JP2011511684A5 - - Google Patents
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- JP2011511684A5 JP2011511684A5 JP2010546211A JP2010546211A JP2011511684A5 JP 2011511684 A5 JP2011511684 A5 JP 2011511684A5 JP 2010546211 A JP2010546211 A JP 2010546211A JP 2010546211 A JP2010546211 A JP 2010546211A JP 2011511684 A5 JP2011511684 A5 JP 2011511684A5
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- Prior art keywords
- cancer
- medical product
- tumor
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2347775T3 (da) | 2005-12-13 | 2020-07-13 | Harvard College | Skabeloner til celletransplantation |
| US10328133B2 (en) | 2008-02-13 | 2019-06-25 | President And Fellows Of Harvard College | Continuous cell programming devices |
| JP5529023B2 (ja) * | 2008-09-04 | 2014-06-25 | 猛 小林 | 抗制御性t細胞抗体と磁性微粒子を含む悪性腫瘍の温熱治療用キット、及びその温熱治療法 |
| JP5463531B2 (ja) * | 2009-07-22 | 2014-04-09 | 国立大学法人 東京大学 | Phd2発現抑制物質搭載ポリイオンコンプレックス |
| JP5926180B2 (ja) | 2009-07-31 | 2016-05-25 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 寛容原性療法のための細胞のプログラミングの方法 |
| ES2600229T3 (es) * | 2009-11-12 | 2017-02-07 | Helmholtz-Zentrum Geesthacht Zentrum für Material- und Küstenforschung GmbH | Nanopartículas magnéticas biocompatibles para el tratamiento de glioblastomas |
| DE102009058769A1 (de) * | 2009-12-16 | 2011-06-22 | MagForce Nanotechnologies AG, 10589 | Temperaturabhängige Aktivierung von katalytischen Nukleinsäuren zur kontrollierten Wirkstofffreisetzung |
| WO2012001577A1 (en) * | 2010-06-29 | 2012-01-05 | Koninklijke Philips Electronics N.V. | Synthesis and use of iron oleate |
| US9572880B2 (en) | 2010-08-27 | 2017-02-21 | Sienna Biopharmaceuticals, Inc. | Ultrasound delivery of nanoparticles |
| CN107441628B (zh) | 2010-08-27 | 2020-06-19 | 斯巴卡有限公司 | 用于靶向热调节的组合物和方法 |
| EP2624873B1 (en) | 2010-10-06 | 2019-12-04 | President and Fellows of Harvard College | Injectable, pore-forming hydrogels for materials-based cell therapies |
| US8944067B2 (en) * | 2010-12-15 | 2015-02-03 | Kci Licensing, Inc. | Targeted delivery of magnetically tagged active agents in combination with negative pressure wound therapy |
| US9764157B2 (en) | 2011-01-17 | 2017-09-19 | University Of Utah Research Foundation | Methods, systems, and apparatus for reducing the frequency and/or severity of photophobic responses or for modulating circadian cycles |
| US10359552B2 (en) | 2011-01-17 | 2019-07-23 | University Of Utah Research Foundation | Methods, systems, and apparatus for reducing the frequency and/or severity of photophobic responses or for modulating circadian cycles |
| EP4245347A3 (en) | 2011-01-17 | 2023-12-06 | University of Utah Research Foundation | Apparatus and methods for reducing frequency or severity of photophobic responses or modulating circadian cycles |
| PL2683440T3 (pl) | 2011-03-10 | 2016-05-31 | Magforce Ag | Wspomagane komputerowo narzędzie symulacyjne do pomocy w planowaniu termoterapii |
| US9675561B2 (en) | 2011-04-28 | 2017-06-13 | President And Fellows Of Harvard College | Injectable cryogel vaccine devices and methods of use thereof |
| ES2685327T3 (es) | 2011-04-28 | 2018-10-08 | President And Fellows Of Harvard College | Armazones tridimensionales macroscópicos preformados inyectables para administración mínimamente invasiva |
| EP2704666A4 (en) * | 2011-05-06 | 2014-12-17 | Mitchel J Doktycz | ACTIVE SUBSTANCES TO PREVENT AND PREVENT POLLUTION OF SURFACES |
