136 pumpkin Nutrition 0.000 description 1
- 239000005297 pyrex Substances 0.000 description 1
- LKUNXBRZDFMZOK-UHFFFAOYSA-N rac-1-monodecanoylglycerol Chemical compound CCCCCCCCCC(=O)OCC(O)CO LKUNXBRZDFMZOK-UHFFFAOYSA-N 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000003753 real-time PCR Methods 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000010839 reverse transcription Methods 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 229960000371 rofecoxib Drugs 0.000 description 1
- RZJQGNCSTQAWON-UHFFFAOYSA-N rofecoxib Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=C(C=2C=CC=CC=2)C(=O)OC1 RZJQGNCSTQAWON-UHFFFAOYSA-N 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 229960000953 salsalate Drugs 0.000 description 1
- 239000010671 sandalwood oil Substances 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000008299 semisolid dosage form Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- 229940032753 sodium iodate Drugs 0.000 description 1
- 239000011697 sodium iodate Substances 0.000 description 1
- 235000015281 sodium iodate Nutrition 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 229940086735 succinate Drugs 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 235000011044 succinic acid Nutrition 0.000 description 1
- 229960003329 sulfinpyrazone Drugs 0.000 description 1
- MBGGBVCUIVRRBF-UHFFFAOYSA-N sulfinpyrazone Chemical compound O=C1N(C=2C=CC=CC=2)N(C=2C=CC=CC=2)C(=O)C1CCS(=O)C1=CC=CC=C1 MBGGBVCUIVRRBF-UHFFFAOYSA-N 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- 150000003464 sulfur compounds Chemical class 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 229960000894 sulindac Drugs 0.000 description 1
- MLKXDPUZXIRXEP-MFOYZWKCSA-N sulindac Chemical compound CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(S(C)=O)C=C1 MLKXDPUZXIRXEP-MFOYZWKCSA-N 0.000 description 1
- 229960004492 suprofen Drugs 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 239000010677 tea tree oil Substances 0.000 description 1
- 229940111630 tea tree oil Drugs 0.000 description 1
- 229960002871 tenoxicam Drugs 0.000 description 1
- WZWYJBNHTWCXIM-UHFFFAOYSA-N tenoxicam Chemical compound O=C1C=2SC=CC=2S(=O)(=O)N(C)C1=C(O)NC1=CC=CC=N1 WZWYJBNHTWCXIM-UHFFFAOYSA-N 0.000 description 1
- 238000011191 terminal modification Methods 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 229960002372 tetracaine Drugs 0.000 description 1
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- 201000003875 tinea corporis Diseases 0.000 description 1
- 229960001017 tolmetin Drugs 0.000 description 1
- UPSPUYADGBWSHF-UHFFFAOYSA-N tolmetin Chemical compound C1=CC(C)=CC=C1C(=O)C1=CC=C(CC(O)=O)N1C UPSPUYADGBWSHF-UHFFFAOYSA-N 0.000 description 1
- FUSNMLFNXJSCDI-UHFFFAOYSA-N tolnaftate Chemical compound C=1C=C2C=CC=CC2=CC=1OC(=S)N(C)C1=CC=CC(C)=C1 FUSNMLFNXJSCDI-UHFFFAOYSA-N 0.000 description 1
- 229960004880 tolnaftate Drugs 0.000 description 1
- 235000015961 tonic Nutrition 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 229960000716 tonics Drugs 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 description 1
- 229960004380 tramadol Drugs 0.000 description 1
- LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
- ZGYICYBLPGRURT-UHFFFAOYSA-N tri(propan-2-yl)silicon Chemical compound CC(C)[Si](C(C)C)C(C)C ZGYICYBLPGRURT-UHFFFAOYSA-N 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- 239000003029 tricyclic antidepressant agent Substances 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- 229960002703 undecylenic acid Drugs 0.000 description 1
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 1
- 239000002691 unilamellar liposome Substances 0.000 description 1
- 229960002004 valdecoxib Drugs 0.000 description 1
- LNPDTQAFDNKSHK-UHFFFAOYSA-N valdecoxib Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=C(S(N)(=O)=O)C=C1 LNPDTQAFDNKSHK-UHFFFAOYSA-N 0.000 description 1
- 229940005605 valeric acid Drugs 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 210000003905 vulva Anatomy 0.000 description 1
- 235000020234 walnut Nutrition 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 239000002759 woven fabric Substances 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 229960001296 zinc oxide Drugs 0.000 description 1
- 229940043810 zinc pyrithione Drugs 0.000 description 1
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 description 1
