JP2011510632A5 - - Google Patents
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- JP2011510632A5 JP2011510632A5 JP2010544476A JP2010544476A JP2011510632A5 JP 2011510632 A5 JP2011510632 A5 JP 2011510632A5 JP 2010544476 A JP2010544476 A JP 2010544476A JP 2010544476 A JP2010544476 A JP 2010544476A JP 2011510632 A5 JP2011510632 A5 JP 2011510632A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- cancer
- chain variable
- variable region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2395808P | 2008-01-28 | 2008-01-28 | |
| US61/023,958 | 2008-01-28 | ||
| US10006308P | 2008-09-25 | 2008-09-25 | |
| US61/100,063 | 2008-09-25 | ||
| US14277809P | 2009-01-06 | 2009-01-06 | |
| US61/142,778 | 2009-01-06 | ||
| PCT/US2009/032224 WO2009097325A1 (en) | 2008-01-28 | 2009-01-28 | Stabilized angiopoietin-2 antibodies and uses thereof |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014009633A Division JP2014128271A (ja) | 2008-01-28 | 2014-01-22 | 安定化アンジオポエチン2抗体とその用途 |
| JP2014161003A Division JP2015038067A (ja) | 2008-01-28 | 2014-08-07 | 安定化アンジオポエチン2抗体とその用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011510632A JP2011510632A (ja) | 2011-04-07 |
| JP2011510632A5 true JP2011510632A5 (https=) | 2012-03-15 |
| JP5596559B2 JP5596559B2 (ja) | 2014-09-24 |
Family
ID=40913201
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010544476A Expired - Fee Related JP5596559B2 (ja) | 2008-01-28 | 2009-01-28 | 安定化アンジオポエチン2抗体とその用途 |
| JP2014009633A Pending JP2014128271A (ja) | 2008-01-28 | 2014-01-22 | 安定化アンジオポエチン2抗体とその用途 |
| JP2014161003A Pending JP2015038067A (ja) | 2008-01-28 | 2014-08-07 | 安定化アンジオポエチン2抗体とその用途 |
| JP2016220483A Expired - Fee Related JP6335249B2 (ja) | 2008-01-28 | 2016-11-11 | 安定化アンジオポエチン2抗体とその用途 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014009633A Pending JP2014128271A (ja) | 2008-01-28 | 2014-01-22 | 安定化アンジオポエチン2抗体とその用途 |
| JP2014161003A Pending JP2015038067A (ja) | 2008-01-28 | 2014-08-07 | 安定化アンジオポエチン2抗体とその用途 |
| JP2016220483A Expired - Fee Related JP6335249B2 (ja) | 2008-01-28 | 2016-11-11 | 安定化アンジオポエチン2抗体とその用途 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US8507656B2 (https=) |
| EP (1) | EP2247305A4 (https=) |
| JP (4) | JP5596559B2 (https=) |
| AU (1) | AU2009209251B8 (https=) |
| CA (1) | CA2712000A1 (https=) |
| MX (1) | MX2010008099A (https=) |
| RU (1) | RU2509085C2 (https=) |
| WO (1) | WO2009097325A1 (https=) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10254601A1 (de) | 2002-11-22 | 2004-06-03 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
| ZA200705695B (en) * | 2004-12-21 | 2009-02-25 | Astrazeneca Ab | Antibodies directed to angiopoietin-2 and uses thereof |
| US8557242B2 (en) | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | ERBB2 antibodies comprising modular recognition domains |
| US8454960B2 (en) | 2008-01-03 | 2013-06-04 | The Scripps Research Institute | Multispecific antibody targeting and multivalency through modular recognition domains |
