JP2011510632A5 - - Google Patents

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JP2011510632A5
JP2011510632A5 JP2010544476A JP2010544476A JP2011510632A5 JP 2011510632 A5 JP2011510632 A5 JP 2011510632A5 JP 2010544476 A JP2010544476 A JP 2010544476A JP 2010544476 A JP2010544476 A JP 2010544476A JP 2011510632 A5 JP2011510632 A5 JP 2011510632A5
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seq
antibody
cancer
chain variable
variable region
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JP2010544476A
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Japanese (ja)
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JP2011510632A (ja
JP5596559B2 (ja
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Priority claimed from PCT/US2009/032224 external-priority patent/WO2009097325A1/en
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Publication of JP2011510632A5 publication Critical patent/JP2011510632A5/ja
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JP2010544476A 2008-01-28 2009-01-28 安定化アンジオポエチン2抗体とその用途 Expired - Fee Related JP5596559B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US2395808P 2008-01-28 2008-01-28
US61/023,958 2008-01-28
US10006308P 2008-09-25 2008-09-25
US61/100,063 2008-09-25
US14277809P 2009-01-06 2009-01-06
US61/142,778 2009-01-06
PCT/US2009/032224 WO2009097325A1 (en) 2008-01-28 2009-01-28 Stabilized angiopoietin-2 antibodies and uses thereof

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2014009633A Division JP2014128271A (ja) 2008-01-28 2014-01-22 安定化アンジオポエチン2抗体とその用途
JP2014161003A Division JP2015038067A (ja) 2008-01-28 2014-08-07 安定化アンジオポエチン2抗体とその用途

Publications (3)

Publication Number Publication Date
JP2011510632A JP2011510632A (ja) 2011-04-07
JP2011510632A5 true JP2011510632A5 (https=) 2012-03-15
JP5596559B2 JP5596559B2 (ja) 2014-09-24

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ID=40913201

Family Applications (4)

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JP2010544476A Expired - Fee Related JP5596559B2 (ja) 2008-01-28 2009-01-28 安定化アンジオポエチン2抗体とその用途
JP2014009633A Pending JP2014128271A (ja) 2008-01-28 2014-01-22 安定化アンジオポエチン2抗体とその用途
JP2014161003A Pending JP2015038067A (ja) 2008-01-28 2014-08-07 安定化アンジオポエチン2抗体とその用途
JP2016220483A Expired - Fee Related JP6335249B2 (ja) 2008-01-28 2016-11-11 安定化アンジオポエチン2抗体とその用途

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2014009633A Pending JP2014128271A (ja) 2008-01-28 2014-01-22 安定化アンジオポエチン2抗体とその用途
JP2014161003A Pending JP2015038067A (ja) 2008-01-28 2014-08-07 安定化アンジオポエチン2抗体とその用途
JP2016220483A Expired - Fee Related JP6335249B2 (ja) 2008-01-28 2016-11-11 安定化アンジオポエチン2抗体とその用途

Country Status (8)

