JP2011510981A - 口腔ケア計画 - Google Patents
口腔ケア計画 Download PDFInfo
- Publication number
- JP2011510981A JP2011510981A JP2010544953A JP2010544953A JP2011510981A JP 2011510981 A JP2011510981 A JP 2011510981A JP 2010544953 A JP2010544953 A JP 2010544953A JP 2010544953 A JP2010544953 A JP 2010544953A JP 2011510981 A JP2011510981 A JP 2011510981A
- Authority
- JP
- Japan
- Prior art keywords
- oral care
- agent
- composition
- regular
- oral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims abstract description 162
- 238000012423 maintenance Methods 0.000 claims abstract description 42
- 238000004140 cleaning Methods 0.000 claims abstract description 32
- 238000000034 method Methods 0.000 claims abstract description 30
- 150000001413 amino acids Chemical class 0.000 claims abstract description 24
- 150000003839 salts Chemical group 0.000 claims abstract description 22
- 239000003795 chemical substances by application Substances 0.000 claims description 41
- -1 triclosan monophosphate Chemical class 0.000 claims description 28
- INVGWHRKADIJHF-UHFFFAOYSA-N Sanguinarin Chemical compound C1=C2OCOC2=CC2=C3[N+](C)=CC4=C(OCO5)C5=CC=C4C3=CC=C21 INVGWHRKADIJHF-UHFFFAOYSA-N 0.000 claims description 16
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 13
- 229960003500 triclosan Drugs 0.000 claims description 13
- ANAAMBRRWOGKGU-UHFFFAOYSA-M 4-ethyl-1-tetradecylpyridin-1-ium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+]1=CC=C(CC)C=C1 ANAAMBRRWOGKGU-UHFFFAOYSA-M 0.000 claims description 11
- 239000003242 anti bacterial agent Substances 0.000 claims description 11
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims description 11
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims description 11
- RYJDNPSQBGFFSF-WCCKRBBISA-N (2s)-2-amino-5-(diaminomethylideneamino)pentanoic acid;carbonic acid Chemical compound OC(O)=O.OC(=O)[C@@H](N)CCCNC(N)=N RYJDNPSQBGFFSF-WCCKRBBISA-N 0.000 claims description 10
- 239000004475 Arginine Substances 0.000 claims description 10
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 10
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 claims description 10
- 238000009472 formulation Methods 0.000 claims description 10
- 239000002253 acid Substances 0.000 claims description 9
- RWMSXNCJNSILON-UHFFFAOYSA-N 2-[4-(2-propylpentyl)piperidin-1-yl]ethanol Chemical compound CCCC(CCC)CC1CCN(CCO)CC1 RWMSXNCJNSILON-UHFFFAOYSA-N 0.000 claims description 8
- FCEXWTOTHXCQCQ-UHFFFAOYSA-N Ethoxydihydrosanguinarine Natural products C12=CC=C3OCOC3=C2C(OCC)N(C)C(C2=C3)=C1C=CC2=CC1=C3OCO1 FCEXWTOTHXCQCQ-UHFFFAOYSA-N 0.000 claims description 8
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims description 8
- 229950002404 octapinol Drugs 0.000 claims description 8
- 229940084560 sanguinarine Drugs 0.000 claims description 8
- YZRQUTZNTDAYPJ-UHFFFAOYSA-N sanguinarine pseudobase Natural products C1=C2OCOC2=CC2=C3N(C)C(O)C4=C(OCO5)C5=CC=C4C3=CC=C21 YZRQUTZNTDAYPJ-UHFFFAOYSA-N 0.000 claims description 8
- NVNLLIYOARQCIX-MSHCCFNRSA-N Nisin Chemical compound N1C(=O)[C@@H](CC(C)C)NC(=O)C(=C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@@H](NC(=O)C(=C/C)/NC(=O)[C@H](N)[C@H](C)CC)CSC[C@@H]1C(=O)N[C@@H]1C(=O)N2CCC[C@@H]2C(=O)NCC(=O)N[C@@H](C(=O)N[C@H](CCCCN)C(=O)N[C@@H]2C(NCC(=O)N[C@H](C)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCSC)C(=O)NCC(=O)N[C@H](CS[C@@H]2C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CCSC)C(=O)N[C@H](CCCCN)C(=O)N[C@@H]2C(N[C@H](C)C(=O)N[C@@H]3C(=O)N[C@@H](C(N[C@H](CC=4NC=NC=4)C(=O)N[C@H](CS[C@@H]3C)C(=O)N[C@H](CO)C(=O)N[C@H]([C@H](C)CC)C(=O)N[C@H](CC=3NC=NC=3)C(=O)N[C@H](C(C)C)C(=O)NC(=C)C(=O)N[C@H](CCCCN)C(O)=O)=O)CS[C@@H]2C)=O)=O)CS[C@@H]1C NVNLLIYOARQCIX-MSHCCFNRSA-N 0.000 claims description 7
- 108010053775 Nisin Proteins 0.000 claims description 7
- 239000003086 colorant Substances 0.000 claims description 7
- QSFOWAYMMZCQNF-UHFFFAOYSA-N delmopinol Chemical compound CCCC(CCC)CCCC1COCCN1CCO QSFOWAYMMZCQNF-UHFFFAOYSA-N 0.000 claims description 7
- 229960003854 delmopinol Drugs 0.000 claims description 7
- USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Chemical class C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 claims description 7
- 239000004309 nisin Substances 0.000 claims description 7
- 235000010297 nisin Nutrition 0.000 claims description 7
- 229960001774 octenidine Drugs 0.000 claims description 7
- SMGTYJPMKXNQFY-UHFFFAOYSA-N octenidine dihydrochloride Chemical compound Cl.Cl.C1=CC(=NCCCCCCCC)C=CN1CCCCCCCCCCN1C=CC(=NCCCCCCCC)C=C1 SMGTYJPMKXNQFY-UHFFFAOYSA-N 0.000 claims description 7
- 229920000642 polymer Polymers 0.000 claims description 7
- 230000001225 therapeutic effect Effects 0.000 claims description 7
- DTOUUUZOYKYHEP-UHFFFAOYSA-N 1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine Chemical compound CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1 DTOUUUZOYKYHEP-UHFFFAOYSA-N 0.000 claims description 6
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims description 6
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims description 6