| US8557243B2 (en) | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | EFGR antibodies comprising modular recognition domains |
| US8574577B2 (en) | 2008-01-03 | 2013-11-05 | The Scripps Research Institute | VEGF antibodies comprising modular recognition domains |
| KR101658247B1 (ko) | 2008-01-03 | 2016-09-22 | 더 스크립스 리서치 인스티튜트 | 모듈 인식 도메인을 통한 항체 표적화 |
| MX2010008099A (es) * | 2008-01-28 | 2010-08-04 | Medimmune Ltd | Anticuerpos y angiopoyetina-2 estabilizados y sus usos. |
| JP2011520804A (ja) * | 2008-05-07 | 2011-07-21 | アストラゼネカ アクチボラグ | 化合物 |
| US8177749B2 (en) | 2008-05-20 | 2012-05-15 | Avant Medical Corp. | Cassette for a hidden injection needle |
| US8052645B2 (en) | 2008-07-23 | 2011-11-08 | Avant Medical Corp. | System and method for an injection using a syringe needle |
| US9974904B2 (en) | 2008-05-20 | 2018-05-22 | Avant Medical Corp. | Autoinjector system |
| US8133979B2 (en) * | 2008-12-16 | 2012-03-13 | Hoffmann-La Roche Inc. | Antibodies against human angiopoietin 2 |
| US20120189635A1 (en) | 2009-07-29 | 2012-07-26 | Regeneron Pharmaceuticals, Inc. | Methods for Treating or Preventing Malaria by Administering an Antibody that Specifically Binds Angiopoietin-2 (Ang-2) |
| JO3182B1 (ar) | 2009-07-29 | 2018-03-08 | Regeneron Pharma | مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2 |
| US8980268B2 (en) | 2009-07-29 | 2015-03-17 | Regeneron Pharamceuticals, Inc. | Methods for treating cancer by administering an anti-Ang-2 antibody |
| JP5898082B2 (ja) * | 2009-10-07 | 2016-04-06 | マクロジェニクス,インコーポレーテッド | フコシル化程度の変更により改良されたエフェクター機能を示すFc領域含有ポリペプチドおよびその使用法 |
| KR101688522B1 (ko) | 2009-12-15 | 2016-12-21 | 삼성전자주식회사 | 안지오포이에틴-2에 특이적으로 결합하는 항체 및 그의 용도 |
| EP2542696B1 (en) | 2010-03-01 | 2016-09-28 | Caris Life Sciences Switzerland Holdings GmbH | Biomarkers for theranostics |
| JP2013526852A (ja) | 2010-04-06 | 2013-06-27 | カリス ライフ サイエンシズ ルクセンブルク ホールディングス | 疾患に対する循環バイオマーカー |
| CA2797247C (en) * | 2010-04-28 | 2019-10-22 | Sunnybrook Health Sciences Centre | Methods and uses of tie2 binding and/or activating agents |
| WO2012009705A1 (en) | 2010-07-15 | 2012-01-19 | Zyngenia, Inc. | Ang-2 binding complexes and uses thereof |
| US9512220B2 (en) | 2011-04-05 | 2016-12-06 | Neopharm Co., Ltd. | Antibodies against angiopoietins 1 and 2, and their use |
| HUE042822T2 (hu) * | 2011-04-20 | 2019-07-29 | Amgen Inc | Automata befecskendezõ szerkezet |
| EP2714738B1 (en) | 2011-05-24 | 2018-10-10 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
| KR102063028B1 (ko) * | 2012-01-23 | 2020-01-07 | 리제너론 파아마슈티컬스, 인크. | 항-ang2 항체를 함유하는 안정화된 제형 |
| US20150044227A1 (en) * | 2012-03-08 | 2015-02-12 | Medimmune, Llc | Methods of treatment with angiopoietin-2 antibodies |
| USD808010S1 (en) | 2012-04-20 | 2018-01-16 | Amgen Inc. | Injection device |
| USD898908S1 (en) | 2012-04-20 | 2020-10-13 | Amgen Inc. | Pharmaceutical product cassette for an injection device |