| EP2714073B1 (en) | 2011-06-03 | 2021-03-10 | President and Fellows of Harvard College | In situ antigen-generating cancer vaccine |
| CN102379762B (zh) * | 2011-08-02 | 2015-03-25 | 上海微创医疗器械(集团)有限公司 | 一种带凹槽的生物可降解支架及其制备方法 |
| AU2012292554B2 (en) * | 2011-08-10 | 2014-10-30 | Magforce Ag | Agglomerating magnetic alkoxysilane-coated nanoparticles |
| US10945965B2 (en) | 2011-12-16 | 2021-03-16 | Nanobiotix | Nanoparticles comprising metallic and hafnium oxide materials, preparation and uses thereof |
| LT2838515T (lt) | 2012-04-16 | 2020-03-10 | President And Fellows Of Harvard College | Mezoporinės silico dioksido kompozicijos, skirtos imuninio atsako moduliavimui |
| PL2906286T3 (pl) | 2012-10-11 | 2018-03-30 | Nanocomposix, Inc. | Kompozycje zawierające nanopłytki srebra i sposoby ich przygotowywania |
| US10406228B2 (en) * | 2012-11-29 | 2019-09-10 | The Johns Hopkins University | Process for making iron oxide nanoparticle preparations for cancer hyperthermia |
| US20140219926A1 (en) * | 2013-02-01 | 2014-08-07 | The Trustees Of Dartmouth College | Biodegradable Iron Oxide Nanoparticle Gel for Tumor Bed Therapy |
| WO2014124329A1 (en) | 2013-02-08 | 2014-08-14 | University Of Louisville Research Foundation, Inc. | Nanoparticles for drug delivery |
| CN103203903A (zh) * | 2013-03-25 | 2013-07-17 | 海龙核材科技(江苏)有限公司 | 一种电场磁场下响应的传感材料及其制备方法 |
| WO2014195374A1 (en) * | 2013-06-04 | 2014-12-11 | Fumedica Ag | Cytotoxic substance for use in combination with radiotherapy in cancer treatment |
| BR112015031977A2 (pt) * | 2013-06-20 | 2017-07-25 | Nanobiotix | gel biocompatível, e, kit |
| EP2823858A1 (en) | 2013-07-12 | 2015-01-14 | Brossel, Rémy | System generating a constraint field, and medical device implementing the same |
| WO2015020936A1 (en) | 2013-08-06 | 2015-02-12 | Ut-Battelle, Llc | Local thermal actuation of material surfaces via micro- and nanowire heating for the prevention of cellular attachment and biological fouling |
| US10234608B2 (en) | 2013-11-15 | 2019-03-19 | University Of Utah Research Foundation | Nanoparticle light filtering method and apparatus |
| WO2015073933A1 (en) | 2013-11-15 | 2015-05-21 | University Of Utah Research Foundation | Nanoparticle light filtering method and apparatus |
| CN103752849B (zh) * | 2014-02-13 | 2016-02-24 | 华东理工大学 | 制备稳定纳米银的方法 |
| US9814631B2 (en) * | 2014-03-03 | 2017-11-14 | Sambhu Choudhury | Container for surgical absorbent articles |
| WO2015161181A1 (en) | 2014-04-17 | 2015-10-22 | Boston Scientific Scimed, Inc. | Devices and methods for therapeutic heat treatment |
| WO2015168379A2 (en) | 2014-04-30 | 2015-11-05 | President And Fellows Of Harvard College | Combination vaccine devices and methods of killing cancer cells |
| CN103989552B (zh) * | 2014-05-07 | 2015-10-28 | 江苏达胜伦比亚生物科技有限公司 | 一种医用水凝胶凉贴 |
| CZ27466U1 (cs) * | 2014-08-21 | 2014-11-10 | Univerzita Tomáše Bati ve Zlíně | Biomateriál na bázi hydrogelu citlivý na magnetické podněty |
| RU2616258C2 (ru) * | 2014-11-10 | 2017-04-13 | федеральное государственное автономное образовательное учреждение высшего образования "Московский физико-технический институт (государственный университет)" | Способ получения полимерных наночастиц низкосиалированного эритропоэтина с высокой степенью сорбции для лечения неврологических заболеваний |