- 108090000790 Enzymes Proteins 0.000 claims description 6
- 102000004190 Enzymes Human genes 0.000 claims description 6
- 241000229143 Hippophae Species 0.000 claims description 6
- 235000003145 Hippophae rhamnoides Nutrition 0.000 claims description 6
- 241000218378 Magnolia Species 0.000 claims description 6
- 241000241413 Propolis Species 0.000 claims description 6
- 229950010221 alexidine Drugs 0.000 claims description 6
- LFVVNPBBFUSSHL-UHFFFAOYSA-N alexidine Chemical compound CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC LFVVNPBBFUSSHL-UHFFFAOYSA-N 0.000 claims description 6
- 230000003095 anti-phagocytic effect Effects 0.000 claims description 6
- 229960003260 chlorhexidine Drugs 0.000 claims description 6
- 235000018597 common camellia Nutrition 0.000 claims description 6
- 239000000796 flavoring agent Substances 0.000 claims description 6
- 235000013355 food flavoring agent Nutrition 0.000 claims description 6
- 229960004867 hexetidine Drugs 0.000 claims description 6
- 229910021645 metal ion Inorganic materials 0.000 claims description 6
- WKEDVNSFRWHDNR-UHFFFAOYSA-N salicylanilide Chemical compound OC1=CC=CC=C1C(=O)NC1=CC=CC=C1 WKEDVNSFRWHDNR-UHFFFAOYSA-N 0.000 claims description 6
- 229950000975 salicylanilide Drugs 0.000 claims description 6
- IUTCEZPPWBHGIX-UHFFFAOYSA-N tin(2+) Chemical compound [Sn+2] IUTCEZPPWBHGIX-UHFFFAOYSA-N 0.000 claims description 6
- 239000000341 volatile oil Substances 0.000 claims description 6
- WCGUUGGRBIKTOS-GPOJBZKASA-N (3beta)-3-hydroxyurs-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C WCGUUGGRBIKTOS-GPOJBZKASA-N 0.000 claims description 5
- 108010062877 Bacteriocins Proteins 0.000 claims description 5
- 229920001661 Chitosan Polymers 0.000 claims description 5
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 claims description 5
- BYTORXDZJWWIKR-UHFFFAOYSA-N Hinokiol Natural products CC(C)c1cc2CCC3C(C)(CO)C(O)CCC3(C)c2cc1O BYTORXDZJWWIKR-UHFFFAOYSA-N 0.000 claims description 5
- 239000000853 adhesive Substances 0.000 claims description 5
- 229940072056 alginate Drugs 0.000 claims description 5
- 235000010443 alginic acid Nutrition 0.000 claims description 5
- 229920000615 alginic acid Polymers 0.000 claims description 5
- 230000000181 anti-adherent effect Effects 0.000 claims description 5
- 229910001431 copper ion Inorganic materials 0.000 claims description 5
- 229960003624 creatine Drugs 0.000 claims description 5
- 239000006046 creatine Substances 0.000 claims description 5
- QOLIPNRNLBQTAU-UHFFFAOYSA-N flavan Chemical compound C1CC2=CC=CC=C2OC1C1=CC=CC=C1 QOLIPNRNLBQTAU-UHFFFAOYSA-N 0.000 claims description 5
- 150000002241 furanones Chemical class 0.000 claims description 5
- FVYXIJYOAGAUQK-UHFFFAOYSA-N honokiol Chemical compound C1=C(CC=C)C(O)=CC=C1C1=CC(CC=C)=CC=C1O FVYXIJYOAGAUQK-UHFFFAOYSA-N 0.000 claims description 5
- VVOAZFWZEDHOOU-UHFFFAOYSA-N honokiol Natural products OC1=CC=C(CC=C)C=C1C1=CC(CC=C)=CC=C1O VVOAZFWZEDHOOU-UHFFFAOYSA-N 0.000 claims description 5
- 150000002978 peroxides Chemical class 0.000 claims description 5
- 229940069949 propolis Drugs 0.000 claims description 5
- 229940096998 ursolic acid Drugs 0.000 claims description 5
- PLSAJKYPRJGMHO-UHFFFAOYSA-N ursolic acid Natural products CC1CCC2(CCC3(C)C(C=CC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C)C(=O)O PLSAJKYPRJGMHO-UHFFFAOYSA-N 0.000 claims description 5
- 241000209507 Camellia Species 0.000 claims description 4
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 claims description 4
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 4
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 4
- 239000003975 dentin desensitizing agent Substances 0.000 claims description 4
- 239000002270 dispersing agent Substances 0.000 claims description 4
- 230000008447 perception Effects 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 230000003442 weekly effect Effects 0.000 claims description 3
- 229940024606 amino acid Drugs 0.000 claims 15
- 238000002360 preparation method Methods 0.000 claims 8
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 5
- 229960003121 arginine Drugs 0.000 claims 5
- 229960003589 arginine hydrochloride Drugs 0.000 claims 5
- CCTIOCVIZPCTGO-BYPYZUCNSA-N phosphoarginine Chemical compound OC(=O)[C@@H](N)CCCNC(=N)NP(O)(O)=O CCTIOCVIZPCTGO-BYPYZUCNSA-N 0.000 claims 5
- 239000003623 enhancer Substances 0.000 claims 3
- 230000036541 health Effects 0.000 abstract description 14
- 230000002708 enhancing effect Effects 0.000 abstract description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 86
- 239000000377 silicon dioxide Substances 0.000 description 37
- 239000002245 particle Substances 0.000 description 32
- 239000003082 abrasive agent Substances 0.000 description 20
- 238000010521 absorption reaction Methods 0.000 description 17
- 239000003921 oil Substances 0.000 description 17
- 230000002272 anti-calculus Effects 0.000 description 9
- 210000000214 mouth Anatomy 0.000 description 9
- 239000000606 toothpaste Substances 0.000 description 9