| WO2013174403A1 (en) * | 2012-05-23 | 2013-11-28 | Ganymed Pharmaceuticals Ag | Combination therapy involving antibodies against claudin 18.2 for treatment of cancer |
| WO2013174404A1 (en) * | 2012-05-23 | 2013-11-28 | Ganymed Pharmaceuticals Ag | Combination therapy involving antibodies against claudin 18.2 for treatment of cancer |
| CN104736174B (zh) * | 2012-07-06 | 2019-06-14 | 根马布私人有限公司 | 具有三重突变的二聚体蛋白质 |
| SG11201408538PA (en) | 2012-07-13 | 2015-02-27 | Roche Glycart Ag | Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases |
| JP6499079B2 (ja) | 2012-11-13 | 2019-04-10 | バイオエヌテック アーゲーBioNTech AG | クローディンを発現するガン疾患を処置するための剤 |
| SG11201504023SA (en) * | 2012-12-03 | 2015-06-29 | Almac Diagnostics Ltd | Molecular diagnostic test for cancer |
| CA2895198A1 (en) * | 2012-12-20 | 2014-06-26 | Medimmune, Llc | Liquid antibody formulation with improved aggregation properties |
| US10150800B2 (en) | 2013-03-15 | 2018-12-11 | Zyngenia, Inc. | EGFR-binding modular recognition domains |
| JP6336564B2 (ja) | 2013-03-15 | 2018-06-06 | アムゲン・インコーポレーテッド | 薬物カセット、自動注入器、および自動注入器システム |
| TWI614041B (zh) | 2013-03-15 | 2018-02-11 | 安美基公司 | 用於注射器之匣盒 |
| KR102060540B1 (ko) | 2013-04-03 | 2019-12-31 | 삼성전자주식회사 | 항 c-Met 항체 및 항 Ang2 항체를 포함하는 병용 투여용 약학 조성물 |
| CA2909080C (en) | 2013-04-11 | 2022-07-26 | Sunnybrook Research Institute | Methods, uses and compositions of tie2 agonists |
| KR102131371B1 (ko) * | 2013-07-02 | 2020-07-08 | 삼성전자주식회사 | Ang-2 특이적 항체 및 그의 용도 |
| US9828422B2 (en) * | 2013-07-29 | 2017-11-28 | Samsung Electronics Co., Ltd. | Anti-Ang2 antibody |
| KR102196450B1 (ko) * | 2013-09-17 | 2020-12-30 | 삼성전자주식회사 | Tie2와 결합을 유도하는 항 Ang2 항체를 포함하는 항암제 |
| KR102206029B1 (ko) | 2014-01-27 | 2021-01-20 | 삼성전자주식회사 | Ang-2에 특이적으로 결합하는 항체 및 그의 용도 |
| RU2016147521A (ru) * | 2014-05-07 | 2018-06-09 | МЕДИММЬЮН, ЭлЭлСи | Способы применения антител к ang2 |
| AR100270A1 (es) | 2014-05-19 | 2016-09-21 | Lilly Co Eli | Anticuerpos ang2 |
| AU2015331602A1 (en) | 2014-10-17 | 2017-04-27 | Amgen Inc. | Antibodies directed to angiopoietin-1 and angiopoietin-2 for ocular therapies |
| EP3383435A4 (en) | 2015-11-30 | 2019-07-10 | Medimmune, LLC | OPTIMIZED RATES OF AMINO ACIDS AND SUGARS AS AMORPHOUS STABILIZING COMPOUNDS IN PHARMACEUTICAL COMPOSITIONS HAVING HIGH CONCENTRATIONS IN PROTEIN-BASED THERAPEUTICS |
| US10836819B2 (en) | 2016-08-23 | 2020-11-17 | Medimmune Limited | Anti-VEGF-A and anti-ANG2 antibodies and uses thereof |
| WO2018093591A1 (en) | 2016-11-03 | 2018-05-24 | Juno Therapeutics, Inc. | Combination therapy of a cell based therapy and a microglia inhibitor |
| WO2018114728A1 (en) | 2016-12-20 | 2018-06-28 | F. Hoffmann-La Roche Ag | Combination therapy with a bispecific anti-ang2/vegf antibody and a bispecific anti-her2 antibody |
| KR102589422B1 (ko) * | 2017-01-09 | 2023-10-13 | 바이오뮤넥스 파마슈티컬스 | 다중특이적 항체를 제조하기 위한 폴리펩티드 링커 |
| AU2018275894B2 (en) | 2017-06-02 | 2025-04-24 | Juno Therapeutics, Inc. | Articles of manufacture and methods for treatment using adoptive cell therapy |