Country Link
US (3) US8507656B2 (https=)
EP (1) EP2247305A4 (https=)
JP (4) JP5596559B2 (https=)
AU (1) AU2009209251B8 (https=)
CA (1) CA2712000A1 (https=)
MX (1) MX2010008099A (https=)
RU (1) RU2509085C2 (https=)
WO (1) WO2009097325A1 (https=)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10254601A1 (de) 2002-11-22 2004-06-03 Ganymed Pharmaceuticals Ag Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
ZA200705695B (en) * 2004-12-21 2009-02-25 Astrazeneca Ab Antibodies directed to angiopoietin-2 and uses thereof
US8557242B2 (en) 2008-01-03 2013-10-15 The Scripps Research Institute ERBB2 antibodies comprising modular recognition domains
US8454960B2 (en) 2008-01-03 2013-06-04 The Scripps Research Institute Multispecific antibody targeting and multivalency through modular recognition domains
US8557243B2 (en) 2008-01-03 2013-10-15 The Scripps Research Institute EFGR antibodies comprising modular recognition domains
US8574577B2 (en) 2008-01-03 2013-11-05 The Scripps Research Institute VEGF antibodies comprising modular recognition domains
KR101658247B1 (ko) 2008-01-03 2016-09-22 더 스크립스 리서치 인스티튜트 모듈 인식 도메인을 통한 항체 표적화
MX2010008099A (es) * 2008-01-28 2010-08-04 Medimmune Ltd Anticuerpos y angiopoyetina-2 estabilizados y sus usos.
JP2011520804A (ja) * 2008-05-07 2011-07-21 アストラゼネカ アクチボラグ 化合物
US8177749B2 (en) 2008-05-20 2012-05-15 Avant Medical Corp. Cassette for a hidden injection needle
US8052645B2 (en) 2008-07-23 2011-11-08 Avant Medical Corp. System and method for an injection using a syringe needle
US9974904B2 (en) 2008-05-20 2018-05-22 Avant Medical Corp. Autoinjector system
US8133979B2 (en) * 2008-12-16 2012-03-13 Hoffmann-La Roche Inc. Antibodies against human angiopoietin 2
US20120189635A1 (en) 2009-07-29 2012-07-26 Regeneron Pharmaceuticals, Inc. Methods for Treating or Preventing Malaria by Administering an Antibody that Specifically Binds Angiopoietin-2 (Ang-2)
JO3182B1 (ar) 2009-07-29 2018-03-08 Regeneron Pharma مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2
US8980268B2 (en) 2009-07-29 2015-03-17 Regeneron Pharamceuticals, Inc. Methods for treating cancer by administering an anti-Ang-2 antibody
JP5898082B2 (ja) * 2009-10-07 2016-04-06 マクロジェニクス,インコーポレーテッド フコシル化程度の変更により改良されたエフェクター機能を示すFc領域含有ポリペプチドおよびその使用法
KR101688522B1 (ko) 2009-12-15 2016-12-21 삼성전자주식회사 안지오포이에틴-2에 특이적으로 결합하는 항체 및 그의 용도
EP2542696B1 (en) 2010-03-01 2016-09-28 Caris Life Sciences Switzerland Holdings GmbH Biomarkers for theranostics
JP2013526852A (ja) 2010-04-06 2013-06-27 カリス ライフ サイエンシズ ルクセンブルク ホールディングス 疾患に対する循環バイオマーカー
CA2797247C (en) * 2010-04-28 2019-10-22 Sunnybrook Health Sciences Centre Methods and uses of tie2 binding and/or activating agents
WO2012009705A1 (en) 2010-07-15 2012-01-19 Zyngenia, Inc. Ang-2 binding complexes and uses thereof
US9512220B2 (en) 2011-04-05 2016-12-06 Neopharm Co., Ltd. Antibodies against angiopoietins 1 and 2, and their use
HUE042822T2 (hu) * 2011-04-20 2019-07-29 Amgen Inc Automata befecskendezõ szerkezet
EP2714738B1 (en) 2011-05-24 2018-10-10 Zyngenia, Inc. Multivalent and monovalent multispecific complexes and their uses
KR102063028B1 (ko) * 2012-01-23 2020-01-07 리제너론 파아마슈티컬스, 인크. 항-ang2 항체를 함유하는 안정화된 제형
US20150044227A1 (en) * 2012-03-08 2015-02-12 Medimmune, Llc Methods of treatment with angiopoietin-2 antibodies
USD808010S1 (en) 2012-04-20 2018-01-16 Amgen Inc. Injection device
USD898908S1 (en) 2012-04-20 2020-10-13 Amgen Inc. Pharmaceutical product cassette for an injection device
WO2013174403A1 (en) * 2012-05-23 2013-11-28 Ganymed Pharmaceuticals Ag Combination therapy involving antibodies against claudin 18.2 for treatment of cancer
WO2013174404A1 (en) * 2012-05-23 2013-11-28 Ganymed Pharmaceuticals Ag Combination therapy involving antibodies against claudin 18.2 for treatment of cancer
CN104736174B (zh) * 2012-07-06 2019-06-14 根马布私人有限公司 具有三重突变的二聚体蛋白质