- 229940091249 fluoride supplement Drugs 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 239000010445 mica Substances 0.000 description 7
- 229910052618 mica group Inorganic materials 0.000 description 7
- 239000000017 hydrogel Substances 0.000 description 6
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- YFVBASFBIJFBAI-UHFFFAOYSA-M 1-tetradecylpyridin-1-ium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+]1=CC=CC=C1 YFVBASFBIJFBAI-UHFFFAOYSA-M 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 5
- 239000000551 dentifrice Substances 0.000 description 5
- 239000000499 gel Substances 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 230000000737 periodic effect Effects 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 229910002027 silica gel Inorganic materials 0.000 description 4
- 239000000741 silica gel Substances 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- 229940034610 toothpaste Drugs 0.000 description 4
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 3
- 208000006558 Dental Calculus Diseases 0.000 description 3
- 229920000388 Polyphosphate Polymers 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 3
- 239000001506 calcium phosphate Substances 0.000 description 3
- 229940043256 calcium pyrophosphate Drugs 0.000 description 3
- 230000036996 cardiovascular health Effects 0.000 description 3
- 239000008119 colloidal silica Substances 0.000 description 3
- 235000009508 confectionery Nutrition 0.000 description 3
- 210000004268 dentin Anatomy 0.000 description 3
- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- ZVVSSOQAYNYNPP-UHFFFAOYSA-N olaflur Chemical compound F.F.CCCCCCCCCCCCCCCCCCN(CCO)CCCN(CCO)CCO ZVVSSOQAYNYNPP-UHFFFAOYSA-N 0.000 description 3
- 229960001245 olaflur Drugs 0.000 description 3
- 239000001205 polyphosphate Substances 0.000 description 3
- 235000011176 polyphosphates Nutrition 0.000 description 3
- 239000011775 sodium fluoride Substances 0.000 description 3
- 235000013024 sodium fluoride Nutrition 0.000 description 3
- 229960000414 sodium fluoride Drugs 0.000 description 3
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 230000009885 systemic effect Effects 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 3
- 239000000080 wetting agent Substances 0.000 description 3
- WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 240000001548 Camellia japonica Species 0.000 description 2
- WEEGYLXZBRQIMU-WAAGHKOSSA-N Eucalyptol Chemical compound C1C[C@H]2CC[C@]1(C)OC2(C)C WEEGYLXZBRQIMU-WAAGHKOSSA-N 0.000 description 2
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 2
- DAOANAATJZWTSJ-UHFFFAOYSA-N N-Decanoylmorpholine Chemical compound CCCCCCCCCC(=O)N1CCOCC1 DAOANAATJZWTSJ-UHFFFAOYSA-N 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 239000002260 anti-inflammatory agent Substances 0.000 description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 description 2
- 229940045110 chitosan Drugs 0.000 description 2
- 229960005233 cineole Drugs 0.000 description 2
- 208000002925 dental caries Diseases 0.000 description 2
- 210000003298 dental enamel Anatomy 0.000 description 2
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 2
- XMOCLSLCDHWDHP-IUODEOHRSA-N epi-Gallocatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-IUODEOHRSA-N 0.000 description 2
- 239000010408 film Substances 0.000 description 2
- 229930003935 flavonoid Natural products 0.000 description 2
- 235000017173 flavonoids Nutrition 0.000 description 2
- 150000002215 flavonoids Chemical class 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 208000007565 gingivitis Diseases 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 2
- 239000008108 microcrystalline cellulose Substances 0.000 description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 2
- 239000002324 mouth wash Substances 0.000 description 2
- 239000006072 paste Substances 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 235000021317 phosphate Nutrition 0.000 description 2
- XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 description 2
- 238000005498 polishing Methods 0.000 description 2
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002285 radioactive effect Effects 0.000 description 2
- 229910002028 silica xerogel Inorganic materials 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- 229940078499 tricalcium phosphate Drugs 0.000 description 2
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 2
- 235000019731 tricalcium phosphate Nutrition 0.000 description 2
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 2
- 239000011746 zinc citrate Substances 0.000 description 2
- 235000006076 zinc citrate Nutrition 0.000 description 2
- 229940068475 zinc citrate Drugs 0.000 description 2
- BHHYHSUAOQUXJK-UHFFFAOYSA-L zinc fluoride Chemical compound F[Zn]F BHHYHSUAOQUXJK-UHFFFAOYSA-L 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 description 1
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 description 1
- UOWIFEANNONTKY-UHFFFAOYSA-N 2-hydroxy-5-octanoyl-n-[3-(trifluoromethyl)phenyl]benzamide Chemical compound CCCCCCCC(=O)C1=CC=C(O)C(C(=O)NC=2C=C(C=CC=2)C(F)(F)F)=C1 UOWIFEANNONTKY-UHFFFAOYSA-N 0.000 description 1