| MA48781A (fr) | 2017-06-02 | 2020-04-08 | Juno Therapeutics Inc | Articles de fabrication et procédés liés à la toxicité associée à la thérapie cellulaire |
| JP2020526194A (ja) | 2017-06-29 | 2020-08-31 | ジュノー セラピューティクス インコーポレイテッド | 免疫療法薬と関連する毒性を評価するためのマウスモデル |
| WO2019046832A1 (en) | 2017-09-01 | 2019-03-07 | Juno Therapeutics, Inc. | GENE EXPRESSION AND EVALUATION OF RISK OF DEVELOPMENT OF TOXICITY FOLLOWING CELL THERAPY |
| US11564946B2 (en) | 2017-11-01 | 2023-01-31 | Juno Therapeutics, Inc. | Methods associated with tumor burden for assessing response to a cell therapy |
| MY195550A (en) | 2018-10-29 | 2023-01-31 | Hoffmann La Roche | Antibody Formulation |
| PT3886875T (pt) | 2018-11-30 | 2024-06-27 | Juno Therapeutics Inc | Métodos para tratamento utilizando terapia celular adotiva |
| CN113692285A (zh) | 2018-11-30 | 2021-11-23 | 朱诺治疗学股份有限公司 | 在过继细胞疗法中给药和治疗b细胞恶性肿瘤的方法 |
| TWI877179B (zh) * | 2019-06-27 | 2025-03-21 | 德商百靈佳殷格翰國際股份有限公司 | 抗-angpt2抗體 |
| MX2022006715A (es) | 2019-12-06 | 2022-09-23 | Juno Therapeutics Inc | Metodos relacionados con toxicidad y respuesta asociada con terapia celular para tratar neoplasias malignas de celulas b. |
| CN113087696A (zh) * | 2019-12-23 | 2021-07-09 | 江苏开元药业有限公司 | 喹啉类化合物及其应用 |
| WO2021236658A1 (en) | 2020-05-19 | 2021-11-25 | Boehringer Ingelheim International Gmbh | Binding molecules for the treatment of cancer |
| US20230312698A1 (en) * | 2020-08-07 | 2023-10-05 | Nanjing GenScript Biotech Co., Ltd. | Antibodies against human angiopoietin-2 and uses thereof |
| WO2024077286A2 (en) * | 2022-10-07 | 2024-04-11 | The Regents Of The University Of California | Compositions and methods for detection and treatment of prostate cancer |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5814464A (en) | 1994-10-07 | 1998-09-29 | Regeneron Pharma | Nucleic acids encoding TIE-2 ligand-2 |
| US5650490A (en) | 1994-10-07 | 1997-07-22 | Regeneron Pharmaceuticals, Inc. | Tie-2 ligand 2 |
| JP4122056B2 (ja) | 1995-04-06 | 2008-07-23 | リジエネロン ファーマシューティカルズ,インコーポレイテッド | Tie−2リガンド、その作製方法および使用方法 |
| RU2242514C2 (ru) * | 1996-07-02 | 2004-12-20 | Ридженерон Фармасьютикалз, Инк. | Изолированный tie-лиганд-4 и его изолированный фибриногеноподобный домен; изолированная молекула нуклеиновой кислоты, кодирующая указанный лиганд; вектор, содержащий указанную нуклеиновую кислоту; способ получения клетки-хозяина, трансформированной указанным вектором; способ получения tie-лиганда-4; конъюгат, содержащий указанный лиганд; лиганд-тело, содержащее указанный фибриногеноподобный домен |
| US6455035B1 (en) | 1999-03-26 | 2002-09-24 | Regeneron Pharmaceuticals, Inc. | Angiopoietins and methods of use thereof |
| ATE241380T1 (de) | 1999-03-26 | 2003-06-15 | Regeneron Pharma | Modulierung der gefässepermeabilität mittels tie2 rezeptoraktivatoren |
| US6521424B2 (en) | 1999-06-07 | 2003-02-18 | Immunex Corporation | Recombinant expression of Tek antagonists |