| HK1247861A1 (zh) | 2015-01-30 | 2018-10-05 | President And Fellows Of Harvard College | 用於癌症治疗的肿瘤周围和肿瘤内部材料 |
| CN107708756A (zh) | 2015-04-10 | 2018-02-16 | 哈佛学院院长等 | 免疫细胞捕获装置及其制备和使用方法 |
| MA43100A (fr) | 2015-05-28 | 2018-09-05 | Nanobiotix | Nanoparticules à utiliser en tant que vaccin thérapeutique |
| EP3344301B1 (en) * | 2015-09-04 | 2020-09-02 | University of the Witwatersrand, Johannesburg | Biodegradable implant |
| CN108289856A (zh) | 2015-10-07 | 2018-07-17 | 波士顿科学国际有限公司 | 用以提高热疗的感应加热效率的具有不同居里温度的LaFeSiH磁性纳米粒子混合物 |
| RU167739U1 (ru) * | 2015-12-02 | 2017-01-10 | Федеральное государственное бюджетное учреждение науки Красноярский научный центр Сибирского отделения Российской академии наук (ФГБУН КНЦ СО РАН) | Нанодиски для разрушения опухолевых клеток |
| CN115487351A (zh) | 2016-02-06 | 2022-12-20 | 哈佛学院校长同事会 | 重塑造血巢以重建免疫 |
| ES3032115T3 (en) | 2016-07-13 | 2025-07-15 | Harvard College | Antigen-presenting cell-mimetic scaffolds and methods for making and using the same |
| WO2018026884A1 (en) | 2016-08-02 | 2018-02-08 | President And Fellows Of Harvard College | Biomaterials for modulating immune responses |
| US11352491B2 (en) * | 2016-09-08 | 2022-06-07 | Schaefer Kalk Gmbh & Co. Kg | Calcium-salt-containing composite powder having microstructured particles |
| EP3305334A1 (en) * | 2016-10-06 | 2018-04-11 | Universitätsklinikum Jena | Magnetic composition and medical material for stimulating vascularisation in internal or external wound of the body |
| WO2018105779A1 (ko) * | 2016-12-07 | 2018-06-14 | 서울대학교산학협력단 | 바이오 패치, 바이오 히터, 바이오 센서, 및 바이오 전자 패치 장치 |
| CZ2016804A3 (cs) * | 2016-12-16 | 2018-04-18 | Synthesia, A. S. | Supramolekulární komplex oxycelulózové matrice s taxolovým derivátem s postupným uvolňováním taxolového derivátu a jeho použití |
| US12396951B2 (en) | 2016-12-27 | 2025-08-26 | Upexmed Co. Ltd. | Prevention of local tumor recurrence following surgery using sustainedand/or delayed release of medicaments contained in micro-particles |
| WO2018125862A1 (en) * | 2016-12-27 | 2018-07-05 | Soon Kap Hahn | Prevention of local tumor recurrence following surgery using sustained and/or delayed release of medicaments contained in micro-particles |
| DE102017214576A1 (de) * | 2017-08-21 | 2019-02-21 | Universität Bielefeld | Anorganisch-organischer Nanokomposit mit zellbiologischer und sensorischer Aktivität |
| RU181003U1 (ru) * | 2017-11-14 | 2018-07-03 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Саратовский государственный технический университет имени Гагарина Ю.А." (СГТУ имени Гагарина Ю.А.) | Пластинчатый дентальный имплантат для многопозиционного протезирования |
| RU181004U1 (ru) * | 2017-11-14 | 2018-07-03 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Саратовский государственный технический университет имени Гагарина Ю.А." (СГТУ имени Гагарина Ю.А.) | Пластинчатый дентальный имплантат для многопозиционного протезирования |
| RU181002U1 (ru) * | 2017-12-25 | 2018-07-03 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Саратовский государственный технический университет имени Гагарина Ю.А." (СГТУ имени Гагарина Ю.А.) | Пластинчатый дентальный имплантат для многопозиционного протезирования |
| KR102200787B1 (ko) * | 2017-12-29 | 2021-01-12 | 한경대학교 산학협력단 | 나노셀룰로오스를 이용한 습윤성 탄력붕대 |
| CN108912628A (zh) * | 2018-05-31 | 2018-11-30 | 苏州乔纳森新材料科技有限公司 | 一种插管用抗菌纳米材料的制备方法 |
