CN105765069A - 肝癌相关的基因特异性siRNA、包含所述siRNA的双链寡RNA分子和包含它们的用于预防或治疗癌症的组合物 - Google Patents

肝癌相关的基因特异性siRNA、包含所述siRNA的双链寡RNA分子和包含它们的用于预防或治疗癌症的组合物 Download PDF

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Publication number
CN105765069A
CN105765069A CN201480048986.8A CN201480048986A CN105765069A CN 105765069 A CN105765069 A CN 105765069A CN 201480048986 A CN201480048986 A CN 201480048986A CN 105765069 A CN105765069 A CN 105765069A
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CN
China
Prior art keywords
sirna
double
strand
cancer
bmi
Prior art date
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Pending
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CN201480048986.8A
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English (en)
Chinese (zh)
Inventor
蔡济旭
朴翰浯
尹坪伍
韩宝兰
金翰娜
尹成
尹成一
朴俊泓
高映浩
磪基恩
程俊顺
金宰恩
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioneer Corp
Sanofi Aventis Korea Co Ltd
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Bioneer Corp
Sanofi Aventis Korea Co Ltd
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Publication of CN105765069A publication Critical patent/CN105765069A/zh
Pending legal-status Critical Current

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201480048986.8A 2013-07-09 2014-07-09 肝癌相关的基因特异性siRNA、包含所述siRNA的双链寡RNA分子和包含它们的用于预防或治疗癌症的组合物 Pending CN105765069A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20130080579A KR20150006742A (ko) 2013-07-09 2013-07-09 간암 연관 유전자 특이적 siRNA, 그러한 siRNA를 포함하는 이중나선 올리고 RNA 구조체 및 이를 포함하는 암 예방 또는 치료용 조성물
KR10-2013-0080579 2013-07-09
PCT/KR2014/006145 WO2015005669A1 (en) 2013-07-09 2014-07-09 LIVER CANCER RELATED GENES-SPECIFIC siRNA, DOUBLE-STRANDED OLIGO RNA MOLECULES COMPRISING THE siRNA, AND COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING THE SAME

Publications (1)

Publication Number Publication Date
CN105765069A true CN105765069A (zh) 2016-07-13

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CN201480048986.8A Pending CN105765069A (zh) 2013-07-09 2014-07-09 肝癌相关的基因特异性siRNA、包含所述siRNA的双链寡RNA分子和包含它们的用于预防或治疗癌症的组合物

Country Status (7)

Country Link
US (1) US20160168573A1 (https=)
EP (1) EP3019611A4 (https=)
JP (1) JP2016531563A (https=)
KR (1) KR20150006742A (https=)
CN (1) CN105765069A (https=)
SG (1) SG11201600076WA (https=)
WO (1) WO2015005669A1 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111132682A (zh) * 2017-07-28 2020-05-08 雷莫内克斯生物制药有限公司 用于预防或治疗肝癌的药物组合物
CN111189808A (zh) * 2019-12-25 2020-05-22 宁夏医科大学总医院 与肝脏损伤、肝细胞凋亡相关特异蛋白分子标志物筛选方法
CN111596059A (zh) * 2020-05-19 2020-08-28 上海长海医院 Gankyrin蛋白作为新型分子标志物在前列腺癌预后评估中的应用
CN117281792A (zh) * 2023-07-25 2023-12-26 浙江大学 一种用于增强肝癌免疫疗法治疗效果的纳米制剂

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110964816A (zh) * 2019-11-20 2020-04-07 深圳市鲲鹏未来科技有限公司 包含血液稳定性纳米颗粒的溶液、其制备方法及miRNA标志物的检测方法
WO2023013818A1 (ko) * 2021-08-06 2023-02-09 주식회사 네오나 변형된 rt-let7을 유효성분으로 포함하는 간암의 예방 또는 치료용 조성물
KR102329524B1 (ko) * 2021-08-06 2021-11-23 주식회사 네오나 변형된 rt-let7을 유효성분으로 포함하는 간암의 예방 또는 치료용 조성물
KR20250075673A (ko) * 2022-09-28 2025-05-28 오하이오 스테이트 이노베이션 파운데이션 암 전이 치료를 위한 rna 복합체 및 나노 구조

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ATE209887T1 (de) * 1993-04-02 2001-12-15 Anticancer Inc Verfahren zur verabreichung von förderlichen zusammensetzungen auf die haarfollikel
EP2305812A3 (en) * 2002-11-14 2012-06-06 Dharmacon, Inc. Fuctional and hyperfunctional sirna
WO2006006948A2 (en) * 2002-11-14 2006-01-19 Dharmacon, Inc. METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY
AU2005292083A1 (en) * 2004-09-29 2006-04-13 Alza Corporation Microparticles and nanoparticles containing a lipopolymer
WO2008087643A2 (en) * 2007-01-16 2008-07-24 Proteologics Ltd Methods for enhancing the therapeutic efficacy of topoisomerase inhibitors
KR101224828B1 (ko) * 2009-05-14 2013-01-22 (주)바이오니아 ｓｉＲＮＡ 접합체 및 그 제조방법
JP2012503494A (ja) * 2009-11-06 2012-02-09 チュン−アン ユニバーシティ インダストリー−アカデミー コーオペレイション ファンデイション ナノ粒子を含む遺伝子運搬体
CA2859127C (en) * 2011-12-15 2017-04-25 Bioneer Corporation Novel oligonucleotide conjugates and use thereof

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111132682A (zh) * 2017-07-28 2020-05-08 雷莫内克斯生物制药有限公司 用于预防或治疗肝癌的药物组合物
CN116236501A (zh) * 2017-07-28 2023-06-09 雷莫内克斯生物制药有限公司 用于预防或治疗肝癌的药物组合物
CN111132682B (zh) * 2017-07-28 2024-04-26 雷莫内克斯生物制药有限公司 用于预防或治疗肝癌的药物组合物
US12076336B2 (en) 2017-07-28 2024-09-03 Lemonex Inc. Pharmaceutical composition for preventing or treating liver cancer
CN111189808A (zh) * 2019-12-25 2020-05-22 宁夏医科大学总医院 与肝脏损伤、肝细胞凋亡相关特异蛋白分子标志物筛选方法
CN111189808B (zh) * 2019-12-25 2022-12-06 宁夏医科大学总医院 与肝脏损伤、肝细胞凋亡相关特异蛋白分子标志物筛选方法
CN111596059A (zh) * 2020-05-19 2020-08-28 上海长海医院 Gankyrin蛋白作为新型分子标志物在前列腺癌预后评估中的应用
CN117281792A (zh) * 2023-07-25 2023-12-26 浙江大学 一种用于增强肝癌免疫疗法治疗效果的纳米制剂

Also Published As

Publication number Publication date
SG11201600076WA (en) 2016-02-26
EP3019611A1 (en) 2016-05-18
KR20150006742A (ko) 2015-01-19
JP2016531563A (ja) 2016-10-13
US20160168573A1 (en) 2016-06-16
EP3019611A4 (en) 2017-06-14
WO2015005669A1 (en) 2015-01-15

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Application publication date: 20160713