JP2016531563A5 - - Google Patents
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- Publication number
- JP2016531563A5 JP2016531563A5 JP2016525279A JP2016525279A JP2016531563A5 JP 2016531563 A5 JP2016531563 A5 JP 2016531563A5 JP 2016525279 A JP2016525279 A JP 2016525279A JP 2016525279 A JP2016525279 A JP 2016525279A JP 2016531563 A5 JP2016531563 A5 JP 2016531563A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- liver
- hcc
- medicament
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 6
- 235000019152 folic acid Nutrition 0.000 description 5
- 239000011724 folic acid Substances 0.000 description 4
- OVRNDRQMDRJTHS-CBQIKETKSA-N N-Acetyl-D-Galactosamine Chemical compound CC(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-CBQIKETKSA-N 0.000 description 2
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 2
- MBLBDJOUHNCFQT-UHFFFAOYSA-N N-acetyl-D-galactosamine Natural products CC(=O)NC(C=O)C(O)C(O)C(O)CO MBLBDJOUHNCFQT-UHFFFAOYSA-N 0.000 description 2
- 229940014144 folate Drugs 0.000 description 2
- 229960000304 folic acid Drugs 0.000 description 2
- -1 glucose and mannose Chemical class 0.000 description 2
- 108091023037 Aptamer Proteins 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 150000002224 folic acids Chemical class 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000010299 hexamethylene tetramine Nutrition 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20130080579A KR20150006742A (ko) | 2013-07-09 | 2013-07-09 | 간암 연관 유전자 특이적 siRNA, 그러한 siRNA를 포함하는 이중나선 올리고 RNA 구조체 및 이를 포함하는 암 예방 또는 치료용 조성물 |
| KR10-2013-0080579 | 2013-07-09 | ||
| PCT/KR2014/006145 WO2015005669A1 (en) | 2013-07-09 | 2014-07-09 | LIVER CANCER RELATED GENES-SPECIFIC siRNA, DOUBLE-STRANDED OLIGO RNA MOLECULES COMPRISING THE siRNA, AND COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING THE SAME |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016531563A JP2016531563A (ja) | 2016-10-13 |
| JP2016531563A5 true JP2016531563A5 (https=) | 2016-12-01 |
Family
ID=52280271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016525279A Withdrawn JP2016531563A (ja) | 2013-07-09 | 2014-07-09 | 肝臓癌関連遺伝子特異的ｓｉＲＮＡ、そのようなｓｉＲＮＡを含む二重らせんオリゴＲＮＡ構造体及びこれを含む癌予防または治療用組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20160168573A1 (https=) |
| EP (1) | EP3019611A4 (https=) |
| JP (1) | JP2016531563A (https=) |
| KR (1) | KR20150006742A (https=) |
| CN (1) | CN105765069A (https=) |
| SG (1) | SG11201600076WA (https=) |
| WO (1) | WO2015005669A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2018306411B2 (en) | 2017-07-28 | 2022-03-31 | Lemonex Inc. | Pharmaceutical composition for preventing or treating liver cancer |
| CN110964816A (zh) * | 2019-11-20 | 2020-04-07 | 深圳市鲲鹏未来科技有限公司 | 包含血液稳定性纳米颗粒的溶液、其制备方法及miRNA标志物的检测方法 |
| CN111189808B (zh) * | 2019-12-25 | 2022-12-06 | 宁夏医科大学总医院 | 与肝脏损伤、肝细胞凋亡相关特异蛋白分子标志物筛选方法 |
| CN111596059A (zh) * | 2020-05-19 | 2020-08-28 | 上海长海医院 | Gankyrin蛋白作为新型分子标志物在前列腺癌预后评估中的应用 |
| WO2023013818A1 (ko) * | 2021-08-06 | 2023-02-09 | 주식회사 네오나 | 변형된 rt-let7을 유효성분으로 포함하는 간암의 예방 또는 치료용 조성물 |
| KR102329524B1 (ko) * | 2021-08-06 | 2021-11-23 | 주식회사 네오나 | 변형된 rt-let7을 유효성분으로 포함하는 간암의 예방 또는 치료용 조성물 |
| KR20250075673A (ko) * | 2022-09-28 | 2025-05-28 | 오하이오 스테이트 이노베이션 파운데이션 | 암 전이 치료를 위한 rna 복합체 및 나노 구조 |
| CN117281792A (zh) * | 2023-07-25 | 2023-12-26 | 浙江大学 | 一种用于增强肝癌免疫疗法治疗效果的纳米制剂 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE209887T1 (de) * | 1993-04-02 | 2001-12-15 | Anticancer Inc | Verfahren zur verabreichung von förderlichen zusammensetzungen auf die haarfollikel |
| EP2305812A3 (en) * | 2002-11-14 | 2012-06-06 | Dharmacon, Inc. | Fuctional and hyperfunctional sirna |
| WO2006006948A2 (en) * | 2002-11-14 | 2006-01-19 | Dharmacon, Inc. | METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY |
| AU2005292083A1 (en) * | 2004-09-29 | 2006-04-13 | Alza Corporation | Microparticles and nanoparticles containing a lipopolymer |
| WO2008087643A2 (en) * | 2007-01-16 | 2008-07-24 | Proteologics Ltd | Methods for enhancing the therapeutic efficacy of topoisomerase inhibitors |
| KR101224828B1 (ko) * | 2009-05-14 | 2013-01-22 | (주)바이오니아 | ｓｉＲＮＡ 접합체 및 그 제조방법 |
| JP2012503494A (ja) * | 2009-11-06 | 2012-02-09 | チュン−アン ユニバーシティ インダストリー−アカデミー コーオペレイション ファンデイション | ナノ粒子を含む遺伝子運搬体 |
| CA2859127C (en) * | 2011-12-15 | 2017-04-25 | Bioneer Corporation | Novel oligonucleotide conjugates and use thereof |
-
2013
- 2013-07-09 KR KR20130080579A patent/KR20150006742A/ko not_active Withdrawn
-
2014
- 2014-07-09 EP EP14822311.8A patent/EP3019611A4/en not_active Withdrawn
- 2014-07-09 WO PCT/KR2014/006145 patent/WO2015005669A1/en not_active Ceased
- 2014-07-09 JP JP2016525279A patent/JP2016531563A/ja not_active Withdrawn
- 2014-07-09 SG SG11201600076WA patent/SG11201600076WA/en unknown
- 2014-07-09 CN CN201480048986.8A patent/CN105765069A/zh active Pending
- 2014-07-09 US US14/902,808 patent/US20160168573A1/en not_active Abandoned
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