- KXGFMDJXCMQABM-UHFFFAOYSA-N 2-methoxy-6-methylphenol Chemical compound [CH]OC1=CC=CC([CH])=C1O KXGFMDJXCMQABM-UHFFFAOYSA-N 0.000 description 1
- SHXWCVYOXRDMCX-UHFFFAOYSA-N 3,4-methylenedioxymethamphetamine Chemical compound CNC(C)CC1=CC=C2OCOC2=C1 SHXWCVYOXRDMCX-UHFFFAOYSA-N 0.000 description 1
- DDFHBQSCUXNBSA-UHFFFAOYSA-N 5-(5-carboxythiophen-2-yl)thiophene-2-carboxylic acid Chemical compound S1C(C(=O)O)=CC=C1C1=CC=C(C(O)=O)S1 DDFHBQSCUXNBSA-UHFFFAOYSA-N 0.000 description 1
- 102000013563 Acid Phosphatase Human genes 0.000 description 1
- 108010051457 Acid Phosphatase Proteins 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- LITUBCVUXPBCGA-WMZHIEFXSA-N Ascorbyl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O LITUBCVUXPBCGA-WMZHIEFXSA-N 0.000 description 1
- 239000004261 Ascorbyl stearate Substances 0.000 description 1
- 241001132374 Asta Species 0.000 description 1
- 229910052580 B4C Inorganic materials 0.000 description 1
- 206010006326 Breath odour Diseases 0.000 description 1
- 241000195940 Bryophyta Species 0.000 description 1
- 229910014497 Ca10(PO4)6(OH)2 Inorganic materials 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- WTEVQBCEXWBHNA-UHFFFAOYSA-N Citral Natural products CC(C)=CCCC(C)=CC=O WTEVQBCEXWBHNA-UHFFFAOYSA-N 0.000 description 1
- 229910021594 Copper(II) fluoride Inorganic materials 0.000 description 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 229940090898 Desensitizer Drugs 0.000 description 1
- GLWQRIMWMLJRIB-UHFFFAOYSA-N F.F.CCO Chemical compound F.F.CCO GLWQRIMWMLJRIB-UHFFFAOYSA-N 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- WMBWREPUVVBILR-UHFFFAOYSA-N GCG Natural products C=1C(O)=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-UHFFFAOYSA-N 0.000 description 1
- 239000005792 Geraniol Substances 0.000 description 1
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 description 1
- 208000034619 Gingival inflammation Diseases 0.000 description 1
- 241000589989 Helicobacter Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 239000005909 Kieselgur Substances 0.000 description 1
- 241000110847 Kochia Species 0.000 description 1
- XMOCLSLCDHWDHP-UHFFFAOYSA-N L-Epigallocatechin Natural products OC1CC2=C(O)C=C(O)C=C2OC1C1=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-UHFFFAOYSA-N 0.000 description 1
- 229920000877 Melamine resin Polymers 0.000 description 1
- 239000004640 Melamine resin Substances 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- YXOLAZRVSSWPPT-UHFFFAOYSA-N Morin Chemical compound OC1=CC(O)=CC=C1C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1 YXOLAZRVSSWPPT-UHFFFAOYSA-N 0.000 description 1
- DIOYAVUHUXAUPX-KHPPLWFESA-N Oleoyl sarcosine Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)N(C)CC(O)=O DIOYAVUHUXAUPX-KHPPLWFESA-N 0.000 description 1
- 208000007117 Oral Ulcer Diseases 0.000 description 1
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
- 241000237509 Patinopecten sp. Species 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 229920000153 Povidone-iodine Polymers 0.000 description 1
- 102000009609 Pyrophosphatases Human genes 0.000 description 1
- 108010009413 Pyrophosphatases Proteins 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 108091008874 T cell receptors Proteins 0.000 description 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 1
- 241001122767 Theaceae Species 0.000 description 1
- 239000005844 Thymol Substances 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 229920001807 Urea-formaldehyde Polymers 0.000 description 1
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 description 1
- HFIGWKOFZLNOQK-UHFFFAOYSA-K [O-]P([O-])(=O)OP(=O)([O-])O.[Ca+2].[Na+] Chemical class [O-]P([O-])(=O)OP(=O)([O-])O.[Ca+2].[Na+] HFIGWKOFZLNOQK-UHFFFAOYSA-K 0.000 description 1
- 238000002679 ablation Methods 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- GZCGUPFRVQAUEE-SLPGGIOYSA-N aldehydo-D-glucose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-SLPGGIOYSA-N 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 150000008051 alkyl sulfates Chemical class 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- TUFYVOCKVJOUIR-UHFFFAOYSA-N alpha-Thujaplicin Natural products CC(C)C=1C=CC=CC(=O)C=1O TUFYVOCKVJOUIR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 229910000323 aluminium silicate Inorganic materials 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- LDDQLRUQCUTJBB-UHFFFAOYSA-N ammonium fluoride Chemical class [NH4+].[F-] LDDQLRUQCUTJBB-UHFFFAOYSA-N 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 230000002882 anti-plaque Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 description 1
- 235000019276 ascorbyl stearate Nutrition 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- OYLGJCQECKOTOL-UHFFFAOYSA-L barium fluoride Chemical compound [F-].[F-].[Ba+2] OYLGJCQECKOTOL-UHFFFAOYSA-L 0.000 description 1
- 229910001632 barium fluoride Inorganic materials 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 229960001716 benzalkonium Drugs 0.000 description 1
