JP2011510632A5 - - Google Patents
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- JP2011510632A5 JP2011510632A5 JP2010544476A JP2010544476A JP2011510632A5 JP 2011510632 A5 JP2011510632 A5 JP 2011510632A5 JP 2010544476 A JP2010544476 A JP 2010544476A JP 2010544476 A JP2010544476 A JP 2010544476A JP 2011510632 A5 JP2011510632 A5 JP 2011510632A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- cancer
- chain variable
- variable region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2395808P | 2008-01-28 | 2008-01-28 | |
| US61/023,958 | 2008-01-28 | ||
| US10006308P | 2008-09-25 | 2008-09-25 | |
| US61/100,063 | 2008-09-25 | ||
| US14277809P | 2009-01-06 | 2009-01-06 | |
| US61/142,778 | 2009-01-06 | ||
| PCT/US2009/032224 WO2009097325A1 (en) | 2008-01-28 | 2009-01-28 | Stabilized angiopoietin-2 antibodies and uses thereof |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014009633A Division JP2014128271A (ja) | 2008-01-28 | 2014-01-22 | 安定化アンジオポエチン2抗体とその用途 |
| JP2014161003A Division JP2015038067A (ja) | 2008-01-28 | 2014-08-07 | 安定化アンジオポエチン2抗体とその用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011510632A JP2011510632A (ja) | 2011-04-07 |
| JP2011510632A5 true JP2011510632A5 (https=) | 2012-03-15 |
| JP5596559B2 JP5596559B2 (ja) | 2014-09-24 |
Family
ID=40913201
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010544476A Expired - Fee Related JP5596559B2 (ja) | 2008-01-28 | 2009-01-28 | 安定化アンジオポエチン2抗体とその用途 |
| JP2014009633A Pending JP2014128271A (ja) | 2008-01-28 | 2014-01-22 | 安定化アンジオポエチン2抗体とその用途 |
| JP2014161003A Pending JP2015038067A (ja) | 2008-01-28 | 2014-08-07 | 安定化アンジオポエチン2抗体とその用途 |
| JP2016220483A Expired - Fee Related JP6335249B2 (ja) | 2008-01-28 | 2016-11-11 | 安定化アンジオポエチン2抗体とその用途 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014009633A Pending JP2014128271A (ja) | 2008-01-28 | 2014-01-22 | 安定化アンジオポエチン2抗体とその用途 |
| JP2014161003A Pending JP2015038067A (ja) | 2008-01-28 | 2014-08-07 | 安定化アンジオポエチン2抗体とその用途 |
| JP2016220483A Expired - Fee Related JP6335249B2 (ja) | 2008-01-28 | 2016-11-11 | 安定化アンジオポエチン2抗体とその用途 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US8507656B2 (https=) |
| EP (1) | EP2247305A4 (https=) |
| JP (4) | JP5596559B2 (https=) |
| AU (1) | AU2009209251B8 (https=) |
| CA (1) | CA2712000A1 (https=) |
| MX (1) | MX2010008099A (https=) |
| RU (1) | RU2509085C2 (https=) |
| WO (1) | WO2009097325A1 (https=) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10254601A1 (de) | 2002-11-22 | 2004-06-03 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
| BRPI0519596B1 (pt) * | 2004-12-21 | 2022-01-18 | Astrazeneca Ab | Agente de ligação alvejado, anticorpo monoclonal que se liga a angiopoietina-2, molécula de ácido nucleico, vetor, e, uso do agente de ligação alvejado |
| US8574577B2 (en) | 2008-01-03 | 2013-11-05 | The Scripps Research Institute | VEGF antibodies comprising modular recognition domains |
| CA2711256C (en) | 2008-01-03 | 2019-01-15 | The Scripps Research Institute | Antibody targeting through a modular recognition domain |
| US8557243B2 (en) | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | EFGR antibodies comprising modular recognition domains |