| WO2020061129A1 (en) | 2018-09-19 | 2020-03-26 | President And Fellows Of Harvard College | Compositions and methods for labeling and modulation of cells in vitro and in vivo |
| RU189308U1 (ru) * | 2019-03-22 | 2019-05-21 | Артем Олегович Бахметьев | Трансдермальный пластырь |
| RU189268U1 (ru) * | 2019-03-22 | 2019-05-17 | Артем Олегович Бахметьев | Акупунктурная игла |
| KR102372213B1 (ko) * | 2019-09-09 | 2022-03-08 | 한국화학연구원 | 히알루론산 또는 그의 염 및 폴리페놀 화합물을 포함하는 수분해성 필름 |
| IL295186A (en) | 2020-01-31 | 2022-09-01 | Magforce Ag | A preparation containing magnetic metallic particles coated with alkoxysilane |
| CN111921003B (zh) * | 2020-09-04 | 2022-06-03 | 东南大学 | 一种磁响应热疗可控降解栓塞微球及其制备方法与应用 |
| CN112972778B (zh) * | 2021-02-05 | 2022-05-27 | 华中科技大学 | 一种人工膀胱铁磁复合物及其制备方法 |
| CN112972779B (zh) * | 2021-02-05 | 2022-07-12 | 武汉磁济科技有限公司 | 一种植入式柔性磁响应人工膀胱基体及其制造方法 |
| CN112933288B (zh) * | 2021-02-08 | 2022-02-22 | 四川大学 | 兼具止血和术后抗肿瘤功能的交联止血海绵及其制备方法 |
| US20230061188A1 (en) * | 2021-08-30 | 2023-03-02 | Apple Inc. | Enhanced mems sensor embedded heater |
| DE102022115394A1 (de) | 2022-06-21 | 2023-12-21 | Rheinisch-Westfälische Technische Hochschule (Rwth) Aachen | Implantat und Anordnung aufweisend eine Strahlungsquelle und ein Implantat |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH31064A (en) * | 1990-09-07 | 1998-02-05 | Nycomed As Of Nycoveten | Polymers containing diester units. |
| US5411730A (en) | 1993-07-20 | 1995-05-02 | Research Corporation Technologies, Inc. | Magnetic microparticles |
| DE4428851C2 (de) | 1994-08-04 | 2000-05-04 | Diagnostikforschung Inst | Eisen enthaltende Nanopartikel, ihre Herstellung und Anwendung in der Diagnostik und Therapie |
| US7611533B2 (en) * | 1995-06-07 | 2009-11-03 | Cook Incorporated | Coated implantable medical device |
| DE19614136A1 (de) | 1996-04-10 | 1997-10-16 | Inst Neue Mat Gemein Gmbh | Verfahren zur Herstellung agglomeratfreier nanoskaliger Eisenoxidteilchen mit hydrolysebeständigem Überzug |
| JPH10328314A (ja) * | 1997-06-02 | 1998-12-15 | Nippon Electric Glass Co Ltd | 温熱治療用セメント材料及び温熱治療用インプラント材 |
| JPH10337335A (ja) * | 1997-06-06 | 1998-12-22 | Nippon Electric Glass Co Ltd | 温熱治療用インプラント材 |
| DE19726282A1 (de) | 1997-06-20 | 1998-12-24 | Inst Neue Mat Gemein Gmbh | Nanoskalige Teilchen mit einem von mindestens zwei Schalen umgebenen eisenoxid-haltigen Kern |
| US20030073663A1 (en) * | 1997-06-25 | 2003-04-17 | David M Wiseman | Bioabsorbable medical devices from oxidized polysaccharides |
| US6267782B1 (en) * | 1997-11-20 | 2001-07-31 | St. Jude Medical, Inc. | Medical article with adhered antimicrobial metal |
| EP1208005B1 (en) * | 1999-07-16 | 2010-04-07 | Wm. MARSH RICE UNIVERSITY | Temperature-sensitive polymer/nanoshell composites for photothermally modulated drug delivery |
| DE10059151C2 (de) | 2000-11-29 | 2003-10-16 | Christoph Alexiou | Magnetische Partikel zur zielgerichteten regionalen Therapie und Verwendung derselben |
| US6527693B2 (en) * | 2001-01-30 | 2003-03-04 | Implant Sciences Corporation | Methods and implants for providing radiation to a patient |
| WO2003026618A1 (en) | 2001-09-28 | 2003-04-03 | Saoirse Corporation | Localized non-invasive biological modulation system |
| DE10164309A1 (de) * | 2001-12-28 | 2003-07-10 | Fraunhofer Ges Forschung | Verbesserte strukturiert-funktionale Bindematrices für Biomoleküle |