- CYDRXTMLKJDRQH-UHFFFAOYSA-N benzododecinium Chemical compound CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 CYDRXTMLKJDRQH-UHFFFAOYSA-N 0.000 description 1
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 1
- 230000032770 biofilm formation Effects 0.000 description 1
- 229920001222 biopolymer Polymers 0.000 description 1
- 229910052626 biotite Inorganic materials 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- INAHAJYZKVIDIZ-UHFFFAOYSA-N boron carbide Chemical compound B12B3B4C32B41 INAHAJYZKVIDIZ-UHFFFAOYSA-N 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 239000004067 bulking agent Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 description 1
- 229910001634 calcium fluoride Inorganic materials 0.000 description 1
- 229940095626 calcium fluoride Drugs 0.000 description 1
- ROPDWRCJTIRLTR-UHFFFAOYSA-L calcium metaphosphate Chemical compound [Ca+2].[O-]P(=O)=O.[O-]P(=O)=O ROPDWRCJTIRLTR-UHFFFAOYSA-L 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 230000001013 cariogenic effect Effects 0.000 description 1
- RECUKUPTGUEGMW-UHFFFAOYSA-N carvacrol Chemical compound CC(C)C1=CC=C(C)C(O)=C1 RECUKUPTGUEGMW-UHFFFAOYSA-N 0.000 description 1
- HHTWOMMSBMNRKP-UHFFFAOYSA-N carvacrol Natural products CC(=C)C1=CC=C(C)C(O)=C1 HHTWOMMSBMNRKP-UHFFFAOYSA-N 0.000 description 1
- 235000007746 carvacrol Nutrition 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
- 235000005487 catechin Nutrition 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
- 235000015111 chews Nutrition 0.000 description 1
- 229910001919 chlorite Inorganic materials 0.000 description 1
- 229910052619 chlorite group Inorganic materials 0.000 description 1
- QBWCMBCROVPCKQ-UHFFFAOYSA-N chlorous acid Chemical compound OCl=O QBWCMBCROVPCKQ-UHFFFAOYSA-N 0.000 description 1
- 229950001002 cianidanol Drugs 0.000 description 1
- 229940043350 citral Drugs 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000000805 composite resin Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 150000001879 copper Chemical class 0.000 description 1
- GWFAVIIMQDUCRA-UHFFFAOYSA-L copper(ii) fluoride Chemical compound [F-].[F-].[Cu+2] GWFAVIIMQDUCRA-UHFFFAOYSA-L 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 201000002170 dentin sensitivity Diseases 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- DGTVXEHQMSJRPE-UHFFFAOYSA-N difluorophosphinic acid Chemical compound OP(F)(F)=O DGTVXEHQMSJRPE-UHFFFAOYSA-N 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 1
- 235000011180 diphosphates Nutrition 0.000 description 1
- YGANSGVIUGARFR-UHFFFAOYSA-N dipotassium dioxosilane oxo(oxoalumanyloxy)alumane oxygen(2-) Chemical compound [O--].[K+].[K+].O=[Si]=O.O=[Al]O[Al]=O YGANSGVIUGARFR-UHFFFAOYSA-N 0.000 description 1
- 230000009429 distress Effects 0.000 description 1
- 229960000878 docusate sodium Drugs 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000002532 enzyme inhibitor Substances 0.000 description 1
- DZYNKLUGCOSVKS-UHFFFAOYSA-N epigallocatechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3cc(O)c(O)c(O)c3 DZYNKLUGCOSVKS-UHFFFAOYSA-N 0.000 description 1
- 229940030275 epigallocatechin gallate Drugs 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 150000004673 fluoride salts Chemical class 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- UPBDXRPQPOWRKR-UHFFFAOYSA-N furan-2,5-dione;methoxyethene Chemical compound COC=C.O=C1OC(=O)C=C1 UPBDXRPQPOWRKR-UHFFFAOYSA-N 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- WTEVQBCEXWBHNA-JXMROGBWSA-N geranial Chemical compound CC(C)=CCC\C(C)=C\C=O WTEVQBCEXWBHNA-JXMROGBWSA-N 0.000 description 1
- 229940113087 geraniol Drugs 0.000 description 1
- 210000004195 gingiva Anatomy 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000007407 health benefit Effects 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 229940005740 hexametaphosphate Drugs 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 159000000014 iron salts Chemical class 0.000 description 1
- WYXXLXHHWYNKJF-UHFFFAOYSA-N isocarvacrol Natural products CC(C)C1=CC=C(O)C(C)=C1 WYXXLXHHWYNKJF-UHFFFAOYSA-N 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229960001047 methyl salicylate Drugs 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 229940074371 monofluorophosphate Drugs 0.000 description 1
- 235000007708 morin Nutrition 0.000 description 1
- UXOUKMQIEVGVLY-UHFFFAOYSA-N morin Natural products OC1=CC(O)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 UXOUKMQIEVGVLY-UHFFFAOYSA-N 0.000 description 1
- 235000011929 mousse Nutrition 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- 229910052627 muscovite Inorganic materials 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 230000001706 oxygenating effect Effects 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- 230000000242 pagocytic effect Effects 0.000 description 1
- 239000011236 particulate material Substances 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 239000005011 phenolic resin Substances 0.000 description 1
- 229920001568 phenolic resin Polymers 0.000 description 1