| US8557242B2 (en) | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | ERBB2 antibodies comprising modular recognition domains |
| US8454960B2 (en) | 2008-01-03 | 2013-06-04 | The Scripps Research Institute | Multispecific antibody targeting and multivalency through modular recognition domains |
| AU2009209251B8 (en) * | 2008-01-28 | 2015-03-26 | Medimmune Limited | Stabilized Angiopoietin-2 antibodies and uses thereof |
| JP2011520804A (ja) * | 2008-05-07 | 2011-07-21 | アストラゼネカ アクチボラグ | 化合物 |
| US8177749B2 (en) | 2008-05-20 | 2012-05-15 | Avant Medical Corp. | Cassette for a hidden injection needle |
| US8052645B2 (en) | 2008-07-23 | 2011-11-08 | Avant Medical Corp. | System and method for an injection using a syringe needle |
| EP2276527B1 (en) * | 2008-05-20 | 2018-02-28 | Avant Medical Corp. | Autoinjector system |
| WO2011109440A1 (en) | 2010-03-01 | 2011-09-09 | Caris Life Sciences Luxembourg Holdings | Biomarkers for theranostics |
| US8133979B2 (en) * | 2008-12-16 | 2012-03-13 | Hoffmann-La Roche Inc. | Antibodies against human angiopoietin 2 |
| US8980268B2 (en) | 2009-07-29 | 2015-03-17 | Regeneron Pharamceuticals, Inc. | Methods for treating cancer by administering an anti-Ang-2 antibody |
| JO3182B1 (ar) | 2009-07-29 | 2018-03-08 | Regeneron Pharma | مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2 |
| US20120189635A1 (en) | 2009-07-29 | 2012-07-26 | Regeneron Pharmaceuticals, Inc. | Methods for Treating or Preventing Malaria by Administering an Antibody that Specifically Binds Angiopoietin-2 (Ang-2) |
| WO2011044368A1 (en) * | 2009-10-07 | 2011-04-14 | Macrogenics, Inc. | Fc region-containing polypeptides that exhibit improved effector function due to alterations of the extent of fucosylation, and methods for their use |
| KR101688522B1 (ko) | 2009-12-15 | 2016-12-21 | 삼성전자주식회사 | 안지오포이에틴-2에 특이적으로 결합하는 항체 및 그의 용도 |
| WO2011127219A1 (en) | 2010-04-06 | 2011-10-13 | Caris Life Sciences Luxembourg Holdings | Circulating biomarkers for disease |
| US9186390B2 (en) * | 2010-04-28 | 2015-11-17 | Sunnybrook Health Sciences Center | Methods and uses of TIE2 binding and/or activating agents |
| US20120100166A1 (en) | 2010-07-15 | 2012-04-26 | Zyngenia, Inc. | Ang-2 Binding Complexes and Uses Thereof |
| US9512220B2 (en) | 2011-04-05 | 2016-12-06 | Neopharm Co., Ltd. | Antibodies against angiopoietins 1 and 2, and their use |
| EP2699293B8 (en) | 2011-04-20 | 2022-07-20 | Amgen Inc. | Autoinjector apparatus |
| EP2714738B1 (en) | 2011-05-24 | 2018-10-10 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
| AU2013212587B2 (en) * | 2012-01-23 | 2017-07-20 | Regeneron Pharmaceuticals, Inc. | Stabilized formulations containing anti-Ang2 antibodies |
| AU2013230750B2 (en) * | 2012-03-08 | 2018-02-01 | Medimmune, Llc | Methods of treatment with Angiopoietin-2 antibodies |
| USD808010S1 (en) | 2012-04-20 | 2018-01-16 | Amgen Inc. | Injection device |
| USD898908S1 (en) | 2012-04-20 | 2020-10-13 | Amgen Inc. | Pharmaceutical product cassette for an injection device |
| WO2013174403A1 (en) * | 2012-05-23 | 2013-11-28 | Ganymed Pharmaceuticals Ag | Combination therapy involving antibodies against claudin 18.2 for treatment of cancer |