SG11201408538PA (en) 2012-07-13 2015-02-27 Roche Glycart Ag Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases
JP6499079B2 (ja) 2012-11-13 2019-04-10 バイオエヌテック アーゲーBioNTech AG クローディンを発現するガン疾患を処置するための剤
SG11201504023SA (en) * 2012-12-03 2015-06-29 Almac Diagnostics Ltd Molecular diagnostic test for cancer
CA2895198A1 (en) * 2012-12-20 2014-06-26 Medimmune, Llc Liquid antibody formulation with improved aggregation properties
US10150800B2 (en) 2013-03-15 2018-12-11 Zyngenia, Inc. EGFR-binding modular recognition domains
JP6336564B2 (ja) 2013-03-15 2018-06-06 アムゲン・インコーポレーテッド 薬物カセット、自動注入器、および自動注入器システム
TWI614041B (zh) 2013-03-15 2018-02-11 安美基公司 用於注射器之匣盒
KR102060540B1 (ko) 2013-04-03 2019-12-31 삼성전자주식회사 항 c-Met 항체 및 항 Ang2 항체를 포함하는 병용 투여용 약학 조성물
CA2909080C (en) 2013-04-11 2022-07-26 Sunnybrook Research Institute Methods, uses and compositions of tie2 agonists
KR102131371B1 (ko) * 2013-07-02 2020-07-08 삼성전자주식회사 Ang-2 특이적 항체 및 그의 용도
US9828422B2 (en) * 2013-07-29 2017-11-28 Samsung Electronics Co., Ltd. Anti-Ang2 antibody
KR102196450B1 (ko) * 2013-09-17 2020-12-30 삼성전자주식회사 Tie2와 결합을 유도하는 항 Ang2 항체를 포함하는 항암제
KR102206029B1 (ko) 2014-01-27 2021-01-20 삼성전자주식회사 Ang-2에 특이적으로 결합하는 항체 및 그의 용도
RU2016147521A (ru) * 2014-05-07 2018-06-09 МЕДИММЬЮН, ЭлЭлСи Способы применения антител к ang2
AR100270A1 (es) 2014-05-19 2016-09-21 Lilly Co Eli Anticuerpos ang2
AU2015331602A1 (en) 2014-10-17 2017-04-27 Amgen Inc. Antibodies directed to angiopoietin-1 and angiopoietin-2 for ocular therapies
EP3383435A4 (en) 2015-11-30 2019-07-10 Medimmune, LLC OPTIMIZED RATES OF AMINO ACIDS AND SUGARS AS AMORPHOUS STABILIZING COMPOUNDS IN PHARMACEUTICAL COMPOSITIONS HAVING HIGH CONCENTRATIONS IN PROTEIN-BASED THERAPEUTICS
US10836819B2 (en) 2016-08-23 2020-11-17 Medimmune Limited Anti-VEGF-A and anti-ANG2 antibodies and uses thereof
WO2018093591A1 (en) 2016-11-03 2018-05-24 Juno Therapeutics, Inc. Combination therapy of a cell based therapy and a microglia inhibitor
WO2018114728A1 (en) 2016-12-20 2018-06-28 F. Hoffmann-La Roche Ag Combination therapy with a bispecific anti-ang2/vegf antibody and a bispecific anti-her2 antibody
KR102589422B1 (ko) * 2017-01-09 2023-10-13 바이오뮤넥스 파마슈티컬스 다중특이적 항체를 제조하기 위한 폴리펩티드 링커
AU2018275894B2 (en) 2017-06-02 2025-04-24 Juno Therapeutics, Inc. Articles of manufacture and methods for treatment using adoptive cell therapy
MA48781A (fr) 2017-06-02 2020-04-08 Juno Therapeutics Inc Articles de fabrication et procédés liés à la toxicité associée à la thérapie cellulaire
JP2020526194A (ja) 2017-06-29 2020-08-31 ジュノー セラピューティクス インコーポレイテッド 免疫療法薬と関連する毒性を評価するためのマウスモデル
WO2019046832A1 (en) 2017-09-01 2019-03-07 Juno Therapeutics, Inc. GENE EXPRESSION AND EVALUATION OF RISK OF DEVELOPMENT OF TOXICITY FOLLOWING CELL THERAPY
US11564946B2 (en) 2017-11-01 2023-01-31 Juno Therapeutics, Inc. Methods associated with tumor burden for assessing response to a cell therapy
MY195550A (en) 2018-10-29 2023-01-31 Hoffmann La Roche Antibody Formulation
PT3886875T (pt) 2018-11-30 2024-06-27 Juno Therapeutics Inc Métodos para tratamento utilizando terapia celular adotiva
CN113692285A (zh) 2018-11-30 2021-11-23 朱诺治疗学股份有限公司 在过继细胞疗法中给药和治疗b细胞恶性肿瘤的方法
TWI877179B (zh) * 2019-06-27 2025-03-21 德商百靈佳殷格翰國際股份有限公司 抗-angpt2抗體
MX2022006715A (es) 2019-12-06 2022-09-23 Juno Therapeutics Inc Metodos relacionados con toxicidad y respuesta asociada con terapia celular para tratar neoplasias malignas de celulas b.
CN113087696A (zh) * 2019-12-23 2021-07-09 江苏开元药业有限公司 喹啉类化合物及其应用
WO2021236658A1 (en) 2020-05-19 2021-11-25 Boehringer Ingelheim International Gmbh Binding molecules for the treatment of cancer
US20230312698A1 (en) * 2020-08-07 2023-10-05 Nanjing GenScript Biotech Co., Ltd. Antibodies against human angiopoietin-2 and uses thereof
WO2024077286A2 (en) * 2022-10-07 2024-04-11 The Regents Of The University Of California Compositions and methods for detection and treatment of prostate cancer