| ATE324444T1 (de) | 1999-06-07 | 2006-05-15 | Immunex Corp | Tek-antagonisten |
| US6808902B1 (en) * | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
| US7642278B2 (en) * | 2001-07-03 | 2010-01-05 | Novartis Vaccines And Diagnostics, Inc. | Indazole benzimidazole compounds |
| US7658924B2 (en) * | 2001-10-11 | 2010-02-09 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| US7521053B2 (en) * | 2001-10-11 | 2009-04-21 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| US7205275B2 (en) | 2001-10-11 | 2007-04-17 | Amgen Inc. | Methods of treatment using specific binding agents of human angiopoietin-2 |
| US7485297B2 (en) | 2003-08-12 | 2009-02-03 | Dyax Corp. | Method of inhibition of vascular development using an antibody |
| ZA200705695B (en) * | 2004-12-21 | 2009-02-25 | Astrazeneca Ab | Antibodies directed to angiopoietin-2 and uses thereof |
| NZ566774A (en) * | 2005-09-07 | 2011-11-25 | Pfizer | Human monoclonal antibodies to activin receptor-like kinase-1 |
| US20070136096A1 (en) | 2005-12-12 | 2007-06-14 | Okalebo Lorna I | Systems and methods for maintaining and accessing medical information |
| EP1962903B1 (en) * | 2005-12-15 | 2013-03-13 | MedImmune Limited | Combination of angiopoietin-2 antagonist and of vegf-a, kdr and/or fltl antagonist for treating cancer |
| CA2646508A1 (en) * | 2006-03-17 | 2007-09-27 | Biogen Idec Ma Inc. | Stabilized polypeptide compositions |
| TW200812616A (en) * | 2006-05-09 | 2008-03-16 | Genentech Inc | Binding polypeptides with optimized scaffolds |
| JP5220131B2 (ja) | 2008-01-28 | 2013-06-26 | リサーチ イン モーション リミテッド | セッション開始プロトコルのリクエストコンテンツを提供する方法およびシステム |
| MX2010008099A (es) * | 2008-01-28 | 2010-08-04 | Medimmune Ltd | Anticuerpos y angiopoyetina-2 estabilizados y sus usos. |
| JO3182B1 (ar) | 2009-07-29 | 2018-03-08 | Regeneron Pharma | مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2 |
-
2009
- 2009-01-28 MX MX2010008099A patent/MX2010008099A/es active IP Right Grant
- 2009-01-28 CA CA2712000A patent/CA2712000A1/en not_active Abandoned
- 2009-01-28 RU RU2010135624/10A patent/RU2509085C2/ru not_active IP Right Cessation
- 2009-01-28 WO PCT/US2009/032224 patent/WO2009097325A1/en not_active Ceased
- 2009-01-28 EP EP09706411A patent/EP2247305A4/en not_active Ceased
- 2009-01-28 AU AU2009209251A patent/AU2009209251B8/en not_active Ceased
- 2009-01-28 JP JP2010544476A patent/JP5596559B2/ja not_active Expired - Fee Related
- 2009-01-28 US US12/864,544 patent/US8507656B2/en not_active Expired - Fee Related
-
2013
- 2013-07-01 US US13/932,485 patent/US20130280251A1/en not_active Abandoned
-
2014
- 2014-01-22 JP JP2014009633A patent/JP2014128271A/ja active Pending
- 2014-08-07 JP JP2014161003A patent/JP2015038067A/ja active Pending
-
2016
- 2016-10-27 US US15/335,610 patent/US10329345B2/en not_active Expired - Fee Related
- 2016-11-11 JP JP2016220483A patent/JP6335249B2/ja not_active Expired - Fee Related
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