| WO2013174404A1 (en) * | 2012-05-23 | 2013-11-28 | Ganymed Pharmaceuticals Ag | Combination therapy involving antibodies against claudin 18.2 for treatment of cancer |
| BR112015000167B1 (pt) * | 2012-07-06 | 2021-11-23 | Genmab B.V. | Proteína dimérica, proteína, composição, kit de partes e seus usos, bem como método para aumentar a oligomerização em solução de uma proteína dimérica compreendendo um primeiro e segundo polipeptídeo, cada um compreendendo pelo menos as regiões ch2 e ch3 de uma cadeia pesada de igg1 humana e proteína dimérica variante |
| LT3495387T (lt) | 2012-07-13 | 2021-11-25 | Roche Glycart Ag | Bispecifiniai anti-vegf / anti-ang-2 antikūnai ir jų panaudojimas akių kraujagyslių ligoms gydyti |
| WO2014075788A1 (en) | 2012-11-13 | 2014-05-22 | Biontech Ag | Agents for treatment of claudin expressing cancer diseases |
| MX2015006955A (es) * | 2012-12-03 | 2016-01-25 | Almac Diagnostics Ltd | Prueba de diagnostico molecular para cancer. |
| US20150344557A1 (en) * | 2012-12-20 | 2015-12-03 | Medlmmune, Llc | Liquid Antibody Formulation With Improved Aggregation Properties |
| CA2904661C (en) | 2013-03-15 | 2022-03-15 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
| BR112015023752B1 (pt) | 2013-03-15 | 2023-11-14 | Zyngenia, Inc. | Domínio de reconhecimento modular (mrd), complexo compreendendo mrd e cetuximabe, usos do complexo para inibir a angiogênese e tratar câncer e composição farmacêutica compreendendo o dito complexo |
| EP2968760B1 (en) | 2013-03-15 | 2024-01-03 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
| KR102060540B1 (ko) | 2013-04-03 | 2019-12-31 | 삼성전자주식회사 | 항 c-Met 항체 및 항 Ang2 항체를 포함하는 병용 투여용 약학 조성물 |
| DK2983695T3 (da) | 2013-04-11 | 2019-09-02 | Sunnybrook Res Inst | Fremgangsmåder, anvendelser og sammensætninger af tie2- agonister |
| KR102131371B1 (ko) * | 2013-07-02 | 2020-07-08 | 삼성전자주식회사 | Ang-2 특이적 항체 및 그의 용도 |
| EP2835380B2 (en) * | 2013-07-29 | 2021-04-07 | Samsung Electronics Co., Ltd | Method of blocking vascular leakage using an anti-Ang2 antibody |
| KR102196450B1 (ko) | 2013-09-17 | 2020-12-30 | 삼성전자주식회사 | Tie2와 결합을 유도하는 항 Ang2 항체를 포함하는 항암제 |
| KR102206029B1 (ko) | 2014-01-27 | 2021-01-20 | 삼성전자주식회사 | Ang-2에 특이적으로 결합하는 항체 및 그의 용도 |
| CA2946906A1 (en) * | 2014-05-07 | 2015-11-12 | Medimmune, Llc | Methods of using anti-ang2 antibodies |
| AR100270A1 (es) | 2014-05-19 | 2016-09-21 | Lilly Co Eli | Anticuerpos ang2 |
| AU2015331602A1 (en) | 2014-10-17 | 2017-04-27 | Amgen Inc. | Antibodies directed to angiopoietin-1 and angiopoietin-2 for ocular therapies |
| JP2018535242A (ja) | 2015-11-30 | 2018-11-29 | メディミューン,エルエルシー | 高濃度のタンパク質ベースの治療剤を含有する医薬組成物中の非晶質安定化化合物としてのアミノ酸と糖との最適比 |
| KR102543878B1 (ko) | 2016-08-23 | 2023-06-14 | 메디뮨 리미티드 | 항-vegf-a 및 항-ang2 항체 및 이의 용도 |
| US20190292246A1 (en) | 2016-11-03 | 2019-09-26 | Juno Therapeutics, Inc. | Combination therapy of a cell based therapy and a microglia imhibitor |
| WO2018114728A1 (en) | 2016-12-20 | 2018-06-28 | F. Hoffmann-La Roche Ag | Combination therapy with a bispecific anti-ang2/vegf antibody and a bispecific anti-her2 antibody |