- 229910052628 phlogopite Inorganic materials 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 230000007406 plaque accumulation Effects 0.000 description 1
- 229920002432 poly(vinyl methyl ether) polymer Polymers 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920005646 polycarboxylate Polymers 0.000 description 1
- 229940045916 polymetaphosphate Drugs 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 239000011698 potassium fluoride Substances 0.000 description 1
- 235000003270 potassium fluoride Nutrition 0.000 description 1
- OQZCJRJRGMMSGK-UHFFFAOYSA-M potassium metaphosphate Chemical compound [K+].[O-]P(=O)=O OQZCJRJRGMMSGK-UHFFFAOYSA-M 0.000 description 1
- 229940099402 potassium metaphosphate Drugs 0.000 description 1
- 229960001621 povidone-iodine Drugs 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000008262 pumice Substances 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 239000000700 radioactive tracer Substances 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 229940092258 rosemary extract Drugs 0.000 description 1
- 235000020748 rosemary extract Nutrition 0.000 description 1
- 239000001233 rosmarinus officinalis l. extract Substances 0.000 description 1
- 235000020637 scallop Nutrition 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 239000000565 sealant Substances 0.000 description 1
- 229910052604 silicate mineral Inorganic materials 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- HBMJWWWQQXIZIP-UHFFFAOYSA-N silicon carbide Chemical compound [Si+]#[C-] HBMJWWWQQXIZIP-UHFFFAOYSA-N 0.000 description 1
- 229910010271 silicon carbide Inorganic materials 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 235000019832 sodium triphosphate Nutrition 0.000 description 1
- MWNQXXOSWHCCOZ-UHFFFAOYSA-L sodium;oxido carbonate Chemical compound [Na+].[O-]OC([O-])=O MWNQXXOSWHCCOZ-UHFFFAOYSA-L 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- 230000036347 tooth sensitivity Effects 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-I triphosphate(5-) Chemical compound [O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O UNXRWKVEANCORM-UHFFFAOYSA-I 0.000 description 1
- WBGSMIRITKHZNA-UHFFFAOYSA-M trisodium;dioxido(oxidooxy)borane Chemical compound [Na+].[Na+].[Na+].[O-]OB([O-])[O-] WBGSMIRITKHZNA-UHFFFAOYSA-M 0.000 description 1
- 239000002966 varnish Substances 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Birds (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
【選択図】なし
Description
[0001] 本出願は、米国特許出願No.12/028,782、2008年2月8日出願;米国特許出願No.61/027,420、2008年2月8日出願;米国特許出願No.61/027,435、2008年2月8日出願;米国特許出願No.61/027,431、2008年2月8日出願;および米国特許出願No.61/027,432、2008年2月8日出願;に基づく優先権を主張し、それらの内容を本明細書に援用する。
a.一次口腔ケア組成物と少なくとも1日1回接触させ、かつ
b.定期口腔ケア維持組成物と少なくとも月1回接触させ、
その際、定期口腔ケア維持組成物は遊離または塩形の塩基性アミノ酸を含む。
a.一次口腔ケア組成物と少なくとも1日1回接触させ、かつ
b.定期口腔ケア維持組成物と少なくとも月1回接触させ、
その際、定期口腔ケア維持組成物は遊離または塩形の塩基性アミノ酸を含む。
[0011] 口腔組織は全身感染の入り口となる可能性があるので、口内の健康状態の増進は全身の健康状態にも有益となる。口内の良好な健康状態は、心血管の健康状態を含めた全身の健康状態に関連する。塩基性アミノ酸、特にアルギニンは、NO合成経路に補給する窒素源であり、したがって口腔組織における微小循環を増強するので、本発明の組成物および方法は格別な有益性を提供する。より酸性の低い口腔環境を提供することは、胃部不快感(gastric distress)の軽減にも役立ち、胃潰瘍に関連するヘリコバクター(Heliobacter)にとって、より好ましくない環境を作り出す。アルギニンは特に特定の免疫細胞受容体、たとえばT細胞受容体の高発現に必要であり、したがってアルギニンは有効な免疫応答を増強することができる。したがって本発明の組成物および方法は、心血管の健康状態を含めた全身の健康状態を増進するのに有用である。
Claims (29)
- 遊離または塩形の塩基性アミノ酸を含む、口腔表面の療法処置に使用するための定期口腔ケア維持組成物であって、その処置が、a.口腔表面を一次口腔ケア組成物と少なくとも1日1回接触させること、およびb.口腔表面を定期口腔ケア維持組成物と少なくとも月1回接触させることを含む、前記定期口腔ケア維持組成物。
- さらに、有効量の抗細菌剤、有効量のフッ化物源、および/またはポリマーのうち少なくとも1種類を含む、請求項1に記載の定期口腔ケア維持組成物。
- 塩基性アミノ酸がアルギニンを含む、請求項1または請求項2に記載の定期口腔ケア維持組成物。
- 塩基性アミノ酸が塩形であり、リン酸アルギニン、重炭酸アルギニン、および塩酸アルギニンから選択される、請求項3に記載の定期口腔ケア維持組成物。
- 口腔表面の療法処置に際して対象に同時、逐次または個別に投与する組合わせ製剤を製造するための、定期口腔ケア維持組成物および一次口腔ケア組成物を含む組合わせ製剤であって、口腔表面を
a.一次口腔ケア組成物と少なくとも1日1回接触させ、かつ
b.定期口腔ケア維持組成物と少なくとも月1回接触させ、
その際、定期口腔ケア維持組成物が遊離または塩形の塩基性アミノ酸を含む、前記組合わせ製剤。 - 定期口腔ケア維持組成物がさらに、有効量の抗細菌剤、有効量のフッ化物源、および/またはポリマーのうち少なくとも1種類を含む、請求項5に記載の組合わせ製剤。
- 塩基性アミノ酸がアルギニンを含む、請求項5または請求項6に記載の組合わせ製剤。
- 塩基性アミノ酸が塩形であり、リン酸アルギニン、重炭酸アルギニン、および塩酸アルギニンから選択される、請求項7に記載の組合わせ製剤。
- 一次口腔ケア組成物が、研磨剤、抗細菌剤、歯垢分散剤、抗付着剤、抗齲食剤、脱感作剤、着香剤、着色剤、および知覚増強剤から選択される作用物質を含む、請求項5〜8のいずれか1項に記載の組合わせ製剤。
- 一次口腔ケア組成物が、スズ(II)イオン剤;トリクロサン;トリクロサンモノホスフェート;クロルヘキシジン;アレキシジン;ヘキセチジン;サンギナリン;塩化ベンザルコニウム;サリチルアニリド;臭化ドミフェン;セチルピリジニウムクロリド(CPC);テトラデシルピリジニウムクロリド(TPC);N−テトラデシル−4−エチルピリジニウムクロリド(TDEPC);オクテニジン;デルモピノール;オクタピノール;ナイシン;亜鉛イオン剤;銅イオン剤;精油;フラノン類;バクテリオシン類、エチルラウロイルアルギネート、モクレンエキス、金属イオン源、重炭酸アルギニン、ホノキオール、マゴノール、ウルソール酸、ウルシン酸、モリン、シーバックソーンエキス、ペルオキシド、酵素、ツバキエキス、フラボノイド、フラバン、ハロゲン化ジフェニルエーテル、クレアチン、キトサンおよびプロポリスから選択される作用物質を含む、請求項5〜9のいずれか1項に記載の組合わせ製剤。
- 口腔表面の療法処置に用いる定期口腔ケア維持組成物を製造するための遊離または塩形の塩基性アミノ酸の使用であって、その処置が、a.口腔表面を一次口腔ケア組成物と少なくとも1日1回接触させること、およびb.口腔表面を定期口腔ケア維持組成物と少なくとも月1回接触させることを含む、前記使用。
- 塩基性アミノ酸がアルギニンを含む、請求項11に記載の使用。
- 塩基性アミノ酸が塩形であり、リン酸アルギニン、重炭酸アルギニン、および塩酸アルギニンから選択される、請求項12に記載の使用。
- 口腔表面の療法処置に際して対象に同時、逐次または個別に投与する組合わせ製剤を製造するための、定期口腔ケア維持組成物および一次口腔ケア組成物の使用であって、口腔表面を
a.一次口腔ケア組成物と少なくとも1日1回接触させ、かつ
b.定期口腔ケア維持組成物と少なくとも月1回接触させ、
その際、定期口腔ケア維持組成物が遊離または塩形の塩基性アミノ酸を含む、前記使用。 - 定期口腔ケア維持組成物がさらに、有効量の抗細菌剤、有効量のフッ化物源、および/またはポリマーのうち少なくとも1種類を含む、請求項14に記載の使用。
- 塩基性アミノ酸がアルギニンを含む、請求項14または請求項15に記載の使用。