- 229930007845 β-thujaplicin Natural products 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
- C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0819—Tripeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1021—Tetrapeptides with the first amino acid being acidic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q3/00—Manicure or pedicure preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Birds (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Cosmetics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
本発明は、内在性β−デフェンシンの産生を刺激することができるペプチド誘導体、ならびに皮膚、粘膜、頭皮および/または爪の処置、保護および/または洗浄のため、好ましくは、微生物増殖による、または微生物増殖のリスクがある皮膚、粘膜、頭皮および/または爪の症状、障害および/または病態の処置のための、これらのペプチド誘導体を含有する化粧品および/または医薬組成物に関する。
哺乳類の皮膚は、化学的攻撃であれ、機械的攻撃であれ、または感染的攻撃であれ、外的攻撃に対する主要な防御バリアである。外的攻撃因子としてはまた、紫外線、煙草の煙、汚染および機構などの環境因子が含まれる。皮膚はその免疫保護系を形成する皮膚微生物叢を有し、このような微生物叢集団の不均衡は、自所性皮膚細菌または通常皮膚には存在しない細菌による皮膚の侵害をしばしば含む機能的免疫欠陥を伴い、そして、臨床的に確立された感染をもたらし得るプロセスが始まる。同様に、皮膚細菌叢も、ホメオスタシスの複数の重要な機能、細菌感染に対する防御(干渉による)、脂質分解および体臭の原因となる揮発性成分の産生を有する。
R1−AA1−AA2−AA3−AA4−R2
(I)
[式中、
AA1は、−Glu−および−Arg−からなる群から選択され;
AA2は、−Met−、−Ahx−および−Phg−からなる群から選択され;
AA3は、−Ala−および−Phg−からなる群から選択され;
AA4は、−Ile−または単結合からなる群から選択され;
R1は、H、置換または非置換非環式脂肪族基、置換または非置換アリシクリル、置換または非置換ヘテロシクリル、置換または非置換ヘテロアリールアルキル、置換または非置換アリール、置換または非置換アラルキルおよびR5−C(O)−からなる群から選択され;かつ、
R2は、−NR3R4、−OR3および−SR3からなる群から選択され;R3およびR4は、H、置換または非置換非環式脂肪族基、置換または非置換アリシクリル、置換または非置換ヘテロシクリル、置換または非置換ヘテロアリールアルキル、置換または非置換アリールおよび置換または非置換アラルキルからなる群から独立に選択され;
R5は、H、置換または非置換非環式脂肪族基、置換または非置換アリシクリル、置換または非置換アリール、置換または非置換アラルキル、置換または非置換ヘテロシクリルおよび置換または非置換ヘテロアリールアルキルからなる群から選択されることを特徴とする]
のペプチド誘導体、その立体異性体、その混合物、またはその化粧上もしくは薬学上許容される塩に関する。
本発明の理解を助けるため、本明細書に用いられているいくつかの用語および表現の意味を示す。
本発明の化合物は一般式(I)
R1−AA1−AA2−AA3−AA4−R2
(I)
(式中、R1、AA1、AA2、AA3、AA4およびR2は従前に定義した意味を有する)
で定義される。
Ac−Arg−Phg−Phg−OH、
Ac−Glu−Phg−Ala−OH、
Ac−Arg−Phg−Ala−Ile−OH、
Ac−Arg−Ahx−Phg−Ile−OH、
H−Glu−Met−Ala−Ile−OH、
Ac−Arg−Met−Phg−Ile−OH、
Ac−Arg−Phg−Ala−OH、
Ac−Glu−Phg−Ala−Ile−OH、
Ac−Glu−Met−Phg−Ile−OH、
Ac−Arg−Ahx−Ala−OH、
Ac−Arg−Phg−Phg−NH−(CH2)15−CH3、
Palm−Glu−Met−Ala−Ile−NH2、
Ac−Arg−Ahx−Ala−Ile−OH、
Ac−Arg−Phg−Phg−Ile−OH、
Ac−Glu−Phg−Phg−Ile−OH、
Ac−Arg−Met−Ala−Ile−OH、および
Ac−Glu−Met−Ala−Ile−OH
からなる群から選択される。
Ac−L−Arg−L−Phg−L−Phg−OH、
Ac−L−Arg−L−Phg−D−Phg−OH、
Ac−L−Arg−D−Phg−L−Phg−OH、
Ac−L−Arg−D−Phg−D−Phg−OH、
Ac−L−Glu−L−Phg−L−Ala−OH、
Ac−L−Glu−D−Phg−L−Ala−OH、
Ac−L−Arg−L−Phg−L−Ala−L−Ile−OH、
Ac−L−Arg−D−Phg−L−Ala−L−Ile−OH、
Ac−L−Arg−Ahx−L−Phg−L−Ile−OH、
Ac−L−Arg−Ahx−D−Phg−L−Ile−OH、
H−L−Glu−L−Met−L−Ala−L−Ile−OH、
Ac−L−Arg−L−Met−L−Phg−L−Ile−OH、
Ac−L−Arg−L−Met−D−Phg−L−Ile−OH、
Ac−L−Arg−L−Phg−L−Ala−OH、
Ac−L−Arg−D−Phg−L−Ala−OH、
Ac−L−Glu−L−Phg−L−Ala−L−Ile−OH、
Ac−L−Glu−D−Phg−L−Ala−L−Ile−OH、
Ac−L−Glu−L−Met−L−Phg−L−Ile−OH、
Ac−L−Glu−L−Met−D−Phg−L−Ile−OH、
Ac−L−Arg−Ahx−L−Ala−OH、
Ac−L−Arg−L−Phg−L−Phg−NH−(CH2)15−CH3、
Ac−L−Arg−L−Phg−D−Phg−NH−(CH2)15−CH3、
Ac−L−Arg−D−Phg−L−Phg−NH−(CH2)15−CH3、
Ac−L−Arg−D−Phg−D−Phg−NH−(CH2)15−CH3、
Palm−L−Glu−L−Met−L−Ala−L−Ile−NH2、
Ac−L−Arg−Ahx−L−Ala−L−Ile−OH、
Ac−L−Arg−L−Phg−L−Phg−L−Ile−OH、
Ac−L−Arg−L−Phg−D−Phg−L−Ile−OH、
Ac−L−Arg−D−Phg−L−Phg−L−Ile−OH、
Ac−L−Arg−D−Phg−D−Phg−L−Ile−OH、
Ac−L−Glu−L−Phg−L−Phg−L−Ile−OH、
Ac−L−Glu−L−Phg−D−Phg−L−Ile−OH、
Ac−L−Glu−D−Phg−L−Phg−L−Ile−OH、
Ac−L−Glu−D−Phg−D−Phg−L−Ile−OH、
Ac−L−Arg−L−Met−L−Ala−L−Ile−OH、
Ac−L−Glu−L−Met−L−Ala−L−Ile−OH、および
それらの混合物またはそれらの化粧上もしくは薬学上許容される塩
からなる群から選択される。
本発明のペプチド誘導体、それらの立体異性体またはそれらの化粧上もしくは薬学上許容される塩の合成は、例えば、固相ペプチド合成法[Stewart J. M. and Young J. D. (1984) "Solid Phase Peptide Synthesis, 2nd edition" Pierce Chemical Company, Rockford, Illinois; Bodanzsky M. and Bodanzsky A. (1984) "The practice of Peptide Synthesis" Springer Verlag, New Cork; Lloyd-Williams P., Albericio F. and Giralt E. (1997) "Chemical Approaches to the Synthesis of Peptides and Proteins" CRC, Boca Raton, FL, USA]、液相合成、固相合成および液相合成法の組合せ、または酵素的合成法[Kullmann W. (1980) "Proteases as catalysts for enzymic syntheses of opioid peptides" J.Biol.Chem. 255:8234-8238]などの、当技術分野の現状において公知の常法に従って行うことができる。ペプチド誘導体はまた、目的の配列を産生するために遺伝子工学により、または少なくとも目的の配列を含むペプチドフラグメントを遊離する動物または植物起源、好ましくは植物起源のタンパク質の制御加水分解により改変された、または改変されていない細菌株の発酵によって得ることもできる。
a.保護されたN末端と遊離のC末端を有するアミノ酸を、遊離のN末端と保護された、または固相支持体に結合されたC末端を有するアミノ酸と結合させる工程;
b.N末端の保護基を除去する工程;
c.この結合とN末端の保護基の除去の一連の手順a.〜b.を、目的の配列−AA1−AA2−AA3−AA4−配列を得るまで繰り返す工程;
d.C末端の保護基を除去するか、または固相支持体から切断する工程
を含んでなる。
R1−AA1−AA2−AA3−AA4−R2
(I)
の本発明のペプチド誘導体を得るためのプロセスの一例は、
遊離のC末端カルボキシル基を有する式(II):
PG1−AAn−OH
(II)
(式中、PG1はN末端基の保護基であり、AAnは従前に記載したようなアミノ酸部分(−AA1−、−AA2−または−AA3−)である)
のフラグメントまたはその反応性誘導体を、N末端に少なくとも1つの遊離水素原子を含むアミノ基を有する相補的フラグメント(III):