| US7101394B2 (en) * | 2002-05-02 | 2006-09-05 | Boston Scientific Scimed, Inc. | Energetically-controlled delivery of biologically active material from an implanted medical device |
| WO2004034876A2 (en) * | 2002-10-15 | 2004-04-29 | Ferx Incorporated | Magnetically guided particles for radiative therapies |
| ITTO20020994A1 (it) * | 2002-11-15 | 2004-05-16 | Torino Politecnico | Materiali magnetici biocompatibili per il trattamento del cancro mediante ipertermia, e processi per la loro realizzazione. |
| DE10350248A1 (de) | 2003-10-28 | 2005-06-16 | Magnamedics Gmbh | Thermosensitive, biokompatible Polymerträger mit veränderbarer physikalischer Struktur für die Therapie, Diagnostik und Analytik |
| WO2005065282A2 (en) | 2003-12-31 | 2005-07-21 | The Regents Of The University Of California | Remote magnetically induced treatment of cancer |
| WO2005070471A2 (en) | 2004-01-20 | 2005-08-04 | Alnis Biosciences, Inc. | Articles comprising magnetic material and bioactive agents |
| CN101010004B (zh) * | 2004-07-30 | 2012-10-03 | 金伯利-克拉克环球有限公司 | 抗微生物的装置和组合物 |
| CN101431983A (zh) * | 2004-09-28 | 2009-05-13 | 香港科技大学 | 作为生物材料的多功能的超分子水凝胶 |
| DE102005016873A1 (de) * | 2005-04-12 | 2006-10-19 | Magforce Nanotechnologies Ag | Nanopartikel-Wirstoff-Konjugate |
| US20090081122A1 (en) * | 2005-05-23 | 2009-03-26 | Universite De Geneve | Injectable superparamagnetic nanoparticles for treatment by hyperthermia and use for forming an hyperthermic implant |
| FR2889449B1 (fr) | 2005-08-05 | 2011-06-10 | Khorionyx | Preparations implantables |
| DE102005039579B4 (de) | 2005-08-19 | 2022-06-30 | Magforce Ag | Verfahren zur Einschleusung von therapeutischen Substanzen in Zellen |
| WO2007095454A2 (en) * | 2006-02-10 | 2007-08-23 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Carbon-encased metal nanoparticles and sponges, methods of synthesis, and methods of use |
| WO2008089478A2 (en) * | 2007-01-19 | 2008-07-24 | Triton Biosystems, Inc. | Thermotherapy susceptors and methods of using same |
-
2008
- 2008-02-11 DE DE102008008522A patent/DE102008008522A1/de not_active Withdrawn
-
2009
- 2009-02-11 AU AU2009214533A patent/AU2009214533B2/en active Active
- 2009-02-11 KR KR1020107017850A patent/KR101581973B1/ko active Active
- 2009-02-11 RU RU2010136311/15A patent/RU2524644C2/ru active
- 2009-02-11 WO PCT/DE2009/000196 patent/WO2009100716A2/de not_active Ceased
- 2009-02-11 US US12/864,793 patent/US20110223255A1/en not_active Abandoned
- 2009-02-11 SG SG2013010590A patent/SG188146A1/en unknown
- 2009-02-11 PL PL09711314T patent/PL2249804T3/pl unknown
- 2009-02-11 BR BRPI0906611A patent/BRPI0906611A8/pt not_active IP Right Cessation
- 2009-02-11 CN CN2009801043533A patent/CN101938993A/zh active Pending
- 2009-02-11 EP EP09711314.6A patent/EP2249804B1/de active Active
- 2009-02-11 PT PT97113146T patent/PT2249804T/pt unknown
- 2009-02-11 MX MX2010008806A patent/MX2010008806A/es active IP Right Grant
- 2009-02-11 DE DE112009000905T patent/DE112009000905A5/de not_active Withdrawn
- 2009-02-11 DK DK09711314.6T patent/DK2249804T3/en active
- 2009-02-11 CA CA2712832A patent/CA2712832C/en active Active
- 2009-02-11 ES ES09711314.6T patent/ES2619509T3/es active Active
- 2009-02-11 JP JP2010546211A patent/JP5649455B2/ja active Active
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2010
- 2010-07-21 IL IL207137A patent/IL207137A/en active IP Right Grant
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