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5814464A (en) 1994-10-07 1998-09-29 Regeneron Pharma Nucleic acids encoding TIE-2 ligand-2
US5650490A (en) 1994-10-07 1997-07-22 Regeneron Pharmaceuticals, Inc. Tie-2 ligand 2
JP4122056B2 (ja) 1995-04-06 2008-07-23 リジエネロン ファーマシューティカルズ,インコーポレイテッド Tie−2リガンド、その作製方法および使用方法
RU2242514C2 (ru) * 1996-07-02 2004-12-20 Ридженерон Фармасьютикалз, Инк. Изолированный tie-лиганд-4 и его изолированный фибриногеноподобный домен; изолированная молекула нуклеиновой кислоты, кодирующая указанный лиганд; вектор, содержащий указанную нуклеиновую кислоту; способ получения клетки-хозяина, трансформированной указанным вектором; способ получения tie-лиганда-4; конъюгат, содержащий указанный лиганд; лиганд-тело, содержащее указанный фибриногеноподобный домен
US6455035B1 (en) 1999-03-26 2002-09-24 Regeneron Pharmaceuticals, Inc. Angiopoietins and methods of use thereof
ATE241380T1 (de) 1999-03-26 2003-06-15 Regeneron Pharma Modulierung der gefässepermeabilität mittels tie2 rezeptoraktivatoren
US6521424B2 (en) 1999-06-07 2003-02-18 Immunex Corporation Recombinant expression of Tek antagonists
ATE324444T1 (de) 1999-06-07 2006-05-15 Immunex Corp Tek-antagonisten
US6808902B1 (en) * 1999-11-12 2004-10-26 Amgen Inc. Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
US7642278B2 (en) * 2001-07-03 2010-01-05 Novartis Vaccines And Diagnostics, Inc. Indazole benzimidazole compounds
US7658924B2 (en) * 2001-10-11 2010-02-09 Amgen Inc. Angiopoietin-2 specific binding agents
US7521053B2 (en) * 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
US7205275B2 (en) 2001-10-11 2007-04-17 Amgen Inc. Methods of treatment using specific binding agents of human angiopoietin-2
US7485297B2 (en) 2003-08-12 2009-02-03 Dyax Corp. Method of inhibition of vascular development using an antibody
ZA200705695B (en) * 2004-12-21 2009-02-25 Astrazeneca Ab Antibodies directed to angiopoietin-2 and uses thereof
NZ566774A (en) * 2005-09-07 2011-11-25 Pfizer Human monoclonal antibodies to activin receptor-like kinase-1
US20070136096A1 (en) 2005-12-12 2007-06-14 Okalebo Lorna I Systems and methods for maintaining and accessing medical information
EP1962903B1 (en) * 2005-12-15 2013-03-13 MedImmune Limited Combination of angiopoietin-2 antagonist and of vegf-a, kdr and/or fltl antagonist for treating cancer
CA2646508A1 (en) * 2006-03-17 2007-09-27 Biogen Idec Ma Inc. Stabilized polypeptide compositions
TW200812616A (en) * 2006-05-09 2008-03-16 Genentech Inc Binding polypeptides with optimized scaffolds
JP5220131B2 (ja) 2008-01-28 2013-06-26 リサーチ イン モーション リミテッド セッション開始プロトコルのリクエストコンテンツを提供する方法およびシステム
MX2010008099A (es) * 2008-01-28 2010-08-04 Medimmune Ltd Anticuerpos y angiopoyetina-2 estabilizados y sus usos.
JO3182B1 (ar) 2009-07-29 2018-03-08 Regeneron Pharma مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2

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