H−AAm−Sop
(III)
(式中、Sopは保護基または固相支持体であり、AAmは従前に記載したようなアミノ酸部分−AA3−または−AA4−である)
と反応させ、その結果としてアミド型結合を形成し、アミノ酸分のペプチド鎖を拡張して式(IV):
PG1−AAn−AAm−Sop
(IV)
のフラグメントを形成する工程;
このようにして得られたフラグメントを洗浄する工程;
このようにして形成されたフラグメントの保護基PG1を切断して、遊離のN末端を有するフラグメント(V):
H−AAn−AAm−Sop
(V)
を得る工程;
この結合、洗浄および保護基の除去の一連の手順を式(VI):
PG−AA1−AA2−AA3−AA4−Sop
(VI)
(式中、PGは保護基であり、SopおよびAA1−AA2−AA3−AA4は従前に記載した意味を有する)
の前駆体を得るまで必要な回数だけ繰り返す工程
を含んでなる。
H−AA1−AA2−AA3−AA4−Sop
(VII)
のフラグメントが得られる。
R1−AA1−AA2−AA3−AA4−OH
(IX)
を反応させる手段により、あるいは例えば塩化チオニルを用いたハロゲン化アシルを予め形成させる手段により導入して、一般式(I)の本発明によるペプチド誘導体を得ることもでき(N−C結合の形成の際に関与しない該フラグメントの官能基は、存在するとしても、一時的または永久的保護基で適切に保護される)、あるいは、他のR2基は、ポリマー支持体からペプチド誘導体を切断するプロセスと同時に組み込む手段により導入することもできる。
n D. and Barany G. (1990) "Preparation and application of 5- (4- (9- fluorenylmethyloxycarbonyl) aminomethyl-3,5-dimethoxy-phenoxy)-valeric acid (PAL) handle for the solid-phase synthesis of C-terminal peptide amides under mild conditions" J. Org. Chem. 55:3730-3743]、2−[4−アミノメチル−(2,4−ジメトキシフェニル)]フェノキシ酢酸(AM)[Rink H. (1987) "Solid-phase synthesis of protected peptide fragments using to trialkoxy-diphenyl-methylester resin" Tetrahedron Lett. 28:3787-3790]、Wang[Wang S. S. (1973) "p-Alkoxybenzyl Alcohol Resin and p-Alkoxybenzyloxycarbonylhydrazide Resin for Solid Phase Synthesis of Protected Peptide Fragments" J.Am.Chem. Soc. 95:1328-1333]などの反応しやすいリンカーを含んでも含まなくてもよい]。
本発明のペプチド誘導体は、ペプチド誘導体と哺乳類の身体、好ましくはヒトの身体におけるその作用部位との接触を生じさせる任意の手段によりhBD合成を刺激するために、それらを含有する組成物の形態で投与することができる。
因子、インスリン様増殖因子、ケラチノサイト増殖因子、コロニー刺激因子、トランスフォーミング増殖因子β、腫瘍壊死因子−α、インターフェロン、インターロイキン、マトリックスメタロプロテイナーゼ、タンパク質チロシンホスファターゼ受容体、Antarcticine(登録商標)[INCI:シュードアルテロモナス・ファーメント(Pseudoalteromonas Ferment)抽出物]またはLipotecにより市販されているDecorinyl(登録商標)[INCI:トリペプチド−10シトルリン]を含んでなる化粧組成物または医薬組成物に関する。
本発明の別の態様は、内在性デフェンシン合成の刺激および/または該処置に伴う洗浄から利益を受ける、哺乳類、好ましくはヒトの症状、障害および/または病態を処置および/または保護するための化粧的または薬学的方法に関し、その方法は、有効量の少なくとも1種類の、一般式(I)のペプチド組成物、その立体異性体、その混合物またはその化粧上もしくは薬学上許容される塩を、好ましくはそれらを含有する化粧組成物または医薬組成物の形態で投与することを含んでなる。本発明はさらに、生物の防御、好ましくは皮膚、粘膜、頭皮および/または爪の防御を刺激するための化粧的または医薬的方法を提供する。同様に、本発明は、外科的介入後、インテンスパルス光(IPL)療法による処置後、単色パルス光(レーザー)療法による処置後、化学角質溶解剤による処置後、または例えば日光もしくは極端な低温もしくは極端な熱への過剰曝露などの攻撃的な外的因子への過剰曝露の後に、皮膚、粘膜、頭皮および/または爪の防御を刺激するための化粧的または薬学的方法を提供する。
試薬および溶媒は総て合成用等級のものであり、付加的な処理を行わずに用いる。
アミノ酸に対して用いる略号は、IUPAC-IUB Commission on Biochemical Nomenclature specified in Eur. J. Biochem. (1984) 138, 9-37およびJ. Biol. Chem. (1989) 264, 633-673の規則に従う。
合成プロセスは総て、多孔質ポリエチレンディスクを備えたポリプロピレンシリンジ、多孔質プレートを備えたパイレックス(登録商標)リアクター、またはACT396Ω児童合成装置(Advanced Chemtech, Inc)で行う。可溶性の溶媒および試薬は吸引により除去する。Fmoc基の除去はピペリジン−DMF(2:8、v/v)(1×1分、1×5分;5mL/g樹脂)で行う[Lloyd-Williams P., Albericio F. and Giralt, E. (1997) "Chemical Approaches to the Synthesis of Peptides and Proteins" CRC, Boca Raton, FL, USA]。脱保護、カップリングおよび再び脱保護の工程間の洗浄は、DMF(3×1分)で各10mL溶媒/g樹脂を用いて行った。カップリング反応は3mL溶媒/g樹脂で行った。カプリングの制御はニンヒドリン試験の手段により行う[Kaiser E., Colescott R. L., Bossinger CD. and Cook P.I. (1970) "Color test for detection of free terminal amino groups in the solid-phase synthesis of peptides" Anal. Biochem. 34:595-598]。合成変換および洗浄は総て室温で行った。
Fmoc−AA 1 −AA 2 −AA 3 −AA 4 −O−2−ClTrt−(R)およびFmoc−AA 1 −AA 2 −AA 3 −AA 4 −AM−MBHA−(R)の合成
250mgの市販の樹脂H−L−Ile−O−2−ClTrt−(R)、H−L−Ala−O−2−ClTrt−(R)、H−L−Phg−O−2−ClTrt−(R)、H−D−Phg−O−2−ClTrt−(R)およびFmoc−AM−MBHA−(R)を秤量し、ACT396Ωマルチプルシンセサイザーの96位リアクターの、それぞれ12、6、6、6および24穴に分配した。これらのペプチドの合成を市販のソフトウエアAdvanced Chemtech v.1.36.03でプログラミングした。アミノ酸Fmoc−Ahx−OH、Fmoc−L−Ala−OH、Fmoc−D−Ala−OH、Fmoc−L−Arg(Pbf)−OH、Fmoc−D−Arg(Pbf)−OH、Fmoc−L−Glu(OtBu)−OH、Fmoc−D−Glu(OtBu)−OH、Fmoc−L−Ile−OH、Fmoc−D−Ile−OH、Fmoc−L−Met−OH、Fmoc−D−Met−OH、Fmoc−L−Phg−OHおよびFmoc−D−Phg−OHの各保存溶液をDMFにて0.5M HOBtを含有する0.5Mの濃度で作製するとともに、DMFにて1mMのDIPCDI溶液および20%のピペリジン溶液を作製した。各場合において、各アミノ酸の組み込みのサイクルを以下の一連の手順でプログラミングした:洗浄(DMF、3×2分)、脱保護(DMF中20%のピペリジン、1×5分+1×20分)、洗浄(DMF、3×2分)、所望のアミノ酸のカップリング(5当量のFmoc−アミノ酸、5当量のDIPCDI、60分)および洗浄(DMF、3×2分)。
H−AA 1 −AA 2 −AA 3 −AA 4 −O−2−ClTrt−(R)およびH−AA 1 −AA 2 −AA 3 −AA 4 −AM−MBHA−(R)の合成
実施例1で得られた50mgのペプチジル−樹脂をアリコートに分け、N末端Fmoc基を一般法に記載のように脱保護した(DMF中20%のピペリジン、1×5分+1×20分)。これらのペプチジル−樹脂をDMF(5×1分)、DCM(4×1分)、ジエチルエーテル(4×1分)で洗浄し、真空乾燥させた。
Palm−AA 1 −AA 2 −AA 3 −AA 4 −O−2−ClTrt−(R)およびPalm−AA 1 −AA 2 −AA 3 −AA 4 −AM−MBHA−(R)の合成
10当量のHOBtと10当量のDIPCDIの存在下で1mLのDMFに溶解させた10当量のパルミチン酸を、実施例1で得られた50mgのペプチジル−樹脂(N末端Fmoc基は一般法に記載のように予め脱保護されている)に組み込んだ。それらを15時間反応させた後、それらのペプチジル−樹脂をTHF(5×1分)、DCM(5×1分)、DMF(5×1分)、MeOH(5×1分)、DMF(5×1分)、THF(5×1分)、DMF(5×1分)、DCM(4×1分)、エーテル(3×1分)で洗浄し、真空乾燥させた。
Ac−AA 1 −AA 2 −AA 3 −AA 4 −O−2−ClTrt−(R)およびAc−AA 1 −AA 2 −AA 3 −AA 4 −AM−MBHA−(R)の合成