- 塩基性アミノ酸が塩形であり、リン酸アルギニン、重炭酸アルギニン、および塩酸アルギニンから選択される、請求項16に記載の使用。
- 一次口腔ケア組成物が、研磨剤、抗細菌剤、歯垢分散剤、抗付着剤、抗齲食剤、脱感作剤、着香剤、着色剤、および知覚増強剤から選択される作用物質を含む、請求項14〜17のいずれか1項に記載の使用。
- 一次口腔ケア組成物が、スズ(II)イオン剤;トリクロサン;トリクロサンモノホスフェート;クロルヘキシジン;アレキシジン;ヘキセチジン;サンギナリン;塩化ベンザルコニウム;サリチルアニリド;臭化ドミフェン;セチルピリジニウムクロリド(CPC);テトラデシルピリジニウムクロリド(TPC);N−テトラデシル−4−エチルピリジニウムクロリド(TDEPC);オクテニジン;デルモピノール;オクタピノール;ナイシン;亜鉛イオン剤;銅イオン剤;精油;フラノン類;バクテリオシン類、エチルラウロイルアルギネート、モクレンエキス、金属イオン源、重炭酸アルギニン、ホノキオール、マゴノール、ウルソール酸、ウルシン酸、モリン、シーバックソーンエキス、ペルオキシド、酵素、ツバキエキス、フラボノイド、フラバン、ハロゲン化ジフェニルエーテル、クレアチン、キトサンおよびプロポリスから選択される作用物質を含む、請求項14〜18のいずれか1項に記載の使用。
- a.口腔表面を一次口腔ケア組成物と少なくとも1日1回接触させ、かつ
b.口腔表面を定期口腔ケア維持組成物と少なくとも月1回接触させる
ことを含み、その際、定期口腔ケア維持組成物が遊離または塩形の塩基性アミノ酸を含む方法。 - さらに、有効量の抗細菌剤、有効量のフッ化物源、および/またはポリマーのうち少なくとも1種類を含む、請求項20に記載の方法。
- 塩基性アミノ酸がアルギニンを含む、請求項20または請求項21に記載の方法。
- 塩基性アミノ酸が塩形であり、リン酸アルギニン、重炭酸アルギニン、および塩酸アルギニンから選択される、請求項22に記載の方法。
- さらに、口腔表面を定期口腔ケアクリーニング組成物と少なくとも月1回接触させることを含む、請求項20〜23のいずれか1項に記載の方法。
- 一次口腔ケア組成物が、研磨剤、抗細菌剤、歯垢分散剤、抗付着剤、抗齲食剤、脱感作剤、着香剤、着色剤、および知覚増強剤から選択される作用物質を含む、請求項20〜24のいずれか1項に記載の方法。
- 一次口腔ケア組成物が、スズ(II)イオン剤;トリクロサン;トリクロサンモノホスフェート;クロルヘキシジン;アレキシジン;ヘキセチジン;サンギナリン;塩化ベンザルコニウム;サリチルアニリド;臭化ドミフェン;セチルピリジニウムクロリド(CPC);テトラデシルピリジニウムクロリド(TPC);N−テトラデシル−4−エチルピリジニウムクロリド(TDEPC);オクテニジン;デルモピノール;オクタピノール;ナイシン;亜鉛イオン剤;銅イオン剤;精油;フラノン類;バクテリオシン類、エチルラウロイルアルギネート、モクレンエキス、金属イオン源、重炭酸アルギニン、ホノキオール、マゴノール、ウルソール酸、ウルシン酸、モリン、シーバックソーンエキス、ペルオキシド、酵素、ツバキエキス、フラボノイド、フラバン、ハロゲン化ジフェニルエーテル、クレアチン、キトサンおよびプロポリスから選択される作用物質を含む、請求項20〜25のいずれか1項に記載の方法。
- 一次口腔ケア組成物を1日2〜5回適用する、請求項20〜26のいずれか1項に記載の方法。
- 口腔表面を定期口腔ケア維持組成物と少なくとも毎週接触させる、請求項20〜27のいずれか1項に記載の方法。
- 口腔表面を定期口腔ケア維持組成物と少なくとも毎日接触させる、請求項20〜28のいずれか1項に記載の方法。
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2742008P | 2008-02-08 | 2008-02-08 | |
US2743508P | 2008-02-08 | 2008-02-08 | |
US2743208P | 2008-02-08 | 2008-02-08 | |
US2743108P | 2008-02-08 | 2008-02-08 | |
US12/028,782 US20080274065A1 (en) | 2006-05-09 | 2008-02-08 | Oral Care Regimen |
PCT/US2008/058650 WO2009099450A1 (en) | 2008-02-08 | 2008-03-28 | Oral care regimen |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2011510981A true JP2011510981A (ja) | 2011-04-07 |
Family
ID=40122498
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010544953A Pending JP2011510981A (ja) | 2008-02-08 | 2008-03-28 | 口腔ケア計画 |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP2240153A1 (ja) |
JP (1) | JP2011510981A (ja) |
CN (1) | CN101938979B (ja) |
AR (1) | AR065888A1 (ja) |
AU (1) | AU2008349845C1 (ja) |
BR (1) | BRPI0821857A2 (ja) |
CA (1) | CA2706481C (ja) |
CL (1) | CL2008000896A1 (ja) |
CO (1) | CO6280462A2 (ja) |
MX (1) | MX2010004708A (ja) |
MY (1) | MY155709A (ja) |
PA (1) | PA8774301A1 (ja) |
PE (1) | PE20091442A1 (ja) |
RU (1) | RU2012121147A (ja) |
TW (1) | TWI459970B (ja) |
WO (1) | WO2009099450A1 (ja) |
ZA (1) | ZA201003676B (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009536663A (ja) * | 2006-05-09 | 2009-10-15 | コルゲート・パーモリブ・カンパニー | 口腔ケア措置 |
JP2014062066A (ja) * | 2012-09-21 | 2014-04-10 | Kao Corp | 口腔用組成物 |
JP2017510609A (ja) * | 2014-04-10 | 2017-04-13 | ビーエーエスエフ ソシエタス・ヨーロピアBasf Se | 口腔ケア組成物 |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY155976A (en) | 2008-02-08 | 2015-12-31 | Colgate Palmolive Co | Oral care product and methods of use and manufacture thereof |
US9376722B2 (en) | 2008-02-08 | 2016-06-28 | Colgate-Palmolive Company | Oral care methods and systems |
MX344840B (es) * | 2010-11-12 | 2017-01-09 | Colgate Palmolive Co | Producto de cuidado oral y metodos de uso y fabricación de los mismos. |
CN107432832A (zh) * | 2010-11-12 | 2017-12-05 | 高露洁-棕榄公司 | 口腔护理产品及其使用和制备方法 |
US10653605B2 (en) | 2011-02-18 | 2020-05-19 | Gaba International Holding Gmbh | Dentifrice composition |
CN104822361B (zh) * | 2012-12-05 | 2018-01-30 | 高露洁-棕榄公司 | 含磷酸锌的组合物 |
CN105916486B (zh) * | 2013-12-27 | 2020-01-14 | 高露洁-棕榄公司 | 含有羧酸的益生元口腔护理组合物 |
WO2016028265A1 (en) * | 2014-08-18 | 2016-02-25 | Colgate-Palmolive Company | Mouthwash composition comprising a peroxide source and an n-acyl-l-arginine alkyl ester salt |
JP2016006102A (ja) * | 2015-08-14 | 2016-01-14 | コルゲート・パーモリブ・カンパニーColgate−Palmolive Company | 口腔ケア製品およびその使用方法および製造方法 |
ES2890074T3 (es) * | 2015-09-11 | 2022-01-17 | Wrigley W M Jun Co | Efectos antibacterianos sinérgicos del extracto de corteza de magnolia y de éster etílico de N-alfa-lauroil-L-arginina sobre biopelícula de placa dental |
CN115350117A (zh) * | 2016-11-08 | 2022-11-18 | 高露洁-棕榄公司 | 口腔护理组合物 |
CA3039261A1 (en) * | 2016-11-08 | 2018-05-17 | Colgate-Palmolive Company | Oral care compositions |
RU2750199C2 (ru) * | 2017-06-14 | 2021-06-23 | Колгейт-Палмолив Компани | Композиции, содержащие фосфат цинка |
CA3083808A1 (en) * | 2017-12-18 | 2019-06-27 | Gaba International Holding Gmbh | Oral care composition comprising a silica blocking agent |
US11642199B2 (en) * | 2018-09-24 | 2023-05-09 | 3M Innovative Properties Company | Dental appliance with cosmetic therapeutic aqueous solution |
US11571374B2 (en) * | 2019-03-29 | 2023-02-07 | Colgate-Palmolive Company | Oral care product and methods of use and manufacture thereof |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06271437A (ja) * | 1992-05-15 | 1994-09-27 | Kao Corp | 口腔用組成物 |
