JP2011510948A5 - - Google Patents
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- Publication number
- JP2011510948A5 JP2011510948A5 JP2010544683A JP2010544683A JP2011510948A5 JP 2011510948 A5 JP2011510948 A5 JP 2011510948A5 JP 2010544683 A JP2010544683 A JP 2010544683A JP 2010544683 A JP2010544683 A JP 2010544683A JP 2011510948 A5 JP2011510948 A5 JP 2011510948A5
- Authority
- JP
- Japan
- Prior art keywords
- indol
- amino
- ylpyrazin
- pyrazin
- pyridin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0800250-3 | 2008-02-01 | ||
| SE0800250 | 2008-02-01 | ||
| US12303908P | 2008-04-04 | 2008-04-04 | |
| US61/123,039 | 2008-04-04 | ||
| SE0801185-0 | 2008-05-21 | ||
| SE0801185 | 2008-05-21 | ||
| PCT/EP2009/050931 WO2009095399A2 (en) | 2008-02-01 | 2009-01-28 | Pyrazine derivatives and their use as protein kinase inhbitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014077470A Division JP2014148522A (ja) | 2008-02-01 | 2014-04-04 | 新規化合物、その使用及び製造 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011510948A JP2011510948A (ja) | 2011-04-07 |
| JP2011510948A5 true JP2011510948A5 (https=) | 2012-03-15 |
| JP5562256B2 JP5562256B2 (ja) | 2014-07-30 |
Family
ID=40527384
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010544683A Expired - Fee Related JP5562256B2 (ja) | 2008-02-01 | 2009-01-28 | 新規化合物、その使用及び製造 |
| JP2014077470A Pending JP2014148522A (ja) | 2008-02-01 | 2014-04-04 | 新規化合物、その使用及び製造 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014077470A Pending JP2014148522A (ja) | 2008-02-01 | 2014-04-04 | 新規化合物、その使用及び製造 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8436171B2 (https=) |
| EP (2) | EP2671876A3 (https=) |
| JP (2) | JP5562256B2 (https=) |
| KR (1) | KR101599082B1 (https=) |
| CN (1) | CN101970418B (https=) |
| AU (1) | AU2009209633C1 (https=) |
| BR (1) | BRPI0907453A2 (https=) |
| CA (1) | CA2713553A1 (https=) |
| CY (1) | CY1115400T1 (https=) |
| DK (1) | DK2252597T3 (https=) |
| ES (1) | ES2459297T3 (https=) |
| HR (1) | HRP20140547T1 (https=) |
| MX (1) | MX2010007973A (https=) |
| PL (1) | PL2252597T3 (https=) |
| PT (1) | PT2252597E (https=) |
| RU (1) | RU2493152C2 (https=) |
| SI (1) | SI2252597T1 (https=) |
| WO (1) | WO2009095399A2 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101599082B1 (ko) * | 2008-02-01 | 2016-03-02 | 어키니언 파마슈티칼스 아베 | 피라진 유도체 및 단백질 키나아제 억제제로서의 이의 용도 |
| US9109227B2 (en) | 2010-01-05 | 2015-08-18 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | FLT3 receptor antagonists for the treatment or the prevention of pain disorders |
| WO2013089636A1 (en) * | 2011-12-15 | 2013-06-20 | Akinion Pharmaceuticals Ab | Processes for manufacturing of a kinase inhibitor |
| MX356102B (es) * | 2012-03-14 | 2018-05-14 | Univ Indiana Res & Tech Corp | Compuestos y métodos para tratar leucemia. |