| JP7612329B2 (ja) * | 2017-01-09 | 2025-01-14 | ビオミューネクス・ファルマシューティカル | 多重特異的抗体を調製するためのポリペプチドリンカー |
| AU2018275894B2 (en) | 2017-06-02 | 2025-04-24 | Juno Therapeutics, Inc. | Articles of manufacture and methods for treatment using adoptive cell therapy |
| CN111201438A (zh) | 2017-06-02 | 2020-05-26 | 朱诺治疗学股份有限公司 | 与和细胞疗法相关的毒性有关的制品和方法 |
| EP3644721A1 (en) | 2017-06-29 | 2020-05-06 | Juno Therapeutics, Inc. | Mouse model for assessing toxicities associated with immunotherapies |
| WO2019046832A1 (en) | 2017-09-01 | 2019-03-07 | Juno Therapeutics, Inc. | GENE EXPRESSION AND EVALUATION OF RISK OF DEVELOPMENT OF TOXICITY FOLLOWING CELL THERAPY |
| US11564946B2 (en) | 2017-11-01 | 2023-01-31 | Juno Therapeutics, Inc. | Methods associated with tumor burden for assessing response to a cell therapy |
| EP3873519A1 (en) | 2018-10-29 | 2021-09-08 | F. Hoffmann-La Roche AG | Antibody formulation |
| PL3886875T3 (pl) | 2018-11-30 | 2024-09-09 | Juno Therapeutics, Inc. | Metody leczenia z wykorzystaniem adoptywnej terapii komórkowej |
| PL3886894T3 (pl) | 2018-11-30 | 2024-07-01 | Juno Therapeutics, Inc. | Metody dawkowania i leczenia nowotworów b-komórkowych w adoptywnej terapii komórkowej |
| TWI877179B (zh) * | 2019-06-27 | 2025-03-21 | 德商百靈佳殷格翰國際股份有限公司 | 抗-angpt2抗體 |
| IL293393A (en) | 2019-12-06 | 2022-07-01 | Juno Therapeutics Inc | Cell therapy-related toxicity and response-related methods for the treatment of b-cell malignancies |
| CN113087696A (zh) * | 2019-12-23 | 2021-07-09 | 江苏开元药业有限公司 | 喹啉类化合物及其应用 |
| KR20230012559A (ko) | 2020-05-19 | 2023-01-26 | 베링거 인겔하임 인터내셔날 게엠베하 | 암 치료를 위한 결합 분자 |
| US20230312698A1 (en) * | 2020-08-07 | 2023-10-05 | Nanjing GenScript Biotech Co., Ltd. | Antibodies against human angiopoietin-2 and uses thereof |
| WO2024077286A2 (en) * | 2022-10-07 | 2024-04-11 | The Regents Of The University Of California | Compositions and methods for detection and treatment of prostate cancer |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5650490A (en) | 1994-10-07 | 1997-07-22 | Regeneron Pharmaceuticals, Inc. | Tie-2 ligand 2 |
| US5814464A (en) | 1994-10-07 | 1998-09-29 | Regeneron Pharma | Nucleic acids encoding TIE-2 ligand-2 |
| WO1996031598A1 (en) | 1995-04-06 | 1996-10-10 | Regeneron Pharmaceuticals, Inc. | Tie-2 ligands, methods of making and uses thereof |
| RU2242514C2 (ru) * | 1996-07-02 | 2004-12-20 | Ридженерон Фармасьютикалз, Инк. | Изолированный tie-лиганд-4 и его изолированный фибриногеноподобный домен; изолированная молекула нуклеиновой кислоты, кодирующая указанный лиганд; вектор, содержащий указанную нуклеиновую кислоту; способ получения клетки-хозяина, трансформированной указанным вектором; способ получения tie-лиганда-4; конъюгат, содержащий указанный лиганд; лиганд-тело, содержащее указанный фибриногеноподобный домен |
| PT1165115E (pt) | 1999-03-26 | 2003-10-31 | Univ California | Modulacao da permeabilidade vascular por meio dos activadores do receptor tie2 |
| US6455035B1 (en) | 1999-03-26 | 2002-09-24 | Regeneron Pharmaceuticals, Inc. | Angiopoietins and methods of use thereof |
| ES2262518T5 (es) | 1999-06-07 | 2009-05-08 | Immunex Corporation | Antagonistas de tek. |