実施例1で得られた50mgのペプチジル−樹脂(N末端Fmoc基は一般法に記載のように予め脱保護されている)を、0.5mLのDMFを溶媒として用い、25当量のDIEAの存在下、25当量の無水酢酸で処理した。それらを30分間反応させた後、それらのペプチジル−樹脂をDMF(5×1分)、DCM(4×1分)、ジエチルエーテル(4×1分)で洗浄し、真空乾燥させた。
H−AA 1 −AA 2 −AA 3 −AA 4 −OH、Ac−AA 1 −AA 2 −AA 3 −AA 4 −OH、Palm−AA 1 −AA 2 −AA 3 −AA 4 −OH、H−AA 1 −AA 2 −AA 3 −AA 4 −NH 2 、Ac−AA 1 −AA 2 −AA 3 −AA 4 −NH 2 およびPalm−AA 1 −AA 2 −AA 3 −AA 4 −NH 2 の取得
実施例2、3および4で得られた5mgの乾燥ペプチジル−樹脂を、室温で攪拌しながら2時間、0.5mLのTFA−TIS−H2O(90:5:5)で処理した。濾液を10mLの冷ジエチルエーテルに回収し、多孔質ポリエチレンディスクを備えたポリプロピレンシリンジで濾過し、10mLのジエチルエーテルで5回洗浄した。最終的な沈殿を真空乾燥させた。
Ac−AA 1 −AA 2 −AA 3 −AA 4 −NH−(CH 2 ) 15 −CH 3 の取得
完全に保護された側鎖を有するペプチド誘導体Ac−AA1−AA2−AA3−AA4−OHは、KOHの存在下で予め真空乾燥させた実施例4のペプチジル−樹脂Ac−AA1−AA2−AA3−AA4−O−2−ClTrt−(R)を、DCM中3%TFA溶液で5分間処理することにより得た。濾液を冷ジエチルエーテルに回収し、この処理を3回繰り返した。これらのエーテル溶液を真空下で蒸発乾固させ、室温で、沈殿をH2O中50%のMeCNに再懸濁させ、凍結乾燥させた。得られた粗生成物10mgをフラスコに秤量し、3当量のヘキサデシルアミンおよび25mLの無水DMFを加えた。2当量のDIPCDIを加え、磁気攪拌しながら47℃で反応させた。反応はHPLCの手段により、最初の生成物の消失によって制御し、24〜48時間後に完了した。溶媒を蒸発乾固させ、DCMとともに2回共蒸発させた。得られた残渣[完全に保護された側鎖を有するAc−AA1−AA2−AA3−AA4−NH−(CH2)9−CH3]を25mLのTFA−DCM−アニソール(49:49:2)混合物に再懸濁させ、室温で30分間反応させた。250mLの冷ジエチルエーテルを加え、溶媒を減圧下で蒸発させ、エーテルとの共蒸発をさらに2回行った。残渣をH2O中50%のMeCN混合物に溶解させ、凍結乾燥させた。
・A相の成分を混合し、70℃で加熱する。
・B相の成分を混合し、70℃で加熱する。
・ホモジナイザー(Silveson)で5分間攪拌中のB相にC相を加える。
・B相とC相の混合物にホモジナイザーを用いてA相を徐々に加え、ホモジナイゼーションを15分間維持する。
・穏やかに攪拌しながら30〜35℃まで冷却を開始する。50℃でD相を加える。攪拌を維持する。予め可溶化させたE相とF相を35〜38℃で加える。
Ac−L−Glu−L−Met−L−Ala−L−He−OHを含有するリポソームの製造および組成
ジパルミトイルホスファチジルコリン(DPPC)を秤量し、クロロホルムに溶解させた。減圧下で溶媒を薄いリン脂質層が得られるまで蒸発させ、この層を55℃にて、所望の濃度のペプチド誘導体水溶液(Phenonip(登録商標)を含有)で処理することにより水和させ、MLVリポソームを得た。ULVリポソームは、MLVリポソームを、55℃の超音波槽に、5分置きに2分間8サイクル浸漬することにより得た。このリポソームULVを高圧下で押出系に通すことにより、その大きさを小さくした。
Ac−L−Glu−L−Met−L−Ala−L−Ile−OHを含有するリポソームゲルの形態の組成物の製造
実施例8のリポソームを穏やかに攪拌しながら、水に保存剤(EDTA、イミダゾリジニル尿素およびPhenonip(登録商標))とともに分散させた。Hispagel(登録商標)200[INCI:アクア、グリセリンおよびグリセリルポリアクリレート]を加え、均一な混合物が得られるまで穏やかに攪拌した。
・A相の成分を混合し、70℃で加熱する。
・B相の成分を混合し、70℃で加熱する。
・ホモジナイザー(Silveson)で5分間攪拌中のB相にA相を加える。
・穏やかに攪拌しながら30〜35℃まで冷却を開始する。あらかじめ可溶化させたC相を35〜28℃で加える。
・A相の成分を混合し、70℃で加熱する。
・B相の成分を混合し、70℃で加熱する。
・ホモジナイザー(Silveson)で5分間攪拌中のB相にC相を加える。
・B相とC相の混合物にホモジナイザーを用いてA相を徐々に加え、ホモジナイゼーションを15分間維持する。
・穏やかに攪拌しながら30〜35℃まで冷却を開始する。50℃でD相を加える。攪拌を維持する。予め可溶化させたE相とF相を35〜38℃で加える。
・A相の成分を混合する。
・B相の成分を混合する。
・完全にホモジナイズするまで攪拌しながらA相にB相をゆっくり加える。
・完全にホモジナイズするまで成分を混合する。
実施例5および6で得られた一般式(I)の化合物による、安定な細胞系統におけるhBD2プロモーターの活性化のアッセイ
A549ヒト上皮細胞系統を、FBSおよびペニシリン−ストレプトマイシンを添加したRPMI−1640培地を用いて培養した。これを通常、1週間に2回、その培養物を分割することにより、トリプシン−EDTAを用い1:10希釈して培養した。106細胞のA549系統を、ポリリジンで処理した60mmディスクに播種した。24時間後、hBD2遺伝子プロモーターとそれに続くルシフェラーゼタンパク質遺伝子(pGL3−hBD2promotor−Luc)により形成された遺伝子構築物10μとゲネチシン抗生物質耐性遺伝子を含むpcDNA3BプラスミドDNAとで、1:5 pcDNA3B.1/pGL3−hBD2プロモーター−Luc比にて同時トランスフェクトした。トランスフェクションには25μLのリポフェクタミン(商標)2000を用いた。24時間後、G418−ゲネチシン(登録商標)抗生物質を添加した完全培地で選択を開始し、選択培地を2日置きに更新した。種々のクローンを単離し、ルシフェラーゼ活性に基づいて同定および選択を行った。選択された安定な系統、親系統用の完全培地にG418を添加したものを用いて培養した。それらは通常、1週間に2回、その培養物を分割することにより、トリプシン−EDTAを用い1:10希釈して培養した。
Ac−L−Glu−L−Met−L−Ala−L−Ile−OH、Ac−L−Arg−Phg−Phg−OHおよびAc−L−Arg−Ahx−L−Ala−OHとともにインキュベートした後にヒトケラチノサイトにおいて分泌されたhBD2 mRNAの定量
分泌されたmRNAの量の定量は、リアルタイム定量的RT−PCRアッセイの手段により行った。3×106細胞のヒトケラチノサイト系統を用い、25cm2フラスコに播種した。これらの細胞を洗浄し、3mL量のDMEM培地中、1mmまたは0.25mmの濃度の種々のペプチド誘導体とともに16〜24時間インキュベートした。LPS(100μg/mL)およびL−Ile(200μg/mL)を陽性対照として用いた。細胞の上清を−80℃で保存し、分泌されたhBD2タンパク質レベルを分析し、それらの細胞から、製造社のプロトコールに従ってRNeasyキット(Quiagen)を用いて全RNAを抽出した。
Ac−L−Glu−L−Met−L−Ala−L−Ile−OH、Ac−L−Arg−Phg−Phg−OHおよびAc−L−Arg−Ahx−L−Ala−OHとともにインキュベートした後にヒトケラチノサイトにおいて分泌されたhBD2の定量
ヒトケラチノサイトにより分泌されたhBD2の量は、実施例15から得られた細胞上清から、ヒトBD−2 ELISA Development市販キット(Peprotech)を用いるELISAアッセイの手段により定量した。
Claims (47)
- 一般式(I)のペプチド誘導体、その立体異性体、その混合物、またはその化粧上もしくは薬学上許容される塩:
R1−AA1−AA2−AA3−AA4−R2
(I)
[式中、
AA1は、−Glu−および−Arg−からなる群から選択され;
AA2は、−Met−、−Ahx−および−Phg−からなる群から選択され;
AA3は、−Ala−および−Phg−からなる群から選択され;
AA4は、−Ile−または単結合からなる群から選択され;
R1は、H、置換または非置換非環式脂肪族基、置換または非置換アリシクリル、置換または非置換ヘテロシクリル、置換または非置換ヘテロアリールアルキル、置換または非置換アリール、置換または非置換アラルキルおよびR5−C(O)−からなる群から選択され;かつ、
R2は、−NR3R4、−OR3および−SR3からなる群から選択され;R3およびR4は、H、置換または非置換非環式脂肪族基、置換または非置換アリシクリル、置換または非置換ヘテロシクリル、置換または非置換ヘテロアリールアルキル、置換または非置換アリールおよび置換または非置換アラルキルからなる群から独立に選択され;
R5は、H、置換または非置換非環式脂肪族基、置換または非置換アリシクリル、置換または非置換アリール、置換または非置換アラルキル、置換または非置換ヘテロシクリルおよび置換または非置換ヘテロアリールアルキルからなる群から選択される]。 - R1がHまたはR5−C(O)−基であり、R5が置換または非置換C1−C24アルキル、置換または非置換C2−C24アルケニル、置換または非置換C2−C24アルキニル、置換または非置換C3−C24シクロアルキル、置換または非置換C5−C24シクロアルケニル、置換または非置換C5−C24シクロアルキニル、置換または非置換C6−C30アリール、置換または非置換C7−C24アラルキル、置換または非置換3〜10員環ヘテロシクリル、ならびに1〜3個の炭素原子のアルキル鎖と、2〜24個の炭素原子および炭素とは異なる1〜3個の原子を有する置換または非置換芳香族ヘテロシクリル基とを含んでなるヘテロアリールアルキルからなる群から選択される、請求項1に記載のペプチド誘導体。
