JP2011510632A5 - - Google Patents

Info

Publication number

JP2011510632A5

JP2011510632A5 JP2010544476A JP2010544476A JP2011510632A5 JP 2011510632 A5 JP2011510632 A5 JP 2011510632A5 JP 2010544476 A JP2010544476 A JP 2010544476A JP 2010544476 A JP2010544476 A JP 2010544476A JP 2011510632 A5 JP2011510632 A5 JP 2011510632A5

Authority

JP

Japan

Prior art keywords

seq

antibody

cancer

chain variable

variable region

Prior art date

2009-01-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000000203 mixture Substances 0.000 claims 9
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
• 206010003246 arthritis Diseases 0.000 claims 3
• 239000000546 pharmaceutical excipient Substances 0.000 claims 3
• 206010009944 Colon cancer Diseases 0.000 claims 2
• 206010028980 Neoplasm Diseases 0.000 claims 2
• 238000004220 aggregation Methods 0.000 claims 2
• 230000002776 aggregation Effects 0.000 claims 2
• 230000033115 angiogenesis Effects 0.000 claims 2
• 230000003110 anti-inflammatory effect Effects 0.000 claims 2
• 201000011510 cancer Diseases 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
• 102000009075 Angiopoietin-2 Human genes 0.000 claims 1
• 108010048036 Angiopoietin-2 Proteins 0.000 claims 1
• 208000036487 Arthropathies Diseases 0.000 claims 1
• 208000003174 Brain Neoplasms Diseases 0.000 claims 1
• 206010006187 Breast cancer Diseases 0.000 claims 1
• 208000026310 Breast neoplasm Diseases 0.000 claims 1
• 206010008342 Cervix carcinoma Diseases 0.000 claims 1
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
• 206010014733 Endometrial cancer Diseases 0.000 claims 1
• 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
• 208000032612 Glial tumor Diseases 0.000 claims 1
• 206010018338 Glioma Diseases 0.000 claims 1
• 208000012659 Joint disease Diseases 0.000 claims 1
• 206010033128 Ovarian cancer Diseases 0.000 claims 1
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
• 206010060862 Prostate cancer Diseases 0.000 claims 1
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
• 206010062164 Seronegative arthritis Diseases 0.000 claims 1
• 206010041067 Small cell lung cancer Diseases 0.000 claims 1
• 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
• 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
• 206010057644 Testis cancer Diseases 0.000 claims 1
• 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
• 239000005557 antagonist Substances 0.000 claims 1
• 239000012830 cancer therapeutic Substances 0.000 claims 1
• 201000007455 central nervous system cancer Diseases 0.000 claims 1
• 201000010881 cervical cancer Diseases 0.000 claims 1
• 208000029742 colonic neoplasm Diseases 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 206010017758 gastric cancer Diseases 0.000 claims 1
• 208000005017 glioblastoma Diseases 0.000 claims 1
• 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
• 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
• 201000007270 liver cancer Diseases 0.000 claims 1
• 208000014018 liver neoplasm Diseases 0.000 claims 1
• 210000004072 lung Anatomy 0.000 claims 1
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
• 201000001441 melanoma Diseases 0.000 claims 1
• 230000008018 melting Effects 0.000 claims 1
• 238000002844 melting Methods 0.000 claims 1
• 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
• 150000007523 nucleic acids Chemical class 0.000 claims 1
• 102000039446 nucleic acids Human genes 0.000 claims 1
• 108020004707 nucleic acids Proteins 0.000 claims 1
• 201000008482 osteoarthritis Diseases 0.000 claims 1
• 201000002528 pancreatic cancer Diseases 0.000 claims 1
• 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
• 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
• 201000011549 stomach cancer Diseases 0.000 claims 1
• 201000003120 testicular cancer Diseases 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1
• 201000002510 thyroid cancer Diseases 0.000 claims 1
• 230000005747 tumor angiogenesis Effects 0.000 claims 1
• 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1