| PT2840080T (pt) * | 2012-04-17 | 2018-02-06 | Fujifilm Corp | Composto heterocíclico que contém azoto ou sal do mesmo |
| UY34807A (es) * | 2012-05-16 | 2013-12-31 | Novartis Ag | Derivados monocíclicos de heteroarilcicloalquil- diamina |
| CN105683167B (zh) | 2013-10-16 | 2018-10-23 | 富士胶片株式会社 | 含氮杂环化合物的盐或其结晶、药品组合物及flt3抑制剂 |
| CN107001283B (zh) | 2014-07-31 | 2021-05-25 | 国家健康与医学研究院 | Flt3受体拮抗剂 |
| WO2016027904A1 (ja) | 2014-08-22 | 2016-02-25 | 富士フイルム株式会社 | Ｆｌｔ３変異陽性癌を処置するための医薬組成物、変異型ｆｌｔ３阻害剤およびそれらの応用 |
| CN105985322A (zh) * | 2015-03-03 | 2016-10-05 | 苏州翔实医药发展有限公司 | 氨基吡嗪化合物及其用途 |
| JP6412471B2 (ja) | 2015-07-15 | 2018-10-24 | 富士フイルム株式会社 | 含窒素複素環化合物の製造方法およびその中間体 |
| EP3254698A1 (en) | 2016-06-08 | 2017-12-13 | Universite De Montpellier | Flt3 receptor inhibitor at low dosage for the treatment of neuropathic pain |
| WO2018211018A1 (en) | 2017-05-17 | 2018-11-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Flt3 inhibitors for improving pain treatments by opioids |
| WO2019018584A1 (en) | 2017-07-18 | 2019-01-24 | GiraFpharma LLC | HETEROCYCLIC COMPOUNDS AS ADENOSINE ANTAGONISTS |
| WO2019057649A1 (en) | 2017-09-19 | 2019-03-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA |
| CN110483366B (zh) * | 2018-05-14 | 2022-09-16 | 中国医学科学院药物研究所 | 吲哚类化合物及其制备方法、药物组合物和用途 |
| EP3911323A4 (en) | 2019-01-18 | 2022-11-16 | Nuvation Bio Inc. | HETEROCYCLIC COMPOUNDS AS ADENOSINE ANTAGONISTS |
| EP3911324A4 (en) | 2019-01-18 | 2022-08-17 | Nuvation Bio Inc. | 1,8-NAPHTHYRIDINONE COMPOUNDS AND THEIR USES |
| JP2022517418A (ja) * | 2019-01-18 | 2022-03-08 | ニューベイション・バイオ・インコーポレイテッド | アデノシンアンタゴニストとしてのヘテロ環式化合物 |
| US20220143049A1 (en) | 2019-03-21 | 2022-05-12 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| EP4054579A1 (en) | 2019-11-08 | 2022-09-14 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| CN112574192B (zh) * | 2020-12-24 | 2021-10-01 | 烟台大学 | 氨基酸衍生联噻唑-色胺类抗癌化合物和应用 |
| KR20250075302A (ko) * | 2023-11-21 | 2025-05-28 | (주)신테카바이오 | 크레놀라닙 또는 이의 약학적으로 허용 가능한 염을 포함하는 아토피 피부염의 예방 또는 치료용 조성물 |
| KR20250075303A (ko) * | 2023-11-21 | 2025-05-28 | (주)신테카바이오 | 크레놀라닙 또는 이의 약학적으로 허용 가능한 염을 포함하는 건선의 예방 또는 치료용 조성물 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW225528B (https=) * | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
| RU2340611C2 (ru) * | 2000-09-15 | 2008-12-10 | Вертекс Фармасьютикалз Инкорпорейтед | Производные пиразола, используемые в качестве ингибиторов протеинкиназы |
| US20040102455A1 (en) * | 2001-01-30 | 2004-05-27 | Burns Christopher John | Method of inhibiting kinases |
| AUPS251502A0 (en) * | 2002-05-23 | 2002-06-13 | Cytopia Pty Ltd | Protein kinase inhibitors |
| DE60317198T2 (de) * | 2002-05-23 | 2008-12-04 | Cytopia Research Pty. Ltd., Richmond | Proteinkinaseinhibitoren |
| GB2400101A (en) * | 2003-03-28 | 2004-10-06 | Biofocus Discovery Ltd | Compounds capable of binding to the active site of protein kinases |