- R1がH、アセチル、tert−ブタノイル、ヘキサノイル、2−メチルヘキサノイル、シクロヘキサンカルボキシル、オクタノイル、デカノイル、ラウロイル、ミリストイル、パルミトイル、ステアロイル、オレオイルおよびリノレオイルからなる群から選択される、請求項2に記載のペプチド誘導体。
- R2が−NR3R4、−OR3または−SR3であり、R3およびR4がH、置換または非置換C1−C24アルキル、置換または非置換C2−C24アルケニル、置換または非置換C2−C24アルキニル、置換または非置換C3−C24シクロアルキル、置換または非置換C5−C24シクロアルケニル、置換または非置換C5−C24シクロアルキニル、置換または非置換C6−C30アリール、置換または非置換C7−C24アラルキル、置換または非置換3〜10員環ヘテロシクリル、ならびに1〜3個の炭素原子のアルキル鎖と、2〜24個の炭素原子および炭素とは異なる1〜3個の原子を有する置換または非置換芳香族ヘテロシクリル基とを含んでなるヘテロアリールアルキルからなる群から独立に選択される、請求項1〜3のいずれか一項に記載のペプチド誘導体。
- R2が−NR3R4および−OR3からなる群から選択され、R3およびR4が同一または異なっている、請求項4に記載のペプチド誘導体。
- R3およびR4がH、メチル、エチル、ヘキシル、ドデシルおよびヘキサデシルからなる群から選択される、請求項5に記載のペプチド誘導体。
- AA1が−Glu−であり、AA2が−Met−であり、AA3が−Ala−であり、AA4が−Ile−である、請求項1〜6のいずれか一項に記載のペプチド誘導体。
- AA1が−Arg−であり、AA2が−Ahx−であり、AA3が−Ala−であり、AA4が単結合である、請求項1〜6のいずれか一項に記載のペプチド誘導体。
- AA1が−Arg−であり、AA2が−Phg−であり、AA3が−Phg−であり、AA4が単結合である、請求項1〜6のいずれか一項に記載のペプチド誘導体。
- R1がH、アセチル、ラウロイル、ミリストイルまたはパルミトイルであり、AA1が−L−Glu−であり、AA2が−L−Met−であり、AA3が−L−Ala−であり、AA4が−L−Ile−であり、R2が−NR3R4または−OR3であり、R3およびR4がH、メチル、エチル、ヘキシル、ドデシルおよびヘキサデシル基から独立に選択される、請求項1〜7のいずれか一項に記載のペプチド誘導体。
- R1がH、アセチル、ラウロイル、ミリストイルまたはパルミトイルであり、AA1が−L−Arg−であり、AA2が−Ahx−であり、AA3が−L−Ala−であり、AA4が単結合であり、R2が−NR3R4または−OR3であり、R3およびR4がH、メチル、エチル、ヘキシル、ドデシルおよびヘキサデシル基から独立に選択される、請求項1〜6または8のいずれか一項に記載のペプチド誘導体。
- R1がH、アセチル、ラウロイル、ミリストイルまたはパルミトイルであり、AA1が−L−Arg−であり、AA2が−L−Phg−または−D−Phg−であり、AA3が−L−Phg−または−D−Phg−であり、AA4が単結合であり、R2が−NR3R4または−OR3であり、R3およびR4がH、メチル、エチル、ヘキシル、ドデシルおよびヘキサデシル基から独立に選択される、請求項1〜6または9のいずれか一項に記載のペプチド誘導体。
- R1がH、アセチルおよびパルミトイルからなる群から選択され、R2が−OHおよび−NH2からなる群から選択される、請求項1〜12のいずれか一項に記載のペプチド誘導体。
- Ac−L−Arg−L−Phg−L−Phg−OH、
Ac−L−Arg−L−Phg−D−Phg−OH、
Ac−L−Arg−D−Phg−L−Phg−OH、
Ac−L−Arg−D−Phg−D−Phg−OH、
Ac−L−Glu−L−Phg−L−Ala−OH、
Ac−L−Glu−D−Phg−L−Ala−OH、
Ac−L−Arg−L−Phg−L−Ala−L−Ile−OH、
Ac−L−Arg−D−Phg−L−Ala−L−Ile−OH、
Ac−L−Arg−Ahx−L−Phg−L−Ile−OH、
Ac−L−Arg−Ahx−D−Phg−L−Ile−OH、
H−L−Glu−L−Met−L−Ala−L−Ile−OH、
Ac−L−Arg−L−Met−L−Phg−L−Ile−OH、
Ac−L−Arg−L−Met−D−Phg−L−Ile−OH、
Ac−L−Arg−L−Phg−L−Ala−OH、
Ac−L−Arg−D−Phg−L−Ala−OH、
Ac−L−Glu−L−Phg−L−Ala−L−Ile−OH、
Ac−L−Glu−D−Phg−L−Ala−L−Ile−OH、
Ac−L−Glu−L−Met−L−Phg−L−Ile−OH、
Ac−L−Glu−L−Met−D−Phg−L−Ile−OH、
Ac−L−Arg−Ahx−L−Ala−OH、
Ac−L−Arg−L−Phg−L−Phg−NH−(CH2)15−CH3、
Ac−L−Arg−L−Phg−D−Phg−NH−(CH2)15−CH3、
Ac−L−Arg−D−Phg−L−Phg−NH−(CH2)15−CH3、
Ac−L−Arg−D−Phg−D−Phg−NH−(CH2)15−CH3、
Palm−L−Glu−L−Met−L−Ala−L−Ile−NH2、
Ac−L−Arg−Ahx−L−Ala−L−Ile−OH、
Ac−L−Arg−L−Phg−L−Phg−L−Ile−OH、
Ac−L−Arg−L−Phg−D−Phg−L−Ile−OH、
Ac−L−Arg−D−Phg−L−Phg−L−Ile−OH、
Ac−L−Arg−D−Phg−D−Phg−L−Ile−OH、
Ac−L−Glu−L−Phg−L−Phg−L−Ile−OH、
Ac−L−Glu−L−Phg−D−Phg−L−Ile−OH、
Ac−L−Glu−D−Phg−L−Phg−L−Ile−OH、
Ac−L−Glu−D−Phg−D−Phg−L−Ile−OH、
Ac−L−Arg−L−Met−L−Ala−L−Ile−OH、
Ac−L−Glu−L−Met−L−Ala−L−Ile−OH、および
その混合物またはその化粧上もしくは薬学上許容される塩
からなる群から選択される、請求項1〜12のいずれか一項に記載のペプチド誘導体。 - 固相または溶相で行われる、請求項1〜14のいずれか一項に記載の一般式(I)のペプチド誘導体、その立体異性体、その混合物、またはその化粧上もしくは薬学上許容される塩を得るための方法。
- 遊離アミノ基がBocまたはFmocの手段により保護され、遊離カルボキシル基がtBu、Bzl、cHex、AllまたはTrtの手段により保護され、アルギニン側鎖がPmc、Pbf、MtrまたはTosで保護され、グルタミン酸側鎖がtBu、All、Trt、cHexまたはBzlで保護される、請求項15に記載の方法。
- 請求項1〜14のいずれか一項に記載の化粧上または薬学上有効な量の少なくとも1種類の一般式(I)のペプチド誘導体、その立体異性体、それらの混合物、またはその化粧上もしくは薬学上許容される塩と、少なくとも1種類の化粧上または薬学上許容される賦形剤またはアジュバントとを含んでなる、化粧組成物または医薬組成物。
- 一般式(I)のペプチド誘導体が、組成物の総重量に対して0.000001〜20重量%の濃度である、請求項17に記載の化粧組成物または医薬組成物。
- 前記濃度が、組成物の総重量に対して0.0001〜5重量%である、請求項18に記載の化粧組成物または医薬組成物。
- 一般式(I)のペプチド誘導体、その立体異性体、その混合物、またはその化粧上もしくは薬学上許容される塩が、送達系、またはリポソーム、ミリカプセル、マイクロカプセル、ナノカプセル、スポンジ、小胞、ミセル、ミリスフェア、マイクロスフェア、ナノスフェア、リポスフェア、マイクロエマルション、ナノエマルション、ミリ粒子、マイクロ粒子、ナノ粒子および固体脂質ナノ粒子からなる群から選択される化粧上もしくは薬学上許容される徐放系に組み込まれている、請求項17〜19のいずれか一項に記載の化粧組成物または医薬組成物。
- 一般式(I)のペプチド誘導体、その立体異性体、その混合物、またはその化粧上もしくは薬学上許容される塩が、タルク、ベントナイト、シリカ、デンプンおよびマルトデキストリンからなる群から選択される化粧上もしくは薬学上許容される個体支持体または固体有機ポリマーに吸着されている、請求項17〜20のいずれか一項に記載の化粧組成物または医薬組成物。
- クリーム、多相エマルション、無水組成物、水性分散液、オイル、ミルク、バルサム、フォーム、ローション、ゲル、ヒドロアルコール溶液、塗布剤、漿液、石鹸、シャンプー、軟膏、ムース、軟膏、パウダー、バー、ペンシル、スプレー、エアゾール、カプセル、ゼラチンカプセル、錠剤、糖衣錠、粒状剤形、チューインガム、溶液、懸濁液、エマルション、シロップ、ゼリーおよびゼラチンからなる群から選択される、請求項17〜21のいずれか一項に記載の化粧組成物または医薬組成物。
- コンシーラー、メイクアップファンデーション、メイクアップリムーバルローション、メイクアップリムーバルミルク、アイシャドウ、リップスティック、リップグロス、リッププロテクター、パウダー、ネールポリッシュ、ネイルポリッシュリムーバルローション、角質リムーバルローション、デオドラントおよび制汗剤からなる群から選択される製品である、請求項17〜21のいずれか一項に記載の化粧組成物または医薬組成物。
- 一般式(I)のペプチド誘導体、その立体異性体、その混合物、またはその化粧上もしくは薬学上許容される塩が、布、不織布または医療装置に組み込まれている、請求項17〜21のいずれか一項に記載の化粧組成物または医薬組成物。
- 布、不織布または医療装置が、帯布、ガーゼ、Tシャツ、パンティーストッキング、ソックス、下着、ガードル、手袋、おむつ、生理用ナプキン、包帯、ベッドスプレッド、ワイプ、ヒドロゲル、粘着パッチ、非粘着パッチおよびフェースマスクからなる群から選択される、請求項24に記載の化粧組成物または医薬組成物。