JPH08151324A (ja) * | 1994-11-28 | 1996-06-11 | Sunstar Inc | 抗菌製剤 |
WO2000078270A1 (en) * | 1999-06-23 | 2000-12-28 | The Research Foundation Of State University Of New York | Dental anti-hypersensitivity composition and method |
JP2001504083A (ja) * | 1996-03-05 | 2001-03-27 | ザ リサーチ ファウンデーション オブ ザ ステイト ユニバーシティ オブ ニューヨーク | 抗齲蝕口用組成物 |
WO2007134003A2 (en) * | 2006-05-09 | 2007-11-22 | Colgate-Palmolive Company | Oral care regimen |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5370865A (en) * | 1992-05-15 | 1994-12-06 | Kao Corporation | Composition for use in oral cavity |
-
2008
- 2008-03-28 BR BRPI0821857-9A2A patent/BRPI0821857A2/pt not_active IP Right Cessation
- 2008-03-28 CL CL2008000896A patent/CL2008000896A1/es unknown
- 2008-03-28 AU AU2008349845A patent/AU2008349845C1/en not_active Ceased
- 2008-03-28 EP EP08769086A patent/EP2240153A1/en not_active Withdrawn
- 2008-03-28 JP JP2010544953A patent/JP2011510981A/ja active Pending
- 2008-03-28 MX MX2010004708A patent/MX2010004708A/es not_active Application Discontinuation
- 2008-03-28 WO PCT/US2008/058650 patent/WO2009099450A1/en active Application Filing
- 2008-03-28 CA CA2706481A patent/CA2706481C/en not_active Expired - Fee Related
- 2008-03-28 PE PE2008000569A patent/PE20091442A1/es not_active Application Discontinuation
- 2008-03-28 PA PA20088774301A patent/PA8774301A1/es unknown
- 2008-03-28 CN CN200880126684.2A patent/CN101938979B/zh not_active Expired - Fee Related
- 2008-03-28 MY MYPI2010001791A patent/MY155709A/en unknown
- 2008-03-31 AR ARP080101325A patent/AR065888A1/es unknown
- 2008-04-07 TW TW097112585A patent/TWI459970B/zh active
-
2010
- 2010-05-21 CO CO10061135A patent/CO6280462A2/es not_active Application Discontinuation
- 2010-05-24 ZA ZA2010/03676A patent/ZA201003676B/en unknown
-
2012
- 2012-05-22 RU RU2012121147/15A patent/RU2012121147A/ru unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06271437A (ja) * | 1992-05-15 | 1994-09-27 | Kao Corp | 口腔用組成物 |
JPH08151324A (ja) * | 1994-11-28 | 1996-06-11 | Sunstar Inc | 抗菌製剤 |
JP2001504083A (ja) * | 1996-03-05 | 2001-03-27 | ザ リサーチ ファウンデーション オブ ザ ステイト ユニバーシティ オブ ニューヨーク | 抗齲蝕口用組成物 |
WO2000078270A1 (en) * | 1999-06-23 | 2000-12-28 | The Research Foundation Of State University Of New York | Dental anti-hypersensitivity composition and method |
WO2007134003A2 (en) * | 2006-05-09 | 2007-11-22 | Colgate-Palmolive Company | Oral care regimen |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009536663A (ja) * | 2006-05-09 | 2009-10-15 | コルゲート・パーモリブ・カンパニー | 口腔ケア措置 |
JP2014062066A (ja) * | 2012-09-21 | 2014-04-10 | Kao Corp | 口腔用組成物 |
JP2017510609A (ja) * | 2014-04-10 | 2017-04-13 | ビーエーエスエフ ソシエタス・ヨーロピアBasf Se | 口腔ケア組成物 |
Also Published As
Publication number | Publication date |
---|---|
BRPI0821857A2 (pt) | 2014-09-30 |
RU2012121147A (ru) | 2013-11-27 |
MX2010004708A (es) | 2010-06-07 |
MY155709A (en) | 2015-11-13 |
TWI459970B (zh) | 2014-11-11 |
CN101938979A (zh) | 2011-01-05 |
WO2009099450A1 (en) | 2009-08-13 |
TW200934519A (en) | 2009-08-16 |
PA8774301A1 (es) | 2009-09-17 |
AR065888A1 (es) | 2009-07-08 |
ZA201003676B (en) | 2014-11-26 |
CL2008000896A1 (es) | 2009-08-14 |
CA2706481C (en) | 2015-06-16 |
PE20091442A1 (es) | 2009-09-24 |
AU2008349845B2 (en) | 2012-02-16 |
CO6280462A2 (es) | 2011-05-20 |
CN101938979B (zh) | 2014-11-26 |
AU2008349845A1 (en) | 2009-08-13 |
EP2240153A1 (en) | 2010-10-20 |
AU2008349845C1 (en) | 2012-09-20 |
CA2706481A1 (en) | 2009-08-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2706481C (en) | Oral care regimen | |
US8501161B2 (en) | Oral care regimen | |
RU2475231C2 (ru) | Продукт для ухода за полостью рта и способы его применения и производства | |
CA2817535C (en) | Dentifrice compositions containing calcium silicate and a basic amino acid | |
RU2396938C2 (ru) | Абразивная система для композиций для ухода за полостью рта | |
AU2009212319B2 (en) | Oral care product and methods of use and manufacture thereof | |
RU2570751C2 (ru) | Средство для ухода за полостью рта, способы его применения и производства | |
WO2012057739A1 (en) | Oral care composition comprising arginine and calcium carbonate | |
US20080274065A1 (en) | Oral Care Regimen | |
US20090202452A1 (en) | Oral care regimen | |
RU2482835C2 (ru) | Продукт для ухода за ротовой полостью и способы его применения и изготовления | |
EP3930672A1 (en) | Oral care product and methods of use and manufacture thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20120924 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20121018 |
|
A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130118 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20130603 |
|
A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20131003 |
|
A911 | Transfer of reconsideration by examiner before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20131113 |
|
A912 | Removal of reconsideration by examiner before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20131220 |
|
A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20140922 |