| US7563748B2 (en) | 2003-06-23 | 2009-07-21 | Cognis Ip Management Gmbh | Alcohol alkoxylate carriers for pesticide active ingredients |
| AU2004278382B2 (en) * | 2003-09-30 | 2008-09-18 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| WO2005058876A1 (en) | 2003-12-16 | 2005-06-30 | Gpc Biotech Ag | Pyrazine derivatives as effective compounds against infectious diseases |
| ATE458730T1 (de) | 2004-04-13 | 2010-03-15 | Icagen Inc | Polycyclische pyrazine als kaliumionenkanal- modulatoren |
| RU2346996C2 (ru) | 2004-06-29 | 2009-02-20 | ЮРОПИЭН НИКЕЛЬ ПиЭлСи | Усовершенствованное выщелачивание основных металлов |
| GB0428082D0 (en) * | 2004-12-22 | 2005-01-26 | Welcome Trust The Ltd | Therapeutic compounds |
| TW200801513A (en) | 2006-06-29 | 2008-01-01 | Fermiscan Australia Pty Ltd | Improved process |
| JP5252404B2 (ja) | 2006-08-16 | 2013-07-31 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ピラジン化合物、その使用及び調製方法 |
| DK2848610T3 (da) * | 2006-11-15 | 2017-11-06 | Ym Biosciences Australia Pty | Hæmmere af kinaseaktivitet |
| KR101599082B1 (ko) * | 2008-02-01 | 2016-03-02 | 어키니언 파마슈티칼스 아베 | 피라진 유도체 및 단백질 키나아제 억제제로서의 이의 용도 |
-
2009
- 2009-01-28 KR KR1020107017417A patent/KR101599082B1/ko not_active Expired - Fee Related
- 2009-01-28 AU AU2009209633A patent/AU2009209633C1/en not_active Ceased
- 2009-01-28 EP EP13182880.8A patent/EP2671876A3/en not_active Withdrawn
- 2009-01-28 DK DK09706385.3T patent/DK2252597T3/da active
- 2009-01-28 MX MX2010007973A patent/MX2010007973A/es active IP Right Grant
- 2009-01-28 PL PL09706385T patent/PL2252597T3/pl unknown
- 2009-01-28 BR BRPI0907453-8A patent/BRPI0907453A2/pt not_active Application Discontinuation
- 2009-01-28 WO PCT/EP2009/050931 patent/WO2009095399A2/en not_active Ceased
- 2009-01-28 CA CA2713553A patent/CA2713553A1/en not_active Abandoned
- 2009-01-28 JP JP2010544683A patent/JP5562256B2/ja not_active Expired - Fee Related
- 2009-01-28 US US12/865,359 patent/US8436171B2/en not_active Expired - Fee Related
- 2009-01-28 CN CN2009801038291A patent/CN101970418B/zh not_active Expired - Fee Related
- 2009-01-28 HR HRP20140547AT patent/HRP20140547T1/hr unknown
- 2009-01-28 PT PT97063853T patent/PT2252597E/pt unknown
- 2009-01-28 SI SI200930949T patent/SI2252597T1/sl unknown
- 2009-01-28 RU RU2010136653/04A patent/RU2493152C2/ru not_active IP Right Cessation
- 2009-01-28 ES ES09706385.3T patent/ES2459297T3/es active Active
- 2009-01-28 EP EP09706385.3A patent/EP2252597B1/en active Active
-
2013
- 2013-03-15 US US13/833,231 patent/US20130203774A1/en not_active Abandoned
-
2014
- 2014-04-04 JP JP2014077470A patent/JP2014148522A/ja active Pending
- 2014-06-17 CY CY20141100435T patent/CY1115400T1/el unknown
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