- メラニン合成刺激または阻害剤、美白または脱色剤、色素沈着促進剤(propigmentation agents)、日焼け剤、アンチエージング剤、NO−シンターゼ阻害剤、抗酸化剤、フリーラジカル−スカベンジャーおよび/または抗大気汚染剤、糖化防止剤、乳化剤、保湿剤、有機溶媒、液体噴射剤、皮膚コンディショナー(例えば、保湿剤)、水分を保持する物質、αヒドロキシ酸、βヒドロキシ酸、モイスチャライザー、ビタミン、顔料または着色剤、色素、ゲル化ポリマー、増粘剤、界面活性剤、軟化剤、しわ改善剤、目の下のたるみを軽減または処置することができる薬剤、剥離剤、抗菌剤、殺真菌剤、制真菌剤、殺菌剤、静菌剤、真皮または上皮高分子の合成を刺激し、かつ/またはそれらの分解を阻害もしくは予防することができる薬剤、コラーゲン合成刺激剤、エラスチン合成刺激剤、デコリン合成刺激剤、ラミニン合成刺激剤、その他のデフェンシン合成刺激剤、シャペロン合成刺激剤、ヒアルロン酸合成刺激剤、脂質および角質層の成分の合成を刺激する薬剤、脈管形成刺激剤、コラーゲン分解阻害剤、エラスチン分解阻害剤、繊維芽細胞増殖刺激剤、ケラチノサイト増殖刺激剤、ケラチノサイト分化刺激剤、皮膚弛緩剤、グリコサミノグリカン合成刺激剤、DNA再対合剤、DNA保護剤、かゆみ止め、敏感皮膚の処置剤、固化剤、妊娠線防止剤、収斂剤、皮脂生産調節剤、脂肪分解刺激剤、セルライト防止剤、治癒刺激剤、治癒補助剤、サイトカイン増殖因子、鎮静剤、抗炎症剤、毛細血管循環および/または微小循環に作用する薬剤、細胞代謝に作用する薬剤、真皮−上皮接合の改善を意図した薬剤、保存剤、香料、キレート剤、植物抽出物、エッセンシャルオイル、海産抽出物、生物発酵プロセスから得られる薬剤、無機塩、細胞抽出物およびサンスクリーン(紫外線Aおよび/またはBに対して活性な有機または無機の光保護剤)、またはその混合物からなる群から選択される、化粧上または薬学上有効な量の少なくとも1種類の有効薬剤をさらに含んでなる、請求項17〜25のいずれか一項に記載の化粧組成物または医薬組成物。
- 有効薬剤が、合成起源のものであるか、または植物抽出物であるか、または生物発酵プロセスにより得られるものである、請求項26に記載の化粧組成物または医薬組成物。
- 有効薬剤が、殺菌剤、殺真菌剤、制真菌剤および/または静菌剤、または固有の殺菌活性、静菌活性、制真菌活性および/または殺真菌活性を有する天然抽出物もしくはエッセンシャルオイルである、請求項26または27に記載の化粧組成物または医薬組成物。
- 有効薬剤が、抗炎症剤および/または鎮痛剤、または固有の鎮痛活性および/または抗炎症活性を有する天然抽出物またはエッセンシャルオイルである、請求項26または27に記載の化粧組成物または医薬組成物。
- 有効薬剤が、治癒活性および/または再上皮化活性を有する薬剤、または固有の治癒活性および/または再上皮化活性を有する天然抽出物もしくはエッセンシャルオイルである、請求項26または27に記載の化粧組成物または医薬組成物。
- 有効薬剤が、デフェンシン合成刺激剤、または固有のデフェンシン合成刺激活性を有する天然抽出物もしくはエッセンシャルオイルである、請求項26または27に記載の化粧組成物または医薬組成物。
- 皮膚、粘膜、頭皮および/または爪の処置、保護および/または洗浄のための化粧組成物または医薬組成物の製造における、請求項1〜14のいずれか一項に記載の一般式(I)のペプチド誘導体、その立体異性体、その混合物またはその化粧上もしくは薬学上許容される塩の使用。
- 処置、保護および/または洗浄が、皮膚、粘膜、頭皮および/または爪の防御の刺激からなる、請求項32に記載の使用。
- 刺激が、内在性のヒトβ−デフェンシン−2および/またはβ−デフェンシン−3タンパク質の誘導により媒介される、請求項33に記載の使用。
- 処置、保護および/または洗浄が、前記化粧組成物または医薬組成物の局所的または経皮的適用の手段により行われる、請求項32〜34のいずれか一項に記載の使用。
- 局所的または経皮的適用が、イオン導入法、超音波導入法、エレクトロポレーション、閉鎖処置、マイクロインジェクション、圧力の手段による無針注射、またはそれらの組合せの手段により行われる、請求項35に記載の使用。
- 処置および/または保護が、皮膚、粘膜、頭皮および/または爪の微生物叢のホメオスタシスを維持することを意図する、請求項32に記載の使用。
- 微生物増殖による、または微生物増殖のリスクがある皮膚、粘膜、頭皮および/または爪の症状、障害および/または病態の処置、保護および/または洗浄のための、請求項32〜37のいずれか一項に記載の使用。
- 前記症状、障害および/または病態が、座瘡、湿疹、アトピー性皮膚炎、敏感皮膚、丘疹性酒さ、臭汗症、脂漏性皮膚炎、毛髪および/または頭皮のべたつき、ふけ、眼科感染、カンジダ症、細菌性膣症、歯肉炎、歯周炎および口臭からなる群から選択される、請求項38に記載の使用。
- 外科的介入後、インテンスパルス光(IPL)療法による処置後、単色パルス光(レーザー)療法による処置後、化学角質溶解剤による処置後または攻撃的な外的因子に曝露した後に、皮膚の防御を刺激するための、請求項33〜38のいずれか一項に記載の使用。
- 攻撃的な外的因子が、日光、極端な低温および極端な熱からなる群から選択される、請求項40に記載の使用。
- 口腔粘膜の処置または口腔衛生のための、請求項32〜41のいずれか一項に記載の使用。
- 毛髪および/もしくは頭皮の処置のため、または毛髪の衛生のための、請求項32〜41のいずれか一項に記載の使用。
- 身体の皮膚もしくは粘膜の処置または身体の衛生のための、請求項32〜41のいずれか一項に記載の使用。
- 前記組成物が、膣粘膜の処置または個人衛生のための組成物である、請求項44に記載の使用。
- 前記組成物がデオドラントおよび/または制汗剤組成物である、請求項44に記載の使用。
- 眼の粘膜の処置または眼の衛生のための、請求項44に記載の使用。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200800243A ES2324192B1 (es) | 2008-01-30 | 2008-01-30 | Derivados peptidicos utiles en el tratamiento, cuidado o limpieza de la piel, mucosa, cuero cabelludo o uñas. |
ESP200800243 | 2008-01-30 | ||
US3959908P | 2008-03-26 | 2008-03-26 | |
US61/039,599 | 2008-03-26 | ||
PCT/EP2009/051041 WO2009095456A1 (en) | 2008-01-30 | 2009-01-30 | Peptide derivatives useful in the treatment, care or cleansing of the skin, mucosae, scalp or nails |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2011511774A true JP2011511774A (ja) | 2011-04-14 |
JP5474827B2 JP5474827B2 (ja) | 2014-04-16 |
Family
ID=40886022
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010544705A Expired - Fee Related JP5474827B2 (ja) | 2008-01-30 | 2009-01-30 | 皮膚、粘膜、頭皮または爪の処置、保護または洗浄において有用なペプチド誘導体 |
Country Status (6)
Country | Link |
---|---|
US (1) | US8815266B2 (ja) |
EP (1) | EP2245045B1 (ja) |
JP (1) | JP5474827B2 (ja) |
AU (1) | AU2009209601B2 (ja) |
ES (1) | ES2324192B1 (ja) |
WO (1) | WO2009095456A1 (ja) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2015514722A (ja) * | 2012-04-16 | 2015-05-21 | ルブリゾル アドバンスド マテリアルズ, インコーポレイテッド | 皮膚および/または粘膜の処置および/またはケアのための組成物ならびに化粧品組成物または医薬組成物におけるその使用 |
JP2017529393A (ja) * | 2014-09-12 | 2017-10-05 | アンティバイオティクス エーピーエスAntibiotx Aps | ハロゲン化サリチルアニリドの抗菌用途 |
US10857164B2 (en) | 2015-05-29 | 2020-12-08 | UNION therapeutics A/S | Halogenated salicylanilides for treating Clostridium infections |
US11419834B2 (en) | 2019-02-25 | 2022-08-23 | Rhode Island Hospital | Methods for treating diseases or infections caused by or associated with H. pylori using a halogenated salicylanilide |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008103345A2 (en) | 2007-02-19 | 2008-08-28 | Marine Polymer Technologies, Inc. | Hemostatic compositions and therapeutic regimens |