| US6521424B2 (en) | 1999-06-07 | 2003-02-18 | Immunex Corporation | Recombinant expression of Tek antagonists |
| US6808902B1 (en) * | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
| US7642278B2 (en) * | 2001-07-03 | 2010-01-05 | Novartis Vaccines And Diagnostics, Inc. | Indazole benzimidazole compounds |
| US7658924B2 (en) * | 2001-10-11 | 2010-02-09 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| US7205275B2 (en) | 2001-10-11 | 2007-04-17 | Amgen Inc. | Methods of treatment using specific binding agents of human angiopoietin-2 |
| US7521053B2 (en) | 2001-10-11 | 2009-04-21 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| US7485297B2 (en) | 2003-08-12 | 2009-02-03 | Dyax Corp. | Method of inhibition of vascular development using an antibody |
| BRPI0519596B1 (pt) * | 2004-12-21 | 2022-01-18 | Astrazeneca Ab | Agente de ligação alvejado, anticorpo monoclonal que se liga a angiopoietina-2, molécula de ácido nucleico, vetor, e, uso do agente de ligação alvejado |
| CA2621371C (en) * | 2005-09-07 | 2018-05-15 | Amgen Fremont Inc. | Human monoclonal antibodies to activin receptor-like kinase-1 |
| US20070136096A1 (en) | 2005-12-12 | 2007-06-14 | Okalebo Lorna I | Systems and methods for maintaining and accessing medical information |
| CA2633211A1 (en) * | 2005-12-15 | 2007-06-21 | Astrazeneca Ab | Combination of angiopoietin-2 antagonist and of vegf-a, kdr and/or flt1 antagonist for treating cancer |
| KR101516823B1 (ko) * | 2006-03-17 | 2015-05-07 | 바이오겐 아이덱 엠에이 인코포레이티드 | 안정화된 폴리펩티드 조성물 |
| JP2009536527A (ja) * | 2006-05-09 | 2009-10-15 | ジェネンテック・インコーポレーテッド | 最適化されたスキャフォールドを備えた結合ポリペプチド |
| CA2713999C (en) | 2008-01-28 | 2016-03-22 | Research In Motion Limited | Providing session initiation protocol request contents method and system |
| AU2009209251B8 (en) * | 2008-01-28 | 2015-03-26 | Medimmune Limited | Stabilized Angiopoietin-2 antibodies and uses thereof |
| JO3182B1 (ar) | 2009-07-29 | 2018-03-08 | Regeneron Pharma | مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2 |
-
2009
- 2009-01-28 AU AU2009209251A patent/AU2009209251B8/en not_active Ceased
- 2009-01-28 EP EP09706411A patent/EP2247305A4/en not_active Ceased
- 2009-01-28 MX MX2010008099A patent/MX2010008099A/es active IP Right Grant
- 2009-01-28 US US12/864,544 patent/US8507656B2/en not_active Expired - Fee Related
- 2009-01-28 WO PCT/US2009/032224 patent/WO2009097325A1/en not_active Ceased
- 2009-01-28 RU RU2010135624/10A patent/RU2509085C2/ru not_active IP Right Cessation
- 2009-01-28 CA CA2712000A patent/CA2712000A1/en not_active Abandoned
- 2009-01-28 JP JP2010544476A patent/JP5596559B2/ja not_active Expired - Fee Related
-
2013
- 2013-07-01 US US13/932,485 patent/US20130280251A1/en not_active Abandoned
-
2014
- 2014-01-22 JP JP2014009633A patent/JP2014128271A/ja active Pending
- 2014-08-07 JP JP2014161003A patent/JP2015038067A/ja active Pending
-
2016
- 2016-10-27 US US15/335,610 patent/US10329345B2/en not_active Expired - Fee Related
- 2016-11-11 JP JP2016220483A patent/JP6335249B2/ja not_active Expired - Fee Related
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