US20110177025A1 (en) * | 2008-07-15 | 2011-07-21 | Living Cell Products Pty Limited | Wound healing |
JP5247548B2 (ja) * | 2009-03-17 | 2013-07-24 | 株式会社ノエビア | 保湿剤、抗老化剤、中性脂肪蓄積抑制剤、美白剤、抗炎症剤、皮膚外用剤、経口用剤 |
NZ703163A (en) | 2010-04-15 | 2016-06-24 | Marinepolymer Tech Inc | Anti-bacterial applications of poly-n-acetylglucosamine nanofibers |
CA2832859C (en) | 2011-04-15 | 2020-06-16 | Marine Polymer Technologies, Inc. | Treatment of disease with poly-n-acetylglucosamine nanofibers |
EP3287781B1 (en) * | 2013-03-15 | 2024-04-17 | The Procter & Gamble Company | A noninvasive method for measuring antimicrobial peptides from skin as an objective measurement of natural protection from microbes |
DK3209319T3 (da) * | 2014-10-21 | 2021-10-04 | Hexima Ltd | En fremgangsmåde til behandling af svampeinfektioner |
US10086035B2 (en) | 2016-02-04 | 2018-10-02 | ALASTIN Skincare, Inc. | Compositions and methods for invasive and non-invasive procedural skincare |
CA3018865A1 (en) * | 2016-03-31 | 2017-10-05 | Gojo Industries, Inc. | Antimicrobial peptide stimulating cleansing composition |
JP2019511505A (ja) * | 2016-03-31 | 2019-04-25 | ゴジョ・インダストリーズ・インコーポレイテッド | 抗菌ペプチド刺激性清浄組成物 |
JP2019510036A (ja) | 2016-03-31 | 2019-04-11 | ゴジョ・インダストリーズ・インコーポレイテッド | プロバイオティクス/プレバイオティクス有効成分を含む清浄剤組成物 |
JP2020500860A (ja) | 2016-11-23 | 2020-01-16 | ゴジョ・インダストリーズ・インコーポレイテッド | プロバイオティック/プレバイオティックな有効成分を含む消毒薬組成物 |
US10493011B2 (en) | 2017-08-03 | 2019-12-03 | ALASTIN Skincare, Inc. | Peptide compositions and methods for ameliorating skin laxity and body contour |
IT201800005585A1 (it) | 2018-05-22 | 2019-11-22 | Composti per prevenire e trattare affezioni della pelle o della mucosa con componente infiammatoria | |
US11103455B2 (en) | 2018-08-02 | 2021-08-31 | ALASTIN Skincare, Inc. | Liposomal compositions and methods of use |
CN109453365A (zh) * | 2019-01-22 | 2019-03-12 | 宇肽生物(东莞)有限公司 | 一种祛除眼袋活性多肽 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999059574A1 (en) * | 1998-05-21 | 1999-11-25 | Magainin Pharmaceuticals, Inc. | A method for stimulation of defensin production by exposure to isoleucin |
WO2001068085A1 (en) * | 2000-03-15 | 2001-09-20 | Genaera Corporation | A method for stimulation of defensin production |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2166139B (en) * | 1984-10-25 | 1988-06-22 | Erba Farmitalia | Biologically active penta-and heptapeptides |
GB8821077D0 (en) * | 1988-09-08 | 1988-10-05 | Wellcome Found | Peptides |
NL8902454A (nl) * | 1989-10-03 | 1991-05-01 | Stichting Centraal Lab | Mutanten van de humane plasminogeen activator inhibitor 1 (pai-1), hun bereiding en toepassing, en recombinante polynucleotiden die voor deze mutanten coderende genetische informatie omvatten. |
WO1999061468A2 (en) * | 1998-05-27 | 1999-12-02 | Gemma Biotechnology Ltd. | The induction of antibiotic peptides by lait (scd14) protein |
WO1999064439A2 (en) * | 1998-06-12 | 1999-12-16 | Case Western Reserve University | Methods for increasing cationic antimicrobial peptides |
AU5300299A (en) * | 1998-08-21 | 2000-03-14 | Yeda Research And Development Co. Ltd. | Anti-inflammatory peptides derived from il-2 and analogues thereof |
EP2275551B1 (en) * | 1999-10-29 | 2015-04-08 | Novartis Vaccines and Diagnostics S.r.l. | Neisserial antigenic peptides |
US20050181464A1 (en) * | 2002-04-04 | 2005-08-18 | Affinium Pharmaceuticals, Inc. | Novel purified polypeptides from bacteria |
WO2004055041A2 (en) * | 2002-12-13 | 2004-07-01 | Case Western Reserve University | Defensin-inducing peptides from fusobacterium |
ES2381359T3 (es) * | 2003-11-17 | 2012-05-25 | Sederma | Composiciones que contienen mezclas de tetrapéptidos y tripéptidos |
NZ548166A (en) * | 2003-12-01 | 2010-06-25 | Meiji Dairies Corp | Peptide inhibiting angiontensin converting enzyme |
US20070185025A1 (en) * | 2005-09-11 | 2007-08-09 | The Trustees Of Columbia University In The City Of New York | Filoviral immunosuppressive peptides and uses thereof |
WO2007041689A2 (en) * | 2005-10-04 | 2007-04-12 | President And Fellows Of Harvard College | Methods of site-specific labeling of molecules and molecules produced thereby |
WO2008041863A1 (en) * | 2006-10-04 | 2008-04-10 | Agresearch Limited | Novel genes and polypeptides associated with insecticidal activity |
WO2008109833A2 (en) * | 2007-03-07 | 2008-09-12 | University Of Florida Research Foundation, Inc. | Polynucleotides and polypeptides identified by iviat screening and methods of use |
-
2008
- 2008-01-30 ES ES200800243A patent/ES2324192B1/es not_active Expired - Fee Related
-
2009
- 2009-01-30 US US12/865,311 patent/US8815266B2/en active Active
- 2009-01-30 EP EP09705290.6A patent/EP2245045B1/en active Active
- 2009-01-30 WO PCT/EP2009/051041 patent/WO2009095456A1/en active Application Filing
- 2009-01-30 AU AU2009209601A patent/AU2009209601B2/en active Active
- 2009-01-30 JP JP2010544705A patent/JP5474827B2/ja not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999059574A1 (en) * | 1998-05-21 | 1999-11-25 | Magainin Pharmaceuticals, Inc. | A method for stimulation of defensin production by exposure to isoleucin |
WO2001068085A1 (en) * | 2000-03-15 | 2001-09-20 | Genaera Corporation | A method for stimulation of defensin production |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2015514722A (ja) * | 2012-04-16 | 2015-05-21 | ルブリゾル アドバンスド マテリアルズ, インコーポレイテッド | 皮膚および/または粘膜の処置および/またはケアのための組成物ならびに化粧品組成物または医薬組成物におけるその使用 |
JP2017529393A (ja) * | 2014-09-12 | 2017-10-05 | アンティバイオティクス エーピーエスAntibiotx Aps | ハロゲン化サリチルアニリドの抗菌用途 |
US10758553B2 (en) | 2014-09-12 | 2020-09-01 | UNION therapeutics A/S | Antibacterial use of halogenated salicylanilides |
JP2021075567A (ja) * | 2014-09-12 | 2021-05-20 | アンティバイオティクス エーピーエスAntibiotx Aps | ハロゲン化サリチルアニリドの抗菌用途 |
US11285164B2 (en) | 2014-09-12 | 2022-03-29 | UNION therapeutics A/S | Antibacterial use of halogenated salicylanilides |
US11324761B2 (en) | 2014-09-12 | 2022-05-10 | UNION therapeutics A/S | Antibacterial use of halogenated salicylanilides |
US11331327B2 (en) | 2014-09-12 | 2022-05-17 | UNION therapeutics A/S | Antibacterial use of halogenated salicylanilides |
US10857164B2 (en) | 2015-05-29 | 2020-12-08 | UNION therapeutics A/S | Halogenated salicylanilides for treating Clostridium infections |
US11529361B2 (en) | 2015-05-29 | 2022-12-20 | UNION therapeutics A/S | Halogenated salicylanilides for treating Clostridium infections |
US11419834B2 (en) | 2019-02-25 | 2022-08-23 | Rhode Island Hospital | Methods for treating diseases or infections caused by or associated with H. pylori using a halogenated salicylanilide |
Also Published As
Publication number | Publication date |
---|---|
AU2009209601B2 (en) | 2014-07-10 |
AU2009209601A1 (en) | 2009-08-06 |
EP2245045A1 (en) | 2010-11-03 |
ES2324192B1 (es) | 2010-06-17 |
ES2324192A1 (es) | 2009-07-31 |
US20110052519A1 (en) | 2011-03-03 |
WO2009095456A1 (en) | 2009-08-06 |
EP2245045B1 (en) | 2017-09-06 |
US8815266B2 (en) | 2014-08-26 |
JP5474827B2 (ja) | 2014-04-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5474827B2 (ja) | 皮膚、粘膜、頭皮または爪の処置、保護または洗浄において有用なペプチド誘導体 | |
RU2557401C2 (ru) | Пептиды, используемые в лечении и/или наблюдении за кожей, слизистыми оболочками и/или волосами, и их применение в косметических или фармацевтических композициях | |
US9315564B2 (en) | Cosmetic or pharmaceutical compositions comprising metalloproteinase inhibitors | |
EP2838547B1 (en) | Compounds for the treatment and/or care of the skin and/or mucous membranes and their use in cosmetic or pharmaceutical compositions | |
JP5818356B2 (ja) | 皮膚、粘膜、頭皮、及び/若しくは毛髪の処置及び/若しくはケアに有用なペプチド並びに/又は化粧品組成物若しくは医薬組成物におけるその使用 | |
WO2024109878A1 (zh) | 具有抗衰老作用的肽及其组合物和用途 | |
EP3954700A1 (en) | Anti-inflammatory peptides derived from rice proteins (oryza sativa) and uses thereof | |
WO2017009488A1 (en) | Topical compositions | |
WO2017009486A1 (en) | Topical compositions | |
EP3329905A1 (en) | Topical cosmetic compositions comprising an oligopeptide against anti-aging of the skin | |
WO2018014936A1 (en) | Topical compositions | |
ES2649762T3 (es) | Derivados peptídicos útiles en el tratamiento, cuidado o limpieza de la piel, mucosas, cuero cabelludo o uñas |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20111220 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20130813 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20131113 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20131120 |
|
A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20131213 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20140110 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20140205 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5474827 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
LAPS | Cancellation because of no payment of annual fees |